Drug Release from Calcium Sulfate-Based Composites
Identifieur interne : 001B40 ( Main/Exploration ); précédent : 001B39; suivant : 001B41Drug Release from Calcium Sulfate-Based Composites
Auteurs : Bryan R. Orellana [États-Unis] ; J. Zach Hilt [États-Unis] ; David A. Puleo [États-Unis]Source :
- Journal of biomedical materials research. Part B, Applied biomaterials [ 1552-4973 ] ; 2014.
Abstract
To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (
Url:
DOI: 10.1002/jbm.b.33181
PubMed: 24788686
PubMed Central: 4302276
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (<italic>i.e.</italic>
, simvastatin), directly loaded hydrophilic protein (<italic>i.e.</italic>
, lysozyme), or 1 and 10 wt% of H6 poly(β-amino ester) (PBAE) particles containing protein. Whereas sustained release of directly loaded simvastatin was achieved, direct loading of small amounts of lysozyme resulted in highly variable release. Direct loading of a larger amount of protein generated a large burst, 65% of total loading, followed by sustained release of protein. Release of lysozyme from 1 wt% PBAE particles embedded into CS was more controllable than when directly loaded, and for 10 wt% of protein-loaded PBAE particles, a higher burst was followed by sustained release, comparable to the results for the high direct loading. Compression testing determined that incorporation of directly loaded drug or drug-loaded PBAE particles weakened CS. In particular, PBAE particles had a significant effect on the strength of the composites, with a 25% and 80% decrease in strength for 1 wt% and 10 wt% particle loadings, respectively. CS-based composites demonstrated the ability to sustainably release both macromolecules and small molecules, supporting the potential for these materials to release a range of therapeutic agents.</p>
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