A study of factors contributing to the development of osteoradionecrosis of the jaws
Identifieur interne : 005457 ( Istex/Corpus ); précédent : 005456; suivant : 005458A study of factors contributing to the development of osteoradionecrosis of the jaws
Auteurs : Edwin V. Kluth ; Pushpa Rani Jain ; Robert N. Stuchell ; John C. FrichSource :
- The Journal of Prosthetic Dentistry [ 0022-3913 ] ; 1988.
English descriptors
- KwdEn :
- Alcohol history, Alveolar ridge, Anterior tongue, Associate professor, Bone complications, Bone involvement, Buccal mucosa, Carcinoma, Cell carcinomas, Chemotherapy, Concurrent moniliasis, Control group, Control patients, Dental extractions, Dentistry, Denture, Denture irritation, Denture irritations, Early stage, Edentulous patients, Extraction, Extraction site, Extraction sites, High dose, Hygiene, Implant, Miniature swine, Oral cavity, Oral hygiene, Osteomyelitis, Osteoradionecrosis, Other patients, Parotid gland, Postsurgical radiation, Presurgical radiation, Radiation necrosis, Radiation oncology, Radiation osteomyelitis, Radiation therapy, Radioactive implant, Radioactive implants, Retromolar trigone, Rodiotion post, Significant mucositis, Smoke cigars, Soft palate, Squamous, Squamous cell carcinoma, Squamous cell carcinomas, Strong tissue irritants, Surgery extraction, Therapy, Tobacco history, Total dose, Treatment modalities, Tumor site, West virginia university.
- Teeft :
- Alcohol history, Alveolar ridge, Anterior tongue, Associate professor, Bone complications, Bone involvement, Buccal mucosa, Carcinoma, Cell carcinomas, Chemotherapy, Concurrent moniliasis, Control group, Control patients, Dental extractions, Dentistry, Denture, Denture irritation, Denture irritations, Early stage, Edentulous patients, Extraction, Extraction site, Extraction sites, High dose, Hygiene, Implant, Miniature swine, Oral cavity, Oral hygiene, Osteomyelitis, Osteoradionecrosis, Other patients, Parotid gland, Postsurgical radiation, Presurgical radiation, Radiation necrosis, Radiation oncology, Radiation osteomyelitis, Radiation therapy, Radioactive implant, Radioactive implants, Retromolar trigone, Rodiotion post, Significant mucositis, Smoke cigars, Soft palate, Squamous, Squamous cell carcinoma, Squamous cell carcinomas, Strong tissue irritants, Surgery extraction, Therapy, Tobacco history, Total dose, Treatment modalities, Tumor site, West virginia university.
Abstract
Abstract: The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.
Url:
DOI: 10.1016/0022-3913(88)90015-7
Links to Exploration step
ISTEX:A9480B6D1EB974714646605DC5523711477A3416Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A study of factors contributing to the development of osteoradionecrosis of the jaws</title>
<author><name sortKey="Kluth, Edwin V" sort="Kluth, Edwin V" uniqKey="Kluth E" first="Edwin V." last="Kluth">Edwin V. Kluth</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Jain, Pushpa Rani" sort="Jain, Pushpa Rani" uniqKey="Jain P" first="Pushpa Rani" last="Jain">Pushpa Rani Jain</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Stuchell, Robert N" sort="Stuchell, Robert N" uniqKey="Stuchell R" first="Robert N." last="Stuchell">Robert N. Stuchell</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Frich, John C" sort="Frich, John C" uniqKey="Frich J" first="John C." last="Frich">John C. Frich</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A9480B6D1EB974714646605DC5523711477A3416</idno>
<date when="1988" year="1988">1988</date>
<idno type="doi">10.1016/0022-3913(88)90015-7</idno>
<idno type="url">https://api.istex.fr/document/A9480B6D1EB974714646605DC5523711477A3416/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">005457</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">005457</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A study of factors contributing to the development of osteoradionecrosis of the jaws</title>
<author><name sortKey="Kluth, Edwin V" sort="Kluth, Edwin V" uniqKey="Kluth E" first="Edwin V." last="Kluth">Edwin V. Kluth</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Jain, Pushpa Rani" sort="Jain, Pushpa Rani" uniqKey="Jain P" first="Pushpa Rani" last="Jain">Pushpa Rani Jain</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Stuchell, Robert N" sort="Stuchell, Robert N" uniqKey="Stuchell R" first="Robert N." last="Stuchell">Robert N. Stuchell</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Frich, John C" sort="Frich, John C" uniqKey="Frich J" first="John C." last="Frich">John C. Frich</name>
<affiliation><mods:affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">The Journal of Prosthetic Dentistry</title>
<title level="j" type="abbrev">YMPR</title>
<idno type="ISSN">0022-3913</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1988">1988</date>
