Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation
Identifieur interne : 002D33 ( Istex/Corpus ); précédent : 002D32; suivant : 002D34Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation
Auteurs : Jaana Helenius-Hietala ; Jukka H. Meurman ; Krister Höckerstedt ; Christian Lindqvist ; Helena IsoniemiSource :
- Transplant International [ 0934-0874 ] ; 2012-02.
English descriptors
- KwdEn :
- Adult patients, Aetiology, Alci, Alci patients, Alcohol cirrhosis, Alveolar bone loss, Antibiotic prophylaxis, Apical periodontitis, Authors transplant, Autoimmune cirrhosis, Biliary, Biliary atresia, Cardiovascular disease, Caries, Chronic liver disease, Chronic liver disease patients, Cirrhosis, Common reason, Crypt, Crypt patients, Cryptogenic cirrhosis, Deep caries cavities, Dental, Dental caries, Dental examination, Dental foci, Dental health status, Dental infection foci, Dental infections, Dental management, Dental procedures, Dental treatment, Dental treatments, Dialysis patients, Different patient groups, European society, Evaluation process, Extraction, Fewer tooth extractions, Finland, Helsinki, Helsinki university, Highest number, Important factor, Infectious foci, Liver disease, Liver transplant patient, Liver transplant patients, Liver transplantation, Lowest number, Median, Medical condition, Medication, Metabolic liver diseases, Mucosal pathologies, Oral health, Oral health data, Oral health status, Oral infections, Oral mucosa, Oral pathol, Oral surg, Organ transplantation, Other cirrhosis, Other group, Other hand, Other liver disease groups, Pathol, Periodontitis, Present study, Pretransplant, Primary biliary cirrhosis, Primary sclerosing cholangitis, Primary syndrome, Radiol endod, Regression analysis, Risk factor, Root remnants, Score group, Several studies, Stage liver disease, Surg, Tooth decay, Tooth extractions, Transplant, Transplantation, Viral hepatitis, Wisdom teeth, Wisdom tooth.
- Teeft :
- Adult patients, Aetiology, Alci, Alci patients, Alcohol cirrhosis, Alveolar bone loss, Antibiotic prophylaxis, Apical periodontitis, Authors transplant, Autoimmune cirrhosis, Biliary, Biliary atresia, Cardiovascular disease, Caries, Chronic liver disease, Chronic liver disease patients, Cirrhosis, Common reason, Crypt, Crypt patients, Cryptogenic cirrhosis, Deep caries cavities, Dental, Dental caries, Dental examination, Dental foci, Dental health status, Dental infection foci, Dental infections, Dental management, Dental procedures, Dental treatment, Dental treatments, Dialysis patients, Different patient groups, European society, Evaluation process, Extraction, Fewer tooth extractions, Finland, Helsinki, Helsinki university, Highest number, Important factor, Infectious foci, Liver disease, Liver transplant patient, Liver transplant patients, Liver transplantation, Lowest number, Median, Medical condition, Medication, Metabolic liver diseases, Mucosal pathologies, Oral health, Oral health data, Oral health status, Oral infections, Oral mucosa, Oral pathol, Oral surg, Organ transplantation, Other cirrhosis, Other group, Other hand, Other liver disease groups, Pathol, Periodontitis, Present study, Pretransplant, Primary biliary cirrhosis, Primary sclerosing cholangitis, Primary syndrome, Radiol endod, Regression analysis, Risk factor, Root remnants, Score group, Several studies, Stage liver disease, Surg, Tooth decay, Tooth extractions, Transplant, Transplantation, Viral hepatitis, Wisdom teeth, Wisdom tooth.
Abstract
Elimination of dental infection foci has been recommended before liver transplantation (LT) because lifelong immunosuppression may predispose to infection spread. Association between pre‐LT oral health and the aetiology and severity of chronic liver disease (CLD) was investigated retrospectively. A total of 212 adult patients (median age 51.1) who had received LT during 2000–2006 in Finland were included. Their oral health had been pre‐operatively examined. Patients were divided into seven different CLD groups. Common indications for LT were primary sclerosing cholangitis (PSC 25.5%), alcohol cirrhosis (ALCI 17.5%) and primary biliary cirrhosis (PBC 14.6%). Patients were also categorized by the Model for End stage Liver Disease (MELD) scoring system. Medical, dental and panoramic jaw x‐ray data were analysed between groups. PBC patients had the lowest number of teeth with significant difference to PSC patients (19.7 vs. 25.6, P < 0.005, anova, t‐test). ALCI patients had the highest number of tooth extractions with significant difference in comparison to PSC patients (5.6 vs. 2.5, P < 0.005). Lower MELD score resulted in fewer tooth extractions but after adjusting for several confounding factors, age was the most important factor associated with extractions (P < 0.005). The aetiology of CLD associated with the oral health status and there was a tendency towards worse dental health with higher MELD scores.
