Genome‐wide association study of chronic periodontitis in a general German population
Identifieur interne : 004290 ( Istex/Corpus ); précédent : 004289; suivant : 004291Genome‐wide association study of chronic periodontitis in a general German population
Auteurs : Alexander Teumer ; Birte Holtfreter ; Uwe Völker ; Astrid Petersmann ; Matthias Nauck ; Reiner Biffar ; Henry Völzke ; Heyo K. Kroemer ; Peter Meisel ; Georg Homuth ; Thomas KocherSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2013-11.
English descriptors
- KwdEn :
- Additive effects, Ageand smoking variance, Association analyses, Association results, Association studies, Association study, Attachment, Attachment loss, Available attachment values, Baseline, Baseline examination, Binary endpoints, Blood pressure association studies, Body mass index, Chronic periodontitis, Clin periodontol, Clinical periodontology, Cohort, Cohort study, Common snps, Common variants, Consortium, Continuous traits, Covariate data, Dental research, Different snps, Divaris, Dpal, East german region, Environmental factors, European workshop, Federal ministry, Federal state, Functional genomics, Gcta software, Gene polymorphisms, Genetic basis, Genetics, Genome, Genome regions, Genomes imputation, Genomewide, Genomewide association studies, Genomewide association study, Greifswald, Gwas, Gwas results, Gwas results quantilequantile plots, Heritability, Imputation, Imputation quality, International consortium, John wiley sons, Laine, Large sample sizes, Lters, Measurement sites, Medical reasons, Mild periodontitis, Multiple testing, Nature genetics, Odds ratio, Omni array, Oral examination, Other phenotypes, Periodontal, Periodontal disease, Periodontal diseases, Periodontal examination, Periodontal examinations, Periodontal pathogen colonization, Periodontitis, Periodontitis case, Periodontology, Phenotype, Pomerania, Probands, Proximal, Proximal attachment loss, Proximal sites, Quality control, Recent gwas, Reference group, Restorative dentistry, Same tooth, Sample size, Several lines, Severe periodontitis, Ship cohort, Short indels, Short insertions, Single snps, Smoking status, Snp, Software, Standard error, Teumer, Third tertile, Trait, Twin studies, University medicine greifswald, Variance, Wellcome trust case control consortium, West pomerania.
- Teeft :
- Additive effects, Ageand smoking variance, Association analyses, Association results, Association studies, Association study, Attachment, Attachment loss, Available attachment values, Baseline, Baseline examination, Binary endpoints, Blood pressure association studies, Body mass index, Chronic periodontitis, Clin periodontol, Clinical periodontology, Cohort, Cohort study, Common snps, Common variants, Consortium, Continuous traits, Covariate data, Dental research, Different snps, Divaris, Dpal, East german region, Environmental factors, European workshop, Federal ministry, Federal state, Functional genomics, Gcta software, Gene polymorphisms, Genetic basis, Genetics, Genome, Genome regions, Genomes imputation, Genomewide, Genomewide association studies, Genomewide association study, Greifswald, Gwas, Gwas results, Gwas results quantilequantile plots, Heritability, Imputation, Imputation quality, International consortium, John wiley sons, Laine, Large sample sizes, Lters, Measurement sites, Medical reasons, Mild periodontitis, Multiple testing, Nature genetics, Odds ratio, Omni array, Oral examination, Other phenotypes, Periodontal, Periodontal disease, Periodontal diseases, Periodontal examination, Periodontal examinations, Periodontal pathogen colonization, Periodontitis, Periodontitis case, Periodontology, Phenotype, Pomerania, Probands, Proximal, Proximal attachment loss, Proximal sites, Quality control, Recent gwas, Reference group, Restorative dentistry, Same tooth, Sample size, Several lines, Severe periodontitis, Ship cohort, Short indels, Short insertions, Single snps, Smoking status, Snp, Software, Standard error, Teumer, Third tertile, Trait, Twin studies, University medicine greifswald, Variance, Wellcome trust case control consortium, West pomerania.
Abstract
To identify loci associated with chronic periodontitis through a genome‐wide association study (GWAS).
