Bone tissue response to implant surfaces functionalized with phosphate‐containing polymers
Identifieur interne : 006D25 ( Istex/Corpus ); précédent : 006D24; suivant : 006D26Bone tissue response to implant surfaces functionalized with phosphate‐containing polymers
Auteurs : Marcio Vivan Cardoso ; Amol Chaudhari ; Yasuhiro Yoshida ; Bart Van Meerbeek ; Ignace Naert ; Joke DuyckSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2014-01.
Abstract
Inorganic polyphosphates are said to stimulate the activity of osteoblast‐like cells in vitro. The purpose of this study was to evaluate in vivo bone regeneration around implants treated with polyphosphoric acid (PPA) and phosphorylated pullulan (PPL).
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DOI: 10.1111/clr.12053
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uniqKey="Yoshida Y" first="Yasuhiro" last="Yoshida">Yasuhiro Yoshida</name><affiliation><mods:affiliation>Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Van Meerbeek, Bart" sort="Van Meerbeek, Bart" uniqKey="Van Meerbeek B" first="Bart" last="Van Meerbeek">Bart Van Meerbeek</name><affiliation><mods:affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Naert, Ignace" sort="Naert, Ignace" uniqKey="Naert I" first="Ignace" last="Naert">Ignace Naert</name><affiliation><mods:affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</mods:affiliation></affiliation></author><author><name 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Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Yoshida, Yasuhiro" sort="Yoshida, Yasuhiro" uniqKey="Yoshida Y" first="Yasuhiro" last="Yoshida">Yasuhiro Yoshida</name><affiliation><mods:affiliation>Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Van Meerbeek, Bart" sort="Van Meerbeek, Bart" uniqKey="Van Meerbeek B" first="Bart" last="Van Meerbeek">Bart Van Meerbeek</name><affiliation><mods:affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Naert, Ignace" sort="Naert, Ignace" uniqKey="Naert I" first="Ignace" last="Naert">Ignace Naert</name><affiliation><mods:affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Duyck, Joke" sort="Duyck, Joke" uniqKey="Duyck J" first="Joke" last="Duyck">Joke Duyck</name><affiliation><mods:affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Catholic University of LeuvenSchool of Dentistry, Oral Pathology and Maxillofacial SurgeryDepartment of Prosthetic DentistryKapucijnenvoer 7B‐3000 LeuvenBelgiumTel.: +32 16 33 24 68Fax: +32 16 33 23 09e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: Joke.Duyck@med.kuleuven.be</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="ISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="91">91</biblScope><biblScope unit="page" to="100">100</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2014-01">2014-01</date></imprint><idno type="ISSN">0905-7161</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0905-7161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Inorganic polyphosphates are said to stimulate the activity of osteoblast‐like cells in vitro. The purpose of this study was to evaluate in vivo bone regeneration around implants treated with polyphosphoric acid (PPA) and phosphorylated pullulan (PPL).</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Marcio Vivan Cardoso</name><affiliations><json:string>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>Amol Chaudhari</name><affiliations><json:string>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>Yasuhiro Yoshida</name><affiliations><json:string>Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</json:string></affiliations></json:item><json:item><name>Bart Van Meerbeek</name><affiliations><json:string>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>Ignace Naert</name><affiliations><json:string>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>Joke Duyck</name><affiliations><json:string>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</json:string><json:string>Catholic