New phosphated poly(methyl methacrylate) polymers for the prevention of denture-induced microbial infection: an in vitro study
Identifieur interne : 004110 ( Main/Exploration ); précédent : 004109; suivant : 004111New phosphated poly(methyl methacrylate) polymers for the prevention of denture-induced microbial infection: an in vitro study
Auteurs : Periathamby Antony Raj [États-Unis] ; Andrew R. Dentino [États-Unis]Source :
- Clinical, Cosmetic and Investigational Dentistry [ 1179-1357 ] ; 2011.
Abstract
Poly(methyl methacrylate) (PMMA) has been widely used as a denture-base acrylic resin due to its excellent physical and mechanical properties. However, the material is highly prone to microbial fouling that often leads to
Six PMMA polymers containing 0%, 5%, 15%, 10%, 20%, and 25% of phosphate group were synthesized by bead (suspension) polymerization technique using mixtures of methyl methacrylate and methallyl phosphate as monomers. The efficacy of the polymers to inhibit the adherence of
The presence of ≥15% phosphate content in PMMA significantly reduced the saliva-mediated adhesion of
Phosphated PMMA polymers have the potential to serve as novel denture-base resins, which may reduce
Url:
DOI: 10.2147/CCIDEN.S16860
PubMed: 23674911
PubMed Central: 3652354
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New phosphated poly(methyl methacrylate) polymers for the prevention of denture-induced microbial infection: an in vitro study</title><author><name sortKey="Raj, Periathamby Antony" sort="Raj, Periathamby Antony" uniqKey="Raj P" first="Periathamby Antony" last="Raj">Periathamby Antony Raj</name><affiliation wicri:level="2"><nlm:aff id="af1-ccide-3-025">Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Dentino, Andrew R" sort="Dentino, Andrew R" uniqKey="Dentino A" first="Andrew R" last="Dentino">Andrew R. Dentino</name><affiliation wicri:level="2"><nlm:aff id="af1-ccide-3-025">Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-ccide-3-025">Division of Periodontics, Department of Surgical Sciences, Marquette University, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Periodontics, Department of Surgical Sciences, Marquette University, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23674911</idno><idno type="pmc">3652354</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652354</idno><idno type="RBID">PMC:3652354</idno><idno type="doi">10.2147/CCIDEN.S16860</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002A98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A98</idno><idno type="wicri:Area/Pmc/Curation">002A98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A98</idno><idno type="wicri:Area/Pmc/Checkpoint">002131</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002131</idno><idno type="wicri:Area/Ncbi/Merge">004680</idno><idno type="wicri:Area/Ncbi/Curation">004680</idno><idno type="wicri:Area/Ncbi/Checkpoint">004680</idno><idno type="wicri:Area/Main/Merge">004135</idno><idno type="wicri:Area/Main/Curation">004110</idno><idno type="wicri:Area/Main/Exploration">004110</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New phosphated poly(methyl methacrylate) polymers for the prevention of denture-induced microbial infection: an in vitro study</title><author><name sortKey="Raj, Periathamby Antony" sort="Raj, Periathamby Antony" uniqKey="Raj P" first="Periathamby Antony" last="Raj">Periathamby Antony Raj</name><affiliation wicri:level="2"><nlm:aff id="af1-ccide-3-025">Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Dentino, Andrew R" sort="Dentino, Andrew R" uniqKey="Dentino A" first="Andrew R" last="Dentino">Andrew R. Dentino</name><affiliation wicri:level="2"><nlm:aff id="af1-ccide-3-025">Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research and Development, Perident Therapeutics, Inc, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-ccide-3-025">Division of Periodontics, Department of Surgical Sciences, Marquette University, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Periodontics, Department of Surgical Sciences, Marquette University, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j">Clinical, Cosmetic and Investigational Dentistry</title><idno type="eISSN">1179-1357</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Poly(methyl methacrylate) (PMMA) has been widely used as a denture-base acrylic resin due to its excellent physical and mechanical properties. However, the material is highly prone to microbial fouling that often leads to <italic>Candida</italic>-associated denture stomatitis. Incorporation of phosphate groups into PMMA could facilitate adsorption of salivary antimicrobials and inhibit microbial adherence on the polymer surface. An in vitro study evaluated PMMA polymers containing varying amounts of phosphate group for their efficacy to inhibit <italic>Candida albicans</italic> adhesion, adsorb salivary histatin 5, and exhibit candidacidal activity.