Relationship Between Disease Characteristics and Orofacial Manifestations in Systemic Sclerosis: Canadian Systemic Sclerosis Oral Health Study III
Identifieur interne : 000D53 ( Main/Curation ); précédent : 000D52; suivant : 000D54Relationship Between Disease Characteristics and Orofacial Manifestations in Systemic Sclerosis: Canadian Systemic Sclerosis Oral Health Study III
Auteurs : Murray Baron [Canada] ; Marie Hudson [Canada] ; Solène Tatibouet [Canada] ; Russell Steele [Canada] ; Ernest Lo [Canada] ; Sabrina Gravel [Canada] ; Geneviève Gyger [Canada] ; Tarek El Sayegh [Canada] ; Janet Pope [Canada] ; Audrey Fontaine [Canada] ; Ariel Masetto [Canada] ; Debora Matthews [Canada] ; Evelyn Sutton [Canada] ; Norman Thie [Canada] ; Niall Jones [Canada] ; Maria Copete [Canada] ; Dean Kolbinson [Canada] ; Janet Markland ; Getulio Nogueira [Canada] ; David Robinson [Canada] ; Marvin Fritzler [Canada] ; Mervyn Gornitsky [Canada]Source :
- Arthritis care & research [ 2151-464X ] ; 2015.
Abstract
Systemic sclerosis (SSc; scleroderma) is associated with decreased saliva production and interincisal distance, more missing teeth, and periodontal disease. We undertook this study to determine the clinical correlates of SSc with these oral abnormalities.
Subjects were recruited from the Canadian Scleroderma Research Group cohort. Detailed dental and clinical examinations were performed according to standardized protocols. Associations between dental abnormalities and selected clinical and serologic manifestations of SSc were examined.
One hundred sixty-three SSc subjects were included: 90% women, mean ± SD age 56 ± 11 years, mean ± SD disease duration 14 ± 8 years, 72% with limited cutaneous disease, and 28% with diffuse cutaneous disease. Decreased saliva production was associated with Sjögren’s syndrome–related autoantibodies (
In SSc, diminished interincisal distance is related to overall disease severity. Decreased saliva production is related to concomitant Sjögren’s syndrome antibodies. Tooth loss is associated with poor upper extremity function, GERD, and decreased saliva. The etiology of excess periodontal disease is likely multifactorial and remains unclear.
Url:
DOI: 10.1002/acr.22490
PubMed: 25303223
PubMed Central: 4464822
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PMC:4464822Le document en format XML
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<author><name sortKey="Copete, Maria" sort="Copete, Maria" uniqKey="Copete M" first="Maria" last="Copete">Maria Copete</name>
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<author><name sortKey="Markland, Janet" sort="Markland, Janet" uniqKey="Markland J" first="Janet" last="Markland">Janet Markland</name>
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<author><name sortKey="Nogueira, Getulio" sort="Nogueira, Getulio" uniqKey="Nogueira G" first="Getulio" last="Nogueira">Getulio Nogueira</name>
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<author><name sortKey="Robinson, David" sort="Robinson, David" uniqKey="Robinson D" first="David" last="Robinson">David Robinson</name>
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<wicri:regionArea>University of Calgary, Calgary, Alberta</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gornitsky, Mervyn" sort="Gornitsky, Mervyn" uniqKey="Gornitsky M" first="Mervyn" last="Gornitsky">Mervyn Gornitsky</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Jewish General Hospital and McGill University, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Arthritis care & research</title>
<idno type="ISSN">2151-464X</idno>
<idno type="eISSN">2151-4658</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Systemic sclerosis (SSc; scleroderma) is associated with decreased saliva production and interincisal distance, more missing teeth, and periodontal disease. We undertook this study to determine the clinical correlates of SSc with these oral abnormalities.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Subjects were recruited from the Canadian Scleroderma Research Group cohort. Detailed dental and clinical examinations were performed according to standardized protocols. Associations between dental abnormalities and selected clinical and serologic manifestations of SSc were examined.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">One hundred sixty-three SSc subjects were included: 90% women, mean ± SD age 56 ± 11 years, mean ± SD disease duration 14 ± 8 years, 72% with limited cutaneous disease, and 28% with diffuse cutaneous disease. Decreased saliva production was associated with Sjögren’s syndrome–related autoantibodies (<italic>β</italic>
= −43.32; 95% confidence interval [95% CI] −80.89, −5.75), but not with disease severity (<italic>β</italic>
= −2.51; 95% CI −8.75, 3.73). Decreased interincisal distance was related to disease severity (<italic>β</italic>
= −1.02; 95% CI −1.63, −0.42) and the modified Rodnan skin thickness score (<italic>β</italic>
= −0.38; 95% CI −0.53, −0.23). The number of missing teeth was associated with decreased saliva production (relative risk [RR] 0.97; 95% CI 0.94, 0.99), worse hand function (RR 1.52; 95% CI 1.13, 2.02), and the presence of gastroesophageal reflux disease (GERD; RR 1.68 [95% CI 1.14, 2.46]). No clinical or serologic variables were correlated with periodontal disease.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">In SSc, diminished interincisal distance is related to overall disease severity. Decreased saliva production is related to concomitant Sjögren’s syndrome antibodies. Tooth loss is associated with poor upper extremity function, GERD, and decreased saliva. The etiology of excess periodontal disease is likely multifactorial and remains unclear.</p>
</sec>
</div>
</front>
</TEI>
</record>
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