Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research
Identifieur interne : 001A22 ( Main/Curation ); précédent : 001A21; suivant : 001A23Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research
Auteurs : Johann Lechner [Allemagne] ; Volker Von Baehr [Allemagne]Source :
- Breast Cancer : Basic and Clinical Research [ 1178-2234 ] ; 2014.
Abstract
Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.
Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).
Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.
RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.
This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.
We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.
Url:
DOI: 10.4137/BCBCR.S15119
PubMed: 24899812
PubMed Central: 4039184
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research</title><author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name><affiliation wicri:level="3"><nlm:aff id="af1-bcbcr-8-2014-089">Head of Clinic for Integrative Dentistry, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Head of Clinic for Integrative Dentistry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name><affiliation wicri:level="3"><nlm:aff id="af2-bcbcr-8-2014-089">Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24899812</idno><idno type="pmc">4039184</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039184</idno><idno type="RBID">PMC:4039184</idno><idno type="doi">10.4137/BCBCR.S15119</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002955</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002955</idno><idno type="wicri:Area/Pmc/Curation">002955</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002955</idno><idno type="wicri:Area/Pmc/Checkpoint">001431</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001431</idno><idno type="wicri:Area/Ncbi/Merge">005153</idno><idno type="wicri:Area/Ncbi/Curation">005153</idno><idno type="wicri:Area/Ncbi/Checkpoint">005153</idno><idno type="wicri:Area/Main/Merge">001A28</idno><idno type="wicri:Area/Main/Curation">001A22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research</title><author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name><affiliation wicri:level="3"><nlm:aff id="af1-bcbcr-8-2014-089">Head of Clinic for Integrative Dentistry, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Head of Clinic for Integrative Dentistry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name><affiliation wicri:level="3"><nlm:aff id="af2-bcbcr-8-2014-089">Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">Breast Cancer : Basic and Clinical Research</title><idno type="eISSN">1178-2234</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND</title><p>Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.</p></sec><sec><title>OBJECTIVES</title><p>Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).</p></sec><sec><title>MATERIAL AND METHODS</title><p>Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.</p></sec><sec><title>RESULTS</title><p>RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.</p></sec><sec><title>DISCUSSION</title><p>This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.</p></sec><sec><title>CONCLUSION</title><p>We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Glueck, Cj" uniqKey="Glueck C">CJ Glueck</name></author><author><name sortKey="Freiberg, Ra" uniqKey="Freiberg R">RA Freiberg</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilke, I" uniqKey="Wilke I">I Wilke</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author><author><name sortKey="Roberts, Am" uniqKey="Roberts A">AM 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