Url:
DOI: 10.1111/jcpe.12154
Links to Exploration step
ISTEX:86D83FDE9BABF430CA4475903E71C429C2BB21A8Le document en format XML
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Kroemer</name><affiliation><mods:affiliation>Department of Pharmacology, Center of Drug Absorption and Transport (CDAT), University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</mods:affiliation></affiliation></author><author><name sortKey="Meisel, Peter" sort="Meisel, Peter" uniqKey="Meisel P" first="Peter" last="Meisel">Peter Meisel</name><affiliation><mods:affiliation>Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</mods:affiliation></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><mods:affiliation>Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kocher, Thomas" sort="Kocher, Thomas" uniqKey="Kocher T" first="Thomas" last="Kocher">Thomas Kocher</name><affiliation><mods:affiliation>Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Address:E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: kocher@uni-greifswald.de</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="977">977</biblScope><biblScope unit="page" to="985">985</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2013-11">2013-11</date></imprint><idno type="ISSN">0303-6979</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6979</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Additive effects</term><term>Ageand smoking variance</term><term>Association analyses</term><term>Association results</term><term>Association studies</term><term>Association study</term><term>Attachment</term><term>Attachment loss</term><term>Available attachment values</term><term>Baseline</term><term>Baseline examination</term><term>Binary endpoints</term><term>Blood pressure association studies</term><term>Body mass index</term><term>Chronic periodontitis</term><term>Clin periodontol</term><term>Clinical periodontology</term><term>Cohort</term><term>Cohort study</term><term>Common snps</term><term>Common variants</term><term>Consortium</term><term>Continuous traits</term><term>Covariate data</term><term>Dental research</term><term>Different snps</term><term>Divaris</term><term>Dpal</term><term>East german region</term><term>Environmental factors</term><term>European workshop</term><term>Federal ministry</term><term>Federal state</term><term>Functional genomics</term><term>Gcta software</term><term>Gene polymorphisms</term><term>Genetic basis</term><term>Genetics</term><term>Genome</term><term>Genome regions</term><term>Genomes imputation</term><term>Genomewide</term><term>Genomewide association studies</term><term>Genomewide association study</term><term>Greifswald</term><term>Gwas</term><term>Gwas results</term><term>Gwas results quantilequantile plots</term><term>Heritability</term><term>Imputation</term><term>Imputation quality</term><term>International consortium</term><term>John wiley sons</term><term>Laine</term><term>Large sample sizes</term><term>Lters</term><term>Measurement sites</term><term>Medical reasons</term><term>Mild periodontitis</term><term>Multiple testing</term><term>Nature genetics</term><term>Odds ratio</term><term>Omni array</term><term>Oral examination</term><term>Other phenotypes</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontal diseases</term><term>Periodontal examination</term><term>Periodontal examinations</term><term>Periodontal pathogen colonization</term><term>Periodontitis</term><term>Periodontitis case</term><term>Periodontology</term><term>Phenotype</term><term>Pomerania</term><term>Probands</term><term>Proximal</term><term>Proximal attachment loss</term><term>Proximal sites</term><term>Quality control</term><term>Recent gwas</term><term>Reference group</term><term>Restorative dentistry</term><term>Same tooth</term><term>Sample size</term><term>Several lines</term><term>Severe periodontitis</term><term>Ship cohort</term><term>Short indels</term><term>Short insertions</term><term>Single snps</term><term>Smoking status</term><term>Snp</term><term>Software</term><term>Standard error</term><term>Teumer</term><term>Third tertile</term><term>Trait</term><term>Twin studies</term><term>University medicine greifswald</term><term>Variance</term><term>Wellcome trust case control consortium</term><term>West pomerania</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Additive effects</term><term>Ageand smoking variance</term><term>Association analyses</term><term>Association results</term><term>Association studies</term><term>Association study</term><term>Attachment</term><term>Attachment loss</term><term>Available attachment values</term><term>Baseline</term><term>Baseline examination</term><term>Binary endpoints</term><term>Blood pressure association studies</term><term>Body mass index</term><term>Chronic periodontitis</term><term>Clin periodontol</term><term>Clinical periodontology</term><term>Cohort</term><term>Cohort study</term><term>Common snps</term><term>Common variants</term><term>Consortium</term><term>Continuous traits</term><term>Covariate data</term><term>Dental research</term><term>Different snps</term><term>Divaris</term><term>Dpal</term><term>East german region</term><term>Environmental factors</term><term>European workshop</term><term>Federal ministry</term><term>Federal state</term><term>Functional genomics</term><term>Gcta software</term><term>Gene polymorphisms</term><term>Genetic basis</term><term>Genetics</term><term>Genome</term><term>Genome regions</term><term>Genomes imputation</term><term>Genomewide</term><term>Genomewide association studies</term><term>Genomewide association study</term><term>Greifswald</term><term>Gwas</term><term>Gwas