EdenteV2, Pmc, Curation, bibRecord, 002755

The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model

Identifieur interne : 002755 ( Pmc/Curation ); précédent : 002754; suivant : 002756

The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model

Auteurs : Hyun-Pil Lim ; Angel E. Mercado-Pagan [États-Unis] ; Kwi-Dug Yun ; Seong-Soo Kang [Corée du Sud] ; Taek-Hue Choi ; Julius Bishop [États-Unis] ; Jeong-Tae Koh ; William Maloney [États-Unis] ; Kwang-Min Lee [Corée du Sud] ; Yunzhi Yang [États-Unis] ; Sang-Won Park

Source :

Journal of materials science. Materials in medicine [ 0957-4530 ] ; 2013.

RBID : PMC:4012921

Abstract

This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (p<0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012921

DOI: 10.1007/s10856-013-4939-9
PubMed: 23779152
PubMed Central: 4012921

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002755

Links to Exploration step

PMC:4012921

Curation

No country items

Hyun-Pil Lim

<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>

Kwi-Dug Yun

<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>

Taek-Hue Choi

<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>

Jeong-Tae Koh

<affiliation><nlm:aff id="A4">Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</nlm:aff>
<wicri:noCountry code="subfield">Gwangju</wicri:noCountry>
</affiliation>

