Dental Prophylaxis Decreases the Risk of Esophageal Cancer in Males; A Nationwide Population-Based Study in Taiwan
Identifieur interne : 000379 ( Pmc/Checkpoint ); précédent : 000378; suivant : 000380Dental Prophylaxis Decreases the Risk of Esophageal Cancer in Males; A Nationwide Population-Based Study in Taiwan
Auteurs : Ya-Ling Lee [Taïwan] ; Hsiao-Yun Hu [Taïwan] ; Nan-Ping Yang [Taïwan] ; Pesus Chou [Taïwan] ; Dachen Chu [Taïwan]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Periodontal disease (PD) is one of the most common chronic inflammatory diseases. Esophageal cancer (EC) is also a common cause of death due to cancer among males. Systemic inflammatory processes have been shown to increase the risk of cancer. We conducted a retrospective cohort study to investigate the association between PD and EC.
A total of 718,409 subjects were recruited from the Taiwan National Health Insurance Research Database (NHIRD) and followed from January 1, 2000 to December 31, 2010. Of these, 519,831 subjects were diagnosed with PD and were grouped according to the most advanced treatment they received: dental prophylaxis, intensive treatment, or no treatment. The IRs of EC were compared among groups.
A total of 682 patients developed EC, resulting in an overall IR of 0.11 case-number per 1000 person-years (‰/y). The dental prophylaxis group had a significantly lower IR of EC (0.06‰/y) than other groups (
For this cohort, subjects received dental prophylaxis reduced the risk of EC compared to all PD and no PD groups among males.
Url:
DOI: 10.1371/journal.pone.0109444
PubMed: 25279666
PubMed Central: 4184879
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dental Prophylaxis Decreases the Risk of Esophageal Cancer in Males; A Nationwide Population-Based Study in Taiwan</title><author><name sortKey="Lee, Ya Ling" sort="Lee, Ya Ling" uniqKey="Lee Y" first="Ya-Ling" last="Lee">Ya-Ling Lee</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Dentistry, Taipei City Hospital, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Dentistry, Taipei City Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Hsiao Yun" sort="Hu, Hsiao Yun" uniqKey="Hu H" first="Hsiao-Yun" last="Hu">Hsiao-Yun Hu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Education and Research, Taipei City Hospital, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Education and Research, Taipei City Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Nan Ping" sort="Yang, Nan Ping" uniqKey="Yang N" first="Nan-Ping" last="Yang">Nan-Ping Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Education and Research, Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Education and Research, Keelung Hospital, Ministry of Health and Welfare, Keelung</wicri:regionArea><wicri:noRegion>Keelung</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Pesus" sort="Chou, Pesus" uniqKey="Chou P" first="Pesus" last="Chou">Pesus Chou</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Dachen" sort="Chu, Dachen" uniqKey="Chu D" first="Dachen" last="Chu">Dachen Chu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Neurosurgery, Taipei City Hospital, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Neurosurgery, Taipei City Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25279666</idno><idno type="pmc">4184879</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184879</idno><idno type="RBID">PMC:4184879</idno><idno type="doi">10.1371/journal.pone.0109444</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000027</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000027</idno><idno type="wicri:Area/Pmc/Curation">000027</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000027</idno><idno type="wicri:Area/Pmc/Checkpoint">000379</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000379</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dental Prophylaxis Decreases the Risk of Esophageal Cancer in Males; A Nationwide Population-Based Study in Taiwan</title><author><name sortKey="Lee, Ya Ling" sort="Lee, Ya Ling" uniqKey="Lee Y" first="Ya-Ling" last="Lee">Ya-Ling Lee</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Dentistry, Taipei City Hospital, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Dentistry, Taipei City Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Hsiao Yun" sort="Hu, Hsiao Yun" uniqKey="Hu H" first="Hsiao-Yun" last="Hu">Hsiao-Yun Hu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Education and Research, Taipei City Hospital, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Education and Research, Taipei City Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Nan Ping" sort="Yang, Nan Ping" uniqKey="Yang N" first="Nan-Ping" last="Yang">Nan-Ping Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Education and Research, Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Education and Research, Keelung Hospital, Ministry of Health