Url:
DOI: 10.1111/j.1432-2277.2011.01381.x
Links to Exploration step
ISTEX:5C55FF224D03BC11E63143F4EC21C822B3A334B6Le document en format XML
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when="2012-02">2012-02</date></imprint><idno type="ISSN">0934-0874</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0934-0874</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult patients</term><term>Aetiology</term><term>Alci</term><term>Alci patients</term><term>Alcohol cirrhosis</term><term>Alveolar bone loss</term><term>Antibiotic prophylaxis</term><term>Apical periodontitis</term><term>Authors transplant</term><term>Autoimmune cirrhosis</term><term>Biliary</term><term>Biliary atresia</term><term>Cardiovascular disease</term><term>Caries</term><term>Chronic liver disease</term><term>Chronic liver disease patients</term><term>Cirrhosis</term><term>Common reason</term><term>Crypt</term><term>Crypt patients</term><term>Cryptogenic cirrhosis</term><term>Deep caries cavities</term><term>Dental</term><term>Dental caries</term><term>Dental examination</term><term>Dental foci</term><term>Dental health status</term><term>Dental infection foci</term><term>Dental infections</term><term>Dental management</term><term>Dental procedures</term><term>Dental treatment</term><term>Dental treatments</term><term>Dialysis patients</term><term>Different patient groups</term><term>European society</term><term>Evaluation process</term><term>Extraction</term><term>Fewer tooth extractions</term><term>Finland</term><term>Helsinki</term><term>Helsinki university</term><term>Highest number</term><term>Important factor</term><term>Infectious foci</term><term>Liver disease</term><term>Liver transplant patient</term><term>Liver transplant patients</term><term>Liver transplantation</term><term>Lowest number</term><term>Median</term><term>Medical condition</term><term>Medication</term><term>Metabolic liver diseases</term><term>Mucosal pathologies</term><term>Oral health</term><term>Oral health data</term><term>Oral health status</term><term>Oral infections</term><term>Oral mucosa</term><term>Oral pathol</term><term>Oral surg</term><term>Organ transplantation</term><term>Other cirrhosis</term><term>Other group</term><term>Other hand</term><term>Other liver disease groups</term><term>Pathol</term><term>Periodontitis</term><term>Present study</term><term>Pretransplant</term><term>Primary biliary cirrhosis</term><term>Primary sclerosing cholangitis</term><term>Primary syndrome</term><term>Radiol endod</term><term>Regression analysis</term><term>Risk factor</term><term>Root remnants</term><term>Score group</term><term>Several studies</term><term>Stage liver disease</term><term>Surg</term><term>Tooth decay</term><term>Tooth extractions</term><term>Transplant</term><term>Transplantation</term><term>Viral hepatitis</term><term>Wisdom teeth</term><term>Wisdom tooth</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adult patients</term><term>Aetiology</term><term>Alci</term><term>Alci patients</term><term>Alcohol cirrhosis</term><term>Alveolar bone loss</term><term>Antibiotic prophylaxis</term><term>Apical periodontitis</term><term>Authors transplant</term><term>Autoimmune cirrhosis</term><term>Biliary</term><term>Biliary atresia</term><term>Cardiovascular disease</term><term>Caries</term><term>Chronic liver disease</term><term>Chronic liver disease patients</term><term>Cirrhosis</term><term>Common reason</term><term>Crypt</term><term>Crypt patients</term><term>Cryptogenic cirrhosis</term><term>Deep caries cavities</term><term>Dental</term><term>Dental caries</term><term>Dental examination</term><term>Dental foci</term><term>Dental health status</term><term>Dental infection foci</term><term>Dental infections</term><term>Dental management</term><term>Dental procedures</term><term>Dental treatment</term><term>Dental treatments</term><term>Dialysis patients</term><term>Different patient groups</term><term>European society</term><term>Evaluation process</term><term>Extraction</term><term>Fewer tooth extractions</term><term>Finland</term><term>Helsinki</term><term>Helsinki university</term><term>Highest number</term><term>Important factor</term><term>Infectious foci</term><term>Liver disease</term><term>Liver transplant patient</term><term>Liver transplant patients</term><term>Liver transplantation</term><term>Lowest number</term><term>Median</term><term>Medical condition</term><term>Medication</term><term>Metabolic liver diseases</term><term>Mucosal pathologies</term><term>Oral health</term><term>Oral health data</term><term>Oral health status</term><term>Oral infections</term><term>Oral mucosa</term><term>Oral pathol</term><term>Oral surg</term><term>Organ transplantation</term><term>Other cirrhosis</term><term>Other group</term><term>Other hand</term><term>Other liver disease groups</term><term>Pathol</term><term>Periodontitis</term><term>Present