<biblScope unit="volume">59</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="194">194</biblScope>
<biblScope unit="page" to="201">201</biblScope>
</imprint>
<idno type="ISSN">0022-3913</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-3913</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol history</term>
<term>Alveolar ridge</term>
<term>Anterior tongue</term>
<term>Associate professor</term>
<term>Bone complications</term>
<term>Bone involvement</term>
<term>Buccal mucosa</term>
<term>Carcinoma</term>
<term>Cell carcinomas</term>
<term>Chemotherapy</term>
<term>Concurrent moniliasis</term>
<term>Control group</term>
<term>Control patients</term>
<term>Dental extractions</term>
<term>Dentistry</term>
<term>Denture</term>
<term>Denture irritation</term>
<term>Denture irritations</term>
<term>Early stage</term>
<term>Edentulous patients</term>
<term>Extraction</term>
<term>Extraction site</term>
<term>Extraction sites</term>
<term>High dose</term>
<term>Hygiene</term>
<term>Implant</term>
<term>Miniature swine</term>
<term>Oral cavity</term>
<term>Oral hygiene</term>
<term>Osteomyelitis</term>
<term>Osteoradionecrosis</term>
<term>Other patients</term>
<term>Parotid gland</term>
<term>Postsurgical radiation</term>
<term>Presurgical radiation</term>
<term>Radiation necrosis</term>
<term>Radiation oncology</term>
<term>Radiation osteomyelitis</term>
<term>Radiation therapy</term>
<term>Radioactive implant</term>
<term>Radioactive implants</term>
<term>Retromolar trigone</term>
<term>Rodiotion post</term>
<term>Significant mucositis</term>
<term>Smoke cigars</term>
<term>Soft palate</term>
<term>Squamous</term>
<term>Squamous cell carcinoma</term>
<term>Squamous cell carcinomas</term>
<term>Strong tissue irritants</term>
<term>Surgery extraction</term>
<term>Therapy</term>
<term>Tobacco history</term>
<term>Total dose</term>
<term>Treatment modalities</term>
<term>Tumor site</term>
<term>West virginia university</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Alcohol history</term>
<term>Alveolar ridge</term>
<term>Anterior tongue</term>
<term>Associate professor</term>
<term>Bone complications</term>
<term>Bone involvement</term>
<term>Buccal mucosa</term>
<term>Carcinoma</term>
<term>Cell carcinomas</term>
<term>Chemotherapy</term>
<term>Concurrent moniliasis</term>
<term>Control group</term>
<term>Control patients</term>
<term>Dental extractions</term>
<term>Dentistry</term>
<term>Denture</term>
<term>Denture irritation</term>
<term>Denture irritations</term>
<term>Early stage</term>
<term>Edentulous patients</term>
<term>Extraction</term>
<term>Extraction site</term>
<term>Extraction sites</term>
<term>High dose</term>
<term>Hygiene</term>
<term>Implant</term>
<term>Miniature swine</term>
<term>Oral cavity</term>
<term>Oral hygiene</term>
<term>Osteomyelitis</term>
<term>Osteoradionecrosis</term>
<term>Other patients</term>
<term>Parotid gland</term>
<term>Postsurgical radiation</term>
<term>Presurgical radiation</term>
<term>Radiation necrosis</term>
<term>Radiation oncology</term>
<term>Radiation osteomyelitis</term>
<term>Radiation therapy</term>
<term>Radioactive implant</term>
<term>Radioactive implants</term>
<term>Retromolar trigone</term>
<term>Rodiotion post</term>
<term>Significant mucositis</term>
<term>Smoke cigars</term>
<term>Soft palate</term>
<term>Squamous</term>
<term>Squamous cell carcinoma</term>
<term>Squamous cell carcinomas</term>
<term>Strong tissue irritants</term>
<term>Surgery extraction</term>
<term>Therapy</term>
<term>Tobacco history</term>
<term>Total dose</term>
<term>Treatment modalities</term>
<term>Tumor site</term>
<term>West virginia university</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.</div>
</front>
</TEI>
<istex><corpusName>elsevier</corpusName>
<keywords><teeft><json:string>osteoradionecrosis</json:string>
<json:string>radiation therapy</json:string>
<json:string>denture</json:string>
<json:string>control group</json:string>
<json:string>osteomyelitis</json:string>
<json:string>control patients</json:string>
<json:string>chemotherapy</json:string>
<json:string>squamous</json:string>
<json:string>carcinoma</json:string>
<json:string>radiation osteomyelitis</json:string>
<json:string>implant</json:string>
<json:string>squamous cell carcinomas</json:string>
<json:string>radioactive implant</json:string>
<json:string>denture irritation</json:string>
<json:string>dentistry</json:string>
<json:string>retromolar trigone</json:string>
<json:string>treatment modalities</json:string>
<json:string>buccal mucosa</json:string>
<json:string>squamous cell carcinoma</json:string>
<json:string>cell carcinomas</json:string>
<json:string>high dose</json:string>
<json:string>bone involvement</json:string>
<json:string>hygiene</json:string>
<json:string>therapy</json:string>
<json:string>alveolar ridge</json:string>
<json:string>anterior tongue</json:string>