results</term><term>Gwas results quantilequantile plots</term><term>Heritability</term><term>Imputation</term><term>Imputation quality</term><term>International consortium</term><term>John wiley sons</term><term>Laine</term><term>Large sample sizes</term><term>Lters</term><term>Measurement sites</term><term>Medical reasons</term><term>Mild periodontitis</term><term>Multiple testing</term><term>Nature genetics</term><term>Odds ratio</term><term>Omni array</term><term>Oral examination</term><term>Other phenotypes</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontal diseases</term><term>Periodontal examination</term><term>Periodontal examinations</term><term>Periodontal pathogen colonization</term><term>Periodontitis</term><term>Periodontitis case</term><term>Periodontology</term><term>Phenotype</term><term>Pomerania</term><term>Probands</term><term>Proximal</term><term>Proximal attachment loss</term><term>Proximal sites</term><term>Quality control</term><term>Recent gwas</term><term>Reference group</term><term>Restorative dentistry</term><term>Same tooth</term><term>Sample size</term><term>Several lines</term><term>Severe periodontitis</term><term>Ship cohort</term><term>Short indels</term><term>Short insertions</term><term>Single snps</term><term>Smoking status</term><term>Snp</term><term>Software</term><term>Standard error</term><term>Teumer</term><term>Third tertile</term><term>Trait</term><term>Twin studies</term><term>University medicine greifswald</term><term>Variance</term><term>Wellcome trust case control consortium</term><term>West pomerania</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">To identify loci associated with chronic periodontitis through a genome‐wide association study (GWAS).</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>periodontitis</json:string><json:string>gwas</json:string><json:string>greifswald</json:string><json:string>cohort</json:string><json:string>periodontal</json:string><json:string>snp</json:string><json:string>periodontology</json:string><json:string>john wiley sons</json:string><json:string>chronic periodontitis</json:string><json:string>consortium</json:string><json:string>dpal</json:string><json:string>proximal attachment loss</json:string><json:string>genome</json:string><json:string>gwas results</json:string><json:string>quality control</json:string><json:string>heritability</json:string><json:string>phenotype</json:string><json:string>lters</json:string><json:string>divaris</json:string><json:string>clinical periodontology</json:string><json:string>genetics</json:string><json:string>pomerania</json:string><json:string>probands</json:string><json:string>software</json:string><json:string>university medicine greifswald</json:string><json:string>proximal sites</json:string><json:string>teumer</json:string><json:string>periodontal disease</json:string><json:string>laine</json:string><json:string>genomewide</json:string><json:string>severe periodontitis</json:string><json:string>proximal</json:string><json:string>variance</json:string><json:string>smoking status</json:string><json:string>association study</json:string><json:string>west pomerania</json:string><json:string>blood pressure association studies</json:string><json:string>environmental factors</json:string><json:string>attachment loss</json:string><json:string>periodontitis case</json:string><json:string>international consortium</json:string><json:string>imputation</json:string><json:string>baseline</json:string><json:string>sample size</json:string><json:string>ship cohort</json:string><json:string>federal ministry</json:string><json:string>third tertile</json:string><json:string>association studies</json:string><json:string>short indels</json:string><json:string>twin studies</json:string><json:string>baseline examination</json:string><json:string>dental research</json:string><json:string>nature genetics</json:string><json:string>common snps</json:string><json:string>trait</json:string><json:string>omni array</json:string><json:string>oral examination</json:string><json:string>periodontal examinations</json:string><json:string>medical reasons</json:string><json:string>available attachment values</json:string><json:string>covariate data</json:string><json:string>genomewide association study</json:string><json:string>genome regions</json:string><json:string>periodontal examination</json:string><json:string>restorative dentistry</json:string><json:string>short insertions</json:string><json:string>recent gwas</json:string><json:string>common variants</json:string><json:string>same tooth</json:string><json:string>measurement sites</json:string><json:string>other phenotypes</json:string><json:string>body mass index</json:string><json:string>continuous traits</json:string><json:string>mild periodontitis</json:string><json:string>reference group</json:string><json:string>single snps</json:string><json:string>binary endpoints</json:string><json:string>standard error</json:string><json:string>imputation quality</json:string><json:string>association results</json:string><json:string>wellcome trust case control consortium</json:string><json:string>different snps</json:string><json:string>odds ratio</json:string><json:string>multiple testing</json:string><json:string>ageand smoking variance</json:string><json:string>gcta software</json:string><json:string>genetic basis</json:string><json:string>gene polymorphisms</json:string><json:string>several lines</json:string><json:string>clin periodontol</json:string><json:string>large sample sizes</json:string><json:string>periodontal pathogen colonization</json:string><json:string>federal