Efficacy of growth factor in promoting early osseointegration.
Identifieur interne : 000599 ( PubMed/Checkpoint ); précédent : 000598; suivant : 000600Efficacy of growth factor in promoting early osseointegration.
Auteurs : Khalid Al-Hezaimi [Arabie saoudite] ; Myron Nevins ; Soo-Woo Kim ; Ardavan Fateh ; David M. KimSource :
- The Journal of oral implantology [ 0160-6972 ] ; 2014.
Descripteurs français
- KwdFr :
- Agents angiogéniques (usage thérapeutique), Animaux, Attribution aléatoire, Chiens, Cicatrisation de plaie (), Conception de prothèse dentaire, Facteurs temps, Femelle, Humains, Implants dentaires, Mandibule (), Mandibule (anatomopathologie), Mandibule (imagerie diagnostique), Matériaux revêtus, biocompatibles (usage thérapeutique), Ostéo-intégration (), Ostéogenèse (), Propriétés de surface, Protéines proto-oncogènes c-sis (usage thérapeutique), Protéines recombinantes, Radiographie rétrocoronaire, Viscosité, Études de faisabilité.
- MESH :
- anatomopathologie : Mandibule.
- imagerie diagnostique : Mandibule.
- usage thérapeutique : Agents angiogéniques, Matériaux revêtus, biocompatibles, Protéines proto-oncogènes c-sis.
- Animaux, Attribution aléatoire, Chiens, Cicatrisation de plaie, Conception de prothèse dentaire, Facteurs temps, Femelle, Humains, Implants dentaires, Mandibule, Ostéo-intégration, Ostéogenèse, Propriétés de surface, Protéines recombinantes, Radiographie rétrocoronaire, Viscosité, Études de faisabilité.
English descriptors
- KwdEn :
- Angiogenesis Inducing Agents (therapeutic use), Animals, Coated Materials, Biocompatible (therapeutic use), Dental Implants, Dental Prosthesis Design, Dogs, Feasibility Studies, Female, Humans, Mandible (diagnostic imaging), Mandible (drug effects), Mandible (pathology), Osseointegration (drug effects), Osteogenesis (drug effects), Proto-Oncogene Proteins c-sis (therapeutic use), Radiography, Bitewing, Random Allocation, Recombinant Proteins, Surface Properties, Time Factors, Viscosity, Wound Healing (drug effects).
- MESH :
- chemical , therapeutic use : Angiogenesis Inducing Agents, Coated Materials, Biocompatible, Proto-Oncogene Proteins c-sis.
- diagnostic imaging : Mandible.
- drug effects : Mandible, Osseointegration, Osteogenesis, Wound Healing.
- pathology : Mandible.
- Animals, Dental Implants, Dental Prosthesis Design, Dogs, Feasibility Studies, Female, Humans, Radiography, Bitewing, Random Allocation, Recombinant Proteins, Surface Properties, Time Factors, Viscosity.
Abstract
A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.
DOI: 10.1563/aaid-joi-D-13-00304
PubMed: 24946082
Affiliations:
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Kim</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24946082</idno><idno type="pmid">24946082</idno><idno type="doi">10.1563/aaid-joi-D-13-00304</idno><idno type="wicri:Area/PubMed/Corpus">000B95</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B95</idno><idno type="wicri:Area/PubMed/Curation">000B95</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B95</idno><idno type="wicri:Area/PubMed/Checkpoint">000B95</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of growth factor in promoting early osseointegration.</title><author><name sortKey="Al Hezaimi, Khalid" sort="Al Hezaimi, Khalid" uniqKey="Al Hezaimi K" first="Khalid" last="Al-Hezaimi">Khalid Al-Hezaimi</name><affiliation wicri:level="1"><nlm:affiliation>1 Department of Periodontology, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1 Department of Periodontology, College of Dentistry, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Nevins, Myron" sort="Nevins, Myron" uniqKey="Nevins M" first="Myron" last="Nevins">Myron Nevins</name></author><author><name sortKey="Kim, Soo Woo" sort="Kim, Soo Woo" uniqKey="Kim S" first="Soo-Woo" last="Kim">Soo-Woo Kim</name></author><author><name sortKey="Fateh, Ardavan" sort="Fateh, Ardavan" uniqKey="Fateh A" first="Ardavan" last="Fateh">Ardavan Fateh</name></author><author><name sortKey="Kim, David M" sort="Kim, David M" uniqKey="Kim D" first="David M" last="Kim">David M. Kim</name></author></analytic><series><title level="j">The Journal of oral implantology</title><idno type="ISSN">0160-6972</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiogenesis Inducing Agents (therapeutic use)</term><term>Animals</term><term>Coated Materials, Biocompatible (therapeutic use)</term><term>Dental Implants</term><term>Dental Prosthesis Design</term><term>Dogs</term><term>Feasibility Studies</term><term>Female</term><term>Humans</term><term>Mandible (diagnostic imaging)</term><term>Mandible (drug effects)</term><term>Mandible (pathology)</term><term>Osseointegration (drug effects)</term><term>Osteogenesis (drug effects)</term><term>Proto-Oncogene Proteins c-sis (therapeutic use)</term><term>Radiography, Bitewing</term><term>Random Allocation</term><term>Recombinant Proteins</term><term>Surface Properties</term><term>Time Factors</term><term>Viscosity</term><term>Wound Healing (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents angiogéniques (usage thérapeutique)</term><term>Animaux</term><term>Attribution aléatoire</term><term>Chiens</term><term>Cicatrisation de plaie ()</term><term>Conception de prothèse dentaire</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Implants dentaires</term><term>Mandibule ()</term><term>Mandibule (anatomopathologie)</term><term>Mandibule (imagerie diagnostique)</term><term>Matériaux