<json:string>radioactive implants</json:string>
<json:string>radiation necrosis</json:string>
<json:string>extraction sites</json:string>
<json:string>soft palate</json:string>
<json:string>miniature swine</json:string>
<json:string>west virginia university</json:string>
<json:string>parotid gland</json:string>
<json:string>associate professor</json:string>
<json:string>other patients</json:string>
<json:string>rodiotion post</json:string>
<json:string>oral hygiene</json:string>
<json:string>early stage</json:string>
<json:string>presurgical radiation</json:string>
<json:string>postsurgical radiation</json:string>
<json:string>radiation oncology</json:string>
<json:string>significant mucositis</json:string>
<json:string>concurrent moniliasis</json:string>
<json:string>edentulous patients</json:string>
<json:string>tobacco history</json:string>
<json:string>smoke cigars</json:string>
<json:string>alcohol history</json:string>
<json:string>bone complications</json:string>
<json:string>surgery extraction</json:string>
<json:string>total dose</json:string>
<json:string>tumor site</json:string>
<json:string>extraction site</json:string>
<json:string>denture irritations</json:string>
<json:string>strong tissue irritants</json:string>
<json:string>oral cavity</json:string>
<json:string>dental extractions</json:string>
<json:string>extraction</json:string>
</teeft>
</keywords>
<author><json:item><name>Edwin V. Kluth D.D.S., M.S.</name>
<affiliations><json:string>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</json:string>
</affiliations>
</json:item>
<json:item><name>Pushpa Rani Jain M.D.</name>
<affiliations><json:string>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</json:string>
</affiliations>
</json:item>
<json:item><name>Robert N. Stuchell D.M.D.</name>
<affiliations><json:string>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</json:string>
</affiliations>
</json:item>
<json:item><name>John C. Frich M.D.</name>
<affiliations><json:string>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</json:string>
</affiliations>
</json:item>
</author>
<subject><json:item><lang><json:string>eng</json:string>
</lang>
<value>Maxillofacial prosthetics • dental implants</value>
</json:item>
</subject>
<articleId><json:string>88900157</json:string>
</articleId>
<arkIstex>ark:/67375/6H6-61KNT05T-2</arkIstex>
<language><json:string>eng</json:string>
</language>
<originalGenre><json:string>Full-length article</json:string>
</originalGenre>
<abstract>Abstract: The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.</abstract>
<qualityIndicators><refBibsNative>true</refBibsNative>
<abstractWordCount>287</abstractWordCount>
<abstractCharCount>1907</abstractCharCount>
<keywordCount>1</keywordCount>
<score>8.477</score>
<pdfWordCount>3477</pdfWordCount>
<pdfCharCount>22758</pdfCharCount>
<pdfVersion>1.3</pdfVersion>
<pdfPageCount>8</pdfPageCount>
<pdfPageSize>576 x 828 pts</pdfPageSize>
</qualityIndicators>
<title>A study of factors contributing to the development of osteoradionecrosis of the jaws</title>
<pmid><json:string>2963910</json:string>
</pmid>
<pii><json:string>0022-3913(88)90015-7</json:string>
</pii>
<genre><json:string>research-article</json:string>
</genre>
<host><title>The Journal of Prosthetic Dentistry</title>
<language><json:string>unknown</json:string>
</language>
<publicationDate>1988</publicationDate>
<issn><json:string>0022-3913</json:string>
</issn>
<pii><json:string>S0022-3913(88)X8005-7</json:string>
</pii>
<volume>59</volume>
<issue>2</issue>
<pages><first>194</first>
<last>201</last>
</pages>
<genre><json:string>journal</json:string>
</genre>
</host>
<namedEntities><unitex><date><json:string>Between July 1973 and June 1983</json:string>
<json:string>5000 to 7000</json:string>
<json:string>1988</json:string>
</date>
<geogName></geogName>
<orgName><json:string>American Academy of Maxillofacial Prosthetics, Seattle, Wash</json:string>
<json:string>Department of Periodontics</json:string>
<json:string>Medical Center</json:string>
<json:string>Department of Prosthodontics</json:string>
<json:string>West Virginia University</json:string>
<json:string>Division of Radiation Oncology</json:string>
<json:string>Radiation Therapy Clinics</json:string>
</orgName>
<orgName_funder></orgName_funder>
<orgName_provider></orgName_provider>
<persName><json:string>Rani Jain</json:string>
<json:string>Nancy Woods</json:string>
<json:string>Total</json:string>
<json:string>Angela Kopich</json:string>
<json:string>Mary Abraham</json:string>
<json:string>El Fig</json:string>
<json:string>Edwin V. Kluth</json:string>
<json:string>I. Location</json:string>
<json:string>W.Va</json:string>
<json:string>Dev Biol</json:string>
<json:string>Mary Taylor</json:string>
<json:string>Robert N. Stuchell</json:string>
</persName>
<placeName><json:string>Morgantown</json:string>