state</json:string><json:string>periodontal diseases</json:string><json:string>east german region</json:string><json:string>association analyses</json:string><json:string>functional genomics</json:string><json:string>genomewide association studies</json:string><json:string>european workshop</json:string><json:string>gwas results quantilequantile plots</json:string><json:string>cohort study</json:string><json:string>additive effects</json:string><json:string>genomes imputation</json:string><json:string>attachment</json:string></teeft></keywords><author><json:item><name>Alexander Teumer</name><affiliations><json:string>Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</json:string></affiliations></json:item><json:item><name>Birte Holtfreter</name><affiliations><json:string>Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</json:string></affiliations></json:item><json:item><name>Uwe Völker</name><affiliations><json:string>Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</json:string></affiliations></json:item><json:item><name>Astrid Petersmann</name><affiliations><json:string>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</json:string></affiliations></json:item><json:item><name>Matthias Nauck</name><affiliations><json:string>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</json:string></affiliations></json:item><json:item><name>Reiner Biffar</name><affiliations><json:string>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</json:string></affiliations></json:item><json:item><name>Henry Völzke</name><affiliations><json:string>Institute for Community Medicine, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</json:string></affiliations></json:item><json:item><name>Heyo K. 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Published by John Wiley & Sons Ltd</licence></availability><date type="published" when="2013-11"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Genome‐wide association study of chronic periodontitis in a general German population</title><author xml:id="author-0000"><persName><forename type="first">Alexander</forename><surname>Teumer</surname></persName><affiliation><orgName>Department of Functional Genomics</orgName><orgName>Interfaculty Institute for Genetics and Functional Genomics</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Birte</forename><surname>Holtfreter</surname></persName><affiliation><orgName>Unit of Periodontology</orgName><orgName>Department of Restorative Dentistry, Periodontology and Endodontology</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Uwe</forename><surname>Völker</surname></persName><affiliation><orgName>Department of Functional Genomics</orgName><orgName>Interfaculty Institute for Genetics and Functional Genomics</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Astrid</forename><surname>Petersmann</surname></persName><affiliation><orgName>Institute of Clinical Chemistry and Laboratory Medicine</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Matthias</forename><surname>Nauck</surname></persName><affiliation><orgName>Institute of Clinical Chemistry and Laboratory Medicine</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Reiner</forename><surname>Biffar</surname></persName><affiliation><orgName>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Henry</forename><surname>Völzke</surname></persName><affiliation><orgName>Institute for Community Medicine</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Heyo K.</forename><surname>Kroemer</surname></persName><affiliation><orgName>Department of Pharmacology</orgName><orgName>Center of Drug Absorption and Transport (CDAT)</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Peter</forename><surname>Meisel</surname></persName><affiliation><orgName>Unit of Periodontology</orgName><orgName>Department of Restorative Dentistry, Periodontology and Endodontology</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Georg</forename><surname>Homuth</surname></persName><affiliation><orgName>Department of Functional Genomics</orgName><orgName>Interfaculty Institute for Genetics and Functional Genomics</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0010" role="corresp"><persName><forename type="first">Thomas</forename><surname>Kocher</surname></persName><affiliation><orgName>Unit of Periodontology</orgName><orgName>Department of Restorative Dentistry, Periodontology and Endodontology</orgName><orgName>University Medicine Greifswald</orgName><orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName><address><settlement type="city">Greifswald</settlement><country key="DE">Germany</country></address></affiliation><affiliation>Address: Thomas Kocher Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Rotgerberstr. 8, 17475 Greifswald, Germany E‐mail: kocher@uni-greifswald.de</affiliation></author><idno type="istex">86D83FDE9BABF430CA4475903E71C429C2BB21A8</idno><idno type="ark">ark:/67375/WNG-ZNGPC76D-V</idno><idno type="DOI">10.1111/jcpe.12154</idno><idno type="unit">JCPE12154</idno><idno type="toTypesetVersion">file:JCPE.JCPE12154.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="book-DOI">10.1111/(ISSN)1600-051X</idno><idno type="book-part-DOI">10.1111/jcpe.2013.40.issue-11</idno><idno type="product">JCPE</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="977">977</biblScope><biblScope unit="page" to="985">985</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2013-11"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="jcpe12154-abs-0001"><head>Abstract</head>
Aim
<p>To identify loci associated with chronic periodontitis through a genome‐wide association study (<hi rend="fc">GWAS</hi>).</p>
