The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development
Identifieur interne : 003C49 ( Istex/Corpus ); précédent : 003C48; suivant : 003C50The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development
Auteurs : S. N. Popoff ; S. C. Marks Jr.Source :
- Bone [ 8756-3282 ] ; 1995.
English descriptors
- KwdEn :
- Abnormality, Acad, Additional studies, Binding protein, Biochem, Biol, Bone cells, Bone miner, Bone resorption, Carbonic anhydrase, Cecchini, Cell biochem, Cell biol, Cell biology, Cellular, Cellular diversity, Cellular diversity bone, Clin, Clinical applications, Congenital osteopetrosis, Cytokine, Defect, Diverse effects, Free radicals, Gene, Gene expression, Growth factor, Growth factors, Hemopoietic, Hemopoietic growth factors, High levels, Immune, Immune cells, Immune regulators, Immune system, Interferon, Kinase, Lineage, Lymphocyte, Macrophage, Macrophage activation, Macrophage development, Macrophage factor, Malignant osteopetrosis, Mammalian osteopetroses, Mature osteoclasts, Miner, Mouse, Mundy, Mutant, Mutation, Natl, Normal littermates, November, Oncogene, Osteoblast, Osteoblast differentiation, Osteoclast, Osteoclast development, Osteoclast function, Osteoclastic bone resorption, Osteopetroses, Osteopetrosis, Osteopetrotic, Osteopetrotic animals, Osteopetrotic children, Osteopetrotic mouse, Osteopetrotic mutations, Osteopetrotic rats, Osteosarcoma, Parathyroid hormone, Phagocyte, Popoff, Potent macrophage, Proc, Proc natl acad, Recent studies, Receptor, Resorption, Schneider, Sclerosis, Skeletal development, Skeletal effects, Skeletal sclerosis, Spleen cells, Superoxide, Transgenic mice, Transplantation, Tyrosine kinases.
- Teeft :
- Abnormality, Acad, Additional studies, Binding protein, Biochem, Biol, Bone cells, Bone miner, Bone resorption, Carbonic anhydrase, Cecchini, Cell biochem, Cell biol, Cell biology, Cellular, Cellular diversity, Cellular diversity bone, Clin, Clinical applications, Congenital osteopetrosis, Cytokine, Defect, Diverse effects, Free radicals, Gene, Gene expression, Growth factor, Growth factors, Hemopoietic, Hemopoietic growth factors, High levels, Immune, Immune cells, Immune regulators, Immune system, Interferon, Kinase, Lineage, Lymphocyte, Macrophage, Macrophage activation, Macrophage development, Macrophage factor, Malignant osteopetrosis, Mammalian osteopetroses, Mature osteoclasts, Miner, Mouse, Mundy, Mutant, Mutation, Natl, Normal littermates, November, Oncogene, Osteoblast, Osteoblast differentiation, Osteoclast, Osteoclast development, Osteoclast function, Osteoclastic bone resorption, Osteopetroses, Osteopetrosis, Osteopetrotic, Osteopetrotic animals, Osteopetrotic children, Osteopetrotic mouse, Osteopetrotic mutations, Osteopetrotic rats, Osteosarcoma, Parathyroid hormone, Phagocyte, Popoff, Potent macrophage, Proc, Proc natl acad, Recent studies, Receptor, Resorption, Schneider, Sclerosis, Skeletal development, Skeletal effects, Skeletal sclerosis, Spleen cells, Superoxide, Transgenic mice, Transplantation, Tyrosine kinases.
Abstract
Abstract: Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.