study</term><term>Pretransplant</term><term>Primary biliary cirrhosis</term><term>Primary sclerosing cholangitis</term><term>Primary syndrome</term><term>Radiol endod</term><term>Regression analysis</term><term>Risk factor</term><term>Root remnants</term><term>Score group</term><term>Several studies</term><term>Stage liver disease</term><term>Surg</term><term>Tooth decay</term><term>Tooth extractions</term><term>Transplant</term><term>Transplantation</term><term>Viral hepatitis</term><term>Wisdom teeth</term><term>Wisdom tooth</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elimination of dental infection foci has been recommended before liver transplantation (LT) because lifelong immunosuppression may predispose to infection spread. Association between pre‐LT oral health and the aetiology and severity of chronic liver disease (CLD) was investigated retrospectively. A total of 212 adult patients (median age 51.1) who had received LT during 2000–2006 in Finland were included. Their oral health had been pre‐operatively examined. Patients were divided into seven different CLD groups. Common indications for LT were primary sclerosing cholangitis (PSC 25.5%), alcohol cirrhosis (ALCI 17.5%) and primary biliary cirrhosis (PBC 14.6%). Patients were also categorized by the Model for End stage Liver Disease (MELD) scoring system. Medical, dental and panoramic jaw x‐ray data were analysed between groups. PBC patients had the lowest number of teeth with significant difference to PSC patients (19.7 vs. 25.6, P < 0.005, anova, t‐test). ALCI patients had the highest number of tooth extractions with significant difference in comparison to PSC patients (5.6 vs. 2.5, P < 0.005). Lower MELD score resulted in fewer tooth extractions but after adjusting for several confounding factors, age was the most important factor associated with extractions (P < 0.005). The aetiology of CLD associated with the oral health status and there was a tendency towards worse dental health with higher MELD scores.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>transplantation</json:string><json:string>alci</json:string><json:string>cirrhosis</json:string><json:string>aetiology</json:string><json:string>tooth extractions</json:string><json:string>organ transplantation</json:string><json:string>liver disease</json:string><json:string>periodontitis</json:string><json:string>pretransplant</json:string><json:string>helsinki</json:string><json:string>surg</json:string><json:string>authors transplant</json:string><json:string>caries</json:string><json:string>oral health</json:string><json:string>european society</json:string><json:string>pathol</json:string><json:string>biliary</json:string><json:string>dental treatment</json:string><json:string>oral surg</json:string><json:string>alcohol cirrhosis</json:string><json:string>liver transplant patients</json:string><json:string>alci patients</json:string><json:string>oral pathol</json:string><json:string>present study</json:string><json:string>transplant</json:string><json:string>crypt</json:string><json:string>stage liver disease</json:string><json:string>lowest number</json:string><json:string>apical periodontitis</json:string><json:string>dental examination</json:string><json:string>dental infection foci</json:string><json:string>oral health status</json:string><json:string>chronic liver disease</json:string><json:string>highest number</json:string><json:string>alveolar bone loss</json:string><json:string>other group</json:string><json:string>primary biliary cirrhosis</json:string><json:string>wisdom teeth</json:string><json:string>liver transplantation</json:string><json:string>radiol endod</json:string><json:string>median</json:string><json:string>medication</json:string><json:string>score group</json:string><json:string>biliary atresia</json:string><json:string>regression analysis</json:string><json:string>dental management</json:string><json:string>common reason</json:string><json:string>primary sclerosing cholangitis</json:string><json:string>oral infections</json:string><json:string>mucosal pathologies</json:string><json:string>other hand</json:string><json:string>helsinki university</json:string><json:string>infectious foci</json:string><json:string>finland</json:string><json:string>extraction</json:string><json:string>cryptogenic cirrhosis</json:string><json:string>several studies</json:string><json:string>other cirrhosis</json:string><json:string>autoimmune cirrhosis</json:string><json:string>dental infections</json:string><json:string>primary syndrome</json:string><json:string>metabolic liver diseases</json:string><json:string>chronic liver disease patients</json:string><json:string>different patient groups</json:string><json:string>dental foci</json:string><json:string>risk factor</json:string><json:string>wisdom tooth</json:string><json:string>evaluation process</json:string><json:string>dialysis patients</json:string><json:string>crypt