Involvement of angiotensin II type 1 receptors in interleukin‐1β‐induced interleukin‐6 production in human gingival fibroblasts
Identifieur interne : 004289 ( Istex/Corpus ); précédent : 004288; suivant : 004290Involvement of angiotensin II type 1 receptors in interleukin‐1β‐induced interleukin‐6 production in human gingival fibroblasts
Auteurs : Toshiaki Nakamura ; Kozue Hasegawa-Nakamura ; Kenji Sakoda ; Takashi Matsuyama ; Kazuyuki NoguchiSource :
- European Journal of Oral Sciences [ 0909-8836 ] ; 2011-10.
English descriptors
- KwdEn :
- Angiotensin, Assay, At1r, At1r hgfs, At1r mrna, At1r protein, Broblastic cells, Broblasts, Cathepsin, Cell types, Control hgfs, Control sirna, Culture supernatants, Cultured hgfs, Dental sciences, Gapdh, Gingival, Gingival tissues, Hgfs, Human gingival, Human gingival tissue, Kagoshima university graduate school, Mrna, Muscle cells, Periodontal, Physiol, Present study, Protein levels, Receptor, Receptor expression, Santa cruz biotechnology, Separate experiments, Sirna.
- Teeft :
- Angiotensin, Assay, At1r, At1r hgfs, At1r mrna, At1r protein, Broblastic cells, Broblasts, Cathepsin, Cell types, Control hgfs, Control sirna, Culture supernatants, Cultured hgfs, Dental sciences, Gapdh, Gingival, Gingival tissues, Hgfs, Human gingival, Human gingival tissue, Kagoshima university graduate school, Mrna, Muscle cells, Periodontal, Physiol, Present study, Protein levels, Receptor, Receptor expression, Santa cruz biotechnology, Separate experiments, Sirna.
Abstract
Nakamura T, Hasegawa‐Nakamura K, Sakoda K, Matsuyama T, Noguchi K. Involvement of angiotensin II type 1 receptors in interleukin‐1β‐induced interleukin‐6 production in human gingival fibroblasts.
Eur J Oral Sci 2011; 119: 345–351. © 2011 Eur J Oral Sci The renin‐angiotensin system is thought to be involved in inflammatory processes such as periodontitis. However, its precise role is still unclear. Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin‐1β (IL‐1β)‐induced interleukin‐6 (IL‐6) production by cultured human gingival fibroblasts (HGFs) was also studied. Immunohistochemical staining revealed that inflammatory cells and fibroblast‐like cells were positive for the AT1R. However, in healthy gingival tissue, AT1R staining was very weak. The levels of AT1R mRNA and AT1R protein increased in HGFs after stimulation with IL‐1β. The levels of IL‐1β‐induced IL6 mRNA and IL‐6 protein were significantly reduced in AT1R gene‐silenced HGFs compared with control HGFs. The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL‐1β‐induced IL‐6 production in HGFs.
Url:
DOI: 10.1111/j.1600-0722.2011.00850.x
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Nakamura T, Hasegawa‐Nakamura K, Sakoda K, Matsuyama T, Noguchi K. Involvement of angiotensin II type 1 receptors in interleukin‐1β‐induced interleukin‐6 production in human gingival fibroblasts.