University of LeuvenSchool of Dentistry, Oral Pathology and Maxillofacial SurgeryDepartment of Prosthetic DentistryKapucijnenvoer 7B‐3000 LeuvenBelgiumTel.: +32 16 33 24 68Fax: +32 16 33 23 09e‐mail:</json:string><json:string>E-mail: Joke.Duyck@med.kuleuven.be</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>implant roughness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osseointegration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>surface characterization</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>surface functionalization</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>titanium</value></json:item></subject><articleId><json:string>CLR12053</json:string></articleId><arkIstex>ark:/67375/WNG-ZTSK66G4-P</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Inorganic polyphosphates are said to stimulate the activity of osteoblast‐like cells in vitro. 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Surgery</orgName><orgName>Catholic University of Leuven</orgName><address><settlement type="city">Leuven</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Amol</forename><surname>Chaudhari</surname></persName><affiliation><orgName>Leuven BIOMAT Research Cluster</orgName><orgName>School of Dentistry, Oral Pathology and Maxillofacial Surgery</orgName><orgName>Catholic University of Leuven</orgName><address><settlement type="city">Leuven</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Yasuhiro</forename><surname>Yoshida</surname></persName><affiliation><orgName>Department of Biomaterials</orgName><orgName>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgName><orgName>Okayama University</orgName><address><settlement type="city">Okayama</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Bart</forename><surname>Meerbeek</surname></persName><affiliation><orgName>Leuven BIOMAT Research Cluster</orgName><orgName>School of Dentistry, Oral Pathology and Maxillofacial Surgery</orgName><orgName>Catholic University of Leuven</orgName><address><settlement type="city">Leuven</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Ignace</forename><surname>Naert</surname></persName><affiliation><orgName>Leuven BIOMAT Research Cluster</orgName><orgName>School of Dentistry, Oral Pathology and Maxillofacial Surgery</orgName><orgName>Catholic University of Leuven</orgName><address><settlement type="city">Leuven</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0005" role="corresp"><persName><forename type="first">Joke</forename><surname>Duyck</surname></persName><affiliation><orgName>Leuven BIOMAT Research Cluster</orgName><orgName>School of Dentistry, Oral Pathology and Maxillofacial Surgery</orgName><orgName>Catholic University of Leuven</orgName><address><settlement type="city">Leuven</settlement><country key="BE">Belgium</country></address></affiliation><affiliation>Corresponding author: Joke Duyck Catholic University of Leuven School of Dentistry, Oral Pathology and Maxillofacial Surgery Department of Prosthetic Dentistry Kapucijnenvoer 7 B‐3000 Leuven Belgium Tel.: +32 16 33 24 68 Fax: +32 16 33 23 09 e‐mail: Joke.Duyck@med.kuleuven.be</affiliation></author><idno type="istex">DC3ABA30CD8D9E73040EBAC23845A87D22BB878C</idno><idno type="ark">ark:/67375/WNG-ZTSK66G4-P</idno><idno type="DOI">10.1111/clr.12053</idno><idno type="unit">CLR12053</idno><idno type="toTypesetVersion">file:CLR.CLR12053.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="pISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><idno type="book-DOI">10.1111/(ISSN)1600-0501</idno><idno type="book-part-DOI">10.1111/clr.2013.25.issue-1</idno><idno type="product">CLR</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="91">91</biblScope><biblScope unit="page" to="100">100</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2014-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="clr12053-abs-0001"><head>Abstract</head>
Objectives
