The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model
Identifieur interne : 002160 ( Main/Curation ); précédent : 002159; suivant : 002161The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model
Auteurs : Hyun-Pil Lim ; Angel E. Mercado-Pagan [États-Unis] ; Kwi-Dug Yun ; Seong-Soo Kang [Corée du Sud] ; Taek-Hue Choi ; Julius Bishop [États-Unis] ; Jeong-Tae Koh ; William Maloney [États-Unis] ; Kwang-Min Lee [Corée du Sud] ; Yunzhi Yang [États-Unis] ; Sang-Won ParkSource :
- Journal of materials science. Materials in medicine [ 0957-4530 ] ; 2013.
Abstract
This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (
Url:
DOI: 10.1007/s10856-013-4939-9
PubMed: 23779152
PubMed Central: 4012921
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Hyun-Pil Lim<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
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<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A4">Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</nlm:aff>
<wicri:noCountry code="subfield">Gwangju</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
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<front><div type="abstract" xml:lang="en"><p id="P1">This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (<italic>p</italic>
<0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.</p>
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