patients</json:string><json:string>oral mucosa</json:string><json:string>medical condition</json:string><json:string>dental caries</json:string><json:string>oral health data</json:string><json:string>adult patients</json:string><json:string>cardiovascular disease</json:string><json:string>dental health status</json:string><json:string>other liver disease groups</json:string><json:string>tooth decay</json:string><json:string>deep caries cavities</json:string><json:string>dental treatments</json:string><json:string>root remnants</json:string><json:string>important factor</json:string><json:string>fewer tooth extractions</json:string><json:string>liver transplant patient</json:string><json:string>dental procedures</json:string><json:string>antibiotic prophylaxis</json:string><json:string>viral hepatitis</json:string><json:string>dental</json:string></teeft></keywords><author><json:item><name>Jaana Helenius‐Hietala</name><affiliations><json:string>University of Helsinki, Institute of Dentistry, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Jukka H. Meurman</name><affiliations><json:string>University of Helsinki, Institute of Dentistry, Helsinki, Finland</json:string><json:string>Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Krister Höckerstedt</name><affiliations><json:string>Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Christian Lindqvist</name><affiliations><json:string>University of Helsinki, Institute of Dentistry, Helsinki, Finland</json:string><json:string>Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Helena Isoniemi</name><affiliations><json:string>Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Helsinki, Finland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>bacterial infection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chronic liver disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dental foci</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MELD score</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>teeth</value></json:item></subject><articleId><json:string>TRI1381</json:string></articleId><arkIstex>ark:/67375/WNG-BVSC36NN-5</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Elimination of dental infection foci has been recommended before liver transplantation (LT) because lifelong immunosuppression may predispose to infection spread. Association between pre‐LT oral health and the aetiology and severity of chronic liver disease (CLD) was investigated retrospectively. A total of 212 adult patients (median age 51.1) who had received LT during 2000–2006 in Finland were included. Their oral health had been pre‐operatively examined. Patients were divided into seven different CLD groups. Common indications for LT were primary sclerosing cholangitis (PSC 25.5%), alcohol cirrhosis (ALCI 17.5%) and primary biliary cirrhosis (PBC 14.6%). Patients were also categorized by the Model for End stage Liver Disease (MELD) scoring system. Medical, dental and panoramic jaw x‐ray data were analysed between groups. PBC patients had the lowest number of teeth with significant difference to PSC patients (19.7 vs. 25.6, P > 0.005, anova, t‐test). ALCI patients had the highest number of tooth extractions with significant difference in comparison to PSC patients (5.6 vs. 2.5, P > 0.005). Lower MELD score resulted in fewer tooth extractions but after adjusting for several confounding factors, age was the most important factor associated with extractions (P > 0.005). The aetiology of CLD associated with the oral health status and there was a tendency towards worse dental health with higher MELD scores.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>207</abstractWordCount><abstractCharCount>1427</abstractCharCount><keywordCount>5</keywordCount><score>9.223</score><pdfWordCount>4739</pdfWordCount><pdfCharCount>29814</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize></qualityIndicators><title>Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation</title><pmid><json:string>22054477</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Transplant International</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1432-2277</json:string></doi><issn><json:string>0934-0874</json:string></issn><eissn><json:string>1432-2277</json:string></eissn><publisherId><json:string>TRI</json:string></publisherId><volume>25</volume><issue>2</issue><pages><first>158</first><last>165</last><total>8</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>ORIGINAL ARTICLE</value></json:item></subject></host><namedEntities><unitex><date><json:string>2000</json:string><json:string>2012</json:string></date><geogName></geogName><orgName><json:string>In Finland the MELD</json:string><json:string>University of Helsinki</json:string><json:string>Helsinki University Central Hospital, Transplantation and Liver Surgery</json:string><json:string>Helsinki University</json:string><json:string>Finland