Eur J Oral Sci 2011; 119: 345–351. © 2011 Eur J Oral Sci The renin‐angiotensin system is thought to be involved in inflammatory processes such as periodontitis. However, its precise role is still unclear. Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin‐1β (IL‐1β)‐induced interleukin‐6 (IL‐6) production by cultured human gingival fibroblasts (HGFs) was also studied. Immunohistochemical staining revealed that inflammatory cells and fibroblast‐like cells were positive for the AT1R. However, in healthy gingival tissue, AT1R staining was very weak. The levels of AT1R mRNA and AT1R protein increased in HGFs after stimulation with IL‐1β. The levels of IL‐1β‐induced IL6 mRNA and IL‐6 protein were significantly reduced in AT1R gene‐silenced HGFs compared with control HGFs. The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL‐1β‐induced IL‐6 production in HGFs.</div>
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<profileDesc><abstract xml:lang="en" style="main"><p><hi rend="italic">Nakamura T, Hasegawa‐Nakamura K, Sakoda K, Matsuyama T, Noguchi K. Involvement of angiotensin II type 1 receptors in interleukin‐1β‐induced interleukin‐6 production in human gingival fibroblasts.</hi>
<hi rend="italic">Eur J Oral Sci 2011; 119: 345–351. © 2011 Eur J Oral Sci</hi>
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<p>The renin‐angiotensin system is thought to be involved in inflammatory processes such as periodontitis. However, its precise role is still unclear. Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin‐1<hi rend="italic">β</hi>
(IL‐1<hi rend="italic">β</hi>
)‐induced interleukin‐6 (IL‐6) production by cultured human gingival fibroblasts (HGFs) was also studied. Immunohistochemical staining revealed that inflammatory cells and fibroblast‐like cells were positive for the AT1R. However, in healthy gingival tissue, AT1R staining was very weak. The levels of <hi rend="italic">AT1R</hi>
mRNA and AT1R protein increased in HGFs after stimulation with IL‐1<hi rend="italic">β</hi>
. The levels of IL‐1<hi rend="italic">β</hi>
‐induced <hi rend="italic">IL6</hi>
mRNA and IL‐6 protein were significantly reduced in AT1R gene‐silenced HGFs compared with control HGFs. The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL‐1<hi rend="italic">β</hi>
‐induced IL‐6 production in HGFs.</p>
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<correspondenceTo>Toshiaki Nakamura, Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, 8‐35‐1 Sakuragaoka, Kagoshima 890‐8544, Japan
Telefax: +81–99–2756209
E‐mail: <email normalForm="toshi-n@dent.kagoshima-u.ac.jp">toshi‐n@dent.kagoshima‐u.ac.jp</email>
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<titleGroup><title type="main">Involvement of angiotensin II type 1 receptors in interleukin‐1<i>β</i>
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<abstractGroup><abstract type="main" xml:lang="en"><p><i>Nakamura T, Hasegawa‐Nakamura K, Sakoda K, Matsuyama T, Noguchi K. Involvement of angiotensin II type 1 receptors in interleukin‐1β‐induced interleukin‐6 production in human gingival fibroblasts.</i>
<i>Eur J Oral Sci 2011; 119: 345–351. © 2011 Eur J Oral Sci</i>
</p>
<p>The renin‐angiotensin system is thought to be involved in inflammatory processes such as periodontitis. However, its precise role is still unclear. Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin‐1<i>β</i>
(IL‐1<i>β</i>
)‐induced interleukin‐6 (IL‐6) production by cultured human gingival fibroblasts (HGFs) was also studied. Immunohistochemical staining revealed that inflammatory cells and fibroblast‐like cells were positive for the AT1R. However, in healthy gingival tissue, AT1R staining was very weak. The levels of <i>AT1R</i>
mRNA and AT1R protein increased in HGFs after stimulation with IL‐1<i>β</i>
. The levels of IL‐1<i>β</i>
‐induced <i>IL6</i>
mRNA and IL‐6 protein were significantly reduced in AT1R gene‐silenced HGFs compared with control HGFs. The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL‐1<i>β</i>
‐induced IL‐6 production in HGFs.</p>
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<abstract lang="en">Nakamura T, Hasegawa‐Nakamura K, Sakoda K, Matsuyama T, Noguchi K. Involvement of angiotensin II type 1 receptors in interleukin‐1β‐induced interleukin‐6 production in human gingival fibroblasts.
Eur J Oral Sci 2011; 119: 345–351. © 2011 Eur J Oral Sci The renin‐angiotensin system is thought to be involved in inflammatory processes such as periodontitis. However, its precise role is still unclear. Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin‐1β (IL‐1β)‐induced interleukin‐6 (IL‐6) production by cultured human gingival fibroblasts (HGFs) was also studied. Immunohistochemical staining revealed that inflammatory cells and fibroblast‐like cells were positive for the AT1R. However, in healthy gingival tissue, AT1R staining was very weak. The levels of AT1R mRNA and AT1R protein increased in HGFs after stimulation with IL‐1β. The levels of IL‐1β‐induced IL6 mRNA and IL‐6 protein were significantly reduced in AT1R gene‐silenced HGFs compared with control HGFs. The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL‐1β‐induced IL‐6 production in HGFs.</abstract>
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