<p>Inorganic polyphosphates are said to stimulate the activity of osteoblast‐like cells <hi rend="italic">in vitro</hi>. The purpose of this study was to evaluate <hi rend="italic">in vivo</hi> bone regeneration around implants treated with polyphosphoric acid (<hi rend="fc">PPA</hi>) and phosphorylated pullulan (<hi rend="fc">PPL</hi>).</p>
Material and Methods
<p>Two types of implants with different surface roughness (<hi rend="fc">R</hi>1: <hi rend="fc">S</hi>a ≈ 0.23 μm; <hi rend="fc">R</hi>2: <hi rend="fc">S</hi>a ≈ 1.35 μm) were treated with three solutions (distilled water, 10%wt <hi rend="fc">PPA</hi>, or 10%wt <hi rend="fc">PPL</hi>) prior to implantation in both tibia of twelve female white rabbits. Each animal received six implants randomly positioned according to their surface roughness and treatment: <hi rend="fc">R</hi>1 + water; <hi rend="fc">R</hi>1 + <hi rend="fc">PPA</hi>;<hi rend="fc"> R</hi>1 + <hi rend="fc">PPL</hi>;<hi rend="fc"> R</hi>2 + water; <hi rend="fc">R</hi>2 + <hi rend="fc">PPA</hi>;<hi rend="fc"> R</hi>2 + <hi rend="fc">PPL</hi>. Animals were sacrificed after 1 or 4 weeks, and samples were prepared for histological and histomorphometrical analysis. Bone regeneration areas were evaluated for bone‐to‐implant contact (<hi rend="fc">BIC</hi>) and bone fraction (<hi rend="fc">BF</hi>) in areas 100 and 500 μm remote from the implant surface. Data were statistically analyzed by means of <hi rend="fc">F</hi>riedman and <hi rend="fc">W</hi>ilcoxon matched‐pair tests (<hi rend="italic">P</hi> < 0.05).</p>
Results
<p>After 1 week, bone tissue was rarely formed in the regeneration areas. After 4 weeks, implants treated with <hi rend="fc">PPA</hi> presented higher ratios of <hi rend="fc">BIC</hi> (<hi rend="fc">R</hi>1 = 52.3 ± 13.1; <hi rend="fc">R</hi>2 = 54.6 ± 11.0) than the ones treated with water (<hi rend="fc">R</hi>1 = 24.1 ± 15.1; <hi rend="fc">R</hi>2 = 32.4 ± 13.0). On the other hand, around the implant surface (100 μm), <hi rend="fc">PPL</hi>‐treated implants induced higher <hi rend="fc">BF</hi> (<hi rend="fc">R</hi>1 = 78.3 ± 34.1; <hi rend="fc">R</hi>2 = 71.2 ± 21.8) as compared with the water‐treated ones (<hi rend="fc">R</hi>1 = 46.1 ± 22.0; <hi rend="fc">R</hi>2 = 49.6 ± 21.0). At 500 μm, however, no statistically significant differences in <hi rend="fc">BF</hi> were found among the groups evaluated (<hi rend="italic">P</hi> > 0.05). Surface roughness influenced neither <hi rend="fc">BIC</hi> nor <hi rend="fc">BF</hi>.</p>
Conclusions
<p>Implant surface treatment with phosphate‐containing polymers may positively influence osseointegration.</p></abstract><textClass><keywords><term xml:id="clr12053-kwd-0001">implant roughness</term><term xml:id="clr12053-kwd-0002">osseointegration</term><term xml:id="clr12053-kwd-0003">surface characterization</term><term xml:id="clr12053-kwd-0004">surface functionalization</term><term xml:id="clr12053-kwd-0005">titanium</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="clr12053" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0501</doi><issn type="print">0905-7161</issn><issn type="electronic">1600-0501</issn><idGroup><id type="product" value="CLR"></id></idGroup><titleGroup><title sort="CLINICAL ORAL IMPLANTS RESEARCH" type="main">Clinical Oral Implants Research</title><title type="short">Clin. 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Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley">10.1111/clr.2013.25.issue-1</doi><copyright ownership="publisher">Copyright © 2014 John Wiley & Sons Ltd</copyright><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2014-01">January 2014</coverDate></publicationMeta><publicationMeta level="unit" position="150" status="forIssue" type="article"><doi>10.1111/clr.12053</doi><idGroup><id type="unit" value="CLR12053"></id></idGroup><countGroup><count number="10" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2012 John Wiley & Sons A/S</copyright><eventGroup><event