Materials and Methods
<p>A <hi rend="fc">GWAS</hi> was performed in 4032 individuals of two independent cross‐sectional studies of West Pomerania (<hi rend="fc">SHIP </hi><hi rend="italic">n</hi> = 3365 and <hi rend="fc">SHIP</hi>‐<hi rend="fc">TREND </hi><hi rend="italic">n</hi> = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome‐Wide Human <hi rend="fc">SNP</hi> Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome‐based autosomal and X‐chromosomal genotypes and short insertions and deletions (<hi rend="fc">INDEL</hi>s) was performed in both cohorts. Finally, more than 17 million <hi rend="fc">SNP</hi>s and short <hi rend="fc">INDEL</hi>s were analysed.</p>
Results
<p>No genome‐wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single <hi rend="fc">SNP</hi> association reached genome‐wide significance, the proportion of variance explained by additive effects of all common <hi rend="fc">SNP</hi>s was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%.</p>
Conclusions
<p>No single <hi rend="fc">SNP</hi>s were found to be genome‐wide significantly associated with chronic periodontitis in this study.</p></abstract><textClass><keywords><term xml:id="jcpe12154-kwd-0001">attachment loss</term><term xml:id="jcpe12154-kwd-0002">genome‐wide association studies</term><term xml:id="jcpe12154-kwd-0003">periodontitis</term><term xml:id="jcpe12154-kwd-0004">Study of Health in Pomerania</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Periodontal Diseases</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/86D83FDE9BABF430CA4475903E71C429C2BB21A8/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jcpe12154" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id></idGroup><titleGroup><title sort="JOURNAL OF CLINICAL PERIODONTOLOGY" type="main">Journal of Clinical Periodontology</title><title type="short">J Clin Periodontol</title></titleGroup></publicationMeta><publicationMeta level="part" position="110"><doi origin="wiley">10.1111/jcpe.2013.40.issue-11</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons A/S</copyright><numberingGroup><numbering type="journalVolume" number="40">40</numbering><numbering type="journalIssue">11</numbering></numberingGroup><coverDate startDate="2013-11">November 2013</coverDate></publicationMeta><publicationMeta level="unit" position="10" status="forIssue" type="article"><doi>10.1111/jcpe.12154</doi><idGroup><id type="unit" value="JCPE12154"></id></idGroup><countGroup><count number="9" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Periodontal Diseases</title></titleGroup><copyright ownership="publisher">© 2013 John Wiley & Sons A/S. 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University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Rotgerberstr. 8, 17475 Greifswald, Germany</i></line><line>E‐mail: <email>kocher@uni-greifswald.de</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="jcpe12154-cit-1001"><author><familyName>Teumer</familyName> <givenNames>A</givenNames></author>, <author><familyName>Holtfreter</familyName> <givenNames>B</givenNames></author>, <author><familyName>Völker</familyName> <givenNames>U</givenNames></author>, <author><familyName>Petersmann</familyName> <givenNames>A</givenNames></author>, <author><familyName>Nauck</familyName> <givenNames>M</givenNames></author>, <author><familyName>Biffar</familyName> <givenNames>R</givenNames></author>, <author><familyName>Völzke</familyName> <givenNames>H</givenNames></author>, <author><familyName>Kroemer</familyName> <givenNames>HK</givenNames></author>, <author><familyName>Meisel</familyName> <givenNames>P</givenNames></author>, 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xml:id="jcpe12154-cr-0006"><personName><givenNames>Reiner</givenNames> <familyName>Biffar</familyName></personName></creator><creator affiliationRef="#jcpe12154-aff-0005" creatorRole="author" xml:id="jcpe12154-cr-0007"><personName><givenNames>Henry</givenNames> <familyName>Völzke</familyName></personName></creator><creator affiliationRef="#jcpe12154-aff-0006" creatorRole="author" xml:id="jcpe12154-cr-0008"><personName><givenNames>Heyo K.</givenNames> <familyName>Kroemer</familyName></personName></creator><creator affiliationRef="#jcpe12154-aff-0002" creatorRole="author" xml:id="jcpe12154-cr-0009"><personName><givenNames>Peter</givenNames> <familyName>Meisel</familyName></personName></creator><creator affiliationRef="#jcpe12154-aff-0001" creatorRole="author" xml:id="jcpe12154-cr-0010"><personName><givenNames>Georg</givenNames> <familyName>Homuth</familyName></personName></creator><creator affiliationRef="#jcpe12154-aff-0002" corresponding="yes" creatorRole="author" xml:id="jcpe12154-cr-0011"><personName><givenNames>Thomas</givenNames> <familyName>Kocher</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="DE" type="organization" xml:id="jcpe12154-aff-0001"><orgDiv>Department of Functional Genomics</orgDiv> <orgDiv>Interfaculty Institute for Genetics and Functional Genomics</orgDiv> <orgName>University Medicine Greifswald</orgName> <orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName> <address><city>Greifswald</city> <country>Germany</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jcpe12154-aff-0002"><orgDiv>Unit of Periodontology</orgDiv> <orgDiv>Department of Restorative Dentistry, Periodontology and Endodontology</orgDiv> <orgName>University Medicine Greifswald</orgName> <orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName> <address><city>Greifswald</city> <country>Germany</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jcpe12154-aff-0003"><orgDiv>Institute of Clinical Chemistry and Laboratory