Relationship Between Disease Characteristics and Orofacial Manifestations in Systemic Sclerosis: Canadian Systemic Sclerosis Oral Health Study III
Identifieur interne : 002655 ( Pmc/Corpus ); précédent : 002654; suivant : 002656Relationship Between Disease Characteristics and Orofacial Manifestations in Systemic Sclerosis: Canadian Systemic Sclerosis Oral Health Study III
Auteurs : Murray Baron ; Marie Hudson ; Solène Tatibouet ; Russell Steele ; Ernest Lo ; Sabrina Gravel ; Geneviève Gyger ; Tarek El Sayegh ; Janet Pope ; Audrey Fontaine ; Ariel Masetto ; Debora Matthews ; Evelyn Sutton ; Norman Thie ; Niall Jones ; Maria Copete ; Dean Kolbinson ; Janet Markland ; Getulio Nogueira ; David Robinson ; Marvin Fritzler ; Mervyn GornitskySource :
- Arthritis care & research [ 2151-464X ] ; 2015.
Abstract
Systemic sclerosis (SSc; scleroderma) is associated with decreased saliva production and interincisal distance, more missing teeth, and periodontal disease. We undertook this study to determine the clinical correlates of SSc with these oral abnormalities.
Subjects were recruited from the Canadian Scleroderma Research Group cohort. Detailed dental and clinical examinations were performed according to standardized protocols. Associations between dental abnormalities and selected clinical and serologic manifestations of SSc were examined.
One hundred sixty-three SSc subjects were included: 90% women, mean ± SD age 56 ± 11 years, mean ± SD disease duration 14 ± 8 years, 72% with limited cutaneous disease, and 28% with diffuse cutaneous disease. Decreased saliva production was associated with Sjögren’s syndrome–related autoantibodies (
In SSc, diminished interincisal distance is related to overall disease severity. Decreased saliva production is related to concomitant Sjögren’s syndrome antibodies. Tooth loss is associated with poor upper extremity function, GERD, and decreased saliva. The etiology of excess periodontal disease is likely multifactorial and remains unclear.
Url:
DOI: 10.1002/acr.22490
PubMed: 25303223
PubMed Central: 4464822
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PMC:4464822Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship Between Disease Characteristics and Orofacial Manifestations in Systemic Sclerosis: Canadian Systemic Sclerosis Oral Health Study III</title><author><name sortKey="Baron, Murray" sort="Baron, Murray" uniqKey="Baron M" first="Murray" last="Baron">Murray Baron</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Hudson, Marie" sort="Hudson, Marie" uniqKey="Hudson M" first="Marie" last="Hudson">Marie Hudson</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Tatibouet, Solene" sort="Tatibouet, Solene" uniqKey="Tatibouet S" first="Solène" last="Tatibouet">Solène Tatibouet</name><affiliation><nlm:aff id="A2">Lady Davis Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Steele, Russell" sort="Steele, Russell" uniqKey="Steele R" first="Russell" last="Steele">Russell Steele</name><affiliation><nlm:aff id="A3">McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Lo, Ernest" sort="Lo, Ernest" uniqKey="Lo E" first="Ernest" last="Lo">Ernest Lo</name><affiliation><nlm:aff id="A2">Lady Davis Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Gravel, Sabrina" sort="Gravel, Sabrina" uniqKey="Gravel S" first="Sabrina" last="Gravel">Sabrina Gravel</name><affiliation><nlm:aff id="A4">Jewish General Hospital, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Gyger, Genevieve" sort="Gyger, Genevieve" uniqKey="Gyger G" first="Geneviève" last="Gyger">Geneviève Gyger</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Sayegh, Tarek El" sort="Sayegh, Tarek El" uniqKey="Sayegh T" first="Tarek El" last="Sayegh">Tarek El Sayegh</name><affiliation><nlm:aff id="A5">University of Western Ontario, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Pope, Janet" sort="Pope, Janet" uniqKey="Pope J" first="Janet" last="Pope">Janet Pope</name><affiliation><nlm:aff id="A5">University of Western Ontario, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Fontaine, Audrey" sort="Fontaine, Audrey" uniqKey="Fontaine A" first="Audrey" last="Fontaine">Audrey Fontaine</name><affiliation><nlm:aff id="A6">Clinique Dentaire Ayotte et