EdenteV2, Istex, Corpus, bibRecord, 006F30

Sequential Shh expression in the development of the mouse upper functional incisor

Identifieur interne : 006F30 ( Istex/Corpus ); précédent : 006F29; suivant : 006F31

Sequential Shh expression in the development of the mouse upper functional incisor

Auteurs : Maria Hovorakova ; Lucie Smrckova ; Herve Lesot ; Katerina Lochovska ; Miroslav Peterka ; Renata Peterkova

Source :

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2013-11.

RBID : ISTEX:E03460753271EAF7D4576BF77FC7BDB3CCB0123C

English descriptors

Abstract

The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed a very detailed investigation of the development of the upper incisor in wild‐type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer‐aided three‐dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (Shh) expression domains have been detected in the upper incisor region during early prenatal development. At ED11.5–13.5, there was a single Shh positive domain present in the anterior part of left or right upper jaw arches, corresponding to the epithelial thickening. More posteriorly, a new Shh expression domain appeared in the incisor bud in the developmentally more advanced ED13.5 embryos. At ED14.5, only this posterior Shh expression in the incisor germ remained detectable. This study brings new insights into the early development of the upper incisor in mice and completes the data on normal mouse incisor development. The temporal–spatial pattern of Shh expression reflects the development of two tooth generations, being detectable in two successive, antero‐posteriorly located areas in the prospective incisor region in the upper jaw. The first, anterior and superficial Shh expression domain reflects the rudimentary tooth development suppressed during evolution. Only the subsequent, posterior and deeper Shh expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild‐type mice. J. Exp. Zool. (Mol. Dev. Evol.) 320B: 455–464, 2013. © 2013 Wiley Periodicals, Inc.

Url:

https://api.istex.fr/document/E03460753271EAF7D4576BF77FC7BDB3CCB0123C/fulltext/pdf