date="2012-09-08" type="manuscriptAccepted"></event><event agent="SPS" date="2012-09-23" type="xmlCreated"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.7 mode:FullText" date="2013-12-17"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-10-08"></event><event type="firstOnline" date="2012-10-08"></event><event type="publishedOnlineFinalForm" date="2013-12-17"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-08"></event></eventGroup><numberingGroup><numbering type="pageFirst">91</numbering><numbering type="pageLast">100</numbering></numberingGroup><correspondenceTo><lineatedText><line><b>Corresponding author:</b></line><line><i>Joke Duyck</i></line><line>Catholic University of Leuven</line><line>School of Dentistry, Oral Pathology and Maxillofacial Surgery</line><line>Department of Prosthetic Dentistry</line><line>Kapucijnenvoer 7</line><line>B‐3000 Leuven</line><line>Belgium</line><line>Tel.: +32 16 33 24 68</line><line>Fax: +32 16 33 23 09</line><line>e‐mail: <email>Joke.Duyck@med.kuleuven.be</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="clr12053-cit-1001"><author><familyName>Cardoso</familyName> <givenNames>MV</givenNames></author>, <author><familyName>Chaudhari</familyName> <givenNames>A</givenNames></author>, <author><familyName>Yoshida</familyName> <givenNames>Y</givenNames></author>, <author><familyName>Van Meerbeek</familyName> <givenNames>B</givenNames></author>, <author><familyName>Naert</familyName> <givenNames>I</givenNames></author>, <author><familyName>Duyck</familyName> <givenNames>J</givenNames></author>. <articleTitle>Bone tissue response to implant surfaces functionalized with phosphate‐containing polymers</articleTitle>. <journalTitle>Clin. Oral Impl. Res.</journalTitle> <vol>25</vol>, <pubYear year="2014">2014</pubYear>, <pageFirst>91</pageFirst>–<pageLast>100</pageLast></citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CLR.CLR12053.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Bone tissue response to implant surfaces functionalized with phosphate‐containing polymers</title><title type="shortAuthors">Cardoso et al</title></titleGroup><creators><creator affiliationRef="#clr12053-aff-0001" creatorRole="author" xml:id="clr12053-cr-0001"><personName><givenNames>Marcio Vivan</givenNames> <familyName>Cardoso</familyName></personName></creator><creator affiliationRef="#clr12053-aff-0001" creatorRole="author" xml:id="clr12053-cr-0002"><personName><givenNames>Amol</givenNames> <familyName>Chaudhari</familyName></personName></creator><creator affiliationRef="#clr12053-aff-0002" creatorRole="author" xml:id="clr12053-cr-0003"><personName><givenNames>Yasuhiro</givenNames> <familyName>Yoshida</familyName></personName></creator><creator affiliationRef="#clr12053-aff-0001" creatorRole="author" xml:id="clr12053-cr-0004"><personName><givenNames>Bart</givenNames> <familyNamePrefix>Van</familyNamePrefix> <familyName>Meerbeek</familyName></personName></creator><creator affiliationRef="#clr12053-aff-0001" creatorRole="author" xml:id="clr12053-cr-0005"><personName><givenNames>Ignace</givenNames> <familyName>Naert</familyName></personName></creator><creator affiliationRef="#clr12053-aff-0001" corresponding="yes" creatorRole="author" xml:id="clr12053-cr-0006"><personName><givenNames>Joke</givenNames> <familyName>Duyck</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="BE" type="organization" xml:id="clr12053-aff-0001"><orgDiv>Leuven BIOMAT Research Cluster</orgDiv> <orgDiv>School of Dentistry, Oral Pathology and Maxillofacial Surgery</orgDiv> <orgName>Catholic University of Leuven</orgName> <address><city>Leuven</city> <country>Belgium</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="clr12053-aff-0002"><orgDiv>Department of Biomaterials</orgDiv> <orgDiv>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgDiv> <orgName>Okayama University</orgName> <address><city>Okayama</city> <country>Japan</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="clr12053-kwd-0001">implant