The association of periodontitis and metabolic syndrome
Identifieur interne : 000051 ( Pmc/Checkpoint ); précédent : 000050; suivant : 000052The association of periodontitis and metabolic syndrome
Auteurs : Abhijit N. Gurav [Inde]Source :
- Dental Research Journal [ 1735-3327 ] ; 2014.
Abstract
Metabolic syndrome (MS) is a condition, which constitutes a group of risk factors that occur together and increase the risk for Coronary Artery Disease, Stroke and type 2 diabetes mellitus. This disorder is found prevalent in the industrialized societies of the world in epidemic proportions. Periodontitis is an oral disease of microbial origin characterized by loss of attachment apparatus of tooth, resulting in edentulism if untreated. Periodontitis has been attributed to produce a low grade systemic inflammatory condition. The link of periodontitis to various systemic disorders has led to the evolution of a new branch termed as “periodontal medicine.” Studies reviewed in the present paper have indicated a positive link between the MS and periodontitis and it is suggested that subjects displaying several components of MS should be submitted to periodontal examination. Present studies have displayed coherent relation between the two entities. This review will address the vicious association between MS and periodontitis, depicting the commonality of pathophysiological pathway between the two entities. Systematic reviews, meta-analysis addressing the concerned subject were screened. Whether the systematic periodontal therapy in individuals exhibiting MS has the potential to reduce the incidence of various adverse systemic complications remains a logical proposition. Further, longitudinal and controlled trials with a large population would be imperative to depict the robustness in the association between MS and periodontal disease in human subjects.
Url:
PubMed: 24688553
PubMed Central: 3955301
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3955301Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The association of periodontitis and metabolic syndrome</title><author><name sortKey="Gurav, Abhijit N" sort="Gurav, Abhijit N" uniqKey="Gurav A" first="Abhijit N." last="Gurav">Abhijit N. Gurav</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24688553</idno><idno type="pmc">3955301</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955301</idno><idno type="RBID">PMC:3955301</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000804</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000804</idno><idno type="wicri:Area/Pmc/Curation">000804</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000804</idno><idno type="wicri:Area/Pmc/Checkpoint">000051</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The association of periodontitis and metabolic syndrome</title><author><name sortKey="Gurav, Abhijit N" sort="Gurav, Abhijit N" uniqKey="Gurav A" first="Abhijit N." last="Gurav">Abhijit N. Gurav</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dental Research Journal</title><idno type="ISSN">1735-3327</idno><idno type="eISSN">2008-0255</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Metabolic syndrome (MS) is a condition, which constitutes a group of risk factors that occur together and increase the risk for Coronary Artery Disease, Stroke and type 2 diabetes mellitus. This disorder is found prevalent in the industrialized societies of the world in epidemic proportions. Periodontitis is an oral disease of microbial origin characterized by loss of attachment apparatus of tooth, resulting in edentulism if untreated. Periodontitis has been attributed to produce a low grade systemic inflammatory condition. The link of periodontitis to various systemic disorders has led to the evolution of a new branch termed as “periodontal medicine.” Studies reviewed in the present paper have indicated a positive link between the MS and periodontitis and it is suggested that subjects displaying several components of MS should be submitted to periodontal examination. Present studies have displayed coherent relation between the two entities. This review will address the vicious association between MS and periodontitis, depicting the commonality of pathophysiological pathway between the two entities. Systematic reviews, meta-analysis addressing the concerned subject were screened. Whether the systematic periodontal therapy in individuals exhibiting MS has the potential to reduce the incidence of various adverse systemic complications remains a logical proposition. Further, longitudinal and controlled trials with a large population would be imperative to depict the robustness in the association between MS and periodontal disease in human subjects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Eckel, Rh" uniqKey="Eckel R">RH Eckel</name></author><author><name sortKey="Grundy, Sm" uniqKey="Grundy S">SM Grundy</name></author><author><name sortKey="Zimmet, Pz" uniqKey="Zimmet P">PZ Zimmet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mensah, Ga" uniqKey="Mensah G">GA Mensah</name></author><author><name sortKey="Mokdad, Ah" uniqKey="Mokdad A">AH Mokdad</name></author><author><name sortKey="Ford, E" uniqKey="Ford E">E Ford</name></author><author><name sortKey="Narayan, Km" uniqKey="Narayan K">KM Narayan</name></author><author><name sortKey="Giles, Wh" uniqKey="Giles W">WH Giles</name></author><author><name sortKey="Vinicor, F" uniqKey="Vinicor F">F Vinicor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alberti, Kg" uniqKey="Alberti K">KG Alberti</name></author><author><name sortKey="Zimmet, P" uniqKey="Zimmet P">P Zimmet</name></author><author><name sortKey="Shaw, J" uniqKey="Shaw J">J Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filoche, S" uniqKey="Filoche S">S Filoche</name></author><author><name sortKey="Wong, L" uniqKey="Wong L">L Wong</name></author><author><name sortKey="Sissons, Ch" uniqKey="Sissons C">CH Sissons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kornman, Ks" uniqKey="Kornman K">KS Kornman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cochran, Dl" uniqKey="Cochran D">DL Cochran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loos, Bg" uniqKey="Loos B">BG Loos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomes Filho, Is" uniqKey="Gomes Filho I">IS Gomes-Filho</name></author><author><name sortKey="Freitas, Coelho Jm" uniqKey="Freitas C">Coelho JM Freitas</name></author><author><name sortKey="Da Cruz, Ss" uniqKey="Da Cruz S">SS da Cruz</name></author><author><name sortKey="Passos, Js" uniqKey="Passos J">JS Passos</name></author><author><name sortKey="Teixeira De Freitas, Co" uniqKey="Teixeira De Freitas C">CO Teixeira de Freitas</name></author><author><name sortKey="Aragao, Farias Ns" uniqKey="Aragao F">Farias NS Aragão</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahingur, Se" uniqKey="Sahingur S">SE Sahingur</name></author><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name></author><author><name sortKey="Genco, Rj" uniqKey="Genco R">RJ Genco</name></author><author><name sortKey="De Nardin, E" uniqKey="De Nardin E">E De Nardin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Km" uniqKey="Yu K">KM Yu</name></author><author><name sortKey="Inoue, Y" uniqKey="Inoue Y">Y Inoue</name></author><author><name sortKey="Umeda, M" uniqKey="Umeda M">M Umeda</name></author><author><name sortKey="Terasaki, H" uniqKey="Terasaki H">H Terasaki</name></author><author><name sortKey="Chen, Zy" uniqKey="Chen Z">ZY Chen</name></author><author><name sortKey="Iwai, T" uniqKey="Iwai T">T Iwai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Tervahartiala, T" uniqKey="Tervahartiala T">T Tervahartiala</name></author><author><name