Drug Release from Calcium Sulfate-Based Composites
Identifieur interne : 005048 ( Ncbi/Merge ); précédent : 005047; suivant : 005049Drug Release from Calcium Sulfate-Based Composites
Auteurs : Bryan R. Orellana [États-Unis] ; J. Zach Hilt [États-Unis] ; David A. Puleo [États-Unis]Source :
- Journal of biomedical materials research. Part B, Applied biomaterials [ 1552-4973 ] ; 2014.
Abstract
To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (
Url:
DOI: 10.1002/jbm.b.33181
PubMed: 24788686
PubMed Central: 4302276
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<front><div type="abstract" xml:lang="en"><p id="P1">To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (<italic>i.e.</italic>
, simvastatin), directly loaded hydrophilic protein (<italic>i.e.</italic>
, lysozyme), or 1 and 10 wt% of H6 poly(β-amino ester) (PBAE) particles containing protein. Whereas sustained release of directly loaded simvastatin was achieved, direct loading of small amounts of lysozyme resulted in highly variable release. Direct loading of a larger amount of protein generated a large burst, 65% of total loading, followed by sustained release of protein. Release of lysozyme from 1 wt% PBAE particles embedded into CS was more controllable than when directly loaded, and for 10 wt% of protein-loaded PBAE particles, a higher burst was followed by sustained release, comparable to the results for the high direct loading. Compression testing determined that incorporation of directly loaded drug or drug-loaded PBAE particles weakened CS. In particular, PBAE particles had a significant effect on the strength of the composites, with a 25% and 80% decrease in strength for 1 wt% and 10 wt% particle loadings, respectively. CS-based composites demonstrated the ability to sustainably release both macromolecules and small molecules, supporting the potential for these materials to release a range of therapeutic agents.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101234238</journal-id>
<journal-id journal-id-type="pubmed-jr-id">32208</journal-id>
<journal-id journal-id-type="nlm-ta">J Biomed Mater Res B Appl Biomater</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Biomed. Mater. Res. Part B Appl. Biomater.</journal-id>
<journal-title-group><journal-title>Journal of biomedical materials research. Part B, Applied biomaterials</journal-title>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Drug Release from Calcium Sulfate-Based Composites</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Orellana</surname>
<given-names>Bryan R.</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Hilt</surname>
<given-names>J. Zach</given-names>
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<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Puleo</surname>
<given-names>David A.</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
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<aff id="A1"><label>1</label>
Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA</aff>
<aff id="A2"><label>2</label>
Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA</aff>
<author-notes><corresp id="cor1"><bold>Corresponding author</bold>
: David Puleo, Ph.D., 209 Wenner-Gren Lab, Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0070, USA, Tel: +1-859-257-2405, Fax: +1-859-257-1856, <email>puleo@uky.edu</email>
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<pub-date pub-type="nihms-submitted"><day>16</day>
<month>1</month>
<year>2015</year>
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<pub-date pub-type="epub"><day>30</day>
<month>4</month>
<year>2014</year>
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<pub-date pub-type="ppub"><month>1</month>
<year>2015</year>
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<pub-date pub-type="pmc-release"><day>01</day>
<month>1</month>
<year>2016</year>
</pub-date>
<volume>103</volume>
<issue>1</issue>
<fpage>135</fpage>
<lpage>142</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/jbm.b.33181</pmc-comment>
<abstract><p id="P1">To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (<italic>i.e.</italic>
, simvastatin), directly loaded hydrophilic protein (<italic>i.e.</italic>
, lysozyme), or 1 and 10 wt% of H6 poly(β-amino ester) (PBAE) particles containing protein. Whereas sustained release of directly loaded simvastatin was achieved, direct loading of small amounts of lysozyme resulted in highly variable release. Direct loading of a larger amount of protein generated a large burst, 65% of total loading, followed by sustained release of protein. Release of lysozyme from 1 wt% PBAE particles embedded into CS was more controllable than when directly loaded, and for 10 wt% of protein-loaded PBAE particles, a higher burst was followed by sustained release, comparable to the results for the high direct loading. Compression testing determined that incorporation of directly loaded drug or drug-loaded PBAE particles weakened CS. In particular, PBAE particles had a significant effect on the strength of the composites, with a 25% and 80% decrease in strength for 1 wt% and 10 wt% particle loadings, respectively. CS-based composites demonstrated the ability to sustainably release both macromolecules and small molecules, supporting the potential for these materials to release a range of therapeutic agents.</p>
</abstract>
<kwd-group><kwd>Calcium sulfate</kwd>
<kwd>drug delivery</kwd>
<kwd>synthetic bone graft</kwd>
<kwd>simvastatin</kwd>
<kwd>lysozyme</kwd>
</kwd-group>
</article-meta>
</front>
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<affiliations><list><country><li>États-Unis</li>
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