Medicine</orgDiv> <orgName>University Medicine Greifswald</orgName> <orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName> <address><city>Greifswald</city> <country>Germany</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jcpe12154-aff-0004"><orgDiv>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials</orgDiv> <orgName>University Medicine Greifswald</orgName> <orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName> <address><city>Greifswald</city> <country>Germany</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jcpe12154-aff-0005"><orgDiv>Institute for Community Medicine</orgDiv> <orgName>University Medicine Greifswald</orgName> <orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName> <address><city>Greifswald</city> <country>Germany</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jcpe12154-aff-0006"><orgDiv>Department of Pharmacology</orgDiv> <orgDiv>Center of Drug Absorption and Transport (CDAT)</orgDiv> <orgName>University Medicine Greifswald</orgName> <orgName>Ernst‐Moritz‐Arndt‐University Greifswald</orgName> <address><city>Greifswald</city> <country>Germany</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jcpe12154-kwd-0001">attachment loss</keyword><keyword xml:id="jcpe12154-kwd-0002">genome‐wide association studies</keyword><keyword xml:id="jcpe12154-kwd-0003">periodontitis</keyword><keyword xml:id="jcpe12154-kwd-0004">Study of Health in Pomerania</keyword></keywordGroup><fundingInfo><fundingAgency>Federal Ministry of Education and Research</fundingAgency><fundingNumber>01ZZ9603</fundingNumber><fundingNumber>01ZZ0103</fundingNumber><fundingNumber>01ZZ0403</fundingNumber><fundingNumber>03IS2061A</fundingNumber><fundingNumber>03ZIK012</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Ministry of Cultural Affairs</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Social Ministry of the Federal State of Mecklenburg‐West Pomerania</fundingAgency></fundingInfo><fundingInfo><fundingAgency>GABA</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Siemens Healthcare</fundingAgency></fundingInfo><supportingInformation><supportingInfoItem><mediaResource alt="supporting" mimeType="application/msword" href="urn-x:wiley:03036979:media:jcpe12154:jcpe12154-sup-0001-FigureS1-S4-TableS1-S11"></mediaResource><caption><p><b>Figure S1.</b> GWAS results quantile‐quantile plots of all analyzed traits. (a) mean PAL (all individuals); (b) mean PAL (age ≤60 years); (c) PAL4Q3 (all individuals); (d) PAL4Q3 (age ≤60 years); (e) CDC/AAP (all individuals); (f) CDC/AAP (age ≤60 years); (g) DPAL (all individuals); (h) DPAL (age ≤60 years); (i) mean PAL (1000G); (j) CDC/AAP (1000G).</p><p><b>Figure S2.</b> GWAS results quantile‐quantile plots of SHIP used for meta‐analysis. (a) mean PAL (all individuals); (b) mean PAL (age ≤60 years); (c) PAL4Q3 (all individuals); (d) PAL4Q3 (age ≤60 years); (e) CDC/AAP (all individuals); (f) CDC/AAP (age ≤60 years); (g) mean PAL (1000G); (h) CDC/AAP (1000G).<b>Figure S3.</b> GWAS results quantile‐quantile plots of SHIP‐TREND used for meta‐analysis.</p><p>(a) mean PAL (all individuals); (b) mean PAL (age ≤60 years); (c) PAL4Q3 (all individuals); (d) PAL4Q3 (age ≤60 years); (e) CDC/AAP (all individuals); (f) CDC/AAP (age ≤60 years); (g) mean PAL (1000G); (h) CDC/AAP (1000G).</p><p><b>Figure S4.</b> Comparison of the effect sizes of the top SNPs reported in Divaris et al. <link href="#jcpe12154-bib-0007"></link> (ARIC) with the CDC/AAP (all individuals) results. The effects directions are set to have higher odds of chronic periodontitis in the ARIC sample. The SNP identifier and the name of the closest gene are shown.</p><p><b>Table S1.</b> Information on genotyping and imputation.</p><p><b>Table S2.</b> GWAS results on mean proximal attachment loss related phenotypes with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. All individuals were included (meta‐analysis of SHIP and SHIP‐TREND cohorts, <i>N</i> = 4032).</p><p><b>Table S3.</b> GWAS results on periodontitis with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. Subjects within the first <i>versus</i> the third tertile of proportion of proximal sites with AL ≥4 mm were opposed. All individuals were included (meta‐analysis of SHIP and SHIP‐TREND cohorts, <i>N</i> = 2969).</p><p><b>Table S4</b>. GWAS results on the CDC/AAP case definition for periodontitis (Page & Eke <link href="#jcpe12154-bib-0022"></link>) with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. All individuals were included (meta‐analysis of SHIP and SHIP‐TREND cohorts, <i>N</i> = 3915).</p><p><b>Table S5.</b> GWAS results on 5‐year change in mean proximal attachment loss related phenotypes with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. All individuals were included (SHIP cohort, <i>N</i>=2501).</p><p><b>Table S6</b> GWAS results on mean proximal attachment loss with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, N=3189).</p><p><b>Table S7.</b> GWAS results on periodontitis with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. Subjects within the first <i>versus</i> the third tertile of proportion of proximal sites with AL ≥4 mm were opposed. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, <i>N</i> = 2412).</p><p><b>Table S8</b>. GWAS results on the CDC/AAP case definition for periodontitis (Page & Eke <link href="#jcpe12154-bib-0022"></link>) with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, <i>N</i> = 3151).</p><p><b>Table S9.</b> GWAS results on 5‐year change in mean proximal attachment loss related phenotypes with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters. Individuals aged >60 years were excluded (SHIP cohort, <i>N</i> = 2098).