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Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital

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Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital

Auteurs : Zaid H. Baqain ; Faleh A. Sawair ; Zaid Tamimi ; Nazzal Bsoul ; Ghazi Al Edwan ; Jamal K. Almasad ; Abdalla A. Abbadi

Source :

Annals of The Royal College of Surgeons of England [ 0035-8843 ] ; 2010.

RBID : PMC:3182791

Abstract

INTRODUCTION

We describe our experience with oncology patients on a frequent dosing schedule of intravenous (i.v.) bisphosphonates at the Jordan University Hospital (JUH).

PATIENTS AND METHODS

Patients treated by i.v. bisphosphonates in the medical oncology unit at the JUH were examined for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Diagnosis was made according to the guidelines of the American Association of Oral and Maxillofacial Surgeons (AAOMS) original position paper.

RESULTS

Of the 41 patients, four developed BRONJ, two in maxilla, one in mandible and one bimaxillary. Patients with BRONJ were older; mean age was 69.3 ±3.1 years compared to 62.8 ± 12.5 years (P = 0.022). Dental co-morbidities were more commonly present in patients with the disease (P = 0.038). Patients who developed BRONJ were on treatment for a longer duration of time; the mean duration of treatment was 23.5 ± 8.4 months compared to 11.9 ± 13.4 months (P = 0.10).

CONCLUSIONS

The results of this case series demonstrated that age and poor oral health status are significant risk factors of BRONJ for oncology patients on long-term frequent dosing schedule of i.v. bisphosphonates.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182791