roughness</keyword><keyword xml:id="clr12053-kwd-0002">osseointegration</keyword><keyword xml:id="clr12053-kwd-0003">surface characterization</keyword><keyword xml:id="clr12053-kwd-0004">surface functionalization</keyword><keyword xml:id="clr12053-kwd-0005">titanium</keyword></keywordGroup><fundingInfo><fundingAgency>K.U. Leuven Research Grant</fundingAgency><fundingNumber>06/55</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:id="clr12053-abs-0001"><title type="main">Abstract</title><section xml:id="clr12053-sec-0001"><title type="main">Objectives</title><p>Inorganic polyphosphates are said to stimulate the activity of osteoblast‐like cells <i>in vitro</i>. The purpose of this study was to evaluate <i>in vivo</i> bone regeneration around implants treated with polyphosphoric acid (<fc>PPA</fc>) and phosphorylated pullulan (<fc>PPL</fc>).</p></section><section xml:id="clr12053-sec-0002"><title type="main">Material and Methods</title><p>Two types of implants with different surface roughness (<fc>R</fc>1: <fc>S</fc>a ≈ 0.23 μm; <fc>R</fc>2: <fc>S</fc>a ≈ 1.35 μm) were treated with three solutions (distilled water, 10%wt <fc>PPA</fc>, or 10%wt <fc>PPL</fc>) prior to implantation in both tibia of twelve female white rabbits. Each animal received six implants randomly positioned according to their surface roughness and treatment: <fc>R</fc>1 + water; <fc>R</fc>1 + <fc>PPA</fc>;<fc> R</fc>1 + <fc>PPL</fc>;<fc> R</fc>2 + water; <fc>R</fc>2 + <fc>PPA</fc>;<fc> R</fc>2 + <fc>PPL</fc>. Animals were sacrificed after 1 or 4 weeks, and samples were prepared for histological and histomorphometrical analysis. Bone regeneration areas were evaluated for bone‐to‐implant contact (<fc>BIC</fc>) and bone fraction (<fc>BF</fc>) in areas 100 and 500 μm remote from the implant surface. Data were statistically analyzed by means of <fc>F</fc>riedman and <fc>W</fc>ilcoxon matched‐pair tests (<i>P</i> < 0.05).</p></section><section xml:id="clr12053-sec-0003"><title type="main">Results</title><p>After 1 week, bone tissue was rarely formed in the regeneration areas. After 4 weeks, implants treated with <fc>PPA</fc> presented higher ratios of <fc>BIC</fc> (<fc>R</fc>1 = 52.3 ± 13.1; <fc>R</fc>2 = 54.6 ± 11.0) than the ones treated with water (<fc>R</fc>1 = 24.1 ± 15.1; <fc>R</fc>2 = 32.4 ± 13.0). On the other hand, around the implant surface (100 μm), <fc>PPL</fc>‐treated implants induced higher <fc>BF</fc> (<fc>R</fc>1 = 78.3 ± 34.1; <fc>R</fc>2 = 71.2 ± 21.8) as compared with the water‐treated ones (<fc>R</fc>1 = 46.1 ± 22.0; <fc>R</fc>2 = 49.6 ± 21.0). At 500 μm, however, no statistically significant differences in <fc>BF</fc> were found among the groups evaluated (<i>P</i> > 0.05). Surface roughness influenced neither <fc>BIC</fc> nor <fc>BF</fc>.</p></section><section xml:id="clr12053-sec-0004"><title type="main">Conclusions</title><p>Implant surface treatment with phosphate‐containing polymers may positively influence osseointegration.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Bone tissue response to implant surfaces functionalized with phosphate‐containing polymers</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Bone tissue response to implant surfaces functionalized with phosphate‐containing polymers</title></titleInfo><name type="personal"><namePart type="given">Marcio Vivan</namePart><namePart type="family">Cardoso</namePart><affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amol</namePart><namePart type="family">Chaudhari</namePart><affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yasuhiro</namePart><namePart type="family">Yoshida</namePart><affiliation>Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bart</namePart><namePart type="family">Van Meerbeek</namePart><affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ignace</namePart><namePart type="family">Naert</namePart><affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joke</namePart><namePart