Hydroxyapatite synthesized by a simplified hydrothermal method
Identifieur interne : 003422 ( Istex/Corpus ); précédent : 003421; suivant : 003423Hydroxyapatite synthesized by a simplified hydrothermal method
Auteurs : H. S. Liu ; T. S. Chin ; L. S. Lai ; S. Y. Chiu ; K. H. Chung ; C. S. Chang ; M. T. LuiSource :
- Ceramics International [ 0272-8842 ] ; 1996.
English descriptors
- KwdEn :
- Bulk ceramics sintered, Calcium phosphates, Ceramics, Considerable grain growth, Crystalline phase, Dense hydroxyapatite, Diffraction patterns, Elsevier science, Excellent biocompatibility, Filter cake, Flexural strength, Fracture, Fracture strength, Fracture toughness, Hard tissue implantation, Hardness, Heating powders, Heating time, High density, High quality, High strength, High surface area, Higher temperatures, Hydrothermal, Hydroxyapatite, Hydroxyapatite ceramics, Large quantity, Mechanical properties, Molar ratio, Particle size, Prosthetic applications, Relative density, Scanning electron micrographs, Simplified hydrothermal method, Sintered, Sintered bulk ceramics, Sintered bulk specimens, Sintered specimen, Sintering, Sintering atmosphere, Sintering temperature, Specific surface area, Stoichiometric composition, Theoretical density, Thermal stability, Tricalcium phosphate.
- Teeft :
- Bulk ceramics sintered, Calcium phosphates, Ceramics, Considerable grain growth, Crystalline phase, Dense hydroxyapatite, Diffraction patterns, Elsevier science, Excellent biocompatibility, Filter cake, Flexural strength, Fracture, Fracture strength, Fracture toughness, Hard tissue implantation, Hardness, Heating powders, Heating time, High density, High quality, High strength, High surface area, Higher temperatures, Hydrothermal, Hydroxyapatite, Hydroxyapatite ceramics, Large quantity, Mechanical properties, Molar ratio, Particle size, Prosthetic applications, Relative density, Scanning electron micrographs, Simplified hydrothermal method, Sintered, Sintered bulk ceramics, Sintered bulk specimens, Sintered specimen, Sintering, Sintering atmosphere, Sintering temperature, Specific surface area, Stoichiometric composition, Theoretical density, Thermal stability, Tricalcium phosphate.
Abstract
Abstract: A simplified hydrothermal method of synthesizing hydroxyapatite powder is described. Heating powders of Ca(OH)2, Ca(H2PO4)2 · H2O and distilled water in a pressurized pot at 109 °C for 1–3 h results in powders consisting of crystallized hydroxyapatite in a needle shape, 130–170 nm in length and 15–25 nm in width. The specific surface area is 31–43 m2/g and the Ca P ratio is 1.640–1.643. The obtained HA powder can be sintered to a high density at 1200–1300 °C. No decomposition was identified by X-ray diffraction. The optimally sintered ceramic has a pore-free surface structure with a flexural strength of 120 MPa, a micro-Vickers hardness of 5.1 GPa and fracture toughness of 1.2 MPa · m 1 2. The biocompatibility of the pulverized sintered-ceramic is excellent and comparable to that of a commercial grade hydroxyapatite by evaluating the implantation in a dog. The synthesis method is simple, economic, and results in a high quality powder which is useful in hard tissue reconstruction applications.