<json:string>Baltimore</json:string>
<json:string>York</json:string>
</placeName>
<ref_url></ref_url>
<ref_bibl><json:string>Academic Press Inc, 1970</json:string>
<json:string>Scientific American Books, 1986</json:string>
</ref_bibl>
<bibl></bibl>
</unitex>
</namedEntities>
<ark><json:string>ark:/67375/6H6-61KNT05T-2</json:string>
</ark>
<categories><wos><json:string>1 - science</json:string>
<json:string>2 - dentistry, oral surgery & medicine</json:string>
</wos>
<scienceMetrix><json:string>1 - health sciences</json:string>
<json:string>2 - clinical medicine</json:string>
<json:string>3 - dentistry</json:string>
</scienceMetrix>
<scopus><json:string>1 - Health Sciences</json:string>
<json:string>2 - Dentistry</json:string>
<json:string>3 - Oral Surgery</json:string>
</scopus>
<inist><json:string>1 - sciences appliquees, technologies et medecines</json:string>
<json:string>2 - sciences biologiques et medicales</json:string>
<json:string>3 - sciences medicales</json:string>
</inist>
</categories>
<publicationDate>1988</publicationDate>
<copyrightDate>1988</copyrightDate>
<doi><json:string>10.1016/0022-3913(88)90015-7</json:string>
</doi>
<id>A9480B6D1EB974714646605DC5523711477A3416</id>
<score>1</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/document/A9480B6D1EB974714646605DC5523711477A3416/fulltext/pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/document/A9480B6D1EB974714646605DC5523711477A3416/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/A9480B6D1EB974714646605DC5523711477A3416/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A study of factors contributing to the development of osteoradionecrosis of the jaws</title>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>ELSEVIER</publisher>
<availability><p>©1988 The C. V. Mosby Company</p>
</availability>
<date>1988</date>
</publicationStmt>
<notesStmt><note>Presented before the American Academy of Maxillofacial Prosthetics, Seattle, Wash.</note>
</notesStmt>
<sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A study of factors contributing to the development of osteoradionecrosis of the jaws</title>
<author xml:id="author-0000"><persName><forename type="first">Edwin V.</forename>
<surname>Kluth</surname>
</persName>
<roleName type="degree">D.D.S., M.S.</roleName>
<note type="biography">Reprint requests to: Dr. Edwin V. Kluth West Virginia University School of Dentistry Morgantown, WV 26505.</note>
<note type="biography">Professor, Department of Prosthodontics.</note>
<affiliation>Reprint requests to: Dr. Edwin V. Kluth West Virginia University School of Dentistry Morgantown, WV 26505.</affiliation>
<affiliation>Professor, Department of Prosthodontics.</affiliation>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
</author>
<author xml:id="author-0001"><persName><forename type="first">Pushpa Rani</forename>
<surname>Jain</surname>
</persName>
<roleName type="degree">M.D.</roleName>
<note type="biography">Associate Professor, Division of Radiation Oncology.</note>
<affiliation>Associate Professor, Division of Radiation Oncology.</affiliation>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
</author>
<author xml:id="author-0002"><persName><forename type="first">Robert N.</forename>
<surname>Stuchell</surname>
</persName>
<roleName type="degree">D.M.D.</roleName>
<note type="biography">Associate Professor, Department of Periodontics.</note>
<affiliation>Associate Professor, Department of Periodontics.</affiliation>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
</author>
<author xml:id="author-0003"><persName><forename type="first">John C.</forename>
<surname>Frich</surname>
</persName>
<roleName type="degree">M.D.</roleName>
<note type="biography">Professor and Chairman, Division of Radiation Oncology.</note>
<affiliation>Professor and Chairman, Division of Radiation Oncology.</affiliation>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
</author>
<idno type="istex">A9480B6D1EB974714646605DC5523711477A3416</idno>
<idno type="DOI">10.1016/0022-3913(88)90015-7</idno>
<idno type="PII">0022-3913(88)90015-7</idno>
<idno type="ArticleID">88900157</idno>
</analytic>
<monogr><title level="j">The Journal of Prosthetic Dentistry</title>
<title level="j" type="abbrev">YMPR</title>
<idno type="pISSN">0022-3913</idno>
<idno type="PII">S0022-3913(88)X8005-7</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1988"></date>
<biblScope unit="volume">59</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="194">194</biblScope>
<biblScope unit="page" to="201">201</biblScope>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><creation><date>1988</date>
</creation>
<langUsage><language ident="en">en</language>
</langUsage>
<abstract xml:lang="en"><p>Abstract: The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.</p>
</abstract>
<textClass><keywords scheme="keyword"><list><head>article-category</head>
