Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and in vitro studies
Identifieur interne : 006777 ( Main/Curation ); précédent : 006776; suivant : 006778Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and in vitro studies
Auteurs : Patricia Yen Bee Ng [États-Unis] ; Maureen Donley [États-Unis] ; Ernest Hausmann [États-Unis] ; Alan D. Hutson [États-Unis] ; Edward F. Rossomando [États-Unis] ; Frank A. Scannapieco [États-Unis]Source :
- FEMS immunology and medical microbiology [ 0928-8244 ] ; 2007.
Abstract
This cross-sectional study evaluated the association between radiographic evidence of alveolar bone loss and the concentration of host-derived bone resorptive factors (interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6, prostaglandin-E2), and markers of bone turnover [pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), osteocalcin, osteonectin] in stimulated human whole saliva collected from 110 untreated dental patients. Alveolar bone loss scores for each patient were derived from radiographic examination. Variables positively associated with increased bone loss score were: age, current smoking, use of bisphosphonate drugs, and salivary interleukin-1beta levels above the median. Salivary osteonectin levels above the median were associated with a decreased bone loss score. Additional
Url:
DOI: 10.1111/j.1574-695X.2006.00187.x
PubMed: 17328758
PubMed Central: 2258090
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002782
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002782
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002711
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001B99
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001B99
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001B99
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006882
Links to Exploration step
PMC:2258090Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and <italic>in vitro</italic>
studies</title>
<author><name sortKey="Ng, Patricia Yen Bee" sort="Ng, Patricia Yen Bee" uniqKey="Ng P" first="Patricia Yen Bee" last="Ng">Patricia Yen Bee Ng</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Donley, Maureen" sort="Donley, Maureen" uniqKey="Donley M" first="Maureen" last="Donley">Maureen Donley</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Hausmann, Ernest" sort="Hausmann, Ernest" uniqKey="Hausmann E" first="Ernest" last="Hausmann">Ernest Hausmann</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Hutson, Alan D" sort="Hutson, Alan D" uniqKey="Hutson A" first="Alan D." last="Hutson">Alan D. Hutson</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Biostatistics, University at Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University at Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Rossomando, Edward F" sort="Rossomando, Edward F" uniqKey="Rossomando E" first="Edward F." last="Rossomando">Edward F. Rossomando</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of BioStructure and Function, University of Connecticut Health Center, Farmington, CT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of BioStructure and Function, University of Connecticut Health Center, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scannapieco, Frank A" sort="Scannapieco, Frank A" uniqKey="Scannapieco F" first="Frank A." last="Scannapieco">Frank A. Scannapieco</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17328758</idno>
<idno type="pmc">2258090</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258090</idno>
<idno type="RBID">PMC:2258090</idno>
<idno type="doi">10.1111/j.1574-695X.2006.00187.x</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">002782</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002782</idno>
<idno type="wicri:Area/Pmc/Curation">002782</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002782</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002711</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002711</idno>
<idno type="wicri:Area/Ncbi/Merge">001B99</idno>
<idno type="wicri:Area/Ncbi/Curation">001B99</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001B99</idno>
<idno type="wicri:doubleKey">0928-8244:2007:Ng P:candidate:salivary:biomarkers</idno>
<idno type="wicri:Area/Main/Merge">006882</idno>
<idno type="wicri:Area/Main/Curation">006777</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and <italic>in vitro</italic>
studies</title>
<author><name sortKey="Ng, Patricia Yen Bee" sort="Ng, Patricia Yen Bee" uniqKey="Ng P" first="Patricia Yen Bee" last="Ng">Patricia Yen Bee Ng</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Donley, Maureen" sort="Donley, Maureen" uniqKey="Donley M" first="Maureen" last="Donley">Maureen Donley</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Hausmann, Ernest" sort="Hausmann, Ernest" uniqKey="Hausmann E" first="Ernest" last="Hausmann">Ernest Hausmann</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Hutson, Alan D" sort="Hutson, Alan D" uniqKey="Hutson A" first="Alan D." last="Hutson">Alan D. Hutson</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Biostatistics, University at Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University at Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
<author><name sortKey="Rossomando, Edward F" sort="Rossomando, Edward F" uniqKey="Rossomando E" first="Edward F." last="Rossomando">Edward F. Rossomando</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of BioStructure and Function, University of Connecticut Health Center, Farmington, CT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of BioStructure and Function, University of Connecticut Health Center, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scannapieco, Frank A" sort="Scannapieco, Frank A" uniqKey="Scannapieco F" first="Frank A." last="Scannapieco">Frank A. Scannapieco</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Buffalo (New York)</settlement>
</placeName>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">FEMS immunology and medical microbiology</title>
<idno type="ISSN">0928-8244</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">This cross-sectional study evaluated the association between radiographic evidence of alveolar bone loss and the concentration of host-derived bone resorptive factors (interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6, prostaglandin-E2), and markers of bone turnover [pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), osteocalcin, osteonectin] in stimulated human whole saliva collected from 110 untreated dental patients. Alveolar bone loss scores for each patient were derived from radiographic examination. Variables positively associated with increased bone loss score were: age, current smoking, use of bisphosphonate drugs, and salivary interleukin-1beta levels above the median. Salivary osteonectin levels above the median were associated with a decreased bone loss score. Additional <italic>in vitro</italic>
studies were carried out to determine the fate of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha added to whole and parotid saliva. All cytokines added to saliva were detected in significantly lower concentrations than when added to buffer alone. Protease inhibitors added to saliva did not prevent the reduction in detection of biomarkers. Variation in time of incubation, repeated cycles of freezing and thawing, or exposure to dimethylsulfoxide did not appreciably affect the measurement of cytokines in saliva. These results suggest that detection of biomarkers by conventional immunoassays may underestimate the actual quantity of molecules in saliva.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006777 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 006777 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Main |étape= Curation |type= RBID |clé= PMC:2258090 |texte= Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and in vitro studies }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:17328758" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
This area was generated with Dilib version V0.6.32. |