Url:
DOI: 10.1016/0272-8842(95)00135-2
Links to Exploration step
ISTEX:699159804AB7B861CC999FAED9DB56C397A388F1Le document en format XML
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Liu</name><affiliation><mods:affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</mods:affiliation></affiliation></author><author><name sortKey="Chin, T S" sort="Chin, T S" uniqKey="Chin T" first="T. S." last="Chin">T. S. Chin</name><affiliation><mods:affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</mods:affiliation></affiliation></author><author><name sortKey="Lai, L S" sort="Lai, L S" uniqKey="Lai L" first="L. S." last="Lai">L. S. Lai</name><affiliation><mods:affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</mods:affiliation></affiliation></author><author><name sortKey="Chiu, S Y" sort="Chiu, S Y" uniqKey="Chiu S" first="S. Y." last="Chiu">S. Y. Chiu</name><affiliation><mods:affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</mods:affiliation></affiliation></author><author><name sortKey="Chung, K H" sort="Chung, K H" uniqKey="Chung K" first="K. H." last="Chung">K. H. Chung</name><affiliation><mods:affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</mods:affiliation></affiliation></author><author><name sortKey="Chang, C S" sort="Chang, C S" uniqKey="Chang C" first="C. S." last="Chang">C. S. Chang</name><affiliation><mods:affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</mods:affiliation></affiliation></author><author><name sortKey="Lui, M T" sort="Lui, M T" uniqKey="Lui M" first="M. T." last="Lui">M. T. Lui</name><affiliation><mods:affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Ceramics International</title><title level="j" type="abbrev">CERI</title><idno type="ISSN">0272-8842</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="19">19</biblScope><biblScope unit="page" to="25">25</biblScope></imprint><idno type="ISSN">0272-8842</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0272-8842</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bulk ceramics sintered</term><term>Calcium phosphates</term><term>Ceramics</term><term>Considerable grain growth</term><term>Crystalline phase</term><term>Dense hydroxyapatite</term><term>Diffraction patterns</term><term>Elsevier science</term><term>Excellent biocompatibility</term><term>Filter cake</term><term>Flexural strength</term><term>Fracture</term><term>Fracture strength</term><term>Fracture toughness</term><term>Hard tissue implantation</term><term>Hardness</term><term>Heating powders</term><term>Heating time</term><term>High density</term><term>High quality</term><term>High strength</term><term>High surface area</term><term>Higher temperatures</term><term>Hydrothermal</term><term>Hydroxyapatite</term><term>Hydroxyapatite ceramics</term><term>Large quantity</term><term>Mechanical properties</term><term>Molar ratio</term><term>Particle size</term><term>Prosthetic applications</term><term>Relative density</term><term>Scanning electron micrographs</term><term>Simplified hydrothermal method</term><term>Sintered</term><term>Sintered bulk ceramics</term><term>Sintered bulk specimens</term><term>Sintered specimen</term><term>Sintering</term><term>Sintering atmosphere</term><term>Sintering temperature</term><term>Specific surface area</term><term>Stoichiometric composition</term><term>Theoretical density</term><term>Thermal stability</term><term>Tricalcium phosphate</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Bulk ceramics sintered</term><term>Calcium phosphates</term><term>Ceramics</term><term>Considerable grain growth</term><term>Crystalline phase</term><term>Dense hydroxyapatite</term><term>Diffraction patterns</term><term>Elsevier science</term><term>Excellent biocompatibility</term><term>Filter cake</term><term>Flexural strength</term><term>Fracture</term><term>Fracture strength</term><term>Fracture toughness</term><term>Hard tissue implantation</term><term>Hardness</term><term>Heating powders</term><term>Heating time</term><term>High density</term><term>High quality</term><term>High strength</term><term>High surface area</term><term>Higher temperatures</term><term>Hydrothermal</term><term>Hydroxyapatite</term><term>Hydroxyapatite ceramics</term><term>Large quantity</term><term>Mechanical properties</term><term>Molar ratio</term><term>Particle size</term><term>Prosthetic applications</term><term>Relative density</term><term>Scanning electron micrographs</term><term>Simplified hydrothermal method</term><term>Sintered</term><term>Sintered bulk ceramics</term><term>Sintered bulk specimens</term><term>Sintered specimen</term><term>Sintering</term><term>Sintering atmosphere</term><term>Sintering temperature</term><term>Specific surface area</term><term>Stoichiometric composition</term><term>Theoretical density</term><term>Thermal stability</term><term>Tricalcium phosphate</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A simplified hydrothermal method of synthesizing hydroxyapatite powder is described. Heating powders of Ca(OH)2, Ca(H2PO4)2 · H2O and distilled water in a pressurized pot at 109 °C for 1–3 h results in powders consisting of crystallized hydroxyapatite in a needle shape, 130–170 nm in length and 15–25 nm in width. The specific surface area is 31–43 m2/g and the Ca P ratio is 1.640–1.643. The obtained HA powder can be sintered to a high density at 1200–1300 °C. No decomposition was identified by X-ray diffraction. The optimally sintered ceramic has a pore-free surface structure with a flexural strength of 120 MPa, a micro-Vickers hardness of 5.1 GPa and fracture toughness of 1.2 MPa · m 1 2. The biocompatibility of the pulverized sintered-ceramic is excellent and comparable to that of a commercial grade hydroxyapatite by evaluating the implantation in a dog. The synthesis method is simple, economic, and results in a high quality powder which is useful in hard tissue reconstruction applications.