The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.
Identifieur interne : 008F90 ( Ncbi/Merge ); précédent : 008F89; suivant : 008F91The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.
Auteurs : L. Ivanyi ; B. Topic ; P M LydyardSource :
- Clinical and Experimental Immunology [ 0009-9104 ] ; 1981.
Abstract
Blood mononuclear cell suspensions from patients with a severe form of periodontal disease failed to respond by in vitro stimulation to a sonicate from the oral bacterium, Veillonella alcalescens. The proliferative response could be restored by the depletion of TG cells by rosetting with IgG-coated ox erythrocytes and by reconstitution of the cell suspension with 10% plastic-adherent monocytes. Small but statistically significant restoration of the Veillonella response was also achieved by the addition of indomethacin or mefenamic acid to unfractionated cell cultures, indicating only a minor role of prostaglandin (PG) synthesis in the expression of suppressor cells. Since the in vitro response to an unrelated antigen PPD had been found unimpaired, the described TG-cell-mediated suppression of the Veillonella response is apparently antigen-specific.
Url:
PubMed: 6978223
PubMed Central: 1536311
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.</title><author><name sortKey="Ivanyi, L" sort="Ivanyi, L" uniqKey="Ivanyi L" first="L" last="Ivanyi">L. Ivanyi</name></author><author><name sortKey="Topic, B" sort="Topic, B" uniqKey="Topic B" first="B" last="Topic">B. Topic</name></author><author><name sortKey="Lydyard, P M" sort="Lydyard, P M" uniqKey="Lydyard P" first="P M" last="Lydyard">P M Lydyard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">6978223</idno><idno type="pmc">1536311</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536311</idno><idno type="RBID">PMC:1536311</idno><date when="1981">1981</date><idno type="wicri:Area/Pmc/Corpus">001507</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001507</idno><idno type="wicri:Area/Pmc/Curation">001507</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001507</idno><idno type="wicri:Area/Pmc/Checkpoint">002A07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002A07</idno><idno type="wicri:Area/Ncbi/Merge">008F90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.</title><author><name sortKey="Ivanyi, L" sort="Ivanyi, L" uniqKey="Ivanyi L" first="L" last="Ivanyi">L. Ivanyi</name></author><author><name sortKey="Topic, B" sort="Topic, B" uniqKey="Topic B" first="B" last="Topic">B. Topic</name></author><author><name sortKey="Lydyard, P M" sort="Lydyard, P M" uniqKey="Lydyard P" first="P M" last="Lydyard">P M Lydyard</name></author></analytic><series><title level="j">Clinical and Experimental Immunology</title><idno type="ISSN">0009-9104</idno><idno type="eISSN">1365-2249</idno><imprint><date when="1981">1981</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Blood mononuclear cell suspensions from patients with a severe form of periodontal disease failed to respond by in vitro stimulation to a sonicate from the oral bacterium, Veillonella alcalescens. The proliferative response could be restored by the depletion of TG cells by rosetting with IgG-coated ox erythrocytes and by reconstitution of the cell suspension with 10% plastic-adherent monocytes. Small but statistically significant restoration of the Veillonella response was also achieved by the addition of indomethacin or mefenamic acid to unfractionated cell cultures, indicating only a minor role of prostaglandin (PG) synthesis in the expression of suppressor cells. Since the in vitro response to an unrelated antigen PPD had been found unimpaired, the described TG-cell-mediated suppression of the Veillonella response is apparently antigen-specific.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Exp Immunol</journal-id><journal-title>Clinical and Experimental Immunology</journal-title><issn pub-type="ppub">0009-9104</issn><issn pub-type="epub">1365-2249</issn></journal-meta><article-meta><article-id pub-id-type="pmid">6978223</article-id><article-id pub-id-type="pmc">1536311</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ivanyi</surname><given-names>L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Topic</surname><given-names>B</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lydyard</surname><given-names>P M</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>12</month><year>1981</year></pub-date><volume>46</volume><issue>3</issue><fpage>633</fpage><lpage>639</lpage><abstract><p>Blood mononuclear cell suspensions from patients with a severe form of periodontal disease failed to respond by in vitro stimulation to a sonicate from the oral bacterium, Veillonella alcalescens. The proliferative response could be restored by the depletion of TG cells by rosetting with IgG-coated ox erythrocytes and by reconstitution of the cell suspension with 10% plastic-adherent monocytes. Small but statistically significant restoration of the Veillonella response was also achieved by the addition of indomethacin or mefenamic acid to unfractionated cell cultures, indicating only a minor role of prostaglandin (PG) synthesis in the expression of suppressor cells. Since the in vitro response to an unrelated antigen PPD had been found unimpaired, the described TG-cell-mediated suppression of the Veillonella response is apparently antigen-specific.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Ivanyi, L" sort="Ivanyi, L" uniqKey="Ivanyi L" first="L" last="Ivanyi">L. Ivanyi</name><name sortKey="Lydyard, P M" sort="Lydyard, P M" uniqKey="Lydyard P" first="P M" last="Lydyard">P M Lydyard</name><name sortKey="Topic, B" sort="Topic, B" uniqKey="Topic B" first="B" last="Topic">B. Topic</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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