revêtus, biocompatibles (usage thérapeutique)</term><term>Ostéo-intégration ()</term><term>Ostéogenèse ()</term><term>Propriétés de surface</term><term>Protéines proto-oncogènes c-sis (usage thérapeutique)</term><term>Protéines recombinantes</term><term>Radiographie rétrocoronaire</term><term>Viscosité</term><term>Études de faisabilité</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Angiogenesis Inducing Agents</term><term>Coated Materials, Biocompatible</term><term>Proto-Oncogene Proteins c-sis</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mandibule</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Mandible</term><term>Osseointegration</term><term>Osteogenesis</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Mandibule</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents angiogéniques</term><term>Matériaux revêtus, biocompatibles</term><term>Protéines proto-oncogènes c-sis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dental Implants</term><term>Dental Prosthesis Design</term><term>Dogs</term><term>Feasibility Studies</term><term>Female</term><term>Humans</term><term>Radiography, Bitewing</term><term>Random Allocation</term><term>Recombinant Proteins</term><term>Surface Properties</term><term>Time Factors</term><term>Viscosity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Chiens</term><term>Cicatrisation de plaie</term><term>Conception de prothèse dentaire</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Implants dentaires</term><term>Mandibule</term><term>Ostéo-intégration</term><term>Ostéogenèse</term><term>Propriétés de surface</term><term>Protéines recombinantes</term><term>Radiographie rétrocoronaire</term><term>Viscosité</term><term>Études de faisabilité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24946082</PMID><DateCompleted><Year>2014</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0160-6972</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of oral implantology</Title><ISOAbbreviation>J Oral Implantol</ISOAbbreviation></Journal><ArticleTitle>Efficacy of growth factor in promoting early osseointegration.</ArticleTitle><Pagination><MedlinePgn>543-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1563/aaid-joi-D-13-00304</ELocationID><Abstract><AbstractText>A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Al-Hezaimi</LastName><ForeName>Khalid</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>1 Department of Periodontology, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nevins</LastName><ForeName>Myron</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Soo-Woo</ForeName><Initials>SW</Initials></Author><Author ValidYN="Y"><LastName>Fateh</LastName><ForeName>Ardavan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>David M</ForeName><Initials>DM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>06</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Oral Implantol</MedlineTA><NlmUniqueID>7801086</NlmUniqueID><ISSNLinking>0160-6972</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D043925">Angiogenesis Inducing Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020099">Coated Materials, Biocompatible</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020574">Proto-Oncogene Proteins c-sis</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>1B56C968OA</RegistryNumber><NameOfSubstance UI="C072194">becaplermin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D043925" MajorTopicYN="N">Angiogenesis Inducing Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020099" MajorTopicYN="N">Coated Materials, Biocompatible</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017267" MajorTopicYN="N">Dental Prosthesis Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005240" MajorTopicYN="N">Feasibility Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016348" MajorTopicYN="N">Osseointegration</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020574" MajorTopicYN="N">Proto-Oncogene Proteins c-sis</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016300" MajorTopicYN="N">Radiography, Bitewing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014783" MajorTopicYN="N">Viscosity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="N">Wound Healing</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bone regeneration</Keyword><Keyword MajorTopicYN="N">dental implant</Keyword><Keyword MajorTopicYN="N">histology</Keyword><Keyword MajorTopicYN="N">osseointegration</Keyword><Keyword MajorTopicYN="N">recombinant human platelet-derived growth factor-BB</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24946082</ArticleId><ArticleId IdType="doi">10.1563/aaid-joi-D-13-00304</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><noCountry><name sortKey="Fateh, Ardavan" sort="Fateh, Ardavan" uniqKey="Fateh A" first="Ardavan" last="Fateh">Ardavan Fateh</name><name sortKey="Kim, David M" sort="Kim, David M" uniqKey="Kim D" first="David M" last="Kim">David M. Kim</name><name sortKey="Kim, Soo Woo" sort="Kim, Soo Woo" uniqKey="Kim S" first="Soo-Woo" last="Kim">Soo-Woo Kim</name><name sortKey="Nevins, Myron" sort="Nevins, Myron" uniqKey="Nevins M" first="Myron" last="Nevins">Myron Nevins</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Al Hezaimi, Khalid" sort="Al Hezaimi, Khalid" uniqKey="Al Hezaimi K" first="Khalid" last="Al-Hezaimi">Khalid Al-Hezaimi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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