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>hydroxyapatite</json:string><json:string>sintering</json:string><json:string>sintered</json:string><json:string>sintering temperature</json:string><json:string>hydrothermal</json:string><json:string>specific surface area</json:string><json:string>diffraction patterns</json:string><json:string>heating time</json:string><json:string>flexural strength</json:string><json:string>fracture toughness</json:string><json:string>fracture</json:string><json:string>sintered bulk specimens</json:string><json:string>relative density</json:string><json:string>mechanical properties</json:string><json:string>tricalcium phosphate</json:string><json:string>fracture strength</json:string><json:string>particle size</json:string><json:string>large quantity</json:string><json:string>heating powders</json:string><json:string>filter cake</json:string><json:string>dense hydroxyapatite</json:string><json:string>crystalline phase</json:string><json:string>sintered specimen</json:string><json:string>elsevier science</json:string><json:string>molar ratio</json:string><json:string>high density</json:string><json:string>stoichiometric composition</json:string><json:string>calcium phosphates</json:string><json:string>high surface area</json:string><json:string>simplified hydrothermal method</json:string><json:string>prosthetic applications</json:string><json:string>high quality</json:string><json:string>bulk ceramics sintered</json:string><json:string>higher temperatures</json:string><json:string>high strength</json:string><json:string>thermal stability</json:string><json:string>sintering atmosphere</json:string><json:string>theoretical density</json:string><json:string>scanning electron micrographs</json:string><json:string>considerable grain growth</json:string><json:string>sintered bulk ceramics</json:string><json:string>hard tissue implantation</json:string><json:string>excellent biocompatibility</json:string><json:string>hydroxyapatite ceramics</json:string><json:string>hardness</json:string><json:string>ceramics</json:string></teeft></keywords><author><json:item><name>H.S. Liu</name><affiliations><json:string>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</json:string></affiliations></json:item><json:item><name>T.S. Chin</name><affiliations><json:string>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</json:string></affiliations></json:item><json:item><name>L.S. Lai</name><affiliations><json:string>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</json:string></affiliations></json:item><json:item><name>S.Y. Chiu</name><affiliations><json:string>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</json:string></affiliations></json:item><json:item><name>K.H. Chung</name><affiliations><json:string>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</json:string></affiliations></json:item><json:item><name>C.S. Chang</name><affiliations><json:string>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</json:string></affiliations></json:item><json:item><name>M.T. Lui</name><affiliations><json:string>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-PKBCNSWQ-5</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: A simplified hydrothermal method of synthesizing hydroxyapatite powder is described. Heating powders of Ca(OH)2, Ca(H2PO4)2 · H2O and distilled water in a pressurized pot at 109 °C for 1–3 h results in powders consisting of crystallized hydroxyapatite in a needle shape, 130–170 nm in length and 15–25 nm in width. The specific surface area is 31–43 m2/g and the Ca P ratio is 1.640–1.643. The obtained HA powder can be sintered to a high density at 1200–1300 °C. No decomposition was identified by X-ray diffraction. The optimally sintered ceramic has a pore-free surface structure with a flexural strength of 120 MPa, a micro-Vickers hardness of 5.1 GPa and fracture toughness of 1.2 MPa · m 1 2. The biocompatibility of the pulverized sintered-ceramic is excellent and comparable to that of a commercial grade hydroxyapatite by evaluating the implantation in a dog. The synthesis method is simple, economic, and results in a high quality powder which is useful in hard tissue reconstruction applications.