Associés, Sherbrooke, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Masetto, Ariel" sort="Masetto, Ariel" uniqKey="Masetto A" first="Ariel" last="Masetto">Ariel Masetto</name><affiliation><nlm:aff id="A7">University of Sherbrooke, Sherbrooke, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Matthews, Debora" sort="Matthews, Debora" uniqKey="Matthews D" first="Debora" last="Matthews">Debora Matthews</name><affiliation><nlm:aff id="A8">Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Sutton, Evelyn" sort="Sutton, Evelyn" uniqKey="Sutton E" first="Evelyn" last="Sutton">Evelyn Sutton</name><affiliation><nlm:aff id="A8">Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Thie, Norman" sort="Thie, Norman" uniqKey="Thie N" first="Norman" last="Thie">Norman Thie</name><affiliation><nlm:aff id="A9">University of Alberta, Edmonton, Alberta, Canada</nlm:aff></affiliation></author><author><name sortKey="Jones, Niall" sort="Jones, Niall" uniqKey="Jones N" first="Niall" last="Jones">Niall Jones</name><affiliation><nlm:aff id="A9">University of Alberta, Edmonton, Alberta, Canada</nlm:aff></affiliation></author><author><name sortKey="Copete, Maria" sort="Copete, Maria" uniqKey="Copete M" first="Maria" last="Copete">Maria Copete</name><affiliation><nlm:aff id="A10">University of Saskatchewan, Saskatoon, Saskatchewan, Canada</nlm:aff></affiliation></author><author><name sortKey="Kolbinson, Dean" sort="Kolbinson, Dean" uniqKey="Kolbinson D" first="Dean" last="Kolbinson">Dean Kolbinson</name><affiliation><nlm:aff id="A10">University of Saskatchewan, Saskatoon, Saskatchewan, Canada</nlm:aff></affiliation></author><author><name sortKey="Markland, Janet" sort="Markland, Janet" uniqKey="Markland J" first="Janet" last="Markland">Janet Markland</name></author><author><name sortKey="Nogueira, Getulio" sort="Nogueira, Getulio" uniqKey="Nogueira G" first="Getulio" last="Nogueira">Getulio Nogueira</name><affiliation><nlm:aff id="A11">University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Robinson, David" sort="Robinson, David" uniqKey="Robinson D" first="David" last="Robinson">David Robinson</name><affiliation><nlm:aff id="A11">University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Fritzler, Marvin" sort="Fritzler, Marvin" uniqKey="Fritzler M" first="Marvin" last="Fritzler">Marvin Fritzler</name><affiliation><nlm:aff id="A12">University of Calgary, Calgary, Alberta, Canada</nlm:aff></affiliation></author><author><name sortKey="Gornitsky, Mervyn" sort="Gornitsky, Mervyn" uniqKey="Gornitsky M" first="Mervyn" last="Gornitsky">Mervyn Gornitsky</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25303223</idno><idno type="pmc">4464822</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464822</idno><idno type="RBID">PMC:4464822</idno><idno type="doi">10.1002/acr.22490</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002655</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002655</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relationship Between Disease Characteristics and Orofacial Manifestations in Systemic Sclerosis: Canadian Systemic Sclerosis Oral Health Study III</title><author><name sortKey="Baron, Murray" sort="Baron, Murray" uniqKey="Baron M" first="Murray" last="Baron">Murray Baron</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Hudson, Marie" sort="Hudson, Marie" uniqKey="Hudson M" first="Marie" last="Hudson">Marie Hudson</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Tatibouet, Solene" sort="Tatibouet, Solene" uniqKey="Tatibouet S" first="Solène" last="Tatibouet">Solène Tatibouet</name><affiliation><nlm:aff id="A2">Lady Davis Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Steele, Russell" sort="Steele, Russell" uniqKey="Steele R" first="Russell" last="Steele">Russell Steele</name><affiliation><nlm:aff id="A3">McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Lo, Ernest" sort="Lo, Ernest" uniqKey="Lo E" first="Ernest" last="Lo">Ernest Lo</name><affiliation><nlm:aff id="A2">Lady Davis Institute, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Gravel, Sabrina" sort="Gravel, Sabrina" uniqKey="Gravel S" first="Sabrina" last="Gravel">Sabrina Gravel</name><affiliation><nlm:aff id="A4">Jewish General Hospital, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Gyger, Genevieve" sort="Gyger, Genevieve" uniqKey="Gyger