Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites
Identifieur interne : 001684 ( Main/Exploration ); précédent : 001683; suivant : 001685Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites
Auteurs : Bryan R. Orellana ; David A. PuleoSource :
- Materials science & engineering. C, Materials for biological applications [ 0928-4931 ] ; 2014.
Abstract
The current standard for treating infected bony defects, such as those caused by periodontal disease, requires multiple time-consuming steps and often multiple procedures to fight the infection and recover lost tissue. Releasing an antibiotic followed by an osteogenic agent from a synthetic bone graft substitute could allow for a streamlined treatment, reducing the need for multiple surgeries and thereby shortening recovery time. Tailorable bilayered calcium sulfate (CS) bone graft substitutes were developed with the ability to sequentially release multiple therapeutic agents. Bilayered composite samples having a shell and core geometry were fabricated with varying amounts (1 or 10 wt%) of metronidazole-loaded poly poly(lactic-co-glycolic acid) (PLGA) particles embedded in the shell and simvastatin directly loaded into either the shell, core, or both. Microcomputed tomography (MicroCT) images showed the overall layered geometry as well as homogenous distribution of PLGA within the shells. Dissolution studies demonstrated that the amount of PLGA particles (
Url:
DOI: 10.1016/j.msec.2014.06.044
PubMed: 25175211
PubMed Central: 4152730
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002651
- to stream Pmc, to step Curation: 002651
- to stream Pmc, to step Checkpoint: 001193
- to stream Ncbi, to step Merge: 005404
- to stream Ncbi, to step Curation: 005404
- to stream Ncbi, to step Checkpoint: 005404
- to stream Main, to step Merge: 001690
- to stream Main, to step Curation: 001684
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites</title>
<author><name sortKey="Orellana, Bryan R" sort="Orellana, Bryan R" uniqKey="Orellana B" first="Bryan R." last="Orellana">Bryan R. Orellana</name>
</author>
<author><name sortKey="Puleo, David A" sort="Puleo, David A" uniqKey="Puleo D" first="David A." last="Puleo">David A. Puleo</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25175211</idno>
<idno type="pmc">4152730</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152730</idno>
<idno type="RBID">PMC:4152730</idno>
<idno type="doi">10.1016/j.msec.2014.06.044</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">002651</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002651</idno>
<idno type="wicri:Area/Pmc/Curation">002651</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002651</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001193</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001193</idno>
<idno type="wicri:Area/Ncbi/Merge">005404</idno>
<idno type="wicri:Area/Ncbi/Curation">005404</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005404</idno>
<idno type="wicri:doubleKey">0928-4931:2014:Orellana B:tailored:sequential:drug</idno>
<idno type="wicri:Area/Main/Merge">001690</idno>
<idno type="wicri:Area/Main/Curation">001684</idno>
<idno type="wicri:Area/Main/Exploration">001684</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites</title>
<author><name sortKey="Orellana, Bryan R" sort="Orellana, Bryan R" uniqKey="Orellana B" first="Bryan R." last="Orellana">Bryan R. Orellana</name>
</author>
<author><name sortKey="Puleo, David A" sort="Puleo, David A" uniqKey="Puleo D" first="David A." last="Puleo">David A. Puleo</name>
</author>
</analytic>
<series><title level="j">Materials science & engineering. C, Materials for biological applications</title>
<idno type="ISSN">0928-4931</idno>
<idno type="eISSN">1873-0191</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The current standard for treating infected bony defects, such as those caused by periodontal disease, requires multiple time-consuming steps and often multiple procedures to fight the infection and recover lost tissue. Releasing an antibiotic followed by an osteogenic agent from a synthetic bone graft substitute could allow for a streamlined treatment, reducing the need for multiple surgeries and thereby shortening recovery time. Tailorable bilayered calcium sulfate (CS) bone graft substitutes were developed with the ability to sequentially release multiple therapeutic agents. Bilayered composite samples having a shell and core geometry were fabricated with varying amounts (1 or 10 wt%) of metronidazole-loaded poly poly(lactic-co-glycolic acid) (PLGA) particles embedded in the shell and simvastatin directly loaded into either the shell, core, or both. Microcomputed tomography (MicroCT) images showed the overall layered geometry as well as homogenous distribution of PLGA within the shells. Dissolution studies demonstrated that the amount of PLGA particles (<italic>i.e.</italic>
, 1 vs. 10 wt%) had a small but significant effect on the erosion rate (3% vs. 3.4% per day). Mechanical testing determined that introducing a layered geometry had a significant effect on the compressive strength, with an average reduction of 35%, but properties were comparable to mandibular trabecular bone. Sustained release of simvastatin directly loaded into CS demonstrated that changing the shell to core volume ratio dictates the duration of drug release from each layer. When loaded together in the shell or in separate layers, sequential release of metronidazole and simvastatin was achieved. By introducing a tunable layered geometry capable of releasing multiple drugs, CS-based bone graft substitutes could be tailored in order to help streamline multiple steps needed to regenerate tissue in infected defects.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Orellana, Bryan R" sort="Orellana, Bryan R" uniqKey="Orellana B" first="Bryan R." last="Orellana">Bryan R. Orellana</name>
<name sortKey="Puleo, David A" sort="Puleo, David A" uniqKey="Puleo D" first="David A." last="Puleo">David A. Puleo</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001684 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001684 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4152730 |texte= Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25175211" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |