Cortical Bone Morphological and Trabecular Bone Microarchitectural Changes in the Mandible and Femoral Neck of Ovariectomized Rats
Identifieur interne : 000933 ( Main/Exploration ); précédent : 000932; suivant : 000934Cortical Bone Morphological and Trabecular Bone Microarchitectural Changes in the Mandible and Femoral Neck of Ovariectomized Rats
Auteurs : Pei-Yu Hsu [Taïwan] ; Ming-Tzu Tsai [République populaire de Chine] ; Shun-Ping Wang [Taïwan] ; Ying-Ju Chen [Taïwan] ; Jay Wu [République populaire de Chine] ; Jui-Ting Hsu [Taïwan]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
This study used microcomputed tomography (micro-CT) to evaluate the effects of ovariectomy on the trabecular bone microarchitecture and cortical bone morphology in the femoral neck and mandible of female rats.
Twelve female Wister rats were divided into two groups: the control and ovariectomized groups. The rats in the ovariectomized group received ovariectomy at 8 weeks of age; all the rats were sacrificed at 20 weeks of age, and their mandibles and femurs were removed and scanned using micro-CT. Four microstructural trabecular bone parameters were measured for the region below the first mandibular molar and the femoral neck region: bone volume fraction (BV/TV), trabecular thickness (TbTh), trabecular separation (TbSp), and trabecular number (TbN). In addition, four cortical bone parameters were measured for the femoral neck region: total cross-sectional area (TtAr), cortical area (CtAr), cortical bone area fraction (CtAr/TtAr), and cortical thickness (CtTh). The CtTh at the masseteric ridge was used to assess the cortical bone morphology in the mandible. The trabecular bone microarchitecture and cortical bone morphology in the femoral necks and mandibles of the control group were compared with those of the ovariectomized group. Furthermore, Spearman’s correlation (
Regarding the trabecular bone microarchitectural parameters, the BV/TV of the trabecular bone microarchitecture in the femoral necks of the control group (61.199±11.288%, median ± interquartile range) was significantly greater than that of the ovariectomized group (40.329±5.153%). Similarly, the BV/TV of the trabecular bone microarchitecture in the mandibles of the control group (51.704±6.253%) was significantly greater than that of the ovariectomized group (38.486±9.111%). Furthermore, the TbSp of the femoral necks in the ovariectomized group (0.185±0.066 mm) was significantly greater than that in the control group (0.130±0.026mm). Similarly, the TbSp of the mandibles in the ovariectomized group (0.322±0.047mm) was significantly greater than that in the control group (0.285±0.041mm). However, the TbTh and TbN trends for the mandibles and femoral necks were inconsistent between the control and ovariectomized groups. Regarding the cortical bone morphology parameters, the TtAr of the femoral necks in the ovariectomized group was significantly smaller than that in the control group. There was no significant difference in the TtAr, CtAr, or CtTh of the femoral necks between the control and ovariectomized groups, and no significant difference in the CtTh of the mandibles between the control and ovariectomized groups. Moreover, the BV/TV and TbSp of the mandibles were highly correlated with those of the femurs (
After the rats were ovariectomized, osteoporosis of the trabecular bone microarchitecture occurred in their femurs and mandibles; however, ovariectomy did not influence the cortical bone morphology. In addition, the parametric values of the trabecular bone microarchitecture in the femoral necks were highly correlated with those of the trabecular bone microarchitecture in the mandibles.
Url:
DOI: 10.1371/journal.pone.0154367
PubMed: 27127909
PubMed Central: 4851407
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000757
- to stream Pmc, to step Curation: 000757
- to stream Pmc, to step Checkpoint: 000787
- to stream Ncbi, to step Merge: 006657
- to stream Ncbi, to step Curation: 006657
- to stream Ncbi, to step Checkpoint: 006657
- to stream Main, to step Merge: 000933
- to stream Main, to step Curation: 000933
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cortical Bone Morphological and Trabecular Bone Microarchitectural Changes in the Mandible and Femoral Neck of Ovariectomized Rats</title><author><name sortKey="Hsu, Pei Yu" sort="Hsu, Pei Yu" uniqKey="Hsu P" first="Pei-Yu" last="Hsu">Pei-Yu Hsu</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, 404, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ming Tzu" sort="Tsai, Ming Tzu" uniqKey="Tsai M" first="Ming-Tzu" last="Tsai">Ming-Tzu Tsai</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Biomedical Engineering, Hungkuang University, Taichung, Taiwan, 433, ROC</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Engineering, Hungkuang University, Taichung, Taiwan, 433</wicri:regionArea><wicri:noRegion>433</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Shun Ping" sort="Wang, Shun Ping" uniqKey="Wang S" first="Shun-Ping" last="Wang">Shun-Ping Wang</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, 407, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, 407</wicri:regionArea><wicri:noRegion>407</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ying Ju" sort="Chen, Ying Ju" uniqKey="Chen Y" first="Ying-Ju" last="Chen">Ying-Ju Chen</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Food and Nutrition, Providence University, Taichung, 433, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Food and Nutrition, Providence University, Taichung, 433</wicri:regionArea><wicri:noRegion>433</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jay" sort="Wu, Jay" uniqKey="Wu J" first="Jay" last="Wu">Jay Wu</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 112, ROC</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 112</wicri:regionArea><wicri:noRegion>112</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Jui Ting" sort="Hsu, Jui Ting" uniqKey="Hsu J" first="Jui-Ting" last="Hsu">Jui-Ting Hsu</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>School of Dentistry, College of Medicine, China Medical University, Taichung, 404, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, College of Medicine, China Medical University, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Department of Bioinformatics and Medical Engineering, Asia University. Taichung, 413, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Bioinformatics and Medical Engineering, Asia University. Taichung, 413</wicri:regionArea><wicri:noRegion>413</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27127909</idno><idno type="pmc">4851407</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851407</idno><idno type="RBID">PMC:4851407</idno><idno type="doi">10.1371/journal.pone.0154367</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000757</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000757</idno><idno type="wicri:Area/Pmc/Curation">000757</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000757</idno><idno type="wicri:Area/Pmc/Checkpoint">000787</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000787</idno><idno type="wicri:Area/Ncbi/Merge">006657</idno><idno type="wicri:Area/Ncbi/Curation">006657</idno><idno type="wicri:Area/Ncbi/Checkpoint">006657</idno><idno type="wicri:Area/Main/Merge">000933</idno><idno type="wicri:Area/Main/Curation">000933</idno><idno type="wicri:Area/Main/Exploration">000933</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cortical Bone Morphological and Trabecular Bone Microarchitectural Changes in the Mandible and Femoral Neck of Ovariectomized Rats</title><author><name sortKey="Hsu, Pei Yu" sort="Hsu, Pei Yu" uniqKey="Hsu P" first="Pei-Yu" last="Hsu">Pei-Yu Hsu</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, 404, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ming Tzu" sort="Tsai, Ming Tzu" uniqKey="Tsai M" first="Ming-Tzu" last="Tsai">Ming-Tzu Tsai</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Biomedical Engineering, Hungkuang University, Taichung, Taiwan, 433, ROC</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Engineering, Hungkuang University, Taichung, Taiwan, 433</wicri:regionArea><wicri:noRegion>433</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Shun Ping" sort="Wang, Shun Ping" uniqKey="Wang S" first="Shun-Ping" last="Wang">Shun-Ping Wang</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, 407, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, 407</wicri:regionArea><wicri:noRegion>407</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ying Ju" sort="Chen, Ying Ju" uniqKey="Chen Y" first="Ying-Ju" last="Chen">Ying-Ju Chen</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Food and Nutrition, Providence University, Taichung, 433, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Food and Nutrition, Providence University, Taichung, 433</wicri:regionArea><wicri:noRegion>433</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jay" sort="Wu, Jay" uniqKey="Wu J" first="Jay" last="Wu">Jay Wu</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 112, ROC</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 112</wicri:regionArea><wicri:noRegion>112</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Jui Ting" sort="Hsu, Jui Ting" uniqKey="Hsu J" first="Jui-Ting" last="Hsu">Jui-Ting Hsu</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>School of Dentistry, College of Medicine, China Medical University, Taichung, 404, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, College of Medicine, China Medical University, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Department of Bioinformatics and Medical Engineering, Asia University. Taichung, 413, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Bioinformatics and Medical Engineering, Asia University. Taichung, 413</wicri:regionArea><wicri:noRegion>413</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objective</title><p>This study used microcomputed tomography (micro-CT) to evaluate the effects of ovariectomy on the trabecular bone microarchitecture and cortical bone morphology in the femoral neck and mandible of female rats.</p></sec><sec id="sec002"><title>Materials and Methods</title><p>Twelve female Wister rats were divided into two groups: the control and ovariectomized groups. The rats in the ovariectomized group received ovariectomy at 8 weeks of age; all the rats were sacrificed at 20 weeks of age, and their mandibles and femurs were removed and scanned using micro-CT. Four microstructural trabecular bone parameters were measured for the region below the first mandibular molar and the femoral neck region: bone volume fraction (BV/TV), trabecular thickness (TbTh), trabecular separation (TbSp), and trabecular number (TbN). In addition, four cortical bone parameters were measured for the femoral neck region: total cross-sectional area (TtAr), cortical area (CtAr), cortical bone area fraction (CtAr/TtAr), and cortical thickness (CtTh). The CtTh at the masseteric ridge was used to assess the cortical bone morphology in the mandible. The trabecular bone microarchitecture and cortical bone morphology in the femoral necks and mandibles of the control group were compared with those of the ovariectomized group. Furthermore, Spearman’s correlation (<italic>r</italic><sub><italic>s</italic></sub>) was conducted to analyze the correlation between the osteoporosis conditions of the mandible and femoral neck.</p></sec><sec id="sec003"><title>Results</title><p>Regarding the trabecular bone microarchitectural parameters, the BV/TV of the trabecular bone microarchitecture in the femoral necks of the control group (61.199±11.288%, median ± interquartile range) was significantly greater than that of the ovariectomized group (40.329±5.153%). Similarly, the BV/TV of the trabecular bone microarchitecture in the mandibles of the control group (51.704±6.253%) was significantly greater than that of the ovariectomized group (38.486±9.111%). Furthermore, the TbSp of the femoral necks in the ovariectomized group (0.185±0.066 mm) was significantly greater than that in the control group (0.130±0.026mm). Similarly, the TbSp of the mandibles in the ovariectomized group (0.322±0.047mm) was significantly greater than that in the control group (0.285±0.041mm). However, the TbTh and TbN trends for the mandibles and femoral necks were inconsistent between the control and ovariectomized groups. Regarding the cortical bone morphology parameters, the TtAr of the femoral necks in the ovariectomized group was significantly smaller than that in the control group. There was no significant difference in the TtAr, CtAr, or CtTh of the femoral necks between the control and ovariectomized groups, and no significant difference in the CtTh of the mandibles between the control and ovariectomized groups. Moreover, the BV/TV and TbSp of the mandibles were highly correlated with those of the femurs (<italic>r</italic><sub><italic>s</italic></sub> = 0.874 and <italic>r</italic><sub><italic>s</italic></sub> = 0.755 for BV/TV and TbSp, respectively). Nevertheless, the TbTh, TbN, and CtTh of the mandibles were not correlated with those of the femoral necks.