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The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development

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The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development

Auteurs : S. N. Popoff [États-Unis] ; S. C. Marks Jr. [États-Unis]

Source :

Bone [ 8756-3282 ] ; 1995.

RBID : ISTEX:7A65D753CF4E33032C2203B2318C95161F8BCF67

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Wicri :
- topic : Mineur (ouvrier).

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Abstract

Abstract: Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.

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https://api.istex.fr/document/7A65D753CF4E33032C2203B2318C95161F8BCF67/fulltext/pdf

DOI: 10.1016/8756-3282(95)00347-4

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Le document en format XML

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<affiliation wicri:level="1"><mods:affiliation>Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA</mods:affiliation>
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<term>Acad</term>
<term>Additional studies</term>
<term>Binding protein</term>
<term>Biochem</term>
<term>Biol</term>
<term>Bone cells</term>
<term>Bone miner</term>
<term>Bone resorption</term>
<term>Carbonic anhydrase</term>
<term>Cecchini</term>
<term>Cell biochem</term>
<term>Cell biol</term>
<term>Cell biology</term>
<term>Cellular</term>
<term>Cellular diversity</term>
<term>Cellular diversity bone</term>
<term>Clin</term>
<term>Clinical applications</term>
<term>Congenital osteopetrosis</term>
<term>Cytokine</term>
<term>Defect</term>
<term>Diverse effects</term>
<term>Free radicals</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Growth factor</term>
<term>Growth factors</term>
<term>Hemopoietic</term>
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<term>Mammalian osteopetroses</term>
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<term>Miner</term>
<term>Mouse</term>
<term>Mundy</term>
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<term>Mutation</term>
<term>Natl</term>
<term>Normal littermates</term>
<term>November</term>
<term>Oncogene</term>
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<term>Osteopetrotic mouse</term>
<term>Osteopetrotic mutations</term>
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<term>Popoff</term>
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<term>Proc</term>
<term>Proc natl acad</term>
<term>Recent studies</term>
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<term>Resorption</term>
<term>Schneider</term>
<term>Sclerosis</term>
<term>Skeletal development</term>
<term>Skeletal effects</term>
<term>Skeletal sclerosis</term>
<term>Spleen cells</term>
<term>Superoxide</term>
<term>Transgenic mice</term>
<term>Transplantation</term>
<term>Tyrosine kinases</term>
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<term>Acad</term>
<term>Additional studies</term>
<term>Binding protein</term>
<term>Biochem</term>
<term>Biol</term>
<term>Bone cells</term>
<term>Bone miner</term>
<term>Bone resorption</term>
<term>Carbonic anhydrase</term>
<term>Cecchini</term>
<term>Cell biochem</term>
<term>Cell biol</term>
<term>Cell biology</term>
<term>Cellular</term>
<term>Cellular diversity</term>
<term>Cellular diversity bone</term>
<term>Clin</term>
<term>Clinical applications</term>
<term>Congenital osteopetrosis</term>
<term>Cytokine</term>
<term>Defect</term>
<term>Diverse effects</term>
<term>Free radicals</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Growth factor</term>
<term>Growth factors</term>
<term>Hemopoietic</term>
<term>Hemopoietic growth factors</term>
<term>High levels</term>
<term>Immune</term>
<term>Immune cells</term>
<term>Immune regulators</term>
<term>Immune system</term>
<term>Interferon</term>
<term>Kinase</term>
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<term>Lymphocyte</term>
<term>Macrophage</term>
<term>Macrophage activation</term>
<term>Macrophage development</term>
<term>Macrophage factor</term>
<term>Malignant osteopetrosis</term>
<term>Mammalian osteopetroses</term>
<term>Mature osteoclasts</term>
<term>Miner</term>
<term>Mouse</term>
<term>Mundy</term>
<term>Mutant</term>
<term>Mutation</term>
<term>Natl</term>
<term>Normal littermates</term>
<term>November</term>
<term>Oncogene</term>
<term>Osteoblast</term>
<term>Osteoblast differentiation</term>
<term>Osteoclast</term>
<term>Osteoclast development</term>
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<term>Osteopetrosis</term>
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<term>Osteopetrotic animals</term>
<term>Osteopetrotic children</term>
<term>Osteopetrotic mouse</term>
<term>Osteopetrotic mutations</term>
<term>Osteopetrotic rats</term>
<term>Osteosarcoma</term>
<term>Parathyroid hormone</term>
<term>Phagocyte</term>
<term>Popoff</term>
<term>Potent macrophage</term>
<term>Proc</term>
<term>Proc natl acad</term>
<term>Recent studies</term>
<term>Receptor</term>
<term>Resorption</term>
<term>Schneider</term>
<term>Sclerosis</term>
<term>Skeletal development</term>
<term>Skeletal effects</term>
<term>Skeletal sclerosis</term>
<term>Spleen cells</term>
<term>Superoxide</term>
<term>Transgenic mice</term>
<term>Transplantation</term>
<term>Tyrosine kinases</term>
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<front><div type="abstract" xml:lang="en">Abstract: Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.</div>
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The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development

The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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