Sang-Won Park

<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model</title>
<author><name sortKey="Lim, Hyun Pil" sort="Lim, Hyun Pil" uniqKey="Lim H" first="Hyun-Pil" last="Lim">Hyun-Pil Lim</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mercado Pagan, Angel E" sort="Mercado Pagan, Angel E" uniqKey="Mercado Pagan A" first="Angel E." last="Mercado-Pagan">Angel E. Mercado-Pagan</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yun, Kwi Dug" sort="Yun, Kwi Dug" uniqKey="Yun K" first="Kwi-Dug" last="Yun">Kwi-Dug Yun</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong-Soo" last="Kang">Seong-Soo Kang</name>
<affiliation wicri:level="1"><nlm:aff id="A3">College of Veterinary Medicine, Chonnam National University, Gwangju, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Veterinary Medicine, Chonnam National University, Gwangju</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, Taek Hue" sort="Choi, Taek Hue" uniqKey="Choi T" first="Taek-Hue" last="Choi">Taek-Hue Choi</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bishop, Julius" sort="Bishop, Julius" uniqKey="Bishop J" first="Julius" last="Bishop">Julius Bishop</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koh, Jeong Tae" sort="Koh, Jeong Tae" uniqKey="Koh J" first="Jeong-Tae" last="Koh">Jeong-Tae Koh</name>
<affiliation><nlm:aff id="A4">Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</nlm:aff>
<wicri:noCountry code="subfield">Gwangju</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Maloney, William" sort="Maloney, William" uniqKey="Maloney W" first="William" last="Maloney">William Maloney</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Kwang Min" sort="Lee, Kwang Min" uniqKey="Lee K" first="Kwang-Min" last="Lee">Kwang-Min Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Materials Science and Engineering, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23779152</idno>
<idno type="pmc">4012921</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012921</idno>
<idno type="RBID">PMC:4012921</idno>
<idno type="doi">10.1007/s10856-013-4939-9</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002755</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002755</idno>
<idno type="wicri:Area/Pmc/Curation">002755</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002755</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model</title>
<author><name sortKey="Lim, Hyun Pil" sort="Lim, Hyun Pil" uniqKey="Lim H" first="Hyun-Pil" last="Lim">Hyun-Pil Lim</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mercado Pagan, Angel E" sort="Mercado Pagan, Angel E" uniqKey="Mercado Pagan A" first="Angel E." last="Mercado-Pagan">Angel E. Mercado-Pagan</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yun, Kwi Dug" sort="Yun, Kwi Dug" uniqKey="Yun K" first="Kwi-Dug" last="Yun">Kwi-Dug Yun</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong-Soo" last="Kang">Seong-Soo Kang</name>
<affiliation wicri:level="1"><nlm:aff id="A3">College of Veterinary Medicine, Chonnam National University, Gwangju, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Veterinary Medicine, Chonnam National University, Gwangju</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, Taek Hue" sort="Choi, Taek Hue" uniqKey="Choi T" first="Taek-Hue" last="Choi">Taek-Hue Choi</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bishop, Julius" sort="Bishop, Julius" uniqKey="Bishop J" first="Julius" last="Bishop">Julius Bishop</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koh, Jeong Tae" sort="Koh, Jeong Tae" uniqKey="Koh J" first="Jeong-Tae" last="Koh">Jeong-Tae Koh</name>
<affiliation><nlm:aff id="A4">Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</nlm:aff>
<wicri:noCountry code="subfield">Gwangju</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Maloney, William" sort="Maloney, William" uniqKey="Maloney W" first="William" last="Maloney">William Maloney</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Kwang Min" sort="Lee, Kwang Min" uniqKey="Lee K" first="Kwang-Min" last="Lee">Kwang-Min Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Materials Science and Engineering, Stanford University, Stanford, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
<wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of materials science. Materials in medicine</title>
<idno type="ISSN">0957-4530</idno>
<idno type="eISSN">1573-4838</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (<italic>p</italic>
<0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">9013087</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22799</journal-id>
<journal-id journal-id-type="nlm-ta">J Mater Sci Mater Med</journal-id>
<journal-id journal-id-type="iso-abbrev">J Mater Sci Mater Med</journal-id>
<journal-title-group><journal-title>Journal of materials science. Materials in medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">0957-4530</issn>
<issn pub-type="epub">1573-4838</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23779152</article-id>
<article-id pub-id-type="pmc">4012921</article-id>
<article-id pub-id-type="doi">10.1007/s10856-013-4939-9</article-id>
<article-id pub-id-type="manuscript">NIHMS495780</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lim</surname>
<given-names>Hyun-Pil</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mercado-Pagan</surname>
<given-names>Angel E.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yun</surname>
<given-names>Kwi-Dug</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kang</surname>
<given-names>Seong-Soo</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Choi</surname>
<given-names>Taek-Hue</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bishop</surname>
<given-names>Julius</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koh</surname>
<given-names>Jeong-Tae</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maloney</surname>
<given-names>William</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Kwang-Min</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Yunzhi</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Park</surname>
<given-names>Sang-Won</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</aff>
<aff id="A2"><label>2</label>
Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</aff>
<aff id="A3"><label>3</label>
College of Veterinary Medicine, Chonnam National University, Gwangju, Korea</aff>
<aff id="A4"><label>4</label>
Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</aff>
<aff id="A5"><label>5</label>
Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju, Korea</aff>
<aff id="A6"><label>6</label>
Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA</aff>
<author-notes><corresp id="FN1">Corresponding authors: Sang-Won Park, Ph.D., D.D.S., Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, 33 Yongbong-ro, Buk-gu, Gwangju 500-757, KOREA, Tel.: +82 62 530 5842, Fax: +82 62 530 5639, <email>psw320@chonnam.ac.kr</email>
. Yunzhi Peter Yang, Ph.D., Department of Orthopedic Surgery, Stanford University, 300 Pasteur Drive, Edwards, R155, Stanford, CA 94305, Mail code: 5341, T: 650-723-0772 (Office), 650-725-8698 (Lab), F: 650-721-5404, <email>ypyang@stanford.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>19</day>
<month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>8</month>
<year>2014</year>
</pub-date>
<volume>24</volume>
<issue>8</issue>
<fpage>1895</fpage>
<lpage>1903</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/s10856-013-4939-9</pmc-comment>
      <abstract><p id="P1">This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (<italic>p</italic>
<0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.</p>
</abstract>
<kwd-group><kwd>rhBMP-2</kwd>
<kwd>PRP</kwd>
<kwd>calvarial defect</kwd>
<kwd>porous scaffolds</kwd>
<kwd>ceramic scaffolds</kwd>
<kwd>vertical augmentation</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002755 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 002755 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV2
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:4012921
   |texte=   The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:23779152" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a EdenteV2

This area was generated with Dilib version V0.6.32.
Data generation: Thu Nov 30 15:26:48 2017. Site generation: Tue Mar 8 16:36:20 2022

	Serveur d'exploration sur le patient édenté
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le patient édenté

The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model

The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Curation

No country items

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki