Arterial Stiffness and Pulse Wave Reflection Are Increased in Patients Suffering from Severe Periodontitis
Identifieur interne : 000466 ( Pmc/Checkpoint ); précédent : 000465; suivant : 000467Arterial Stiffness and Pulse Wave Reflection Are Increased in Patients Suffering from Severe Periodontitis
Auteurs : Yvonne Jockel-Schneider [Allemagne] ; Inga Harks [Allemagne] ; Imme Haubitz [Allemagne] ; Stefan Fickl [Allemagne] ; Martin Eigenthaler [Allemagne] ; Ulrich Schlagenhauf [Allemagne] ; Johannes Baulmann [Allemagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
This single blind cross-sectional study compared the vascular health of subjects suffering from severe chronic periodontitis, severe aggressive periodontitis and periodontal healthy controls by evaluating pulse wave velocity (PWV), augmentation index (AIx) and pulse pressure amplification (PPA).
In a total of 158 subjects, 92 suffering from severe periodontitis and 66 matched periodontal healthy controls, PWV, AIx, central and peripheral blood pressure were recorded using an oscillometric device (Arteriograph).
Subjects suffering from severe chronic or aggressive periodontitis exhibited significantly higher PWV (p = 0.00004), higher AIx (p = 0.0049) and lower PPA (p = 0.028) than matched periodontal healthy controls.
The results of this study confirm the association between periodontal inflammation and increased cardiovascular risk shown by impaired vascular health in case of severe periodontitis. As impaired vascular health is a common finding in patients suffering from severe periodontal disease a concomitant routine cardiovascular evaluation may be advised.
Url:
DOI: 10.1371/journal.pone.0103449
PubMed: 25084111
PubMed Central: 4119014
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Arterial Stiffness and Pulse Wave Reflection Are Increased in Patients Suffering from Severe Periodontitis</title><author><name sortKey="Jockel Schneider, Yvonne" sort="Jockel Schneider, Yvonne" uniqKey="Jockel Schneider Y" first="Yvonne" last="Jockel-Schneider">Yvonne Jockel-Schneider</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Harks, Inga" sort="Harks, Inga" uniqKey="Harks I" first="Inga" last="Harks">Inga Harks</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Periodontology, University Hospital Muenster, Muenster, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Haubitz, Imme" sort="Haubitz, Imme" uniqKey="Haubitz I" first="Imme" last="Haubitz">Imme Haubitz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Fickl, Stefan" sort="Fickl, Stefan" uniqKey="Fickl S" first="Stefan" last="Fickl">Stefan Fickl</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Eigenthaler, Martin" sort="Eigenthaler, Martin" uniqKey="Eigenthaler M" first="Martin" last="Eigenthaler">Martin Eigenthaler</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Schlagenhauf, Ulrich" sort="Schlagenhauf, Ulrich" uniqKey="Schlagenhauf U" first="Ulrich" last="Schlagenhauf">Ulrich Schlagenhauf</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Baulmann, Johannes" sort="Baulmann, Johannes" uniqKey="Baulmann J" first="Johannes" last="Baulmann">Johannes Baulmann</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Clinic of Internal Medicine II, University Hospital Schleswig-Holstein, Luebeck, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Internal Medicine II, University Hospital Schleswig-Holstein, Luebeck</wicri:regionArea><wicri:noRegion>Luebeck</wicri:noRegion><wicri:noRegion>Luebeck</wicri:noRegion><wicri:noRegion>Luebeck</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25084111</idno><idno type="pmc">4119014</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119014</idno><idno type="RBID">PMC:4119014</idno><idno type="doi">10.1371/journal.pone.0103449</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000021</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000021</idno><idno type="wicri:Area/Pmc/Curation">000021</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000021</idno><idno type="wicri:Area/Pmc/Checkpoint">000466</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000466</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Arterial Stiffness and Pulse Wave Reflection Are Increased in Patients Suffering from Severe Periodontitis</title><author><name sortKey="Jockel Schneider, Yvonne" sort="Jockel Schneider, Yvonne" uniqKey="Jockel Schneider Y" first="Yvonne" last="Jockel-Schneider">Yvonne Jockel-Schneider</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Harks, Inga" sort="Harks, Inga" uniqKey="Harks I" first="Inga" last="Harks">Inga Harks</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Periodontology, University Hospital Muenster, Muenster, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Haubitz, Imme" sort="Haubitz, Imme" uniqKey="Haubitz I" first="Imme" last="Haubitz">Imme Haubitz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Fickl, Stefan" sort="Fickl, Stefan" uniqKey="Fickl S" first="Stefan" last="Fickl">Stefan Fickl</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Eigenthaler, Martin" sort="Eigenthaler, Martin" uniqKey="Eigenthaler M" first="Martin" last="Eigenthaler">Martin Eigenthaler</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Schlagenhauf, Ulrich" sort="Schlagenhauf, Ulrich" uniqKey="Schlagenhauf U" first="Ulrich" last="Schlagenhauf">Ulrich Schlagenhauf</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Baulmann, Johannes" sort="Baulmann, Johannes" uniqKey="Baulmann J" first="Johannes" last="Baulmann">Johannes Baulmann</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Clinic of Internal Medicine II, University Hospital Schleswig-Holstein, Luebeck, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Internal Medicine II, University Hospital Schleswig-Holstein, Luebeck</wicri:regionArea><wicri:noRegion>Luebeck</wicri:noRegion><wicri:noRegion>Luebeck</wicri:noRegion><wicri:noRegion>Luebeck</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>This single blind cross-sectional study compared the vascular health of subjects suffering from severe chronic periodontitis, severe aggressive periodontitis and periodontal healthy controls by evaluating pulse wave velocity (PWV), augmentation index (AIx) and pulse pressure amplification (PPA).</p></sec><sec><title>Material and Methods</title><p>In a total of 158 subjects, 92 suffering from severe periodontitis and 66 matched periodontal healthy controls, PWV, AIx, central and peripheral blood pressure were recorded using an oscillometric device (Arteriograph).</p></sec><sec><title>Results</title><p>Subjects suffering from severe chronic or aggressive periodontitis exhibited significantly higher PWV (p = 0.00004), higher AIx (p = 0.0049) and lower PPA (p = 0.028) than matched periodontal healthy controls.</p></sec><sec><title>Conclusions</title><p>The results of this study confirm the association between periodontal inflammation and increased cardiovascular risk shown by impaired vascular health in case of severe periodontitis. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25084111</article-id><article-id pub-id-type="pmc">4119014</article-id><article-id pub-id-type="publisher-id">PONE-D-14-13233</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0103449</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Oral Medicine</subject><subj-group><subject>Oral Diseases</subject><subj-group><subject>Periodontal Diseases</subject><subj-group><subject>Periodontitis</subject></subj-group></subj-group></subj-group><subj-group><subject>Oral Health</subject></subj-group></subj-group><subj-group><subject>Vascular Medicine</subject><subj-group><subject>Blood Pressure</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Arterial Stiffness and Pulse Wave Reflection Are Increased in Patients Suffering from Severe Periodontitis</article-title><alt-title alt-title-type="running-head">Vascular Health and Periodontitis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jockel-Schneider</surname><given-names>Yvonne</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harks</surname><given-names>Inga</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haubitz</surname><given-names>Imme</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fickl</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eigenthaler</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schlagenhauf</surname><given-names>Ulrich</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baulmann</surname><given-names>Johannes</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Periodontology, University Hospital Muenster, Muenster, Germany</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Clinic of Internal Medicine II, University Hospital Schleswig-Holstein, Luebeck, Germany</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Schillaci</surname><given-names>Giuseppe</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Perugia, Italy</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>jockel_y@klinik.uni-wuerzburg.de</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: YJ I. Harks I. Haubitz SF ME US JB. Performed the experiments: YJ JB. Analyzed the data: YJ I. Harks I. Haubitz SF ME US JB. Contributed reagents/materials/analysis tools: YJ I. Harks ME US JB. Contributed to the writing of the manuscript: YJ I. Harks I. Haubitz ME US JB.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>1</day><month>8</month><year>2014</year></pub-date><volume>9</volume><issue>8</issue><elocation-id>e103449</elocation-id><history><date date-type="received"><day>27</day><month>3</month><year>2014</year></date><date date-type="accepted"><day>30</day><month>6</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Jockel-Schneider et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Aim</title><p>This single blind cross-sectional study compared the vascular health of subjects suffering from severe chronic periodontitis, severe aggressive periodontitis and periodontal healthy controls by evaluating pulse wave velocity (PWV), augmentation index (AIx) and pulse pressure amplification (PPA).</p></sec><sec><title>Material and Methods</title><p>In a total of 158 subjects, 92 suffering from severe periodontitis and 66 matched periodontal healthy controls, PWV, AIx, central and peripheral blood pressure were recorded using an oscillometric device (Arteriograph).</p></sec><sec><title>Results</title><p>Subjects suffering from severe chronic or aggressive periodontitis exhibited significantly higher PWV (p = 0.00004), higher AIx (p = 0.0049) and lower PPA (p = 0.028) than matched periodontal healthy controls.</p></sec><sec><title>Conclusions</title><p>The results of this study confirm the association between periodontal inflammation and increased cardiovascular risk shown by impaired vascular health in case of severe periodontitis. As impaired vascular health is a common finding in patients suffering from severe periodontal disease a concomitant routine cardiovascular evaluation may be advised.</p></sec></abstract><funding-group><funding-statement>This study was funded externally by a grant of the German Research Foundation (EH 365/1-1) and by the IZKF Wuerzburg (Z-2/34). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="8"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Jockel Schneider, Yvonne" sort="Jockel Schneider, Yvonne" uniqKey="Jockel Schneider Y" first="Yvonne" last="Jockel-Schneider">Yvonne Jockel-Schneider</name></noRegion><name sortKey="Baulmann, Johannes" sort="Baulmann, Johannes" uniqKey="Baulmann J" first="Johannes" last="Baulmann">Johannes Baulmann</name><name sortKey="Eigenthaler, Martin" sort="Eigenthaler, Martin" uniqKey="Eigenthaler M" first="Martin" last="Eigenthaler">Martin Eigenthaler</name><name sortKey="Fickl, Stefan" sort="Fickl, Stefan" uniqKey="Fickl S" first="Stefan" last="Fickl">Stefan Fickl</name><name sortKey="Harks, Inga" sort="Harks, Inga" uniqKey="Harks I" first="Inga" last="Harks">Inga Harks</name><name sortKey="Haubitz, Imme" sort="Haubitz, Imme" uniqKey="Haubitz I" first="Imme" last="Haubitz">Imme Haubitz</name><name sortKey="Schlagenhauf, Ulrich" sort="Schlagenhauf, Ulrich" uniqKey="Schlagenhauf U" first="Ulrich" last="Schlagenhauf">Ulrich Schlagenhauf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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