G" first="Geneviève" last="Gyger">Geneviève Gyger</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Sayegh, Tarek El" sort="Sayegh, Tarek El" uniqKey="Sayegh T" first="Tarek El" last="Sayegh">Tarek El Sayegh</name><affiliation><nlm:aff id="A5">University of Western Ontario, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Pope, Janet" sort="Pope, Janet" uniqKey="Pope J" first="Janet" last="Pope">Janet Pope</name><affiliation><nlm:aff id="A5">University of Western Ontario, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Fontaine, Audrey" sort="Fontaine, Audrey" uniqKey="Fontaine A" first="Audrey" last="Fontaine">Audrey Fontaine</name><affiliation><nlm:aff id="A6">Clinique Dentaire Ayotte et Associés, Sherbrooke, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Masetto, Ariel" sort="Masetto, Ariel" uniqKey="Masetto A" first="Ariel" last="Masetto">Ariel Masetto</name><affiliation><nlm:aff id="A7">University of Sherbrooke, Sherbrooke, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Matthews, Debora" sort="Matthews, Debora" uniqKey="Matthews D" first="Debora" last="Matthews">Debora Matthews</name><affiliation><nlm:aff id="A8">Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Sutton, Evelyn" sort="Sutton, Evelyn" uniqKey="Sutton E" first="Evelyn" last="Sutton">Evelyn Sutton</name><affiliation><nlm:aff id="A8">Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Thie, Norman" sort="Thie, Norman" uniqKey="Thie N" first="Norman" last="Thie">Norman Thie</name><affiliation><nlm:aff id="A9">University of Alberta, Edmonton, Alberta, Canada</nlm:aff></affiliation></author><author><name sortKey="Jones, Niall" sort="Jones, Niall" uniqKey="Jones N" first="Niall" last="Jones">Niall Jones</name><affiliation><nlm:aff id="A9">University of Alberta, Edmonton, Alberta, Canada</nlm:aff></affiliation></author><author><name sortKey="Copete, Maria" sort="Copete, Maria" uniqKey="Copete M" first="Maria" last="Copete">Maria Copete</name><affiliation><nlm:aff id="A10">University of Saskatchewan, Saskatoon, Saskatchewan, Canada</nlm:aff></affiliation></author><author><name sortKey="Kolbinson, Dean" sort="Kolbinson, Dean" uniqKey="Kolbinson D" first="Dean" last="Kolbinson">Dean Kolbinson</name><affiliation><nlm:aff id="A10">University of Saskatchewan, Saskatoon, Saskatchewan, Canada</nlm:aff></affiliation></author><author><name sortKey="Markland, Janet" sort="Markland, Janet" uniqKey="Markland J" first="Janet" last="Markland">Janet Markland</name></author><author><name sortKey="Nogueira, Getulio" sort="Nogueira, Getulio" uniqKey="Nogueira G" first="Getulio" last="Nogueira">Getulio Nogueira</name><affiliation><nlm:aff id="A11">University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Robinson, David" sort="Robinson, David" uniqKey="Robinson D" first="David" last="Robinson">David Robinson</name><affiliation><nlm:aff id="A11">University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Fritzler, Marvin" sort="Fritzler, Marvin" uniqKey="Fritzler M" first="Marvin" last="Fritzler">Marvin Fritzler</name><affiliation><nlm:aff id="A12">University of Calgary, Calgary, Alberta, Canada</nlm:aff></affiliation></author><author><name sortKey="Gornitsky, Mervyn" sort="Gornitsky, Mervyn" uniqKey="Gornitsky M" first="Mervyn" last="Gornitsky">Mervyn Gornitsky</name><affiliation><nlm:aff id="A1">Jewish General Hospital and McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Arthritis care & research</title><idno type="ISSN">2151-464X</idno><idno type="eISSN">2151-4658</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Systemic sclerosis (SSc; scleroderma) is associated with decreased saliva production and interincisal distance, more missing teeth, and periodontal disease. We undertook this study to determine the clinical correlates of SSc with these oral abnormalities.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Subjects were recruited from the Canadian Scleroderma Research Group cohort. Detailed dental and clinical examinations were performed according to standardized protocols. Associations between dental abnormalities and selected clinical and serologic manifestations of SSc were examined.