and Welfare, Keelung</wicri:regionArea><wicri:noRegion>Keelung</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Pesus" sort="Chou, Pesus" uniqKey="Chou P" first="Pesus" last="Chou">Pesus Chou</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Dachen" sort="Chu, Dachen" uniqKey="Chu D" first="Dachen" last="Chu">Dachen Chu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Neurosurgery, Taipei City Hospital, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Neurosurgery, Taipei City Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Periodontal disease (PD) is one of the most common chronic inflammatory diseases. Esophageal cancer (EC) is also a common cause of death due to cancer among males. Systemic inflammatory processes have been shown to increase the risk of cancer. We conducted a retrospective cohort study to investigate the association between PD and EC.</p></sec><sec><title>Methods</title><p>A total of 718,409 subjects were recruited from the Taiwan National Health Insurance Research Database (NHIRD) and followed from January 1, 2000 to December 31, 2010. Of these, 519,831 subjects were diagnosed with PD and were grouped according to the most advanced treatment they received: dental prophylaxis, intensive treatment, or no treatment. The IRs of EC were compared among groups.</p></sec><sec><title>Results</title><p>A total of 682 patients developed EC, resulting in an overall IR of 0.11 case-number per 1000 person-years (‰/y). The dental prophylaxis group had a significantly lower IR of EC (0.06‰/y) than other groups (<italic>p</italic><0.001). Multivariable Cox regression analysis further revealed that male subjects [hazard ratio (HR) = 10.04, 95% confidence interval (CI) = 7.58–13.30], as well as a history of esophageal ulcers (HR = 7.10, 95% CI = 5.03–10.01), alcohol abuse (HR = 5.46, 95% CI = 2.26–13.18), or esophageal reflux (HR = 1.86, 95% CI = 1.02–3.52), were factors associated with a higher risk of EC. And the dental prophylaxis group showed a significantly lower risk for EC (HR = 0.53, 95% CI = 0.44–0.65). Further subgroup analysis showed that the dental prophylaxis group among males had a significant lower risk (HR = 0.54, 95% CI = 0.44–0.66) for EC, while that of the females did not has statistically significant difference.</p></sec><sec><title>Conclusion</title><p>For this cohort, subjects received dental prophylaxis reduced the risk of EC compared to all PD and no PD groups among males.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Paster, Bj" uniqKey="Paster B">BJ Paster</name></author><author><name sortKey="Boches, Sk" uniqKey="Boches S">SK Boches</name></author><author><name sortKey="Galvin, Jl" uniqKey="Galvin J">JL Galvin</name></author><author><name sortKey="Ericson, Re" uniqKey="Ericson R">RE Ericson</name></author><author><name sortKey="Lau, Cn" uniqKey="Lau C">CN Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albandar, Jm" uniqKey="Albandar J">JM 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25279666</article-id><article-id pub-id-type="pmc">4184879</article-id><article-id pub-id-type="publisher-id">PONE-D-14-15367</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0109444</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>Cancer Epidemiology</subject><subject>Clinical Epidemiology</subject></subj-group></subj-group><subj-group><subject>Gastroenterology and Hepatology</subject><subj-group><subject>Gastrointestinal Cancers</subject></subj-group></subj-group><subj-group><subject>Oral Medicine</subject><subj-group><subject>Oral Diseases</subject><subj-group><subject>Periodontal Diseases</subject></subj-group></subj-group><subj-group><subject>Dentistry</subject><subject>Oral Health</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Dental Prophylaxis Decreases the Risk of Esophageal Cancer in Males; A Nationwide Population-Based Study in Taiwan</article-title><alt-title alt-title-type="running-head">Dental Prophylaxis Decreases the Risk of Esophageal Cancer</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Ya-Ling</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Hsiao-Yun</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Nan-Ping</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chou</surname><given-names>Pesus</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Dachen</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Dentistry, Taipei City Hospital, Taipei, Taiwan</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Neurosurgery, Taipei City Hospital, Taipei, Taiwan</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Education and Research, Taipei City Hospital, Taipei, Taiwan</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Department of Education and Research, Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Glogauer</surname><given-names>Michael</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Toronto, Canada</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>DAD57@tpech.gov.tw</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: YL PC DC. Performed the experiments: HH YL. Analyzed the data: HH YL. Contributed reagents/materials/analysis tools: NY. Contributed to the writing of the manuscript: YL DC.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>3</day><month>10</month><year>2014</year></pub-date><volume>9</volume><issue>10</issue><elocation-id>e109444</elocation-id><history><date date-type="received"><day>2</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>8</day><month>9</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Lee et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Periodontal disease (PD) is one of the most common chronic inflammatory diseases. Esophageal cancer (EC) is also a common cause of death due to cancer among males. Systemic inflammatory processes have been shown to increase the risk of cancer. We conducted a retrospective cohort study to investigate the association between PD and EC.</p></sec><sec><title>Methods</title><p>A total of 718,409 subjects were recruited from the Taiwan National Health Insurance Research Database (NHIRD) and followed from January 1, 2000 to December 31, 2010. Of these, 519,831 subjects were diagnosed with PD and were grouped according to the most advanced treatment they received: dental prophylaxis, intensive treatment, or no treatment. The IRs of EC were compared among groups.</p></sec><sec><title>Results</title><p>A total of 682 patients developed EC, resulting in an overall IR of 0.11 case-number per 1000 person-years (‰/y). The dental prophylaxis group had a significantly lower IR of EC (0.06‰/y) than other groups (<italic>p</italic><0.001). Multivariable Cox regression analysis further revealed that male subjects [hazard ratio (HR) = 10.04, 95% confidence interval (CI) = 7.58–13.30], as well as a history of esophageal ulcers (HR = 7.10, 95% CI = 5.03–10.01), alcohol abuse (HR = 5.46, 95% CI = 2.26–13.18), or esophageal reflux (HR = 1.86, 95% CI = 1.02–3.52), were factors associated with a higher risk of EC. And the dental prophylaxis group showed a significantly lower risk for EC (HR = 0.53, 95% CI = 0.44–0.65). Further subgroup analysis showed that the dental prophylaxis group among males had a significant lower risk (HR = 0.54, 95% CI = 0.44–0.66) for EC, while that of the females did not has statistically significant difference.</p></sec><sec><title>Conclusion</title><p>For this cohort, subjects received dental prophylaxis reduced the risk of EC compared to all PD and no PD groups among males.</p></sec></abstract><funding-group><funding-statement>These authors have no support or funding to report.</funding-statement></funding-group><counts><page-count count="6"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. Data are available from the National Health Research Institutes for researchers who meet the criteria for access to confidential data. Despite the personal ID being encrypted in NHIRD for protection of privacy, the re-distribution of full data to researchers other than the original applicants is still prohibited by law, because it contains the details of personal health data.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. Data are available from the National Health Research Institutes for researchers who meet the criteria for access to confidential data. Despite the personal ID being encrypted in NHIRD for protection of privacy, the re-distribution of full data to researchers other than the original applicants is still prohibited by law, because it contains the details of personal health data.</p></notes></front></pmc><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Lee, Ya Ling" sort="Lee, Ya Ling" uniqKey="Lee Y" first="Ya-Ling" last="Lee">Ya-Ling Lee</name></noRegion><name sortKey="Chou, Pesus" sort="Chou, Pesus" uniqKey="Chou P" first="Pesus" last="Chou">Pesus Chou</name><name sortKey="Chu, Dachen" sort="Chu, Dachen" uniqKey="Chu D" first="Dachen" last="Chu">Dachen Chu</name><name sortKey="Chu, Dachen" sort="Chu, Dachen" uniqKey="Chu D" first="Dachen" last="Chu">Dachen Chu</name><name sortKey="Chu, Dachen" sort="Chu, Dachen" uniqKey="Chu D" first="Dachen" last="Chu">Dachen Chu</name><name sortKey="Hu, Hsiao Yun" sort="Hu, Hsiao Yun" uniqKey="Hu H" first="Hsiao-Yun" last="Hu">Hsiao-Yun Hu</name><name sortKey="Hu, Hsiao Yun" sort="Hu, Hsiao Yun" uniqKey="Hu H" first="Hsiao-Yun" last="Hu">Hsiao-Yun Hu</name><name sortKey="Lee, Ya Ling" sort="Lee, Ya Ling" uniqKey="Lee Y" first="Ya-Ling" last="Lee">Ya-Ling Lee</name><name sortKey="Yang, Nan Ping" sort="Yang, Nan Ping" uniqKey="Yang N" first="Nan-Ping" last="Yang">Nan-Ping Yang</name><name sortKey="Yang, Nan Ping" sort="Yang, Nan Ping" uniqKey="Yang N" first="Nan-Ping" last="Yang">Nan-Ping Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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