type="family">Duyck</namePart><affiliation>Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium</affiliation><affiliation>Catholic University of LeuvenSchool of Dentistry, Oral Pathology and Maxillofacial SurgeryDepartment of Prosthetic DentistryKapucijnenvoer 7B‐3000 LeuvenBelgiumTel.: +32 16 33 24 68Fax: +32 16 33 23 09e‐mail:</affiliation><affiliation>E-mail: Joke.Duyck@med.kuleuven.be</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-01</dateIssued><dateCreated encoding="w3cdtf">2012-09-23</dateCreated><dateValid encoding="w3cdtf">2012-09-08</dateValid><edition>Cardoso MV, Chaudhari A, Yoshida Y, Van Meerbeek B, Naert I, Duyck J. Bone tissue response to implant surfaces functionalized with phosphate‐containing polymers. Clin. Oral Impl. Res. 25, 2014, 91–100</edition><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Inorganic polyphosphates are said to stimulate the activity of osteoblast‐like cells in vitro. The purpose of this study was to evaluate in vivo bone regeneration around implants treated with polyphosphoric acid (PPA) and phosphorylated pullulan (PPL).</abstract><abstract>Two types of implants with different surface roughness (R1: Sa ≈ 0.23 μm; R2: Sa ≈ 1.35 μm) were treated with three solutions (distilled water, 10%wt PPA, or 10%wt PPL) prior to implantation in both tibia of twelve female white rabbits. Each animal received six implants randomly positioned according to their surface roughness and treatment: R1 + water; R1 + PPA; R1 + PPL; R2 + water; R2 + PPA; R2 + PPL. Animals were sacrificed after 1 or 4 weeks, and samples were prepared for histological and histomorphometrical analysis. Bone regeneration areas were evaluated for bone‐to‐implant contact (BIC) and bone fraction (BF) in areas 100 and 500 μm remote from the implant surface. Data were statistically analyzed by means of Friedman and Wilcoxon matched‐pair tests (P < 0.05).</abstract><abstract>After 1 week, bone tissue was rarely formed in the regeneration areas. After 4 weeks, implants treated with PPA presented higher ratios of BIC (R1 = 52.3 ± 13.1; R2 = 54.6 ± 11.0) than the ones treated with water (R1 = 24.1 ± 15.1; R2 = 32.4 ± 13.0). On the other hand, around the implant surface (100 μm), PPL‐treated implants induced higher BF (R1 = 78.3 ± 34.1; R2 = 71.2 ± 21.8) as compared with the water‐treated ones (R1 = 46.1 ± 22.0; R2 = 49.6 ± 21.0). At 500 μm, however, no statistically significant differences in BF were found among the groups evaluated (P > 0.05). Surface roughness influenced neither BIC nor BF.</abstract><abstract>Implant surface treatment with phosphate‐containing polymers may positively influence osseointegration.</abstract><note type="funding">K.U. Leuven Research Grant - No. 06/55; </note><subject><genre>keywords</genre><topic>implant roughness</topic><topic>osseointegration</topic><topic>surface characterization</topic><topic>surface functionalization</topic><topic>titanium</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title></titleInfo><titleInfo type="abbreviated"><title>Clin. Oral Impl. Res.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0905-7161</identifier><identifier type="eISSN">1600-0501</identifier><identifier type="DOI">10.1111/(ISSN)1600-0501</identifier><identifier type="PublisherID">CLR</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>91</start><end>100</end><total>10</total></extent></part></relatedItem><identifier type="istex">DC3ABA30CD8D9E73040EBAC23845A87D22BB878C</identifier><identifier type="ark">ark:/67375/WNG-ZTSK66G4-P</identifier><identifier type="DOI">10.1111/clr.12053</identifier><identifier type="ArticleID">CLR12053</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 John Wiley & Sons Ltd© 2012 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/DC3ABA30CD8D9E73040EBAC23845A87D22BB878C/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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