</p></sec><sec id="S3"><title>Results</title><p id="P3">One hundred sixty-three SSc subjects were included: 90% women, mean ± SD age 56 ± 11 years, mean ± SD disease duration 14 ± 8 years, 72% with limited cutaneous disease, and 28% with diffuse cutaneous disease. Decreased saliva production was associated with Sjögren’s syndrome–related autoantibodies (<italic>β</italic> = −43.32; 95% confidence interval [95% CI] −80.89, −5.75), but not with disease severity (<italic>β</italic> = −2.51; 95% CI −8.75, 3.73). Decreased interincisal distance was related to disease severity (<italic>β</italic> = −1.02; 95% CI −1.63, −0.42) and the modified Rodnan skin thickness score (<italic>β</italic> = −0.38; 95% CI −0.53, −0.23). The number of missing teeth was associated with decreased saliva production (relative risk [RR] 0.97; 95% CI 0.94, 0.99), worse hand function (RR 1.52; 95% CI 1.13, 2.02), and the presence of gastroesophageal reflux disease (GERD; RR 1.68 [95% CI 1.14, 2.46]). No clinical or serologic variables were correlated with periodontal disease.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">In SSc, diminished interincisal distance is related to overall disease severity. Decreased saliva production is related to concomitant Sjögren’s syndrome antibodies. Tooth loss is associated with poor upper extremity function, GERD, and decreased saliva. The etiology of excess periodontal disease is likely multifactorial and remains unclear.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101518086</journal-id><journal-id journal-id-type="pubmed-jr-id">37048</journal-id><journal-id journal-id-type="nlm-ta">Arthritis Care Res (Hoboken)</journal-id><journal-id journal-id-type="iso-abbrev">Arthritis Care Res (Hoboken)</journal-id><journal-title-group><journal-title>Arthritis care & research</journal-title></journal-title-group><issn pub-type="ppub">2151-464X</issn><issn pub-type="epub">2151-4658</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25303223</article-id><article-id pub-id-type="pmc">4464822</article-id><article-id pub-id-type="doi">10.1002/acr.22490</article-id><article-id pub-id-type="manuscript">CAMS4711</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Relationship Between Disease Characteristics and Orofacial Manifestations in Systemic Sclerosis: Canadian Systemic Sclerosis Oral Health Study III</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>BARON</surname><given-names>MURRAY</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>HUDSON</surname><given-names>MARIE</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>TATIBOUET</surname><given-names>SOLÈNE</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>STEELE</surname><given-names>RUSSELL</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>LO</surname><given-names>ERNEST</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>GRAVEL</surname><given-names>SABRINA</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>GYGER</surname><given-names>GENEVIÈVE</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>SAYEGH</surname><given-names>TAREK EL</given-names></name><degrees>DDS, PhD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>POPE</surname><given-names>JANET</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>FONTAINE</surname><given-names>AUDREY</given-names></name><degrees>DMD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>MASETTO</surname><given-names>ARIEL</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>MATTHEWS</surname><given-names>DEBORA</given-names></name><degrees>DDS, DipPerio</degrees><degrees>MSc</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>SUTTON</surname><given-names>EVELYN</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>THIE</surname><given-names>NORMAN</given-names></name><degrees>DDS, MSc</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>JONES</surname><given-names>NIALL</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>COPETE</surname><given-names>MARIA</given-names></name><degrees>DDS, MS</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>KOLBINSON</surname><given-names>DEAN</given-names></name><degrees>DMD, MSD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>MARKLAND</surname><given-names>JANET</given-names></name><xref