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Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Identifieur interne : 001B23 ( Istex/Corpus ); précédent : 001B22; suivant : 001B24

Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Auteurs : Daniel S. Thoma ; Manuel Sancho-Puchades ; Dominik A. Ettlin ; Christoph H. F. H Mmerle ; Ronald E. Jung

Source :

RBID : ISTEX:37AAFEB2585572038031C64B0444AC7E57D250F0

English descriptors

Abstract

To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing.

Url:
DOI: 10.1111/j.1600-051X.2011.01823.x

Links to Exploration step

ISTEX:37AAFEB2585572038031C64B0444AC7E57D250F0

Le document en format XML

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Aim
<p>To test whether a collagen matrix (
<hi rend="fc">CM</hi>
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Methods
<p>In 15 volunteers, 6‐mm punch biopsies were harvested at both palatal sites. A
<hi rend="fc">CM</hi>
was sutured in one site; the other one was left untreated (control). Measurements included the remaining defect area, the colour match to surrounding tissue and somatosensory parameters at various time‐points (pre‐operative, post‐operative, 4, 8, 15, 29 days).</p>
Results
<p>The defect area decreased over time for both treatments. Re‐epithelization was completed in all subjects by day 15. The defect area was significantly smaller for
<hi rend="fc">CM</hi>
(mean ± SD: 19.3 ± 3.4 mm
<hi rend="superscript">2</hi>
) compared with control (21.3 ± 3.3 mm
<hi rend="superscript">2</hi>
) at day 4 (
<hi rend="italic">p</hi>
 < 0.05), and at day 8 (
<hi rend="fc">CM</hi>
: 11.7 ± 2.5 mm
<hi rend="superscript">2</hi>
; control: 13.6 ± 2.9 mm
<hi rend="superscript">2</hi>
;
<hi rend="italic">p</hi>
 < 0.01). The colour match was more favourable for
<hi rend="fc">CM</hi>
at day 4, 8 and 29 (
<hi rend="italic">p</hi>
 > 0.05). Somatosensory measurements revealed slightly lower wound sensitivity at day 4 for
<hi rend="fc">CM</hi>
compared with control.</p>
Conclusions
<p>The use of
<hi rend="fc">CM</hi>
can enhance wound healing compared with spontaneous healing during the first week. This was mainly documented by a faster re‐epithelization. Colour match and wound sensitivity measurements did not reach statistical significance between
<hi rend="fc">CM</hi>
and control sites.</p>
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<p>To test whether a collagen matrix (
<fc>CM</fc>
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<p>In 15 volunteers, 6‐mm punch biopsies were harvested at both palatal sites. A
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was sutured in one site; the other one was left untreated (control). Measurements included the remaining defect area, the colour match to surrounding tissue and somatosensory parameters at various time‐points (pre‐operative, post‐operative, 4, 8, 15, 29 days).</p>
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<p>The defect area decreased over time for both treatments. Re‐epithelization was completed in all subjects by day 15. The defect area was significantly smaller for
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<p>The use of
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<p>This study was funded by the Clinic of Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Switzerland and by a research grant from Geistlich Pharma AG, Wolhusen, Switzerland. The development of the air jet stimulator was funded by GlaxoSmithKline, Consumer Healthcare, Weybridge, UK. Dres. Hämmerle, Jung and Thoma have received lecture fees from Geistlich Pharma AG, Wolhusen, Switzerland and are member (Jung, Thoma) of the Osteology Foundation Expert Council or president (Hämmerle) of the Osteology Foundation. Other than mentioned, the authors do not report any conflict of interest for this study.</p>
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<namePart type="given">Christoph H. F.</namePart>
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<affiliation>Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland</affiliation>
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</name>
<name type="personal">
<namePart type="given">Ronald E.</namePart>
<namePart type="family">Jung</namePart>
<affiliation>Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland</affiliation>
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<publisher>Blackwell Publishing Ltd</publisher>
<dateIssued encoding="w3cdtf">2012-02</dateIssued>
<dateCreated encoding="w3cdtf">2011-11-14</dateCreated>
<dateValid encoding="w3cdtf">2011-11-02</dateValid>
<copyrightDate encoding="w3cdtf">2012</copyrightDate>
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<language>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<abstract>To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing.</abstract>
<abstract>In 15 volunteers, 6‐mm punch biopsies were harvested at both palatal sites. A CM was sutured in one site; the other one was left untreated (control). Measurements included the remaining defect area, the colour match to surrounding tissue and somatosensory parameters at various time‐points (pre‐operative, post‐operative, 4, 8, 15, 29 days).</abstract>
<abstract>The defect area decreased over time for both treatments. Re‐epithelization was completed in all subjects by day 15. The defect area was significantly smaller for CM (mean ± SD: 19.3 ± 3.4 mm2) compared with control (21.3 ± 3.3 mm2) at day 4 (p < 0.05), and at day 8 (CM: 11.7 ± 2.5 mm2; control: 13.6 ± 2.9 mm2; p < 0.01). The colour match was more favourable for CM at day 4, 8 and 29 (p > 0.05). Somatosensory measurements revealed slightly lower wound sensitivity at day 4 for CM compared with control.</abstract>
<abstract>The use of CM can enhance wound healing compared with spontaneous healing during the first week. This was mainly documented by a faster re‐epithelization. Colour match and wound sensitivity measurements did not reach statistical significance between CM and control sites.</abstract>
<note type="funding">University of Zurich</note>
<note type="funding">Geistlich Pharma AG</note>
<note type="funding">University of Zurich</note>
<note type="funding">Geistlich Pharma AG</note>
<note type="funding">GlaxoSmithKline, Consumer Healthcare</note>
<note type="funding">Geistlich Pharma AG</note>
<subject>
<genre>keywords</genre>
<topic>collagen matrix</topic>
<topic>keratinized tissue</topic>
<topic>soft tissue augmentation</topic>
<topic>substitute</topic>
<topic>transplant</topic>
<topic>wound healing</topic>
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<title>Journal of Clinical Periodontology</title>
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<title>J Clin Periodontol</title>
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<subject>
<genre>article-category</genre>
<topic>Periodontal Therapy</topic>
</subject>
<identifier type="ISSN">0303-6979</identifier>
<identifier type="eISSN">1600-051X</identifier>
<identifier type="DOI">10.1111/(ISSN)1600-051X</identifier>
<identifier type="PublisherID">JCPE</identifier>
<part>
<date>2012</date>
<detail type="volume">
<caption>vol.</caption>
<number>39</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>2</number>
</detail>
<extent unit="pages">
<start>157</start>
<end>165</end>
<total>9</total>
</extent>
</part>
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<identifier type="istex">37AAFEB2585572038031C64B0444AC7E57D250F0</identifier>
<identifier type="ark">ark:/67375/WNG-6SVPTS5D-6</identifier>
<identifier type="DOI">10.1111/j.1600-051X.2011.01823.x</identifier>
<identifier type="ArticleID">JCPE1823</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 John Wiley & Sons A/S© 2011 John Wiley & Sons A/S</accessCondition>
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