Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research
Identifieur interne : 001431 ( Pmc/Checkpoint ); précédent : 001430; suivant : 001432Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research
Auteurs : Johann Lechner [Allemagne] ; Volker Von Baehr [Allemagne]Source :
- Breast Cancer : Basic and Clinical Research [ 1178-2234 ] ; 2014.
Abstract
Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.
Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).
Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.
RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.
This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.
We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.
Url:
DOI: 10.4137/BCBCR.S15119
PubMed: 24899812
PubMed Central: 4039184
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research</title><author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name><affiliation wicri:level="3"><nlm:aff id="af1-bcbcr-8-2014-089">Head of Clinic for Integrative Dentistry, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Head of Clinic for Integrative Dentistry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name><affiliation wicri:level="3"><nlm:aff id="af2-bcbcr-8-2014-089">Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24899812</idno><idno type="pmc">4039184</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039184</idno><idno type="RBID">PMC:4039184</idno><idno type="doi">10.4137/BCBCR.S15119</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002955</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002955</idno><idno type="wicri:Area/Pmc/Curation">002955</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002955</idno><idno type="wicri:Area/Pmc/Checkpoint">001431</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001431</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research</title><author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name><affiliation wicri:level="3"><nlm:aff id="af1-bcbcr-8-2014-089">Head of Clinic for Integrative Dentistry, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Head of Clinic for Integrative Dentistry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name><affiliation wicri:level="3"><nlm:aff id="af2-bcbcr-8-2014-089">Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">Breast Cancer : Basic and Clinical Research</title><idno type="eISSN">1178-2234</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND</title><p>Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.</p></sec><sec><title>OBJECTIVES</title><p>Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).</p></sec><sec><title>MATERIAL AND METHODS</title><p>Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.</p></sec><sec><title>RESULTS</title><p>RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.</p></sec><sec><title>DISCUSSION</title><p>This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.</p></sec><sec><title>CONCLUSION</title><p>We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Glueck, Cj" uniqKey="Glueck C">CJ Glueck</name></author><author><name sortKey="Freiberg, Ra" uniqKey="Freiberg R">RA Freiberg</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilke, I" uniqKey="Wilke I">I Wilke</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author><author><name sortKey="Roberts, Am" uniqKey="Roberts A">AM 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Breast Cancer (Auckl)</journal-id><journal-id journal-id-type="iso-abbrev">Breast Cancer (Auckl)</journal-id><journal-title-group><journal-title>Breast Cancer : Basic and Clinical Research</journal-title></journal-title-group><issn pub-type="epub">1178-2234</issn><publisher><publisher-name>Libertas Academica</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24899812</article-id><article-id pub-id-type="pmc">4039184</article-id><article-id pub-id-type="doi">10.4137/BCBCR.S15119</article-id><article-id pub-id-type="publisher-id">bcbcr-8-2014-089</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lechner</surname><given-names>Johann</given-names></name><xref ref-type="aff" rid="af1-bcbcr-8-2014-089">1</xref><xref ref-type="corresp" rid="c1-bcbcr-8-2014-089"></xref></contrib><contrib contrib-type="author"><name><surname>von Baehr</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="af2-bcbcr-8-2014-089">2</xref></contrib></contrib-group><aff id="af1-bcbcr-8-2014-089"><label>1</label>Head of Clinic for Integrative Dentistry, Munich, Germany.</aff><aff id="af2-bcbcr-8-2014-089"><label>2</label>Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.</aff><author-notes><corresp id="c1-bcbcr-8-2014-089">CORRESPONDENCE: <email>drlechner@aol.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>21</day><month>5</month><year>2014</year></pub-date><volume>8</volume><fpage>89</fpage><lpage>96</lpage><history><date date-type="received"><day>02</day><month>3</month><year>2014</year></date><date date-type="rev-recd"><day>27</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>28</day><month>4</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 the author(s), publisher and licensee Libertas Academica Ltd.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 license.</license-p></license></permissions><abstract><sec><title>BACKGROUND</title><p>Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.</p></sec><sec><title>OBJECTIVES</title><p>Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).</p></sec><sec><title>MATERIAL AND METHODS</title><p>Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.</p></sec><sec><title>RESULTS</title><p>RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.</p></sec><sec><title>DISCUSSION</title><p>This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.</p></sec><sec><title>CONCLUSION</title><p>We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.</p></sec></abstract><kwd-group><kwd>RANTES/CCL5</kwd><kwd>breast cancer</kwd><kwd>jawbone</kwd><kwd>osteonecrosis</kwd><kwd>metastasis</kwd><kwd>signaling pathways</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-bcbcr-8-2014-089" position="float"><label>Figure 1</label><caption><p>FDOJ sample completely converted the marrow of the JB to fatty tissue.</p></caption><graphic xlink:href="bcbcr-8-2014-089f1"></graphic></fig><fig id="f2-bcbcr-8-2014-089" position="float"><label>Figure 2</label><caption><p>Pathohistological structure of typical FDOJ—inconspicuous tissue in direct comparison with degenerative changed fatty tissue (Hematoxylin eosin stain HE 400-fold).</p></caption><graphic xlink:href="bcbcr-8-2014-089f2"></graphic></fig><fig id="f3-bcbcr-8-2014-089" position="float"><label>Figure 3</label><caption><p>Tumor cells in the retromolar area of FDOJ tissue (HE 400-fold).</p></caption><graphic xlink:href="bcbcr-8-2014-089f3"></graphic></fig><fig id="f4-bcbcr-8-2014-089" position="float"><label>Figure 4</label><caption><p>Analysis of seven cytokines in excised FDOJ tissue (retromolar area of the right mandible) from a MaCa patient in comparison to a normal JB.</p></caption><graphic xlink:href="bcbcr-8-2014-089f4"></graphic></fig><fig id="f5-bcbcr-8-2014-089" position="float"><label>Figure 5</label><caption><p>Bead-based processing of FDOJ samples.</p></caption><graphic xlink:href="bcbcr-8-2014-089f5"></graphic></fig><fig id="f6-bcbcr-8-2014-089" position="float"><label>Figure 6</label><caption><p>Distribution of seven cytokines in FDOJ in MaCa cases and in a normal JB (n = 23 and n = 19, respectively) (pg/mL).</p></caption><graphic xlink:href="bcbcr-8-2014-089f6"></graphic></fig><fig id="f7-bcbcr-8-2014-089" position="float"><label>Figure 7</label><caption><p>Distribution of individual RANTES values in FDOJ MaCa cases compared to the normal JB (in green; baseline) (n = 23 and n = 19, respectively) (pg/mL).</p></caption><graphic xlink:href="bcbcr-8-2014-089f7"></graphic></fig><fig id="f8-bcbcr-8-2014-089" position="float"><label>Figure 8</label><caption><p>Comparison of RANTES expression in MaCa tissues taken from the literature and in FDOJ among 23 MaCa patients.</p></caption><graphic xlink:href="bcbcr-8-2014-089f8"></graphic></fig><fig id="f9-bcbcr-8-2014-089" position="float"><label>Figure 9</label><caption><p>RANTES in the serum of 13 MaCa patients compared to normal values.</p></caption><graphic xlink:href="bcbcr-8-2014-089f9"></graphic></fig><fig id="f10-bcbcr-8-2014-089" position="float"><label>Figure 10</label><caption><p>Matched correlations of RANTES in FDOJ and in serum.</p></caption><graphic xlink:href="bcbcr-8-2014-089f10"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>Berlin</li><li>District de Haute-Bavière</li></region><settlement><li>Berlin</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name></region><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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