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Tissue reactions after simultaneous alveolar ridge augmentation with biphasic calcium phosphate and implant insertion--histological and immunohistochemical evaluation in humans.

Identifieur interne : 000B78 ( PubMed/Curation ); précédent : 000B77; suivant : 000B79

Tissue reactions after simultaneous alveolar ridge augmentation with biphasic calcium phosphate and implant insertion--histological and immunohistochemical evaluation in humans.

Auteurs : Anton Friedmann [Allemagne] ; Kirsten Gissel ; Anna Konermann ; Werner Götz

Source :

RBID : pubmed:25511386

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English descriptors

Abstract

Simultaneous lateral augmentation and implant placement is considered as standard procedure in deficient edentulous ridges in oral implantology. Histological studies monitoring osteogenesis after application of alloplastic bone substitutes in humans are scarce. Bone formation upon simultaneous augmentation with biphasic calcium phosphate (BCP) and implantation was histologically investigated after 6 months in situ. The results of this secondary analysis are reported tempting to ascribe specific observations to uneventful submerged healing or compromised healing of soft tissues including occurrence of dehiscences and premature graft exposure.

DOI: 10.1007/s00784-014-1385-0
PubMed: 25511386

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pubmed:25511386

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<title xml:lang="en">Tissue reactions after simultaneous alveolar ridge augmentation with biphasic calcium phosphate and implant insertion--histological and immunohistochemical evaluation in humans.</title>
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<name sortKey="Friedmann, Anton" sort="Friedmann, Anton" uniqKey="Friedmann A" first="Anton" last="Friedmann">Anton Friedmann</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Periodontology, School of Dentistry, Faculty of Health, Witten-Herdecke University, Witten, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Periodontology, School of Dentistry, Faculty of Health, Witten-Herdecke University, Witten</wicri:regionArea>
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<name sortKey="Gissel, Kirsten" sort="Gissel, Kirsten" uniqKey="Gissel K" first="Kirsten" last="Gissel">Kirsten Gissel</name>
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<name sortKey="Konermann, Anna" sort="Konermann, Anna" uniqKey="Konermann A" first="Anna" last="Konermann">Anna Konermann</name>
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<name sortKey="Gotz, Werner" sort="Gotz, Werner" uniqKey="Gotz W" first="Werner" last="Götz">Werner Götz</name>
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<title xml:lang="en">Tissue reactions after simultaneous alveolar ridge augmentation with biphasic calcium phosphate and implant insertion--histological and immunohistochemical evaluation in humans.</title>
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<name sortKey="Friedmann, Anton" sort="Friedmann, Anton" uniqKey="Friedmann A" first="Anton" last="Friedmann">Anton Friedmann</name>
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<nlm:affiliation>Department of Periodontology, School of Dentistry, Faculty of Health, Witten-Herdecke University, Witten, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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<name sortKey="Gissel, Kirsten" sort="Gissel, Kirsten" uniqKey="Gissel K" first="Kirsten" last="Gissel">Kirsten Gissel</name>
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<name sortKey="Konermann, Anna" sort="Konermann, Anna" uniqKey="Konermann A" first="Anna" last="Konermann">Anna Konermann</name>
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<name sortKey="Gotz, Werner" sort="Gotz, Werner" uniqKey="Gotz W" first="Werner" last="Götz">Werner Götz</name>
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<title level="j">Clinical oral investigations</title>
<idno type="eISSN">1436-3771</idno>
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<term>Adult</term>
<term>Aged</term>
<term>Alveolar Ridge Augmentation (methods)</term>
<term>Calcium Phosphates (therapeutic use)</term>
<term>Dental Implants</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Implants dentaires</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Phosphates de calcium (usage thérapeutique)</term>
<term>Reconstruction de crête alvéolaire ()</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Calcium Phosphates</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en">
<term>Alveolar Ridge Augmentation</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Phosphates de calcium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Dental Implants</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Implants dentaires</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Reconstruction de crête alvéolaire</term>
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<front>
<div type="abstract" xml:lang="en">Simultaneous lateral augmentation and implant placement is considered as standard procedure in deficient edentulous ridges in oral implantology. Histological studies monitoring osteogenesis after application of alloplastic bone substitutes in humans are scarce. Bone formation upon simultaneous augmentation with biphasic calcium phosphate (BCP) and implantation was histologically investigated after 6 months in situ. The results of this secondary analysis are reported tempting to ascribe specific observations to uneventful submerged healing or compromised healing of soft tissues including occurrence of dehiscences and premature graft exposure.</div>
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<DateCompleted>
<Year>2017</Year>
<Month>02</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>10</Month>
<Day>13</Day>
</DateRevised>
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<Journal>
<ISSN IssnType="Electronic">1436-3771</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>19</Volume>
<Issue>7</Issue>
<PubDate>
<Year>2015</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Clinical oral investigations</Title>
<ISOAbbreviation>Clin Oral Investig</ISOAbbreviation>
</Journal>
<ArticleTitle>Tissue reactions after simultaneous alveolar ridge augmentation with biphasic calcium phosphate and implant insertion--histological and immunohistochemical evaluation in humans.</ArticleTitle>
<Pagination>
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</Pagination>
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<Abstract>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Simultaneous lateral augmentation and implant placement is considered as standard procedure in deficient edentulous ridges in oral implantology. Histological studies monitoring osteogenesis after application of alloplastic bone substitutes in humans are scarce. Bone formation upon simultaneous augmentation with biphasic calcium phosphate (BCP) and implantation was histologically investigated after 6 months in situ. The results of this secondary analysis are reported tempting to ascribe specific observations to uneventful submerged healing or compromised healing of soft tissues including occurrence of dehiscences and premature graft exposure.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Histology of biopsies from lateral, crestal bone augmentations using alloplastic BCP comprising seven sites with compromised, prematurely exposed healing and six sites with uneventful submerged healing was investigated for expression of osteogenic, osteoclastogenic, and angiogenic differentiation markers.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Histology revealed alkaline phosphatase (ALP)-positive osteoblasts and immunoreactivity for osteogenic markers osteocalcin and collagen type I in biopsies with submerged healing, while inflammatory infiltrates and accumulations of multinucleated giant cells around BCP granules were observed in compromised sites. All specimens presented adequate vessel density. Multinucleated giant cells showed inconsistent staining for the osteoclast marker tartrate-resistant acid phosphatase (TRAP).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The histological findings of this study indicate an osteoconductive nature of the BCP applied. Premature exposure of the bone substitute reduced new bone formation and may bear a risk for inflammatory and foreign body reactions.</AbstractText>
<AbstractText Label="CLINICAL RELEVANCE" NlmCategory="CONCLUSIONS">A predictable appositional bone formation in simultaneously augmented sites using BCP is linked to an uneventful healing process.</AbstractText>
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<CommentsCorrections RefType="Cites">
<RefSource>Biomaterials. 2008 May;29(14):2249-58</RefSource>
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<RefSource>J Clin Periodontol. 2005 Feb;32(2):193-9</RefSource>
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<RefSource>Clin Oral Implants Res. 2005 Apr;16(2):210-9</RefSource>
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