</abstract><qualityIndicators><score>7.224</score><pdfWordCount>3268</pdfWordCount><pdfCharCount>22021</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>612 x 864 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>163</abstractWordCount><abstractCharCount>1017</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Hydroxyapatite synthesized by a simplified hydrothermal method</title><pii><json:string>0272-8842(95)00135-2</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Ceramics International</title><language><json:string>unknown</json:string></language><publicationDate>1997</publicationDate><issn><json:string>0272-8842</json:string></issn><pii><json:string>S0272-8842(00)X0014-4</json:string></pii><volume>23</volume><issue>1</issue><pages><first>19</first><last>25</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1250</json:string><json:string>1200</json:string><json:string>1996</json:string></date><geogName></geogName><orgName><json:string>Taiwan, Republic of China</json:string><json:string>Veterans General Hospital University</json:string><json:string>John Wiley and Sons Inc.</json:string><json:string>National Yang-Ming Medical University and Veterans</json:string><json:string>National Tsing Hua University, Hsinchu</json:string><json:string>Department of Materials Science and Engineering</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>L. 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Surfaces, Coatings and Films</json:string><json:string>1 - Physical Sciences</json:string><json:string>2 - Chemical Engineering</json:string><json:string>3 - Process Chemistry and Technology</json:string><json:string>1 - Physical Sciences</json:string><json:string>2 - Materials Science</json:string><json:string>3 - Ceramics and Composites</json:string><json:string>1 - Physical Sciences</json:string><json:string>2 - Materials Science</json:string><json:string>3 - Electronic, Optical and Magnetic Materials</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1016/0272-8842(95)00135-2</json:string></doi><id>699159804AB7B861CC999FAED9DB56C397A388F1</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/699159804AB7B861CC999FAED9DB56C397A388F1/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/699159804AB7B861CC999FAED9DB56C397A388F1/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/699159804AB7B861CC999FAED9DB56C397A388F1/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Hydroxyapatite synthesized by a simplified hydrothermal method</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1996</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Hydroxyapatite synthesized by a simplified hydrothermal method</title><author xml:id="author-0000"><persName><forename type="first">H.S.</forename><surname>Liu</surname></persName><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation></author><author xml:id="author-0001"><persName><forename type="first">T.S.</forename><surname>Chin</surname></persName><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation></author><author xml:id="author-0002"><persName><forename type="first">L.S.</forename><surname>Lai</surname></persName><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation></author><author xml:id="author-0003"><persName><forename type="first">S.Y.</forename><surname>Chiu</surname></persName><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation></author><author xml:id="author-0004"><persName><forename type="first">K.H.</forename><surname>Chung</surname></persName><affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</affiliation></author><author xml:id="author-0005"><persName><forename type="first">C.S.</forename><surname>Chang</surname></persName><affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</affiliation></author><author xml:id="author-0006"><persName><forename type="first">M.T.</forename><surname>Lui</surname></persName><affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</affiliation></author><idno type="istex">699159804AB7B861CC999FAED9DB56C397A388F1</idno><idno type="DOI">10.1016/0272-8842(95)00135-2</idno><idno type="PII">0272-8842(95)00135-2</idno></analytic><monogr><title level="j">Ceramics International</title><title level="j" type="abbrev">CERI</title><idno type="pISSN">0272-8842</idno><idno type="PII">S0272-8842(00)X0014-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="19">19</biblScope><biblScope unit="page" to="25">25</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A simplified hydrothermal method of synthesizing hydroxyapatite powder is described. Heating powders of Ca(OH)2, Ca(H2PO4)2 · H2O and distilled water in a pressurized pot at 109 °C for 1–3 h results in powders consisting of crystallized hydroxyapatite in a needle shape, 130–170 nm in length and 15–25 nm in width. The specific surface area is 31–43 m2/g and the Ca P ratio is 1.640–1.643. The obtained HA powder can be sintered to a high density at 1200–1300 °C. No decomposition was identified by X-ray diffraction. The optimally sintered ceramic has a pore-free surface structure with a flexural strength of 120 MPa, a micro-Vickers hardness of 5.1 GPa and fracture toughness of 1.2 MPa · m 1 2. The biocompatibility of the pulverized sintered-ceramic is excellent and comparable to that of a commercial grade hydroxyapatite by evaluating the implantation in a dog. The synthesis method is simple, economic, and results in a high quality powder which is useful in hard tissue reconstruction applications.</p></abstract></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/699159804AB7B861CC999FAED9DB56C397A388F1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>CERI</jid><aid>95001352</aid><ce:pii>0272-8842(95)00135-2</ce:pii><ce:doi>10.1016/0272-8842(95)00135-2</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright></item-info><head><ce:title>Hydroxyapatite synthesized by a simplified hydrothermal method</ce:title><ce:author-group><ce:author><ce:given-name>H.S.