DOI: 10.1308/003588410X12699663903395
PubMed: 20522306
PubMed Central: 3182791

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PMC:3182791

Le document en format XML

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<author><name sortKey="Baqain, Zaid H" sort="Baqain, Zaid H" uniqKey="Baqain Z" first="Zaid H" last="Baqain">Zaid H. Baqain</name>
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<author><name sortKey="Sawair, Faleh A" sort="Sawair, Faleh A" uniqKey="Sawair F" first="Faleh A" last="Sawair">Faleh A. Sawair</name>
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<front><div type="abstract" xml:lang="en"><sec><title>INTRODUCTION</title>
<p>We describe our experience with oncology patients on a frequent dosing schedule of intravenous (i.v.) bisphosphonates at the Jordan University Hospital (JUH).</p>
</sec>
<sec><title>PATIENTS AND METHODS</title>
<p>Patients treated by i.v. bisphosphonates in the medical oncology unit at the JUH were examined for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Diagnosis was made according to the guidelines of the American Association of Oral and Maxillofacial Surgeons (AAOMS) original position paper.</p>
</sec>
<sec><title>RESULTS</title>
<p>Of the 41 patients, four developed BRONJ, two in maxilla, one in mandible and one bimaxillary. Patients with BRONJ were older; mean age was 69.3 ±3.1 years compared to 62.8 ± 12.5 years (<italic>P</italic>
 = 0.022). Dental co-morbidities were more commonly present in patients with the disease (P = 0.038). Patients who developed BRONJ were on treatment for a longer duration of time; the mean duration of treatment was 23.5 ± 8.4 months compared to 11.9 ± 13.4 months (<italic>P</italic>
 = 0.10).</p>
</sec>
<sec><title>CONCLUSIONS</title>
<p>The results of this case series demonstrated that age and poor oral health status are significant risk factors of BRONJ for oncology patients on long-term frequent dosing schedule of i.v. bisphosphonates.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Ann R Coll Surg Engl</journal-id>
<journal-id journal-id-type="publisher-id">rcse</journal-id>
<journal-title-group><journal-title>Annals of The Royal College of Surgeons of England</journal-title>
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<issn pub-type="ppub">0035-8843</issn>
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<article-id pub-id-type="doi">10.1308/003588410X12699663903395</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Maxillofacial Surgery</subject>
</subj-group>
</article-categories>
<title-group><article-title>Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Baqain</surname>
<given-names>Zaid H</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
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<contrib contrib-type="author"><name><surname>Sawair</surname>
<given-names>Faleh A</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tamimi</surname>
<given-names>Zaid</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
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<contrib contrib-type="author"><name><surname>Bsoul</surname>
<given-names>Nazzal</given-names>
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<xref ref-type="aff" rid="au2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Al Edwan</surname>
<given-names>Ghazi</given-names>
</name>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Almasad</surname>
<given-names>Jamal K</given-names>
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<xref ref-type="aff" rid="au4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abbadi</surname>
<given-names>Abdalla A</given-names>
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<aff id="au1"><label>1</label>
<institution>Department of Oral and Maxillofacial Surgery, Oral Medicine and Periodontology, Faculty of Dentistry, University of Jordan</institution>
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<aff id="au2"><label>2</label>
<institution>Department of Internal Medicine, Faculty of Medicine, University of Jordan</institution>
<addr-line>Jordan</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>Department of Special Surgery, Faculty of Medicine, University of Jordan</institution>
<addr-line>Jordan</addr-line>
</aff>
<aff id="au4"><label>4</label>
<institution>Department of General Surgery, Faculty of Medicine, University of Jordan</institution>
<addr-line>Jordan</addr-line>
</aff>
</contrib-group>
<author-notes><corresp><bold>CORRESPONDENCE TO Zaid H Baqain</bold>
, PO Box 13930, Amman 11942, Jordan T: +962 79 5609063; E: <email>zbaqain@ju.edu.jo</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>01</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2010</year>
</pub-date>
<volume>92</volume>
<issue>6</issue>
<fpage>489</fpage>
<lpage>494</lpage>
<history><date date-type="accepted"><day>01</day>
<month>4</month>
<year>2010</year>
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</history>
<permissions><copyright-statement>Copyright © 2010 by the Annals of The Royal College of Surgeons of England</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><sec><title>INTRODUCTION</title>
<p>We describe our experience with oncology patients on a frequent dosing schedule of intravenous (i.v.) bisphosphonates at the Jordan University Hospital (JUH).</p>
</sec>
<sec><title>PATIENTS AND METHODS</title>
<p>Patients treated by i.v. bisphosphonates in the medical oncology unit at the JUH were examined for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Diagnosis was made according to the guidelines of the American Association of Oral and Maxillofacial Surgeons (AAOMS) original position paper.</p>
</sec>
<sec><title>RESULTS</title>
<p>Of the 41 patients, four developed BRONJ, two in maxilla, one in mandible and one bimaxillary. Patients with BRONJ were older; mean age was 69.3 ±3.1 years compared to 62.8 ± 12.5 years (<italic>P</italic>
 = 0.022). Dental co-morbidities were more commonly present in patients with the disease (P = 0.038). Patients who developed BRONJ were on treatment for a longer duration of time; the mean duration of treatment was 23.5 ± 8.4 months compared to 11.9 ± 13.4 months (<italic>P</italic>
 = 0.10).</p>
</sec>
<sec><title>CONCLUSIONS</title>
<p>The results of this case series demonstrated that age and poor oral health status are significant risk factors of BRONJ for oncology patients on long-term frequent dosing schedule of i.v. bisphosphonates.</p>
</sec>
</abstract>
<kwd-group><kwd>Bisphosphonates</kwd>
<kwd>Osteonecrosis of jaw</kwd>
<kwd>Chemotherapy</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Abbadi, Abdalla A" sort="Abbadi, Abdalla A" uniqKey="Abbadi A" first="Abdalla A" last="Abbadi">Abdalla A. Abbadi</name>
<name sortKey="Al Edwan, Ghazi" sort="Al Edwan, Ghazi" uniqKey="Al Edwan G" first="Ghazi" last="Al Edwan">Ghazi Al Edwan</name>
<name sortKey="Almasad, Jamal K" sort="Almasad, Jamal K" uniqKey="Almasad J" first="Jamal K" last="Almasad">Jamal K. Almasad</name>
<name sortKey="Baqain, Zaid H" sort="Baqain, Zaid H" uniqKey="Baqain Z" first="Zaid H" last="Baqain">Zaid H. Baqain</name>
<name sortKey="Bsoul, Nazzal" sort="Bsoul, Nazzal" uniqKey="Bsoul N" first="Nazzal" last="Bsoul">Nazzal Bsoul</name>
<name sortKey="Sawair, Faleh A" sort="Sawair, Faleh A" uniqKey="Sawair F" first="Faleh A" last="Sawair">Faleh A. Sawair</name>
<name sortKey="Tamimi, Zaid" sort="Tamimi, Zaid" uniqKey="Tamimi Z" first="Zaid" last="Tamimi">Zaid Tamimi</name>
</noCountry>
</tree>
</affiliations>
</record>

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Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital

Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital

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