Keywords</json:string><json:string>The Authors Transplant International</json:string><json:string>Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases</json:string><json:string>Society for Organ Transplantation</json:string><json:string>Institute of Dentistry, Helsinki, Finland</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>P.O. Box</json:string><json:string>Jaana Helenius-Hietala</json:string><json:string>Table</json:string><json:string>Christian Lindqvist</json:string><json:string>Helena Isoniemi</json:string></persName><placeName><json:string>IL</json:string><json:string>Finland</json:string><json:string>Helsinki</json:string><json:string>USA</json:string><json:string>Chicago</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[23]</json:string><json:string>[18]</json:string><json:string>[22]</json:string><json:string>[20,21]</json:string><json:string>[8]</json:string><json:string>Guggenheimer et al. [3]</json:string><json:string>Richards et al. [18]</json:string><json:string>[10]</json:string><json:string>Melkos et al. [6]</json:string><json:string>Rustemeyer et al. [7]</json:string><json:string>[3]</json:string><json:string>[6,7]</json:string><json:string>Novacek et al. [22]</json:string><json:string>[9]</json:string><json:string>Helenius-Hietala et al.</json:string><json:string>[2]</json:string><json:string>[24]</json:string><json:string>[19]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-BVSC36NN-5</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - transplantation</json:string><json:string>2 - surgery</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - surgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Transplantation</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1111/j.1432-2277.2011.01381.x</json:string></doi><id>5C55FF224D03BC11E63143F4EC21C822B3A334B6</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/5C55FF224D03BC11E63143F4EC21C822B3A334B6/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/5C55FF224D03BC11E63143F4EC21C822B3A334B6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/5C55FF224D03BC11E63143F4EC21C822B3A334B6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation</licence></availability><date type="published" when="2012-02"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation</title><title level="a" type="short">Pretransplant oral health in liver transplant patients</title><author xml:id="author-0000"><persName><forename type="first">Jaana</forename><surname>Helenius‐Hietala</surname></persName><affiliation> University of Helsinki, Institute of Dentistry, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Jukka H.</forename><surname>Meurman</surname></persName><affiliation> University of Helsinki, Institute of Dentistry, Helsinki, Finland<address><country key="FI"></country></address></affiliation><affiliation> Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Krister</forename><surname>Höckerstedt</surname></persName><affiliation> Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Christian</forename><surname>Lindqvist</surname></persName><affiliation> University of Helsinki, Institute of Dentistry, Helsinki, Finland<address><country key="FI"></country></address></affiliation><affiliation> Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Helena</forename><surname>Isoniemi</surname></persName><affiliation> Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><idno type="istex">5C55FF224D03BC11E63143F4EC21C822B3A334B6</idno><idno type="ark">ark:/67375/WNG-BVSC36NN-5</idno><idno type="DOI">10.1111/j.1432-2277.2011.01381.x</idno><idno type="unit">TRI1381</idno><idno type="toTypesetVersion">file:TRI.TRI1381.pdf</idno></analytic><monogr><title level="j" type="main">Transplant International</title><title level="j" type="alt">TRANSPLANT INTERNATIONAL</title><idno type="pISSN">0934-0874</idno><idno type="eISSN">1432-2277</idno><idno type="book-DOI">10.1111/(ISSN)1432-2277</idno><idno type="book-part-DOI">10.1111/tri.2012.25.issue-2</idno><idno type="product">TRI</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="158">158</biblScope><biblScope unit="page" to="165">165</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Summary</head><p>Elimination of dental infection foci has been recommended before liver transplantation (LT) because lifelong immunosuppression may predispose to infection spread. Association between pre‐LT oral health and the aetiology and severity of chronic liver disease (CLD) was investigated retrospectively. A total of 212 adult patients (median age 51.1) who had received LT during 2000–2006 in Finland were included. Their oral health had been pre‐operatively examined. Patients were divided into seven different CLD groups. Common indications for LT were primary sclerosing cholangitis (PSC 25.5%), alcohol cirrhosis (ALCI 17.5%) and primary biliary cirrhosis (PBC 14.6%). Patients were also categorized by the Model for End stage Liver