</p><p><b>Table S10.</b> GWAS results on proximal attachment loss related phenotypes with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters using the 1000 Genomes imputation. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, <i>N</i> = 3189).</p><p><b>Table S11.</b> GWAS results on the CDC/AAP case definition for periodontitis (Page & Eke <link href="#jcpe12154-bib-0022"></link>) with GC corrected <i>p</i>‐value < 1E‐5 after quality control filters using the 1000 Genomes imputation. Individuals aged >60 years excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, <i>N</i> = 3151).</p></caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:id="jcpe12154-abs-0001"><title type="main">Abstract</title><section xml:id="jcpe12154-sec-0001"><title type="main">Aim</title><p>To identify loci associated with chronic periodontitis through a genome‐wide association study (<fc>GWAS</fc>).</p></section><section xml:id="jcpe12154-sec-0002"><title type="main">Materials and Methods</title><p>A <fc>GWAS</fc> was performed in 4032 individuals of two independent cross‐sectional studies of West Pomerania (<fc>SHIP </fc><i>n</i> = 3365 and <fc>SHIP</fc>‐<fc>TREND </fc><i>n</i> = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome‐Wide Human <fc>SNP</fc> Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome‐based autosomal and X‐chromosomal genotypes and short insertions and deletions (<fc>INDEL</fc>s) was performed in both cohorts. Finally, more than 17 million <fc>SNP</fc>s and short <fc>INDEL</fc>s were analysed.</p></section><section xml:id="jcpe12154-sec-0003"><title type="main">Results</title><p>No genome‐wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single <fc>SNP</fc> association reached genome‐wide significance, the proportion of variance explained by additive effects of all common <fc>SNP</fc>s was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%.</p></section><section xml:id="jcpe12154-sec-0004"><title type="main">Conclusions</title><p>No single <fc>SNP</fc>s were found to be genome‐wide significantly associated with chronic periodontitis in this study.</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="jcpe12154-ntgp-0001"><note numbered="no" xml:id="jcpe12154-note-0001"><p><b>Conflict of interest and source of funding statement</b></p><p>There are no conflicts of interest associated with this study. SHIP is part of the Community Medicine Research net (CMR, <url href="http://www.community-medicine.de">http://www.community-medicine.de</url>) of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of Mecklenburg‐West Pomerania, and the network “Greifswald Approach to Individualized Medicine (GANI_MED)” funded by the Federal Ministry of Education and Research (grant 03IS2061A). This study was granted by BMBF‐01‐ZZ‐9603/0 and BH was supported by GABA, Switzerland. Generation of genome‐wide SNP data has been supported by the Federal Ministry of Education and Research (grant no. 03ZIK012) and a joint grant from Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg, West Pomerania. The University of Greifswald is a member of the “Center of Knowledge Interchange” programme of the Siemens AG and the Caché Campus programme of the InterSystems GmbH.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Genome‐wide association study of chronic periodontitis in a general German population</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Genome‐wide association study of chronic periodontitis in a general German population</title></titleInfo><name type="personal"><namePart type="given">Alexander</namePart><namePart type="family">Teumer</namePart><affiliation>Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Birte</namePart><namePart type="family">Holtfreter</namePart><affiliation>Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Uwe</namePart><namePart type="family">Völker</namePart><affiliation>Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Astrid</namePart><namePart type="family">Petersmann</namePart><affiliation>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthias</namePart><namePart type="family">Nauck</namePart><affiliation>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Reiner</namePart><namePart type="family">Biffar</namePart><affiliation>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Henry</namePart><namePart type="family">Völzke</namePart><affiliation>Institute for Community Medicine, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heyo K.</namePart><namePart type="family">Kroemer</namePart><affiliation>Department of Pharmacology, Center of Drug Absorption and Transport (CDAT), University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Meisel</namePart><affiliation>Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georg</namePart><namePart type="family">Homuth</namePart><affiliation>Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Kocher</namePart><affiliation>Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Ernst‐Moritz‐Arndt‐University Greifswald, Greifswald, Germany</affiliation><affiliation>Address:E‐mail:</affiliation><affiliation>E-mail: kocher@uni-greifswald.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-11</dateIssued><dateCreated encoding="w3cdtf">2013-08-14</dateCreated><dateValid encoding="w3cdtf">2013-08-03</dateValid><edition>Teumer A, Holtfreter B, Völker U, Petersmann A, Nauck M, Biffar R, Völzke H, Kroemer HK, Meisel P, Homuth G, Kocher T. Genome‐wide association study of chronic periodontitis in a general German population. J Clin Periodontol 2013; 40: 977–985. doi: 10.1111/jcpe.12154.