<item><term>Maxillofacial prosthetics • dental implants</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc><change when="1988">Published</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/document/A9480B6D1EB974714646605DC5523711477A3416/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration>
<istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType>
<istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>YMPR</jid>
<aid>88900157</aid>
<ce:pii>0022-3913(88)90015-7</ce:pii>
<ce:doi>10.1016/0022-3913(88)90015-7</ce:doi>
<ce:copyright type="unknown" year="1988">The C. V. Mosby Company</ce:copyright>
<ce:doctopics><ce:doctopic><ce:text>Maxillofacial prosthetics • dental implants</ce:text>
</ce:doctopic>
</ce:doctopics>
</item-info>
<head><ce:article-footnote><ce:note-para>Presented before the American Academy of Maxillofacial Prosthetics, Seattle, Wash.</ce:note-para>
</ce:article-footnote>
<ce:title>A study of factors contributing to the development of osteoradionecrosis of the jaws</ce:title>
<ce:author-group><ce:author><ce:given-name>Edwin V.</ce:given-name>
<ce:surname>Kluth</ce:surname>
<ce:degrees>D.D.S., M.S.</ce:degrees>
<ce:cross-ref refid="cor1"><ce:sup>*</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="fn1"><ce:sup>*</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Pushpa Rani</ce:given-name>
<ce:surname>Jain</ce:surname>
<ce:degrees>M.D.</ce:degrees>
<ce:cross-ref refid="fn2"><ce:sup>**</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Robert N.</ce:given-name>
<ce:surname>Stuchell</ce:surname>
<ce:degrees>D.M.D.</ce:degrees>
<ce:cross-ref refid="fn3"><ce:sup>***</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>John C.</ce:given-name>
<ce:surname>Frich</ce:surname>
<ce:degrees>M.D.</ce:degrees>
<ce:cross-ref refid="fn4"><ce:sup>****</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:affiliation><ce:textfn>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</ce:textfn>
</ce:affiliation>
<ce:correspondence id="cor1"><ce:label>*</ce:label>
<ce:text><ce:italic>Reprint requests to:</ce:italic>
<ce:small-caps>Dr. Edwin V. Kluth West Virginia University School of Dentistry Morgantown, WV</ce:small-caps>
26505.</ce:text>
</ce:correspondence>
<ce:footnote id="fn1"><ce:label>*</ce:label>
<ce:note-para>Professor, Department of Prosthodontics.</ce:note-para>
</ce:footnote>
<ce:footnote id="fn2"><ce:label>**</ce:label>
<ce:note-para>Associate Professor, Division of Radiation Oncology.</ce:note-para>
</ce:footnote>
<ce:footnote id="fn3"><ce:label>***</ce:label>
<ce:note-para>Associate Professor, Department of Periodontics.</ce:note-para>
</ce:footnote>
<ce:footnote id="fn4"><ce:label>****</ce:label>
<ce:note-para>Professor and Chairman, Division of Radiation Oncology.</ce:note-para>
</ce:footnote>
</ce:author-group>
<ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.<ce:list><ce:list-item><ce:para>1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.</ce:para>
</ce:list-item>
<ce:list-item><ce:para>2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.</ce:para>
</ce:list-item>
<ce:list-item><ce:para>3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.</ce:para>
</ce:list-item>
<ce:list-item><ce:para>4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.</ce:para>
</ce:list-item>
<ce:list-item><ce:para>5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.</ce:para>
</ce:list-item>
</ce:list>
</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
</head>
<tail><ce:bibliography><ce:section-title>Reference</ce:section-title>
<ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Beumer</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:author>
<sb:author><ce:surname>Curtis</ce:surname>
<ce:given-name>T</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Radiation therapy of the head and neck tumors: oral effects and dental manifestations</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Beumer</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:editor>
<sb:editor><ce:surname>Curtis</ce:surname>
<ce:given-name>T</ce:given-name>
</sb:editor>
<sb:editor><ce:surname>Firtell</ce:surname>
<ce:given-name>D</ce:given-name>
</sb:editor>
</sb:editors>
<sb:title><sb:maintitle>Maxillofacial rehabilitation</sb:maintitle>
</sb:title>
<sb:date>1979</sb:date>
<sb:publisher><sb:name>The CV Mosby Co</sb:name>
<sb:location>St. Louis</sb:location>
</sb:publisher>
</sb:edited-book>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib2"><ce:label>2.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Baker</ce:surname>
<ce:given-name>D</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>The radiobiological basis for tissue reactions in the oral cavity following therapeutic x-irradiation</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch Otolaryngol</sb:maintitle>
</sb:title>