</p></sec><sec><title>Methods</title><p>Six PMMA polymers containing 0%, 5%, 15%, 10%, 20%, and 25% of phosphate group were synthesized by bead (suspension) polymerization technique using mixtures of methyl methacrylate and methallyl phosphate as monomers. The efficacy of the polymers to inhibit the adherence of <italic>C. albicans</italic> was examined by using human saliva-coated polymer beads and radio-labeled <italic>C. albicans</italic> cells, as compared with that of PMMA. The potency of the phosphated PMMA polymers to adsorb histatin 5 was determined by measuring the radioactivity of the adsorbed labeled-peptide on the polymer surface. The candidacidal activity of the histatin 5-adsorbed polymers was assessed by using the fluorescence technique. The percent release of the fluorescent probe calcein from the <italic>C. albicans</italic> membrane caused by the disruption of the cell membrane was determined. The data were analyzed statistically by one-way ANOVA followed by Scheffé’s test (α = 0.05 and n = 6).</p></sec><sec><title>Results</title><p>The presence of ≥15% phosphate content in PMMA significantly reduced the saliva-mediated adhesion of <italic>C. albicans</italic>. Phosphated PMMA polymers showed significantly enhanced adsorption of histatin 5 in a phosphate density-dependent manner. The candidacidal activity of the histatin 5-bound polymers increased significantly with the increase in the phosphate content of the polymer.</p></sec><sec><title>Conclusion</title><p>Phosphated PMMA polymers have the potential to serve as novel denture-base resins, which may reduce <italic>C. albicans</italic> colonization and prevent denture stomatitis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Edgerton, M" uniqKey="Edgerton M">M Edgerton</name></author><author><name sortKey="Raj, Pa" uniqKey="Raj P">PA Raj</name></author><author><name sortKey="Levine, Mj" uniqKey="Levine M">MJ Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Se" uniqKey="Park S">SE Park</name></author><author><name sortKey="Periathamby, Ar" uniqKey="Periathamby A">AR Periathamby</name></author><author><name sortKey="Loza, Jc" uniqKey="Loza J">JC 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Dentino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iacopino, Am" uniqKey="Iacopino A">AM Iacopino</name></author><author><name sortKey="Wathen, Wf" uniqKey="Wathen W">WF Wathen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramage, G" uniqKey="Ramage G">G Ramage</name></author><author><name sortKey="Tomsett, K" uniqKey="Tomsett K">K Tomsett</name></author><author><name sortKey="Wickes, Bl" uniqKey="Wickes B">BL Wickes</name></author><author><name sortKey="Lopez Ribot, Jl" uniqKey="Lopez Ribot J">JL Lopez-Ribot</name></author><author><name sortKey="Redding, Sw" uniqKey="Redding S">SW Redding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samaranayake, Lp" uniqKey="Samaranayake L">LP Samaranayake</name></author><author><name sortKey="Leung, Wk" uniqKey="Leung W">WK Leung</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L 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sortKey="Berzins, Dw" uniqKey="Berzins D">DW Berzins</name></author><author><name sortKey="Dhuru, Vb" uniqKey="Dhuru V">VB Dhuru</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Raj, Periathamby Antony" sort="Raj, Periathamby Antony" uniqKey="Raj P" first="Periathamby Antony" last="Raj">Periathamby Antony Raj</name></region><name sortKey="Dentino, Andrew R" sort="Dentino, Andrew R" uniqKey="Dentino A" first="Andrew R" last="Dentino">Andrew R. Dentino</name><name sortKey="Dentino, Andrew R" sort="Dentino, Andrew R" uniqKey="Dentino A" first="Andrew R" last="Dentino">Andrew R. Dentino</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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