DOI: 10.1002/jez.b.22522

Links to Exploration step

ISTEX:E03460753271EAF7D4576BF77FC7BDB3CCB0123C

Le document en format XML

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<front><div type="abstract" xml:lang="en">The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed a very detailed investigation of the development of the upper incisor in wild‐type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer‐aided three‐dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (Shh) expression domains have been detected in the upper incisor region during early prenatal development. At ED11.5–13.5, there was a single Shh positive domain present in the anterior part of left or right upper jaw arches, corresponding to the epithelial thickening. More posteriorly, a new Shh expression domain appeared in the incisor bud in the developmentally more advanced ED13.5 embryos. At ED14.5, only this posterior Shh expression in the incisor germ remained detectable. This study brings new insights into the early development of the upper incisor in mice and completes the data on normal mouse incisor development. The temporal–spatial pattern of Shh expression reflects the development of two tooth generations, being detectable in two successive, antero‐posteriorly located areas in the prospective incisor region in the upper jaw. The first, anterior and superficial Shh expression domain reflects the rudimentary tooth development suppressed during evolution. Only the subsequent, posterior and deeper Shh expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild‐type mice. J. Exp. Zool. (Mol. Dev. Evol.) 320B: 455–464, 2013. © 2013 Wiley Periodicals, Inc.</div>
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<p>The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed a very detailed investigation of the development of the upper incisor in wild‐type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer‐aided three‐dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (<hi rend="italic">Shh</hi>
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 expression in the incisor germ remained detectable. This study brings new insights into the early development of the upper incisor in mice and completes the data on normal mouse incisor development. The temporal–spatial pattern of <hi rend="italic">Shh</hi>
 expression reflects the development of two tooth generations, being detectable in two successive, antero‐posteriorly located areas in the prospective incisor region in the upper jaw. The first, anterior and superficial <hi rend="italic">Shh</hi>
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 expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild‐type mice. <hi rend="italic">J. Exp. Zool. (Mol. Dev. Evol.) 320B: 455–464, 2013</hi>
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<affiliation>Correspondence to: Maria Hovorakova, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague 4, Czech Republic.E‐mail:</affiliation>
<affiliation>E-mail: marhor@biomed.cas.cz</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Lucie</namePart>
<namePart type="family">Smrckova</namePart>
<affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</affiliation>
<affiliation>Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Herve</namePart>
<namePart type="family">Lesot</namePart>
<affiliation>INSERM UMR 1109, Team “Osteoarticular and Dental Regenerative NanoMedicine”, University of Strasbourg, Strasbourg, France</affiliation>
<affiliation>Faculté de Chirurgie Dentaire, Université de Strasbourg, Strasbourg, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Katerina</namePart>
<namePart type="family">Lochovska</namePart>
<affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</affiliation>
<affiliation>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague, Czech Republic</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Miroslav</namePart>
<namePart type="family">Peterka</namePart>
<affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Renata</namePart>
<namePart type="family">Peterkova</namePart>
<affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</affiliation>
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<originInfo><publisher>Blackwell Publishing Ltd</publisher>
<dateIssued encoding="w3cdtf">2013-11</dateIssued>
<dateCreated encoding="w3cdtf">2013-07-22</dateCreated>
<dateCaptured encoding="w3cdtf">2013-02-21</dateCaptured>
<dateValid encoding="w3cdtf">2013-06-03</dateValid>
<edition>Hovorakova M, Smrckova L, Lesot H, Lochovska K, Peterka M, Peterkova R. 2013. Sequential Shh expression in the development of the mouse upper functional incisor. J. Exp. Zool. (Mol. Dev. Evol.) 320B:455–464.</edition>
<copyrightDate encoding="w3cdtf">2013</copyrightDate>
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<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<abstract lang="en">The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed a very detailed investigation of the development of the upper incisor in wild‐type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer‐aided three‐dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (Shh) expression domains have been detected in the upper incisor region during early prenatal development. At ED11.5–13.5, there was a single Shh positive domain present in the anterior part of left or right upper jaw arches, corresponding to the epithelial thickening. More posteriorly, a new Shh expression domain appeared in the incisor bud in the developmentally more advanced ED13.5 embryos. At ED14.5, only this posterior Shh expression in the incisor germ remained detectable. This study brings new insights into the early development of the upper incisor in mice and completes the data on normal mouse incisor development. The temporal–spatial pattern of Shh expression reflects the development of two tooth generations, being detectable in two successive, antero‐posteriorly located areas in the prospective incisor region in the upper jaw. The first, anterior and superficial Shh expression domain reflects the rudimentary tooth development suppressed during evolution. Only the subsequent, posterior and deeper Shh expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild‐type mice. J. Exp. Zool. (Mol. Dev. Evol.) 320B: 455–464, 2013. © 2013 Wiley Periodicals, Inc.</abstract>
<note type="funding">Grant Agency of the Czech Republic - No. CZ:GA ČR:GA304/09/1579; No. CZ:GA ČR:GAP305/12/1766; </note>
<relatedItem type="host"><titleInfo><title>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</title>
</titleInfo>
<titleInfo type="abbreviated"><title>J. Exp. Zool. (Mol. Dev. Evol.)</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<subject><genre>article-category</genre>
<topic>Research Article</topic>
</subject>
<identifier type="ISSN">1552-5007</identifier>
<identifier type="eISSN">1552-5015</identifier>
<identifier type="DOI">10.1002/(ISSN)1552-5015</identifier>
<identifier type="PublisherID">JEZ</identifier>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>320</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>455</start>
<end>464</end>
<total>10</total>
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<identifier type="ark">ark:/67375/WNG-QDQQT6XT-Z</identifier>
<identifier type="DOI">10.1002/jez.b.22522</identifier>
<identifier type="ArticleID">JEZB22522</identifier>
<accessCondition type="use and reproduction" contentType="copyright">© 2013 Wiley Periodicals, Inc.© 2013 Wiley Periodicals, Inc.</accessCondition>
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Sequential Shh expression in the development of the mouse upper functional incisor

Sequential Shh expression in the development of the mouse upper functional incisor

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