<sb:volume-nr>108</sb:volume-nr>
</sb:series>
<sb:date>1982</sb:date>
</sb:issue>
<sb:pages><sb:first-page>21</sb:first-page>
<sb:last-page>24</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib3"><ce:label>3.</ce:label>
<sb:reference><sb:host><sb:book><sb:title><sb:maintitle>Maintenance of oral and general health in the management of the oral cancer patient</sb:maintitle>
</sb:title>
<sb:date>1969</sb:date>
<sb:publisher><sb:name>American Cancer Society</sb:name>
</sb:publisher>
</sb:book>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib4"><ce:label>4.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Wildermuth</ce:surname>
<ce:given-name>O</ce:given-name>
</sb:author>
<sb:author><ce:surname>Cantril</ce:surname>
<ce:given-name>ST</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Radiation necrosis of the mandible</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Radiology</sb:maintitle>
</sb:title>
<sb:volume-nr>61</sb:volume-nr>
</sb:series>
<sb:date>1953</sb:date>
</sb:issue>
<sb:pages><sb:first-page>771</sb:first-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib5"><ce:label>5.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Beumer</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:author>
<sb:author><ce:surname>Harrison</ce:surname>
<ce:given-name>R</ce:given-name>
</sb:author>
<sb:author><ce:surname>Sanders</ce:surname>
<ce:given-name>B</ce:given-name>
</sb:author>
<sb:author><ce:surname>Kurrasch</ce:surname>
<ce:given-name>M</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Osteoradionecrosis: predisposing factors and outcome of therapy</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Head and Neck Surg</sb:maintitle>
</sb:title>
<sb:volume-nr>6</sb:volume-nr>
</sb:series>
<sb:date>1984</sb:date>
</sb:issue>
<sb:pages><sb:first-page>8919</sb:first-page>
<sb:last-page>8927</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib6"><ce:label>6.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Murray</ce:surname>
<ce:given-name>C</ce:given-name>
</sb:author>
<sb:author><ce:surname>Herson</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:author>
<sb:author><ce:surname>Daly</ce:surname>
<ce:given-name>T</ce:given-name>
</sb:author>
<sb:author><ce:surname>Zimmerman</ce:surname>
<ce:given-name>S</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Radiation necrosis of the mandible: a 10-year study. Part I. Factors influencing the onset of necrosis</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Int J Radiat Oncol Biol Phys</sb:maintitle>
</sb:title>
<sb:volume-nr>6</sb:volume-nr>
</sb:series>
<sb:date>1980</sb:date>
</sb:issue>
<sb:pages><sb:first-page>543</sb:first-page>
<sb:last-page>548</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib7"><ce:label>7.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Bedwinek</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:author>
<sb:author><ce:surname>Shukovsky</ce:surname>
<ce:given-name>L</ce:given-name>
</sb:author>
<sb:author><ce:surname>Fletcher</ce:surname>
<ce:given-name>G</ce:given-name>
</sb:author>
<sb:author><ce:surname>Daley</ce:surname>
<ce:given-name>T</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Osteoradionecrosis in patients treated with definite radiotherapy for squamous cell carcinomas of the oral cavity and naso- and oropharynx</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Radiology</sb:maintitle>
</sb:title>
<sb:volume-nr>119</sb:volume-nr>
</sb:series>
<sb:date>1976</sb:date>
</sb:issue>
<sb:pages><sb:first-page>665</sb:first-page>
<sb:last-page>667</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib8"><ce:label>8.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Rankow</ce:surname>
<ce:given-name>R</ce:given-name>
</sb:author>
<sb:author><ce:surname>Weissman</ce:surname>
<ce:given-name>B</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Osteoradionecrosis of the mandible</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann Otolaryngol</sb:maintitle>
</sb:title>
<sb:volume-nr>80</sb:volume-nr>
</sb:series>
<sb:date>1980</sb:date>
</sb:issue>
<sb:pages><sb:first-page>603</sb:first-page>
<sb:last-page>611</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib9"><ce:label>9.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Grant</ce:surname>
<ce:given-name>B</ce:given-name>
</sb:author>
<sb:author><ce:surname>Fletcher</ce:surname>
<ce:given-name>G</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Analysis of complications following metavoltage therapy for squamous cell carcinomas of the tonsillar area</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am J Roentgenol Radium Ther Nucl Med</sb:maintitle>
</sb:title>
<sb:volume-nr>96</sb:volume-nr>
</sb:series>
<sb:date>1966</sb:date>
</sb:issue>
<sb:pages><sb:first-page>28</sb:first-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib10"><ce:label>10.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Beumer</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:author>
<sb:author><ce:surname>Harrison</ce:surname>
<ce:given-name>R</ce:given-name>
</sb:author>
<sb:author><ce:surname>Sanders</ce:surname>
<ce:given-name>B</ce:given-name>
</sb:author>
<sb:author><ce:surname>Kurrasch</ce:surname>
<ce:given-name>M</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Post-radiation dental extractions: a review of the literature and a report of 72 episodes</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Head Neck Surg</sb:maintitle>
</sb:title>
<sb:volume-nr>6</sb:volume-nr>
</sb:series>
<sb:date>1983</sb:date>
</sb:issue>
<sb:pages><sb:first-page>581</sb:first-page>
<sb:last-page>586</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib11"><ce:label>11.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Beumer</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:author>
<sb:author><ce:surname>Harrison</ce:surname>
<ce:given-name>R</ce:given-name>
</sb:author>
<sb:author><ce:surname>Sanders</ce:surname>
<ce:given-name>B</ce:given-name>
</sb:author>
<sb:author><ce:surname>Kurrasch</ce:surname>
<ce:given-name>M</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Pre-radiation dental extractions and the incidence of bone necrosis</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Head and Neck Surg</sb:maintitle>
</sb:title>
<sb:volume-nr>5</sb:volume-nr>
</sb:series>
<sb:date>1983</sb:date>
</sb:issue>
<sb:pages><sb:first-page>514</sb:first-page>
<sb:last-page>521</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib12"><ce:label>12.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Beumer</ce:surname>
<ce:given-name>J</ce:given-name>
</sb:author>
<sb:author><ce:surname>Curtis</ce:surname>
<ce:given-name>T</ce:given-name>
</sb:author>
<sb:author><ce:surname>Morrish</ce:surname>
<ce:given-name>R</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Radiation complications in edentulous patients</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Prosthet Dent</sb:maintitle>
</sb:title>
<sb:volume-nr>36</sb:volume-nr>
</sb:series>
<sb:date>1976</sb:date>
</sb:issue>
<sb:pages><sb:first-page>193</sb:first-page>
<sb:last-page>203</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib13"><ce:label>13.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Carl</ce:surname>
<ce:given-name>W</ce:given-name>
</sb:author>
<sb:author><ce:surname>Schaaf</ce:surname>
<ce:given-name>N</ce:given-name>
</sb:author>
<sb:author><ce:surname>Chen</ce:surname>
<ce:given-name>T</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Oral care of patients irradiated for cancer of the head and neck</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Cancer</sb:maintitle>
</sb:title>
<sb:volume-nr>30</sb:volume-nr>
</sb:series>
<sb:date>1972</sb:date>
</sb:issue>
<sb:pages><sb:first-page>448</sb:first-page>
<sb:last-page>453</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
<ce:bib-reference id="bib14"><ce:label>14.</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Culliton</ce:surname>
<ce:given-name>BJ</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Osteoporosis reexamined: complexity of bone biology is a challenge</sb:maintitle>
</sb:title>
</sb:contribution>
<sb:host><sb:issue><sb:series><sb:title><sb:maintitle>News & Comment section of Science</sb:maintitle>
</sb:title>
<sb:volume-nr>235</sb:volume-nr>
</sb:series>
<sb:date>1987</sb:date>
</sb:issue>
<sb:pages><sb:first-page>833</sb:first-page>
<sb:last-page>834</sb:last-page>
</sb:pages>
</sb:host>
</sb:reference>
</ce:bib-reference>
</ce:bibliography-sec>
</ce:bibliography>
</tail>
</article>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo lang="en"><title>A study of factors contributing to the development of osteoradionecrosis of the jaws</title>
</titleInfo>
<titleInfo type="alternative" lang="en" contentType="CDATA"><title>A study of factors contributing to the development of osteoradionecrosis of the jaws</title>
</titleInfo>
<name type="personal"><namePart type="given">Edwin V.</namePart>
<namePart type="family">Kluth</namePart>
<namePart type="termsOfAddress">D.D.S., M.S.</namePart>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
<description>Reprint requests to: Dr. Edwin V. Kluth West Virginia University School of Dentistry Morgantown, WV 26505.</description>
<description>Professor, Department of Prosthodontics.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Pushpa Rani</namePart>
<namePart type="family">Jain</namePart>
<namePart type="termsOfAddress">M.D.</namePart>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
<description>Associate Professor, Division of Radiation Oncology.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Robert N.</namePart>
<namePart type="family">Stuchell</namePart>