</p></sec><sec id="sec004"><title>Conclusion</title><p>After the rats were ovariectomized, osteoporosis of the trabecular bone microarchitecture occurred in their femurs and mandibles; however, ovariectomy did not influence the cortical bone morphology. In addition, the parametric values of the trabecular bone microarchitecture in the femoral necks were highly correlated with those of the trabecular bone microarchitecture in the mandibles.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Piscitelli, P" uniqKey="Piscitelli P">P Piscitelli</name></author><author><name sortKey="Iolascon, G" uniqKey="Iolascon G">G Iolascon</name></author><author><name sortKey="Gimigliano, F" uniqKey="Gimigliano F">F Gimigliano</name></author><author><name sortKey="Gimigliano, A" uniqKey="Gimigliano A">A Gimigliano</name></author><author><name sortKey="Marinelli, A" uniqKey="Marinelli A">A Marinelli</name></author><author><name sortKey="Di Nuzzo, R" uniqKey="Di Nuzzo R">R Di Nuzzo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samelson, Ej" uniqKey="Samelson E">EJ Samelson</name></author><author><name sortKey="Hannan, Mt" uniqKey="Hannan M">MT Hannan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reginster, Jy" uniqKey="Reginster J">JY Reginster</name></author><author><name sortKey="Burlet, N" uniqKey="Burlet N">N Burlet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peck, W" uniqKey="Peck W">W Peck</name></author><author><name sortKey="Burckhardt, P" uniqKey="Burckhardt P">P Burckhardt</name></author><author><name sortKey="Christiansen, C" uniqKey="Christiansen C">C Christiansen</name></author><author><name sortKey="Fleisch, H" uniqKey="Fleisch H">H Fleisch</name></author><author><name sortKey="Genant, H" uniqKey="Genant H">H Genant</name></author><author><name sortKey="Gennari, C" uniqKey="Gennari C">C Gennari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Compston, Je" uniqKey="Compston J">JE Compston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riggs, Bl" uniqKey="Riggs B">BL Riggs</name></author><author><name sortKey="Melton, Lj" uniqKey="Melton L">LJ Melton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author><author><name sortKey="Atkinson, Ej" uniqKey="Atkinson E">EJ Atkinson</name></author><author><name sortKey="Jacobsen, Sj" uniqKey="Jacobsen S">SJ Jacobsen</name></author><author><name sortKey="O Allon, Wm" uniqKey="O Allon W">WM O’Fallon</name></author><author><name sortKey="Melton, Lj" uniqKey="Melton L">LJ Melton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lips, P" uniqKey="Lips P">P Lips</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author><author><name sortKey="Agnusdei, Df" uniqKey="Agnusdei D">Df Agnusdei</name></author><author><name sortKey="Caulin, F" uniqKey="Caulin F">F Caulin</name></author><author><name sortKey="Egger, P" uniqKey="Egger P">P Egger</name></author><author><name sortKey="Johnell, O" uniqKey="Johnell O">O Johnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riggs, Bl" uniqKey="Riggs B">BL Riggs</name></author><author><name sortKey="Khosla, S" uniqKey="Khosla S">S Khosla</name></author><author><name sortKey="Melton, Lj" uniqKey="Melton L">LJ Melton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seeman, E" uniqKey="Seeman E">E Seeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanis, J" uniqKey="Kanis J">J Kanis</name></author><author><name sortKey="Johnell, O" uniqKey="Johnell O">O Johnell</name></author><author><name sortKey="Oden, A" uniqKey="Oden A">A Odén</name></author><author><name sortKey="Johansson, H" uniqKey="Johansson H">H Johansson</name></author><author><name sortKey="Mccloskey, E" uniqKey="Mccloskey E">E McCloskey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Pham, Sm" uniqKey="Pham S">SM Pham</name></author><author><name sortKey="Crabbe, Dl" uniqKey="Crabbe D">DL Crabbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, G" uniqKey="Jiang G">G Jiang</name></author><author><name sortKey="Matsumoto, H" uniqKey="Matsumoto H">H Matsumoto</name></author><author><name sortKey="Yamane, J" uniqKey="Yamane J">J Yamane</name></author><author><name sortKey="Kuboyama, N" uniqKey="Kuboyama N">N Kuboyama</name></author><author><name sortKey="Akimoto, Y" uniqKey="Akimoto Y">Y Akimoto</name></author><author><name sortKey="Fujii, A" uniqKey="Fujii A">A Fujii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brouwers, J" uniqKey="Brouwers J">J Brouwers</name></author><author><name sortKey="Lambers, F" uniqKey="Lambers F">F Lambers</name></author><author><name sortKey="Gasser, Ja" uniqKey="Gasser J">JA Gasser</name></author><author><name sortKey="Van Rietbergen, B" uniqKey="Van Rietbergen B">B Van Rietbergen</name></author><author><name sortKey="Huiskes, R" uniqKey="Huiskes R">R Huiskes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ames, Ms" uniqKey="Ames M">MS Ames</name></author><author><name sortKey="Hong, S" uniqKey="Hong S">S Hong</name></author><author><name sortKey="Lee, Hr" uniqKey="Lee H">HR Lee</name></author><author><name sortKey="Fields, Hw" uniqKey="Fields H">HW Fields</name></author><author><name sortKey="Johnston, Wm" uniqKey="Johnston W">WM Johnston</name></author><author><name sortKey="Kim D, G" uniqKey="Kim D G">G Kim D-</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elkomy, Mm" uniqKey="Elkomy M">MM Elkomy</name></author><author><name sortKey="Elsaid, Fg" uniqKey="Elsaid F">FG Elsaid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiaolei, S" uniqKey="Xiaolei S">S Xiaolei</name></author><author><name sortKey="Fengbo, L" uniqKey="Fengbo L">L Fengbo</name></author><author><name sortKey="Xinlong, M" uniqKey="Xinlong M">M Xinlong</name></author><author><name sortKey="Jianxiong, M" uniqKey="Jianxiong M">M Jianxiong</name></author><author><name sortKey="Bin, Z" uniqKey="Bin Z">Z Bin</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melton, Lj" uniqKey="Melton L">LJ Melton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schnell, S" uniqKey="Schnell S">S Schnell</name></author><author><name sortKey="Friedman, Sm" uniqKey="Friedman S">SM Friedman</name></author><author><name sortKey="Mendelson, Da" uniqKey="Mendelson D">DA Mendelson</name></author><author><name sortKey="Bingham, Kw" uniqKey="Bingham K">KW Bingham</name></author><author><name sortKey="Kates, Sl" uniqKey="Kates S">SL Kates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ip, T" uniqKey="Ip T">T Ip</name></author><author><name sortKey="Leung, J" uniqKey="Leung J">J Leung</name></author><author><name sortKey="Kung, A" uniqKey="Kung A">A Kung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwasaki, M" uniqKey="Iwasaki M">M Iwasaki</name></author><author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name></author><author><name sortKey="Yoshihara, A" uniqKey="Yoshihara A">A Yoshihara</name></author><author><name sortKey="Miyazaki, H" uniqKey="Miyazaki H">H Miyazaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Streckfus, Cf" uniqKey="Streckfus C">CF Streckfus</name></author><author><name sortKey="Johnson, Rb" uniqKey="Johnson R">RB Johnson</name></author><author><name sortKey="Nick, T" uniqKey="Nick T">T Nick</name></author><author><name sortKey="Tsao, A" uniqKey="Tsao A">A Tsao</name></author><author><name sortKey="Tucci, M" uniqKey="Tucci M">M Tucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A Taguchi</name></author><author><name sortKey="Suei, Y" uniqKey="Suei Y">Y Suei</name></author><author><name sortKey="Ohtsuka, M" uniqKey="Ohtsuka M">M Ohtsuka</name></author><author><name sortKey="Otani, K" uniqKey="Otani K">K Otani</name></author><author><name sortKey="Tanimoto, K" uniqKey="Tanimoto K">K Tanimoto</name></author><author><name sortKey="Hollender, L" uniqKey="Hollender L">L Hollender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaffin, Ra" uniqKey="Jaffin R">RA Jaffin</name></author><author><name sortKey="Berman, Cl" uniqKey="Berman C">CL Berman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouxsein, Ml" uniqKey="Bouxsein M">ML Bouxsein</name></author><author><name sortKey="Boyd, Sk" uniqKey="Boyd S">SK Boyd</name></author><author><name sortKey="Christiansen, Ba" uniqKey="Christiansen B">BA Christiansen</name></author><author><name sortKey="Guldberg, Re" uniqKey="Guldberg R">RE Guldberg</name></author><author><name sortKey="Jepsen, Kj" uniqKey="Jepsen K">KJ Jepsen</name></author><author><name sortKey="Muller, R" uniqKey="Muller R">R Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Particelli, F" uniqKey="Particelli F">F Particelli</name></author><author><name sortKey="Mecozzi, L" uniqKey="Mecozzi L">L Mecozzi</name></author><author><name sortKey="Beraudi, A" uniqKey="Beraudi A">A Beraudi</name></author><author><name sortKey="Montesi, M" uniqKey="Montesi M">M Montesi</name></author><author><name sortKey="Baruffaldi, F" uniqKey="Baruffaldi F">F Baruffaldi</name></author><author><name sortKey="Viceconti, M" uniqKey="Viceconti M">M