Disease (MELD) scoring system. Medical, dental and panoramic jaw x‐ray data were analysed between groups. PBC patients had the lowest number of teeth with significant difference to PSC patients (19.7 vs. 25.6, <hi rend="italic">P</hi> < 0.005, <hi rend="smallCaps">anova</hi>, <hi rend="italic">t</hi>‐test). ALCI patients had the highest number of tooth extractions with significant difference in comparison to PSC patients (5.6 vs. 2.5, <hi rend="italic">P</hi> < 0.005). Lower MELD score resulted in fewer tooth extractions but after adjusting for several confounding factors, age was the most important factor associated with extractions (<hi rend="italic">P</hi> < 0.005). The aetiology of CLD associated with the oral health status and there was a tendency towards worse dental health with higher MELD scores.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">bacterial infection</term><term xml:id="k2">chronic liver disease</term><term xml:id="k3">dental foci</term><term xml:id="k4">MELD score</term><term xml:id="k5">teeth</term></keywords><keywords rend="tocHeading1"><term>CLINICAL RESEARCH</term></keywords><keywords rend="articleCategory"><term>ORIGINAL ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/5C55FF224D03BC11E63143F4EC21C822B3A334B6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1432-2277</doi><issn type="print">0934-0874</issn><issn type="electronic">1432-2277</issn><idGroup><id type="product" value="TRI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="TRANSPLANT INTERNATIONAL">Transplant International</title></titleGroup></publicationMeta><publicationMeta level="part" position="02102"><doi origin="wiley">10.1111/tri.2012.25.issue-2</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2012-02">February 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.1432-2277.2011.01381.x</doi><idGroup><id type="unit" value="TRI1381"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">CLINICAL RESEARCH</title><title type="articleCategory">ORIGINAL ARTICLE</title></titleGroup><copyright>© 2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-16"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-11-05"></event><event type="firstOnline" date="2011-11-05"></event><event type="publishedOnlineFinalForm" date="2012-01-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.7 mode:FullText" date="2015-03-24"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="158">158</numbering><numbering type="pageLast" number="165">165</numbering></numberingGroup><correspondenceTo>Dr. Jaana Helenius‐Hietala, P.O. Box 41, FI‐00014 University of Helsinki. Tel.: +358 40 724 7275; fax: +358 9 191 27286; e‐mail: <email>jaana.s.helenius@helsinki.fi</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:TRI.TRI1381.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received: 23 June 2011 Revision requested: 12 July 2011 Accepted: 7 October 2011 Published online: 5 November 2011</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation</title><title type="shortAuthors">Helenius‐Hietala <i>et al.</i></title><title type="short"><b>Pretransplant oral health in liver transplant patients</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Jaana</givenNames><familyName>Helenius‐Hietala</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a2"><personName><givenNames>Jukka H.</givenNames><familyName>Meurman</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Krister</givenNames><familyName>Höckerstedt</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a2"><personName><givenNames>Christian</givenNames><familyName>Lindqvist</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a3"><personName><givenNames>Helena</givenNames><familyName>Isoniemi</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FI"><unparsedAffiliation> University of Helsinki, Institute of Dentistry, Helsinki, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FI"><unparsedAffiliation> Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, Helsinki, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="FI"><unparsedAffiliation> Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Helsinki, Finland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">bacterial infection</keyword><keyword xml:id="k2">chronic liver disease</keyword><keyword xml:id="k3">dental foci</keyword><keyword xml:id="k4">MELD score</keyword><keyword xml:id="k5">teeth</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>Elimination of dental infection foci has been recommended before liver transplantation (LT) because lifelong immunosuppression may predispose to infection spread. Association between pre‐LT oral health and the aetiology and severity of chronic liver disease (CLD) was investigated retrospectively. A total of 212 adult patients (median age 51.1) who had received LT during 2000–2006 in Finland were included. Their oral health had been pre‐operatively examined. Patients were divided into