<namePart type="termsOfAddress">D.M.D.</namePart>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
<description>Associate Professor, Department of Periodontics.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">John C.</namePart>
<namePart type="family">Frich</namePart>
<namePart type="termsOfAddress">M.D.</namePart>
<affiliation>West Virginia University, Schools of Dentistry and Medicine, Morgantown, W.Va., USA</affiliation>
<description>Professor and Chairman, Division of Radiation Oncology.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre>
<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1988</dateIssued>
<copyrightDate encoding="w3cdtf">1988</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="iso639-2b">eng</languageTerm>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
</language>
<abstract lang="en">Abstract: The histories of 14 patients in whom osteoradionecrosis developed were compared with those of 28 patients who had similar tumors and/or treatment and were not afflicted with osteoradionecrosis.1. Fourteen of 15 episodes of bone complications occurred in the mandible, and 70% occurred within 1 year after the completion of radiation therapy.2. A high dose of radiation, with conventional fractionation, did not specifically predispose patients to osteoradionecrosis. Fifty percent of the ORN patients actually received a total dose of 6000 rad or less. Combined radiation therapy and surgery did not seem to significantly i:ncrease the risk inasmuch as both groups of patients had similar combinations. In two of four patients who received methotrexate, however, osteoradionecrosis developed during the time of administration.3. One of the most prevalent negative factors associated with the ORN patients was the continued heavy use of alcohol and tobacco by 86% of them. These strong tissue irritants could have significantly contributed to the breakdown of mucosa and exposure of bone. Alcohol and tobacco could also have potentiated the combined effects of the other negative factors, such as contributing to poor oral hygiene.4. The ORN patients had poorer oral hygiene than the control group. Seventy-five percent of the patients with teeth who had osteoradionecrosis continued to have poor oral hygiene. In contrast, none of the control patients had poor oral hygiene.5. A combination of factors relating to stage of tumor and treatment was found in the ORN patients. These factors included more advanced stages of tumors with presence of bone involvement, osteoradionecrosis occurring at or near the site of the tumor, surgery, extraction sites, and/or denture irritations. These conditions were found even though the control patients had a similar pattern of extractions and denture usage.</abstract>
<note>Presented before the American Academy of Maxillofacial Prosthetics, Seattle, Wash.</note>
<subject><genre>article-category</genre>
<topic>Maxillofacial prosthetics • dental implants</topic>
</subject>
<relatedItem type="host"><titleInfo><title>The Journal of Prosthetic Dentistry</title>
</titleInfo>
<titleInfo type="abbreviated"><title>YMPR</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">198802</dateIssued>
</originInfo>
<identifier type="ISSN">0022-3913</identifier>
<identifier type="PII">S0022-3913(88)X8005-7</identifier>
<part><date>198802</date>
<detail type="volume"><number>59</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>2</number>
<caption>no.</caption>
</detail>
<extent unit="issue-pages"><start>131</start>
<end>262</end>
</extent>
<extent unit="issue-pages"><start>A36</start>
</extent>
<extent unit="pages"><start>194</start>
<end>201</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">A9480B6D1EB974714646605DC5523711477A3416</identifier>
<identifier type="ark">ark:/67375/6H6-61KNT05T-2</identifier>
<identifier type="DOI">10.1016/0022-3913(88)90015-7</identifier>
<identifier type="PII">0022-3913(88)90015-7</identifier>
<identifier type="ArticleID">88900157</identifier>
<accessCondition type="use and reproduction" contentType="copyright">©1988 The C. V. Mosby Company</accessCondition>
<recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource>
<recordOrigin>The C. V. Mosby Company, ©1988</recordOrigin>
</recordInfo>
</mods>
<json:item><extension>json</extension>
<original>false</original>
<mimetype>application/json</mimetype>
<uri>https://api.istex.fr/document/A9480B6D1EB974714646605DC5523711477A3416/metadata/json</uri>
</json:item>
</metadata>
<serie></serie>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005457 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 005457 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:A9480B6D1EB974714646605DC5523711477A3416 |texte= A study of factors contributing to the development of osteoradionecrosis of the jaws }}
![]() | This area was generated with Dilib version V0.6.32. | ![]() |