Viceconti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verdelis, K" uniqKey="Verdelis K">K Verdelis</name></author><author><name sortKey="Lukashova, L" uniqKey="Lukashova L">L Lukashova</name></author><author><name sortKey="Atti, E" uniqKey="Atti E">E Atti</name></author><author><name sortKey="Mayer Kuckuk, P" uniqKey="Mayer Kuckuk P">P Mayer-Kuckuk</name></author><author><name sortKey="Peterson, M" uniqKey="Peterson M">M Peterson</name></author><author><name sortKey="Tetradis, S" uniqKey="Tetradis S">S Tetradis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Jt" uniqKey="Hsu J">JT Hsu</name></author><author><name sortKey="Chen, Yj" uniqKey="Chen Y">YJ Chen</name></author><author><name sortKey="Ho, Jt" uniqKey="Ho J">JT Ho</name></author><author><name sortKey="Huang, Hl" uniqKey="Huang H">HL Huang</name></author><author><name sortKey="Wang, Sp" uniqKey="Wang S">SP Wang</name></author><author><name sortKey="Cheng, Fc" uniqKey="Cheng F">FC Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Jt" uniqKey="Hsu J">JT Hsu</name></author><author><name sortKey="Wang, Sp" uniqKey="Wang S">SP Wang</name></author><author><name sortKey="Huang, Hl" uniqKey="Huang H">HL Huang</name></author><author><name sortKey="Chen, Yj" uniqKey="Chen Y">YJ Chen</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Tsai, Mt" uniqKey="Tsai M">MT Tsai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnston, Bd" uniqKey="Johnston B">BD Johnston</name></author><author><name sortKey="Ward, We" uniqKey="Ward W">WE Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buckbinder, L" uniqKey="Buckbinder L">L Buckbinder</name></author><author><name sortKey="Crawford, Dt" uniqKey="Crawford D">DT Crawford</name></author><author><name sortKey="Qi, H" uniqKey="Qi H">H Qi</name></author><author><name sortKey="Ke, Hz" uniqKey="Ke H">HZ Ke</name></author><author><name sortKey="Olson, Lm" uniqKey="Olson L">LM Olson</name></author><author><name sortKey="Long, Kr" uniqKey="Long K">KR Long</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jee, W" uniqKey="Jee W">W Jee</name></author><author><name sortKey="Yao, W" uniqKey="Yao W">W Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kasabi Shivakumar, Hm" uniqKey="Kasabi Shivakumar H">HM Kasabi Shivakumar</name></author><author><name sortKey="Rabin, P" uniqKey="Rabin P">P Rabin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lelovas, Pp" uniqKey="Lelovas P">PP Lelovas</name></author><author><name sortKey="Xanthos, Tt" uniqKey="Xanthos T">TT Xanthos</name></author><author><name sortKey="Thoma, Se" uniqKey="Thoma S">SE Thoma</name></author><author><name sortKey="Lyritis, Gp" uniqKey="Lyritis G">GP Lyritis</name></author><author><name sortKey="Dontas, Ia" uniqKey="Dontas I">IA Dontas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Si, H" uniqKey="Si H">H Si</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsukawa, N" uniqKey="Matsukawa N">N Matsukawa</name></author><author><name sortKey="Matsumono, M" uniqKey="Matsumono M">M Matsumono</name></author><author><name sortKey="Bukawa, W" uniqKey="Bukawa W">W Bukawa</name></author><author><name sortKey="Chiji, H" uniqKey="Chiji H">H Chiji</name></author><author><name sortKey="Hara, H" uniqKey="Hara H">H Hara</name></author><author><name sortKey="Tsukahara, T" uniqKey="Tsukahara T">T Tsukahara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uchiyama, S" uniqKey="Uchiyama S">S Uchiyama</name></author><author><name sortKey="Yamaguchi, M" uniqKey="Yamaguchi M">M Yamaguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Butezloff, Mm" uniqKey="Butezloff M">MM Butezloff</name></author><author><name sortKey="Zamarioli, A" uniqKey="Zamarioli A">A Zamarioli</name></author><author><name sortKey="Leoni, Gb" uniqKey="Leoni G">GB Leoni</name></author><author><name sortKey="Sousa Neto, Md" uniqKey="Sousa Neto M">MD Sousa-Neto</name></author><author><name sortKey="Volpon, Jb" uniqKey="Volpon J">JB Volpon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leitner, M" uniqKey="Leitner M">M Leitner</name></author><author><name sortKey="Tami, A" uniqKey="Tami A">A Tami</name></author><author><name sortKey="Montavon, P" uniqKey="Montavon P">P Montavon</name></author><author><name sortKey="Ito, K" uniqKey="Ito K">K Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, M" uniqKey="Tanaka M">M Tanaka</name></author><author><name sortKey="Ejiri, S" uniqKey="Ejiri S">S Ejiri</name></author><author><name sortKey="Toyooka, E" uniqKey="Toyooka E">E Toyooka</name></author><author><name sortKey="Kohno, S" uniqKey="Kohno S">S Kohno</name></author><author><name sortKey="Ozawa, H" uniqKey="Ozawa H">H Ozawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Yan, C" uniqKey="Yan C">C Yan</name></author><author><name sortKey="Kang, C" uniqKey="Kang C">C Kang</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Irie, K" uniqKey="Irie K">K Irie</name></author><author><name sortKey="Sakakura, Y" uniqKey="Sakakura Y">Y Sakakura</name></author><author><name sortKey="Tsuruga, E" uniqKey="Tsuruga E">E Tsuruga</name></author><author><name sortKey="Hosokawa, Y" uniqKey="Hosokawa Y">Y Hosokawa</name></author><author><name sortKey="Yajima, T" uniqKey="Yajima T">T Yajima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westerlind, Kc" uniqKey="Westerlind K">KC Westerlind</name></author><author><name sortKey="Wronski, Tj" uniqKey="Wronski T">TJ Wronski</name></author><author><name sortKey="Ritman, El" uniqKey="Ritman E">EL Ritman</name></author><author><name sortKey="Luo Z, P" uniqKey="Luo Z P">P Luo Z-</name></author><author><name sortKey="An K, N" uniqKey="An K N">N An K-</name></author><author><name sortKey="Bell, Nh" uniqKey="Bell N">NH Bell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Washimi, Y" uniqKey="Washimi Y">Y Washimi</name></author><author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name></author><author><name sortKey="Morishima, Y" uniqKey="Morishima Y">Y Morishima</name></author><author><name sortKey="Taguma, K" uniqKey="Taguma K">K Taguma</name></author><author><name sortKey="Ojima, Y" uniqKey="Ojima Y">Y Ojima</name></author><author><name sortKey="Uzawa, T" uniqKey="Uzawa T">T Uzawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilsanz, V" uniqKey="Gilsanz V">V Gilsanz</name></author><author><name sortKey="Roe, Tf" uniqKey="Roe T">TF Roe</name></author><author><name sortKey="Gibbens, Dt" uniqKey="Gibbens D">DT Gibbens</name></author><author><name sortKey="Schulz, Ee" uniqKey="Schulz E">EE Schulz</name></author><author><name sortKey="Carlson, Me" uniqKey="Carlson M">ME Carlson</name></author><author><name sortKey="Gonzalez, O" uniqKey="Gonzalez O">O Gonzalez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mavropoulos, A" uniqKey="Mavropoulos A">A Mavropoulos</name></author><author><name sortKey="Rizzoli, R" uniqKey="Rizzoli R">R Rizzoli</name></author><author><name sortKey="Ammann, P" uniqKey="Ammann P">P Ammann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, M" uniqKey="Tanaka M">M Tanaka</name></author><author><name sortKey="Toyooka, E" uniqKey="Toyooka E">E Toyooka</name></author><author><name sortKey="Kohno, S" uniqKey="Kohno S">S Kohno</name></author><author><name sortKey="Ozawa, H" uniqKey="Ozawa H">H Ozawa</name></author><author><name sortKey="Ejiri, S" uniqKey="Ejiri S">S Ejiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, Cy" uniqKey="Tsai C">CY Tsai</name></author><author><name sortKey="Shyr, Ym" uniqKey="Shyr Y">YM Shyr</name></author><author><name sortKey="Chiu, Wc" uniqKey="Chiu W">WC Chiu</name></author><author><name sortKey="Lee, Cm" uniqKey="Lee C">CM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name></author><author><name sortKey="Parkinson, I" uniqKey="Parkinson I">I Parkinson</name></author><author><name sortKey="Thomas, Cdl" uniqKey="Thomas C">CDL Thomas</name></author><author><name sortKey="Clement, Jg" uniqKey="Clement J">JG Clement</name></author><author><name sortKey="Fazzalari, N" uniqKey="Fazzalari N">N Fazzalari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marks, R" uniqKey="Marks R">R Marks</name></author><author><name sortKey="Allegrante, Jp" uniqKey="Allegrante J">JP Allegrante</name></author><author><name sortKey="Mackenzie, Cr" uniqKey="Mackenzie C">CR MacKenzie</name></author><author><name sortKey="Lane, Jm" uniqKey="Lane J">JM Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Jt" uniqKey="Hsu J">JT Hsu</name></author><author><name sortKey="Fuh, Lj" uniqKey="Fuh L">LJ Fuh</name></author><author><name sortKey="Tu, Mg" uniqKey="Tu M">MG Tu</name></author><author><name sortKey="Li, Yf" uniqKey="Li Y">YF Li</name></author><author><name sortKey="Chen, Kt" uniqKey="Chen K">KT Chen</name></author><author><name sortKey="Huang, Hl" uniqKey="Huang H">HL Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Branemark, Pi" uniqKey="Branemark P">PI Branemark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mavropoulos, A" uniqKey="Mavropoulos A">A Mavropoulos</name></author><author><name sortKey="Kiliaridis, S" uniqKey="Kiliaridis S">S Kiliaridis</name></author><author><name sortKey="Bresin, A" uniqKey="Bresin A">A Bresin</name></author><author><name sortKey="Ammann, P" uniqKey="Ammann P">P Ammann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, D" uniqKey="Thompson