Url:
DOI: 10.1016/8756-3282(95)00347-4
Links to Exploration step
ISTEX:7A65D753CF4E33032C2203B2318C95161F8BCF67Le document en format XML
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We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>osteoclast</json:string><json:string>osteopetrotic</json:string><json:string>macrophage</json:string><json:string>osteopetrosis</json:string><json:string>mutation</json:string><json:string>resorption</json:string><json:string>osteoblast</json:string><json:string>popoff</json:string><json:string>bone resorption</json:string><json:string>immune</json:string><json:string>osteopetrotic mutations</json:string><json:string>cytokine</json:string><json:string>kinase</json:string><json:string>skeletal development</json:string><json:string>biol</json:string><json:string>bone miner</json:string><json:string>acad</json:string><json:string>proc</json:string><json:string>transplantation</json:string><json:string>oncogene</json:string><json:string>superoxide</json:string><json:string>hemopoietic</json:string><json:string>proc natl acad</json:string><json:string>schneider</json:string><json:string>natl</json:string><json:string>growth factor</json:string><json:string>receptor</json:string><json:string>lymphocyte</json:string><json:string>abnormality</json:string><json:string>mutant</json:string><json:string>binding protein</json:string><json:string>osteoclast development</json:string><json:string>cecchini</json:string><json:string>biochem</json:string><json:string>phagocyte</json:string><json:string>osteopetroses</json:string><json:string>clin</json:string><json:string>mundy</json:string><json:string>osteosarcoma</json:string><json:string>interferon</json:string><json:string>november</json:string><json:string>skeletal effects</json:string><json:string>cell biol</json:string><json:string>growth factors</json:string><json:string>skeletal sclerosis</json:string><json:string>miner</json:string><json:string>malignant osteopetrosis</json:string><json:string>osteopetrotic children</json:string><json:string>cellular diversity</json:string><json:string>macrophage factor</json:string><json:string>gene expression</json:string><json:string>cell biochem</json:string><json:string>immune regulators</json:string><json:string>normal littermates</json:string><json:string>osteopetrotic rats</json:string><json:string>transgenic mice</json:string><json:string>macrophage activation</json:string><json:string>osteoclastic bone resorption</json:string><json:string>sclerosis</json:string><json:string>mouse</json:string><json:string>free radicals</json:string><json:string>carbonic anhydrase</json:string><json:string>osteoblast differentiation</json:string><json:string>macrophage development</json:string><json:string>bone cells</json:string><json:string>potent macrophage</json:string><json:string>diverse effects</json:string><json:string>cellular diversity bone</json:string><json:string>mature osteoclasts</json:string><json:string>parathyroid hormone</json:string><json:string>clinical applications</json:string><json:string>additional studies</json:string><json:string>high levels</json:string><json:string>osteoclast function</json:string><json:string>spleen cells</json:string><json:string>hemopoietic growth factors</json:string><json:string>congenital osteopetrosis</json:string><json:string>immune cells</json:string><json:string>mammalian osteopetroses</json:string><json:string>immune system</json:string><json:string>osteopetrotic animals</json:string><json:string>osteopetrotic mouse</json:string><json:string>recent studies</json:string><json:string>cell biology</json:string><json:string>tyrosine kinases</json:string><json:string>cellular</json:string><json:string>lineage</json:string><json:string>gene</json:string><json:string>defect</json:string></teeft></keywords><author><json:item><name>S.N. 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We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.</abstract><qualityIndicators><score>7.912</score><pdfWordCount>8389</pdfWordCount><pdfCharCount>52707</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>591 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>76</abstractWordCount><abstractCharCount>571</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development</title><pmid><json:string>8579954</json:string></pmid><pii><json:string>8756-3282(95)00347-4</json:string></pii><genre><json:string>review-article</json:string></genre><serie><title>The Oncogene Handbook</title><language><json:string>unknown</json:string></language><pages><first>149</first><last>173</last></pages></serie><host><title>Bone</title><language><json:string>unknown</json:string></language><publicationDate>1995</publicationDate><issn><json:string>8756-3282</json:string></issn><pii><json:string>S8756-3282(00)X0007-5</json:string></pii><volume>17</volume><issue>5</issue><pages><first>437</first><last>445</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1995</json:string></date><geogName></geogName><orgName><json:string>Temple University</json:string><json:string>Elsevier Science Inc.</json:string><json:string>Department of Cell Biology, Universityof Massachusetts Medical Center</json:string><json:string>Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA, USA</json:string><json:string>National Institutes of Health</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>S. C. Marks</json:string><json:string>J. Bollerslev</json:string><json:string>S.N. Popoff</json:string><json:string>Grant Nos</json:string></persName><placeName><json:string>USA</json:string><json:string>MA</json:string><json:string>Worcester</json:string><json:string>PA</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Schneider et al.