</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>To identify loci associated with chronic periodontitis through a genome‐wide association study (GWAS).</abstract><abstract>A GWAS was performed in 4032 individuals of two independent cross‐sectional studies of West Pomerania (SHIP n = 3365 and SHIP‐TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome‐Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome‐based autosomal and X‐chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed.</abstract><abstract>No genome‐wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome‐wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%.</abstract><abstract>No single SNPs were found to be genome‐wide significantly associated with chronic periodontitis in this study.</abstract><note type="additional physical form">Figure S1. GWAS results quantile‐quantile plots of all analyzed traits. (a) mean PAL (all individuals); (b) mean PAL (age ≤60 years); (c) PAL4Q3 (all individuals); (d) PAL4Q3 (age ≤60 years); (e) CDC/AAP (all individuals); (f) CDC/AAP (age ≤60 years); (g) DPAL (all individuals); (h) DPAL (age ≤60 years); (i) mean PAL (1000G); (j) CDC/AAP (1000G). Figure S2. GWAS results quantile‐quantile plots of SHIP used for meta‐analysis. (a) mean PAL (all individuals); (b) mean PAL (age ≤60 years); (c) PAL4Q3 (all individuals); (d) PAL4Q3 (age ≤60 years); (e) CDC/AAP (all individuals); (f) CDC/AAP (age ≤60 years); (g) mean PAL (1000G); (h) CDC/AAP (1000G).Figure S3. GWAS results quantile‐quantile plots of SHIP‐TREND used for meta‐analysis. (a) mean PAL (all individuals); (b) mean PAL (age ≤60 years); (c) PAL4Q3 (all individuals); (d) PAL4Q3 (age ≤60 years); (e) CDC/AAP (all individuals); (f) CDC/AAP (age ≤60 years); (g) mean PAL (1000G); (h) CDC/AAP (1000G). Figure S4. Comparison of the effect sizes of the top SNPs reported in Divaris et al. (ARIC) with the CDC/AAP (all individuals) results. The effects directions are set to have higher odds of chronic periodontitis in the ARIC sample. The SNP identifier and the name of the closest gene are shown. Table S1. Information on genotyping and imputation. Table S2. GWAS results on mean proximal attachment loss related phenotypes with GC corrected p‐value < 1E‐5 after quality control filters. All individuals were included (meta‐analysis of SHIP and SHIP‐TREND cohorts, N = 4032). Table S3. GWAS results on periodontitis with GC corrected p‐value < 1E‐5 after quality control filters. Subjects within the first versus the third tertile of proportion of proximal sites with AL ≥4 mm were opposed. All individuals were included (meta‐analysis of SHIP and SHIP‐TREND cohorts, N = 2969). Table S4. GWAS results on the CDC/AAP case definition for periodontitis (Page & Eke ) with GC corrected p‐value < 1E‐5 after quality control filters. All individuals were included (meta‐analysis of SHIP and SHIP‐TREND cohorts, N = 3915). Table S5. GWAS results on 5‐year change in mean proximal attachment loss related phenotypes with GC corrected p‐value < 1E‐5 after quality control filters. All individuals were included (SHIP cohort, N=2501). Table S6 GWAS results on mean proximal attachment loss with GC corrected p‐value < 1E‐5 after quality control filters. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, N=3189). Table S7. GWAS results on periodontitis with GC corrected p‐value < 1E‐5 after quality control filters. Subjects within the first versus the third tertile of proportion of proximal sites with AL ≥4 mm were opposed. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, N = 2412). Table S8. GWAS results on the CDC/AAP case definition for periodontitis (Page & Eke ) with GC corrected p‐value < 1E‐5 after quality control filters. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, N = 3151). Table S9. GWAS results on 5‐year change in mean proximal attachment loss related phenotypes with GC corrected p‐value < 1E‐5 after quality control filters. Individuals aged >60 years were excluded (SHIP cohort, N = 2098). Table S10. GWAS results on proximal attachment loss related phenotypes with GC corrected p‐value < 1E‐5 after quality control filters using the 1000 Genomes imputation. Individuals aged >60 years were excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, N = 3189). Table S11. GWAS results on the CDC/AAP case definition for periodontitis (Page & Eke ) with GC corrected p‐value < 1E‐5 after quality control filters using the 1000 Genomes imputation. Individuals aged >60 years excluded (meta‐analysis of SHIP and SHIP‐TREND cohorts, N = 3151).</note><note type="funding">Federal Ministry of Education and Research - No. 01ZZ9603; No. 01ZZ0103; No. 01ZZ0403; No. 03IS2061A; No. 03ZIK012; </note><note type="funding">Ministry of Cultural Affairs</note><note type="funding">Social Ministry of the Federal State of Mecklenburg‐West Pomerania</note><note type="funding">GABA</note><note type="funding">Siemens Healthcare</note><subject><genre>keywords</genre><topic>attachment loss</topic><topic>genome‐wide association studies</topic><topic>periodontitis</topic><topic>Study of Health in Pomerania</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><titleInfo type="abbreviated"><title>J Clin Periodontol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>977</start><end>985</end><total>9</total></extent></part></relatedItem><identifier type="istex">86D83FDE9BABF430CA4475903E71C429C2BB21A8</identifier><identifier type="ark">ark:/67375/WNG-ZNGPC76D-V</identifier><identifier type="DOI">10.1111/jcpe.12154</identifier><identifier type="ArticleID">JCPE12154</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons A/S© 2013 John Wiley & Sons A/S. 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