A study of factors contributing to the development of osteoradionecrosis of the jaws
Identifieur interne : 005457 ( Istex/Curation ); précédent : 005456; suivant : 005458A study of factors contributing to the development of osteoradionecrosis of the jaws
Auteurs : Edwin V. Kluth [États-Unis] ; Pushpa Rani Jain [États-Unis] ; Robert N. Stuchell [États-Unis] ; John C. Frich [États-Unis]Source :
- The Journal of Prosthetic Dentistry [ 0022-3913 ] ; 1988.
English descriptors
- KwdEn :
- Alcohol history, Alveolar ridge, Anterior tongue, Associate professor, Bone complications, Bone involvement, Buccal mucosa, Carcinoma, Cell carcinomas, Chemotherapy, Concurrent moniliasis, Control group, Control patients, Dental extractions, Dentistry, Denture, Denture irritation, Denture irritations, Early stage, Edentulous patients, Extraction, Extraction site, Extraction sites, High dose, Hygiene, Implant, Miniature swine, Oral cavity, Oral hygiene, Osteomyelitis, Osteoradionecrosis, Other patients, Parotid gland, Postsurgical radiation, Presurgical radiation, Radiation necrosis, Radiation oncology, Radiation osteomyelitis, Radiation therapy, Radioactive implant, Radioactive implants, Retromolar trigone, Rodiotion post, Significant mucositis, Smoke cigars, Soft palate, Squamous, Squamous cell carcinoma, Squamous cell carcinomas, Strong tissue irritants, Surgery extraction, Therapy, Tobacco history, Total dose, Treatment modalities, Tumor site, West virginia university.
- Teeft :
- Alcohol history, Alveolar ridge, Anterior tongue, Associate professor, Bone complications, Bone involvement, Buccal mucosa, Carcinoma, Cell carcinomas, Chemotherapy, Concurrent moniliasis, Control group, Control patients, Dental extractions, Dentistry, Denture, Denture irritation, Denture irritations, Early stage, Edentulous patients, Extraction, Extraction site, Extraction sites, High dose, Hygiene, Implant, Miniature swine, Oral cavity, Oral hygiene, Osteomyelitis, Osteoradionecrosis, Other patients, Parotid gland, Postsurgical radiation, Presurgical radiation, Radiation necrosis, Radiation oncology, Radiation osteomyelitis, Radiation therapy, Radioactive implant, Radioactive implants, Retromolar trigone, Rodiotion post, Significant mucositis, Smoke cigars, Soft palate, Squamous, Squamous cell carcinoma, Squamous cell carcinomas, Strong tissue irritants, Surgery extraction, Therapy, Tobacco history, Total dose, Treatment modalities, Tumor site, West virginia university.
Abstract
Abstract: The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.
Url:
DOI: 10.1016/0022-3913(88)90015-7
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<term>Bone complications</term>
<term>Bone involvement</term>
<term>Buccal mucosa</term>
<term>Carcinoma</term>
<term>Cell carcinomas</term>
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<term>Edentulous patients</term>
<term>Extraction</term>
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<term>High dose</term>
<term>Hygiene</term>
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<front><div type="abstract" xml:lang="en">Abstract: The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.</div>
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