rid="FN2" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>NOGUEIRA</surname><given-names>GETULIO</given-names></name><degrees>DDS, MSc, PhD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>ROBINSON</surname><given-names>DAVID</given-names></name><degrees>MD, MSc</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>FRITZLER</surname><given-names>MARVIN</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>GORNITSKY</surname><given-names>MERVYN</given-names></name><degrees>DDS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Jewish General Hospital and McGill University, Montreal, Quebec, Canada</aff><aff id="A2"><label>2</label>Lady Davis Institute, Montreal, Quebec, Canada</aff><aff id="A3"><label>3</label>McGill University, Montreal, Quebec, Canada</aff><aff id="A4"><label>4</label>Jewish General Hospital, Montreal, Quebec, Canada</aff><aff id="A5"><label>5</label>University of Western Ontario, London, Ontario, Canada</aff><aff id="A6"><label>6</label>Clinique Dentaire Ayotte et Associés, Sherbrooke, Quebec, Canada</aff><aff id="A7"><label>7</label>University of Sherbrooke, Sherbrooke, Quebec, Canada</aff><aff id="A8"><label>8</label>Dalhousie University, Halifax, Nova Scotia, Canada</aff><aff id="A9"><label>9</label>University of Alberta, Edmonton, Alberta, Canada</aff><aff id="A10"><label>10</label>University of Saskatchewan, Saskatoon, Saskatchewan, Canada</aff><aff id="A11"><label>11</label>University of Manitoba, Winnipeg, Manitoba, Canada</aff><aff id="A12"><label>12</label>University of Calgary, Calgary, Alberta, Canada</aff><author-notes><corresp id="FN1">Address correspondence to: Murray Baron, MD, Chief Division of Rheumatology, Jewish General Hospital, 3755 Cote St. Catherine Road, A-725, Montreal, Quebec, Canada H3T 1E2. <email>mbaron@rhu.jgh.mcgill.ca</email></corresp><fn id="FN2" fn-type="deceased"><label>†</label><p>Dr. Markland is deceased.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2015</year></pub-date><volume>67</volume><issue>5</issue><fpage>681</fpage><lpage>690</lpage><pmc-comment>elocation-id from pubmed: 10.1002/acr.22490</pmc-comment>
<permissions><copyright-statement>© 2015, American College of Rheumatology</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><sec id="S1"><title>Objective</title><p id="P1">Systemic sclerosis (SSc; scleroderma) is associated with decreased saliva production and interincisal distance, more missing teeth, and periodontal disease. We undertook this study to determine the clinical correlates of SSc with these oral abnormalities.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Subjects were recruited from the Canadian Scleroderma Research Group cohort. Detailed dental and clinical examinations were performed according to standardized protocols. Associations between dental abnormalities and selected clinical and serologic manifestations of SSc were examined.</p></sec><sec id="S3"><title>Results</title><p id="P3">One hundred sixty-three SSc subjects were included: 90% women, mean ± SD age 56 ± 11 years, mean ± SD disease duration 14 ± 8 years, 72% with limited cutaneous disease, and 28% with diffuse cutaneous disease. Decreased saliva production was associated with Sjögren’s syndrome–related autoantibodies (<italic>β</italic> = −43.32; 95% confidence interval [95% CI] −80.89, −5.75), but not with disease severity (<italic>β</italic> = −2.51; 95% CI −8.75, 3.73). Decreased interincisal distance was related to disease severity (<italic>β</italic> = −1.02; 95% CI −1.63, −0.42) and the modified Rodnan skin thickness score (<italic>β</italic> = −0.38; 95% CI −0.53, −0.23). The number of missing teeth was associated with decreased saliva production (relative risk [RR] 0.97; 95% CI 0.94, 0.99), worse hand function (RR 1.52; 95% CI 1.13, 2.02), and the presence of gastroesophageal reflux disease (GERD; RR 1.68 [95% CI 1.14, 2.46]). No clinical or serologic variables were correlated with periodontal disease.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">In SSc, diminished interincisal distance is related to overall disease severity. Decreased saliva production is related to concomitant Sjögren’s syndrome antibodies. Tooth loss is associated with poor upper extremity function, GERD, and decreased saliva. The etiology of excess periodontal disease is likely multifactorial and remains unclear.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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