</json:string><json:string>Kubo et al.</json:string><json:string>Sorell et al.</json:string><json:string>Orchard et al.</json:string><json:string>Key et al.</json:string><json:string>Glorieux et al</json:string><json:string>Coccia et al.</json:string><json:string>Marks et al.</json:string><json:string>Popoff et al.</json:string><json:string>Peters et al.</json:string><json:string>Grigoriadis et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-VJS34HQV-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - endocrinology & metabolism</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - endocrinology & metabolism</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Histology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Physiology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Endocrinology, Diabetes and Metabolism</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1995</publicationDate><copyrightDate>1995</copyrightDate><doi><json:string>10.1016/8756-3282(95)00347-4</json:string></doi><id>7A65D753CF4E33032C2203B2318C95161F8BCF67</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/7A65D753CF4E33032C2203B2318C95161F8BCF67/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/7A65D753CF4E33032C2203B2318C95161F8BCF67/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/7A65D753CF4E33032C2203B2318C95161F8BCF67/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1995</date></publicationStmt><notesStmt><note type="content">Section title: Review article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development</title><author xml:id="author-0000"><persName><forename type="first">S.N.</forename><surname>Popoff</surname></persName><affiliation>Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">S.C.</forename><surname>Marks, Jr.</surname></persName><affiliation>Address for correspondence and reprints: Dr. Sandy C. 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We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Skeleton</term></item><item><term>Growth factors</term></item><item><term>Oncogenes</term></item><item><term>Cytokines</term></item><item><term>Osteopetrosis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995-08-11">Modified</change><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/7A65D753CF4E33032C2203B2318C95161F8BCF67/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev"><item-info><jid>BON</jid><aid>95003474</aid><ce:pii>8756-3282(95)00347-4</ce:pii><ce:doi>10.1016/8756-3282(95)00347-4</ce:doi><ce:copyright type="unknown" year="1995"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Review article</ce:textfn></ce:dochead><ce:title>The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development</ce:title><ce:author-group><ce:author><ce:given-name>S.N.</ce:given-name><ce:surname>Popoff</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.C.</ce:given-name><ce:surname>Marks</ce:surname><ce:suffix>Jr.</ce:suffix><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>2</ce:label><ce:textfn>Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for correspondence and reprints: Dr. Sandy C. Marks, Jr., Department of Cell Biology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="11" month="5" year="1995"></ce:date-received><ce:date-revised day="11" month="8" year="1995"></ce:date-revised><ce:date-accepted day="16" month="8" year="1995"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Skeleton</ce:text></ce:keyword><ce:keyword><ce:text>Growth factors</ce:text></ce:keyword><ce:keyword><ce:text>Oncogenes</ce:text></ce:keyword><ce:keyword><ce:text>Cytokines</ce:text></ce:keyword><ce:keyword><ce:text>Osteopetrosis</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development</title></titleInfo><name type="personal"><namePart type="given">S.N.</namePart><namePart type="family">Popoff</namePart><affiliation>Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.C.</namePart><namePart type="family">Marks, Jr.</namePart><affiliation>Address for correspondence and reprints: Dr. Sandy C. Marks, Jr., Department of Cell Biology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655.</affiliation><affiliation>Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><dateModified encoding="w3cdtf">1995-08-11</dateModified><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.</abstract><note type="content">Section title: Review article</note><subject><genre>Keywords</genre><topic>Skeleton</topic><topic>Growth factors</topic><topic>Oncogenes</topic><topic>Cytokines</topic><topic>Osteopetrosis</topic></subject><relatedItem type="host"><titleInfo><title>Bone</title></titleInfo><titleInfo type="abbreviated"><title>BON</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">199511</dateIssued></originInfo><identifier type="ISSN">8756-3282</identifier><identifier type="PII">S8756-3282(00)X0007-5</identifier><part><date>199511</date><detail type="volume"><number>17</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>437</start><end>497</end></extent><extent unit="pages"><start>437</start><end>445</end></extent></part></relatedItem><identifier type="istex">7A65D753CF4E33032C2203B2318C95161F8BCF67</identifier><identifier type="ark">ark:/67375/6H6-VJS34HQV-R</identifier><identifier type="DOI">10.1016/8756-3282(95)00347-4</identifier><identifier type="PII">8756-3282(95)00347-4</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/7A65D753CF4E33032C2203B2318C95161F8BCF67/metadata/json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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