Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites
Identifieur interne : 002651 ( Pmc/Corpus ); précédent : 002650; suivant : 002652Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites
Auteurs : Bryan R. Orellana ; David A. PuleoSource :
- Materials science & engineering. C, Materials for biological applications [ 0928-4931 ] ; 2014.
Abstract
The current standard for treating infected bony defects, such as those caused by periodontal disease, requires multiple time-consuming steps and often multiple procedures to fight the infection and recover lost tissue. Releasing an antibiotic followed by an osteogenic agent from a synthetic bone graft substitute could allow for a streamlined treatment, reducing the need for multiple surgeries and thereby shortening recovery time. Tailorable bilayered calcium sulfate (CS) bone graft substitutes were developed with the ability to sequentially release multiple therapeutic agents. Bilayered composite samples having a shell and core geometry were fabricated with varying amounts (1 or 10 wt%) of metronidazole-loaded poly poly(lactic-co-glycolic acid) (PLGA) particles embedded in the shell and simvastatin directly loaded into either the shell, core, or both. Microcomputed tomography (MicroCT) images showed the overall layered geometry as well as homogenous distribution of PLGA within the shells. Dissolution studies demonstrated that the amount of PLGA particles (
Url:
DOI: 10.1016/j.msec.2014.06.044
PubMed: 25175211
PubMed Central: 4152730
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PMC:4152730Le document en format XML
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<series><title level="j">Materials science & engineering. C, Materials for biological applications</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">The current standard for treating infected bony defects, such as those caused by periodontal disease, requires multiple time-consuming steps and often multiple procedures to fight the infection and recover lost tissue. Releasing an antibiotic followed by an osteogenic agent from a synthetic bone graft substitute could allow for a streamlined treatment, reducing the need for multiple surgeries and thereby shortening recovery time. Tailorable bilayered calcium sulfate (CS) bone graft substitutes were developed with the ability to sequentially release multiple therapeutic agents. Bilayered composite samples having a shell and core geometry were fabricated with varying amounts (1 or 10 wt%) of metronidazole-loaded poly poly(lactic-co-glycolic acid) (PLGA) particles embedded in the shell and simvastatin directly loaded into either the shell, core, or both. Microcomputed tomography (MicroCT) images showed the overall layered geometry as well as homogenous distribution of PLGA within the shells. Dissolution studies demonstrated that the amount of PLGA particles (<italic>i.e.</italic>
, 1 vs. 10 wt%) had a small but significant effect on the erosion rate (3% vs. 3.4% per day). Mechanical testing determined that introducing a layered geometry had a significant effect on the compressive strength, with an average reduction of 35%, but properties were comparable to mandibular trabecular bone. Sustained release of simvastatin directly loaded into CS demonstrated that changing the shell to core volume ratio dictates the duration of drug release from each layer. When loaded together in the shell or in separate layers, sequential release of metronidazole and simvastatin was achieved. By introducing a tunable layered geometry capable of releasing multiple drugs, CS-based bone graft substitutes could be tailored in order to help streamline multiple steps needed to regenerate tissue in infected defects.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101484109</journal-id>
<journal-id journal-id-type="pubmed-jr-id">38985</journal-id>
<journal-id journal-id-type="nlm-ta">Mater Sci Eng C Mater Biol Appl</journal-id>
<journal-id journal-id-type="iso-abbrev">Mater Sci Eng C Mater Biol Appl</journal-id>
<journal-title-group><journal-title>Materials science & engineering. C, Materials for biological applications</journal-title>
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<issn pub-type="ppub">0928-4931</issn>
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<article-id pub-id-type="manuscript">NIHMS612485</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Tailored Sequential Drug Release from Bilayered Calcium Sulfate Composites</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Orellana</surname>
<given-names>Bryan R.</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Puleo</surname>
<given-names>David A.</given-names>
</name>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<aff id="A1">Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA</aff>
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<author-notes><corresp id="cor1"><label>*</label>
<bold>Corresponding author</bold>
: David Puleo, Ph.D., 522A Robotics and Manufacturing Building, Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0108, USA, Tel: +1-859-257-2405, Fax: +1-859-257-1856, <email>puleo@uky.edu</email>
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<pub-date pub-type="nihms-submitted"><day>11</day>
<month>7</month>
<year>2014</year>
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<pub-date pub-type="epub"><day>09</day>
<month>7</month>
<year>2014</year>
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<pub-date pub-type="ppub"><day>1</day>
<month>10</month>
<year>2014</year>
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<pub-date pub-type="pmc-release"><day>01</day>
<month>10</month>
<year>2015</year>
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<volume>43</volume>
<fpage>243</fpage>
<lpage>252</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.msec.2014.06.044</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p id="P1">The current standard for treating infected bony defects, such as those caused by periodontal disease, requires multiple time-consuming steps and often multiple procedures to fight the infection and recover lost tissue. Releasing an antibiotic followed by an osteogenic agent from a synthetic bone graft substitute could allow for a streamlined treatment, reducing the need for multiple surgeries and thereby shortening recovery time. Tailorable bilayered calcium sulfate (CS) bone graft substitutes were developed with the ability to sequentially release multiple therapeutic agents. Bilayered composite samples having a shell and core geometry were fabricated with varying amounts (1 or 10 wt%) of metronidazole-loaded poly poly(lactic-co-glycolic acid) (PLGA) particles embedded in the shell and simvastatin directly loaded into either the shell, core, or both. Microcomputed tomography (MicroCT) images showed the overall layered geometry as well as homogenous distribution of PLGA within the shells. Dissolution studies demonstrated that the amount of PLGA particles (<italic>i.e.</italic>
, 1 vs. 10 wt%) had a small but significant effect on the erosion rate (3% vs. 3.4% per day). Mechanical testing determined that introducing a layered geometry had a significant effect on the compressive strength, with an average reduction of 35%, but properties were comparable to mandibular trabecular bone. Sustained release of simvastatin directly loaded into CS demonstrated that changing the shell to core volume ratio dictates the duration of drug release from each layer. When loaded together in the shell or in separate layers, sequential release of metronidazole and simvastatin was achieved. By introducing a tunable layered geometry capable of releasing multiple drugs, CS-based bone graft substitutes could be tailored in order to help streamline multiple steps needed to regenerate tissue in infected defects.</p>
</abstract>
<kwd-group><kwd>calcium sulfate</kwd>
<kwd>sequential drug release</kwd>
<kwd>bioceramic</kwd>
<kwd>simvastatin</kwd>
<kwd>metronidazole</kwd>
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</front>
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