</ce:given-name><ce:surname>Liu</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T.S.</ce:given-name><ce:surname>Chin</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>L.S.</ce:given-name><ce:surname>Lai</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.Y.</ce:given-name><ce:surname>Chiu</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.H.</ce:given-name><ce:surname>Chung</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>C.S.</ce:given-name><ce:surname>Chang</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.T.</ce:given-name><ce:surname>Lui</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="28" month="8" year="1995"></ce:date-received><ce:date-accepted day="26" month="9" year="1995"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>A simplified hydrothermal method of synthesizing hydroxyapatite powder is described. Heating powders of Ca(OH)<ce:inf>2</ce:inf>, Ca(H<ce:inf>2</ce:inf>PO<ce:inf>4</ce:inf>)<ce:inf>2</ce:inf> · H<ce:inf>2</ce:inf>O and distilled water in a pressurized pot at 109 °C for 1–3 h results in powders consisting of crystallized hydroxyapatite in a needle shape, 130–170 nm in length and 15–25 nm in width. The specific surface area is 31–43 m<ce:sup>2</ce:sup>/g and the <math altimg="si1.gif"><fr shape="sol"><nu><rm>Ca</rm></nu><de><rm>P</rm></de></fr></math> ratio is 1.640–1.643. The obtained HA powder can be sintered to a high density at 1200–1300 °C. No decomposition was identified by X-ray diffraction. The optimally sintered ceramic has a pore-free surface structure with a flexural strength of 120 MPa, a micro-Vickers hardness of 5.1 GPa and fracture toughness of <math altimg="si2.gif">1.2 <rm>MPa · m</rm><sup><fr shape="sol"><nu>1</nu><de>2</de></fr></sup></math>. The biocompatibility of the pulverized sintered-ceramic is excellent and comparable to that of a commercial grade hydroxyapatite by evaluating the implantation in a dog. The synthesis method is simple, economic, and results in a high quality powder which is useful in hard tissue reconstruction applications.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Hydroxyapatite synthesized by a simplified hydrothermal method</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Hydroxyapatite synthesized by a simplified hydrothermal method</title></titleInfo><name type="personal"><namePart type="given">H.S.</namePart><namePart type="family">Liu</namePart><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.S.</namePart><namePart type="family">Chin</namePart><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.S.</namePart><namePart type="family">Lai</namePart><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.Y.</namePart><namePart type="family">Chiu</namePart><affiliation>Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.H.</namePart><namePart type="family">Chung</namePart><affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.S.</namePart><namePart type="family">Chang</namePart><affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.T.</namePart><namePart type="family">Lui</namePart><affiliation>National Yang-Ming Medical University and Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: A simplified hydrothermal method of synthesizing hydroxyapatite powder is described. Heating powders of Ca(OH)2, Ca(H2PO4)2 · H2O and distilled water in a pressurized pot at 109 °C for 1–3 h results in powders consisting of crystallized hydroxyapatite in a needle shape, 130–170 nm in length and 15–25 nm in width. The specific surface area is 31–43 m2/g and the Ca P ratio is 1.640–1.643. The obtained HA powder can be sintered to a high density at 1200–1300 °C. No decomposition was identified by X-ray diffraction. The optimally sintered ceramic has a pore-free surface structure with a flexural strength of 120 MPa, a micro-Vickers hardness of 5.1 GPa and fracture toughness of 1.2 MPa · m 1 2. The biocompatibility of the pulverized sintered-ceramic is excellent and comparable to that of a commercial grade hydroxyapatite by evaluating the implantation in a dog. The synthesis method is simple, economic, and results in a high quality powder which is useful in hard tissue reconstruction applications.</abstract><relatedItem type="host"><titleInfo><title>Ceramics International</title></titleInfo><titleInfo type="abbreviated"><title>CERI</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued></originInfo><identifier type="ISSN">0272-8842</identifier><identifier type="PII">S0272-8842(00)X0014-4</identifier><part><date>1997</date><detail type="volume"><number>23</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>98</end></extent><extent unit="pages"><start>19</start><end>25</end></extent></part></relatedItem><identifier type="istex">699159804AB7B861CC999FAED9DB56C397A388F1</identifier><identifier type="ark">ark:/67375/6H6-PKBCNSWQ-5</identifier><identifier type="DOI">10.1016/0272-8842(95)00135-2</identifier><identifier type="PII">0272-8842(95)00135-2</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/699159804AB7B861CC999FAED9DB56C397A388F1/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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