D">D Thompson</name></author><author><name sortKey="Simmons, H" uniqKey="Simmons H">H Simmons</name></author><author><name sortKey="Pirie, C" uniqKey="Pirie C">C Pirie</name></author><author><name sortKey="Ke, H" uniqKey="Ke H">H Ke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellido, M" uniqKey="Bellido M">M Bellido</name></author><author><name sortKey="Lugo, L" uniqKey="Lugo L">L Lugo</name></author><author><name sortKey="Castaneda, S" uniqKey="Castaneda S">S Castaneda</name></author><author><name sortKey="Roman Blas, Ja" uniqKey="Roman Blas J">JA Roman-Blas</name></author><author><name sortKey="Rufian Henares, Ja" uniqKey="Rufian Henares J">JA Rufian-Henares</name></author><author><name sortKey="Navarro Alarcon, M" uniqKey="Navarro Alarcon M">M Navarro-Alarcon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Newman, E" uniqKey="Newman E">E Newman</name></author><author><name sortKey="Turner, A" uniqKey="Turner A">A Turner</name></author><author><name sortKey="Wark, J" uniqKey="Wark J">J Wark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bagi, Cm" uniqKey="Bagi C">CM Bagi</name></author><author><name sortKey="Berryman, E" uniqKey="Berryman E">E Berryman</name></author><author><name sortKey="Moalli, Mr" uniqKey="Moalli M">MR Moalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandes, Dj" uniqKey="Fernandes D">DJ Fernandes</name></author><author><name sortKey="Elias, Cn" uniqKey="Elias C">CN Elias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiang, A" uniqKey="Xiang A">A Xiang</name></author><author><name sortKey="Kanematsu, M" uniqKey="Kanematsu M">M Kanematsu</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author><author><name sortKey="Yamashita, D" uniqKey="Yamashita D">D Yamashita</name></author><author><name sortKey="Kaise, T" uniqKey="Kaise T">T Kaise</name></author><author><name sortKey="Kikkawa, H" uniqKey="Kikkawa H">H Kikkawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Francisco, Ji" uniqKey="Francisco J">JI Francisco</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Oliver, Ra" uniqKey="Oliver R">RA Oliver</name></author><author><name sortKey="Walsh, Wr" uniqKey="Walsh W">WR Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giavaresi, G" uniqKey="Giavaresi G">G Giavaresi</name></author><author><name sortKey="Fini, M" uniqKey="Fini M">M Fini</name></author><author><name sortKey="Gnudi, S" uniqKey="Gnudi S">S Gnudi</name></author><author><name sortKey="De Terlizzi, F" uniqKey="De Terlizzi F">F De Terlizzi</name></author><author><name sortKey="Carpi, A" uniqKey="Carpi A">A Carpi</name></author><author><name sortKey="Giardino, R" uniqKey="Giardino R">R Giardino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, Np" uniqKey="Reddy N">NP Reddy</name></author><author><name sortKey="Lakshmana, M" uniqKey="Lakshmana M">M Lakshmana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey=" Ipos, Rs" uniqKey=" Ipos R">RS Şipos</name></author><author><name sortKey="Fechete, R" uniqKey="Fechete R">R Fechete</name></author><author><name sortKey="Moldovan, D" uniqKey="Moldovan D">D Moldovan</name></author><author><name sortKey=" U, I" uniqKey=" U I">I Şuş</name></author><author><name sortKey="Szasz, S" uniqKey="Szasz S">S Szasz</name></author><author><name sortKey="Pavai, Z" uniqKey="Pavai Z">Z Pávai</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Hsu, Pei Yu" sort="Hsu, Pei Yu" uniqKey="Hsu P" first="Pei-Yu" last="Hsu">Pei-Yu Hsu</name></noRegion><name sortKey="Chen, Ying Ju" sort="Chen, Ying Ju" uniqKey="Chen Y" first="Ying-Ju" last="Chen">Ying-Ju Chen</name><name sortKey="Hsu, Jui Ting" sort="Hsu, Jui Ting" uniqKey="Hsu J" first="Jui-Ting" last="Hsu">Jui-Ting Hsu</name><name sortKey="Hsu, Jui Ting" sort="Hsu, Jui Ting" uniqKey="Hsu J" first="Jui-Ting" last="Hsu">Jui-Ting Hsu</name><name sortKey="Wang, Shun Ping" sort="Wang, Shun Ping" uniqKey="Wang S" first="Shun-Ping" last="Wang">Shun-Ping Wang</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Tsai, Ming Tzu" sort="Tsai, Ming Tzu" uniqKey="Tsai M" first="Ming-Tzu" last="Tsai">Ming-Tzu Tsai</name></noRegion><name sortKey="Wu, Jay" sort="Wu, Jay" uniqKey="Wu J" first="Jay" last="Wu">Jay Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000933 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000933 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4851407
|texte= Cortical Bone Morphological and Trabecular Bone Microarchitectural Changes in the Mandible and Femoral Neck of Ovariectomized Rats
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27127909" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |