The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.
Identifieur interne : 00D648 ( Main/Curation ); précédent : 00D647; suivant : 00D649The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.
Auteurs : L. Ivanyi ; B. Topic ; P M LydyardSource :
- Clinical and Experimental Immunology [ 0009-9104 ] ; 1981.
Abstract
Blood mononuclear cell suspensions from patients with a severe form of periodontal disease failed to respond by in vitro stimulation to a sonicate from the oral bacterium, Veillonella alcalescens. The proliferative response could be restored by the depletion of TG cells by rosetting with IgG-coated ox erythrocytes and by reconstitution of the cell suspension with 10% plastic-adherent monocytes. Small but statistically significant restoration of the Veillonella response was also achieved by the addition of indomethacin or mefenamic acid to unfractionated cell cultures, indicating only a minor role of prostaglandin (PG) synthesis in the expression of suppressor cells. Since the in vitro response to an unrelated antigen PPD had been found unimpaired, the described TG-cell-mediated suppression of the Veillonella response is apparently antigen-specific.
Url:
PubMed: 6978223
PubMed Central: 1536311
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PMC:1536311Le document en format XML
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