seven different CLD groups. Common indications for LT were primary sclerosing cholangitis (PSC 25.5%), alcohol cirrhosis (ALCI 17.5%) and primary biliary cirrhosis (PBC 14.6%). Patients were also categorized by the Model for End stage Liver Disease (MELD) scoring system. Medical, dental and panoramic jaw x‐ray data were analysed between groups. PBC patients had the lowest number of teeth with significant difference to PSC patients (19.7 vs. 25.6, <i>P</i> < 0.005, <sc>anova</sc>, <i>t</i>‐test). ALCI patients had the highest number of tooth extractions with significant difference in comparison to PSC patients (5.6 vs. 2.5, <i>P</i> < 0.005). Lower MELD score resulted in fewer tooth extractions but after adjusting for several confounding factors, age was the most important factor associated with extractions (<i>P</i> < 0.005). The aetiology of CLD associated with the oral health status and there was a tendency towards worse dental health with higher MELD scores.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Conflicts of Interest</b>
The authors have declared no conflicts of interest.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pretransplant oral health in liver transplant patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation</title></titleInfo><name type="personal"><namePart type="given">Jaana</namePart><namePart type="family">Helenius‐Hietala</namePart><affiliation> University of Helsinki, Institute of Dentistry, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jukka H.</namePart><namePart type="family">Meurman</namePart><affiliation> University of Helsinki, Institute of Dentistry, Helsinki, Finland</affiliation><affiliation> Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Krister</namePart><namePart type="family">Höckerstedt</namePart><affiliation> Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christian</namePart><namePart type="family">Lindqvist</namePart><affiliation> University of Helsinki, Institute of Dentistry, Helsinki, Finland</affiliation><affiliation> Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helena</namePart><namePart type="family">Isoniemi</namePart><affiliation> Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2012-02</dateIssued><edition>Received: 23 June 2011 Revision requested: 12 July 2011 Accepted: 7 October 2011 Published online: 5 November 2011</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">2</extent></physicalDescription><abstract lang="en">Elimination of dental infection foci has been recommended before liver transplantation (LT) because lifelong immunosuppression may predispose to infection spread. Association between pre‐LT oral health and the aetiology and severity of chronic liver disease (CLD) was investigated retrospectively. A total of 212 adult patients (median age 51.1) who had received LT during 2000–2006 in Finland were included. Their oral health had been pre‐operatively examined. Patients were divided into seven different CLD groups. Common indications for LT were primary sclerosing cholangitis (PSC 25.5%), alcohol cirrhosis (ALCI 17.5%) and primary biliary cirrhosis (PBC 14.6%). Patients were also categorized by the Model for End stage Liver Disease (MELD) scoring system. Medical, dental and panoramic jaw x‐ray data were analysed between groups. PBC patients had the lowest number of teeth with significant difference to PSC patients (19.7 vs. 25.6, P < 0.005, anova, t‐test). ALCI patients had the highest number of tooth extractions with significant difference in comparison to PSC patients (5.6 vs. 2.5, P < 0.005). Lower MELD score resulted in fewer tooth extractions but after adjusting for several confounding factors, age was the most important factor associated with extractions (P < 0.005). The aetiology of CLD associated with the oral health status and there was a tendency towards worse dental health with higher MELD scores.</abstract><subject lang="en"><genre>keywords</genre><topic>bacterial infection</topic><topic>chronic liver disease</topic><topic>dental foci</topic><topic>MELD score</topic><topic>teeth</topic></subject><relatedItem type="host"><titleInfo><title>Transplant International</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ORIGINAL ARTICLE</topic></subject><identifier type="ISSN">0934-0874</identifier><identifier type="eISSN">1432-2277</identifier><identifier type="DOI">10.1111/(ISSN)1432-2277</identifier><identifier type="PublisherID">TRI</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>158</start><end>165</end><total>8</total></extent></part></relatedItem><identifier type="istex">5C55FF224D03BC11E63143F4EC21C822B3A334B6</identifier><identifier type="ark">ark:/67375/WNG-BVSC36NN-5</identifier><identifier type="DOI">10.1111/j.1432-2277.2011.01381.x</identifier><identifier type="ArticleID">TRI1381</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 The Authors. 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