sortKey="Leppilahti, J" uniqKey="Leppilahti J">J Leppilahti</name></author><author><name sortKey="Hernandez, M" uniqKey="Hernandez M">M Hernandez</name></author><author><name sortKey="Gamonal, J" uniqKey="Gamonal J">J Gamonal</name></author><author><name sortKey="Tuomainen, Am" uniqKey="Tuomainen A">AM Tuomainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrukhov, O" uniqKey="Andrukhov O">O Andrukhov</name></author><author><name sortKey="Ulm, C" uniqKey="Ulm C">C Ulm</name></author><author><name sortKey="Reischl, H" uniqKey="Reischl H">H Reischl</name></author><author><name sortKey="Nguyen, Pq" uniqKey="Nguyen P">PQ Nguyen</name></author><author><name sortKey="Matejka, M" uniqKey="Matejka M">M Matejka</name></author><author><name sortKey="Rausch Fan, X" uniqKey="Rausch Fan X">X Rausch-Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loesche, Wj" uniqKey="Loesche W">WJ Loesche</name></author><author><name sortKey="Lopatin, De" uniqKey="Lopatin D">DE Lopatin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ebersole, Jl" uniqKey="Ebersole J">JL Ebersole</name></author><author><name sortKey="Stevens, J" uniqKey="Stevens J">J Stevens</name></author><author><name sortKey="Steffen, Mj" uniqKey="Steffen M">MJ Steffen</name></author><author><name sortKey="Dawson, Iii D" uniqKey="Dawson I">Iii D Dawson</name></author><author><name sortKey="Novak, Mj" uniqKey="Novak M">MJ Novak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beck, J" uniqKey="Beck J">J Beck</name></author><author><name sortKey="Garcia, R" uniqKey="Garcia R">R Garcia</name></author><author><name sortKey="Heiss, G" uniqKey="Heiss G">G Heiss</name></author><author><name sortKey="Vokonas, Ps" uniqKey="Vokonas P">PS Vokonas</name></author><author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Yw" uniqKey="Chen Y">YW Chen</name></author><author><name sortKey="Umeda, M" uniqKey="Umeda M">M Umeda</name></author><author><name sortKey="Nagasawa, T" uniqKey="Nagasawa T">T Nagasawa</name></author><author><name sortKey="Takeuchi, Y" uniqKey="Takeuchi Y">Y Takeuchi</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Inoue, Y" uniqKey="Inoue Y">Y Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, Lc" uniqKey="Kuo L">LC Kuo</name></author><author><name sortKey="Polson, Am" uniqKey="Polson A">AM Polson</name></author><author><name sortKey="Kang, T" uniqKey="Kang T">T Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Defronzo, Ra" uniqKey="Defronzo R">RA DeFronzo</name></author><author><name sortKey="Abdul Ghani, M" uniqKey="Abdul Ghani M">M Abdul-Ghani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shoelson, Se" uniqKey="Shoelson S">SE Shoelson</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Goldfine, Ab" uniqKey="Goldfine A">AB Goldfine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bastard, Jp" uniqKey="Bastard J">JP Bastard</name></author><author><name sortKey="Maachi, M" uniqKey="Maachi M">M Maachi</name></author><author><name sortKey="Lagathu, C" uniqKey="Lagathu C">C Lagathu</name></author><author><name sortKey="Kim, Mj" uniqKey="Kim M">MJ Kim</name></author><author><name sortKey="Caron, M" uniqKey="Caron M">M Caron</name></author><author><name sortKey="Vidal, H" uniqKey="Vidal H">H Vidal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janket, Sj" uniqKey="Janket S">SJ Janket</name></author><author><name sortKey="Jones, Ja" uniqKey="Jones J">JA Jones</name></author><author><name sortKey="Meurman, Jh" uniqKey="Meurman J">JH Meurman</name></author><author><name sortKey="Baird, Ae" uniqKey="Baird A">AE Baird</name></author><author><name sortKey="Van Dyke, Te" uniqKey="Van Dyke T">TE Van Dyke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allen, Em" uniqKey="Allen E">EM Allen</name></author><author><name sortKey="Matthews, Jb" uniqKey="Matthews J">JB Matthews</name></author><author><name sortKey="O Halloran, Dj" uniqKey="O Halloran D">DJ O’ Halloran</name></author><author><name sortKey="Griffiths, Hr" uniqKey="Griffiths H">HR Griffiths</name></author><author><name sortKey="Chapple, Il" uniqKey="Chapple I">IL Chapple</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Iuto, F" uniqKey="D Iuto F">F D’Aiuto</name></author><author><name sortKey="Nibali, L" uniqKey="Nibali L">L Nibali</name></author><author><name sortKey="Parkar, M" uniqKey="Parkar M">M Parkar</name></author><author><name sortKey="Patel, K" uniqKey="Patel K">K Patel</name></author><author><name sortKey="Suvan, J" uniqKey="Suvan J">J Suvan</name></author><author><name sortKey="Donos, N" uniqKey="Donos N">N Donos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishimura, F" uniqKey="Nishimura F">F Nishimura</name></author><author><name sortKey="Soga, Y" uniqKey="Soga Y">Y Soga</name></author><author><name sortKey="Iwamoto, Y" uniqKey="Iwamoto Y">Y Iwamoto</name></author><author><name sortKey="Kudo, C" uniqKey="Kudo C">C Kudo</name></author><author><name sortKey="Murayama, Y" uniqKey="Murayama Y">Y Murayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Gw" uniqKey="Taylor G">GW Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishimura, F" uniqKey="Nishimura F">F Nishimura</name></author><author><name sortKey="Iwamoto, Y" uniqKey="Iwamoto Y">Y Iwamoto</name></author><author><name sortKey="Mineshiba, J" uniqKey="Mineshiba J">J Mineshiba</name></author><author><name sortKey="Shimizu, A" uniqKey="Shimizu A">A Shimizu</name></author><author><name sortKey="Soga, Y" uniqKey="Soga Y">Y Soga</name></author><author><name sortKey="Murayama, Y" uniqKey="Murayama Y">Y Murayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Yh" uniqKey="Choi Y">YH Choi</name></author><author><name sortKey="Mckeown, Re" uniqKey="Mckeown R">RE McKeown</name></author><author><name sortKey="Mayer Davis, Ej" uniqKey="Mayer Davis E">EJ Mayer-Davis</name></author><author><name sortKey="Liese, Ad" uniqKey="Liese A">AD Liese</name></author><author><name sortKey="Song, Kb" uniqKey="Song K">KB Song</name></author><author><name sortKey="Merchant, At" uniqKey="Merchant A">AT Merchant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Shimazaki, Y" uniqKey="Shimazaki Y">Y Shimazaki</name></author><author><name sortKey="Kiyohara, Y" uniqKey="Kiyohara Y">Y Kiyohara</name></author><author><name sortKey="Kato, I" uniqKey="Kato I">I Kato</name></author><author><name sortKey="Kubo, M" uniqKey="Kubo M">M Kubo</name></author><author><name sortKey="Iida, M" uniqKey="Iida M">M Iida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morita, I" uniqKey="Morita I">I Morita</name></author><author><name sortKey="Inagaki, K" uniqKey="Inagaki K">K Inagaki</name></author><author><name sortKey="Nakamura, F" uniqKey="Nakamura F">F Nakamura</name></author><author><name sortKey="Noguchi, T" uniqKey="Noguchi T">T Noguchi</name></author><author><name sortKey="Matsubara, T" uniqKey="Matsubara T">T Matsubara</name></author><author><name sortKey="Yoshii, S" uniqKey="Yoshii S">S Yoshii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aronne, Lj" uniqKey="Aronne L">LJ Aronne</name></author><author><name sortKey="Segal, Kr" uniqKey="Segal K">KR Segal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehr, S" uniqKey="Lehr S">S Lehr</name></author><author><name sortKey="Hartwig, S" uniqKey="Hartwig S">S Hartwig</name></author><author><name sortKey="Sell, H" uniqKey="Sell H">H Sell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frayn, Kn" uniqKey="Frayn K">KN Frayn</name></author><author><name sortKey="Williams, Cm" uniqKey="Williams C">CM Williams</name></author><author><name sortKey="Arner, P" uniqKey="Arner P">P Arner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Shimazaki, Y" uniqKey="Shimazaki Y">Y Shimazaki</name></author><author><name sortKey="Koga, T" uniqKey="Koga T">T Koga</name></author><author><name sortKey="Tsuzuki, M" uniqKey="Tsuzuki M">M Tsuzuki</name></author><author><name sortKey="Ohshima, A" uniqKey="Ohshima A">A Ohshima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Shimazaki, Y" uniqKey="Shimazaki Y">Y Shimazaki</name></author><author><name sortKey="Kiyohara, Y" uniqKey="Kiyohara Y">Y Kiyohara</name></author><author><name sortKey="Kato, I" uniqKey="Kato I">I Kato</name></author><author><name sortKey="Kubo, M" uniqKey="Kubo M">M Kubo</name></author><author><name sortKey="Iida, M" uniqKey="Iida M">M Iida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Zahrani, Ms" uniqKey="Al Zahrani M">MS Al-Zahrani</name></author><author><name sortKey="Bissada, Nf" uniqKey="Bissada N">NF Bissada</name></author><author><name sortKey="Borawskit, Ea" uniqKey="Borawskit E">EA Borawskit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wood, N" uniqKey="Wood N">N Wood</name></author><author><name sortKey="Johnson, Rb" uniqKey="Johnson R">RB Johnson</name></author><author><name sortKey="Streckfus, Cf" uniqKey="Streckfus C">CF Streckfus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Linden, G" uniqKey="Linden G">G Linden</name></author><author><name sortKey="Patterson, C" uniqKey="Patterson C">C Patterson</name></author><author><name sortKey="Evans, A" uniqKey="Evans A">A Evans</name></author><author><name sortKey="Kee, F" uniqKey="Kee F">F Kee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarlati, F" uniqKey="Sarlati F">F Sarlati</name></author><author><name sortKey="Akhondi, N" uniqKey="Akhondi N">N Akhondi</name></author><author><name sortKey="Ettehad, T" uniqKey="Ettehad T">T Ettehad</name></author><author><name sortKey="Neyestani, T" uniqKey="Neyestani T">T Neyestani</name></author><author><name sortKey="Kamali, Z" uniqKey="Kamali Z">Z Kamali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khader, Ys" uniqKey="Khader Y">YS Khader</name></author><author><name sortKey="Bawadi, Ha" uniqKey="Bawadi H">HA Bawadi</name></author><author><name sortKey="Haroun, Tf" uniqKey="Haroun T">TF Haroun</name></author><author><name sortKey="Alomari, M" uniqKey="Alomari M">M Alomari</name></author><author><name sortKey="Tayyem, Rf" uniqKey="Tayyem R">RF Tayyem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaffee, Bw" uniqKey="Chaffee B">BW Chaffee</name></author><author><name sortKey="Weston, Sj" uniqKey="Weston S">SJ Weston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Dh" uniqKey="Han D">DH Han</name></author><author><name sortKey="Lim, Sy" uniqKey="Lim S">SY Lim</name></author><author><name sortKey="Sun, Bc" uniqKey="Sun B">BC Sun</name></author><author><name sortKey="Paek, Dm" uniqKey="Paek D">DM Paek</name></author><author><name sortKey="Kim, Hd" uniqKey="Kim H">HD Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bullon, P" uniqKey="Bullon P">P Bullon</name></author><author><name sortKey="Morillo, Jm" uniqKey="Morillo J">JM Morillo</name></author><author><name sortKey="Ramirez Tortosa, Mc" uniqKey="Ramirez Tortosa M">MC Ramirez-Tortosa</name></author><author><name sortKey="Quiles, Jl" uniqKey="Quiles J">JL Quiles</name></author><author><name sortKey="Newman, Hn" uniqKey="Newman H">HN Newman</name></author><author><name sortKey="Battino, M" uniqKey="Battino M">M Battino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cutler, Cw" uniqKey="Cutler C">CW Cutler</name></author><author><name sortKey="Shinedling, Ea" uniqKey="Shinedling E">EA Shinedling</name></author><author><name sortKey="Nunn, M" uniqKey="Nunn M">M Nunn</name></author><author><name sortKey="Jotwani, R" uniqKey="Jotwani R">R Jotwani</name></author><author><name sortKey="Kim, Bo" uniqKey="Kim B">BO Kim</name></author><author><name sortKey="Nares, S" uniqKey="Nares S">S Nares</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Losche, W" uniqKey="Losche W">W Lösche</name></author><author><name sortKey="Karapetow, F" uniqKey="Karapetow F">F Karapetow</name></author><author><name sortKey="Pohl, A" uniqKey="Pohl A">A Pohl</name></author><author><name sortKey="Pohl, C" uniqKey="Pohl C">C Pohl</name></author><author><name sortKey="Kocher, T" uniqKey="Kocher T">T Kocher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noack, B" uniqKey="Noack B">B Noack</name></author><author><name sortKey="Jachmann, I" uniqKey="Jachmann I">I Jachmann</name></author><author><name sortKey="Roscher, S" uniqKey="Roscher S">S Roscher</name></author><author><name sortKey="Sieber, L" uniqKey="Sieber L">L Sieber</name></author><author><name sortKey="Kopprasch, S" uniqKey="Kopprasch S">S Kopprasch</name></author><author><name sortKey="Luck, C" uniqKey="Luck C">C Lück</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name></author><author><name sortKey="Chaushu, G" uniqKey="Chaushu G">G Chaushu</name></author><author><name sortKey="Sharabi, Y" uniqKey="Sharabi Y">Y Sharabi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name></author><author><name sortKey="Flugelman, My" uniqKey="Flugelman M">MY Flugelman</name></author><author><name sortKey="Goldberg, A" uniqKey="Goldberg A">A Goldberg</name></author><author><name sortKey="Heft, M" uniqKey="Heft M">M Heft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machado, Ac" uniqKey="Machado A">AC Machado</name></author><author><name sortKey="Quirino, Mr" uniqKey="Quirino M">MR Quirino</name></author><author><name sortKey="Nascimento, Lf" uniqKey="Nascimento L">LF Nascimento</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moeintaghavi, A" uniqKey="Moeintaghavi A">A Moeintaghavi</name></author><author><name sortKey="Haerian Ardakani, A" uniqKey="Haerian Ardakani A">A Haerian-Ardakani</name></author><author><name sortKey="Talebi Ardakani, M" uniqKey="Talebi Ardakani M">M Talebi-Ardakani</name></author><author><name sortKey="Tabatabaie, I" uniqKey="Tabatabaie I">I Tabatabaie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nibali, L" uniqKey="Nibali L">L Nibali</name></author><author><name sortKey="D Iuto, F" uniqKey="D Iuto F">F D’Aiuto</name></author><author><name sortKey="Griffiths, G" uniqKey="Griffiths G">G Griffiths</name></author><author><name sortKey="Patel, K" uniqKey="Patel K">K Patel</name></author><author><name sortKey="Suvan, J" uniqKey="Suvan J">J Suvan</name></author><author><name sortKey="Tonetti, Ms" uniqKey="Tonetti M">MS Tonetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Shimazaki, Y" uniqKey="Shimazaki Y">Y Shimazaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fento Lu, O" uniqKey="Fento Lu O">Ö Fentoğlu</name></author><author><name sortKey="Koro Lu, Bk" uniqKey="Koro Lu B">BK Köroğlu</name></author><author><name sortKey="Hicy Lmaz, H" uniqKey="Hicy Lmaz H">H Hiçyılmaz</name></author><author><name sortKey="Sert, T" uniqKey="Sert T">T Sert</name></author><author><name sortKey="Ozdem, M" uniqKey="Ozdem M">M Özdem</name></author><author><name sortKey="Sutcu, R" uniqKey="Sutcu R">R Sütçü</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huck, O" uniqKey="Huck O">O Huck</name></author><author><name sortKey="Saadi Thiers, K" uniqKey="Saadi Thiers K">K Saadi-Thiers</name></author><author><name sortKey="Tenenbaum, H" uniqKey="Tenenbaum H">H Tenenbaum</name></author><author><name sortKey="Davideau, Jl" uniqKey="Davideau J">JL Davideau</name></author><author><name sortKey="Romagna, C" uniqKey="Romagna C">C Romagna</name></author><author><name sortKey="Laurent, Y" uniqKey="Laurent Y">Y Laurent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angeli, F" uniqKey="Angeli F">F Angeli</name></author><author><name sortKey="Verdecchia, P" uniqKey="Verdecchia P">P Verdecchia</name></author><author><name sortKey="Pellegrino, C" uniqKey="Pellegrino C">C Pellegrino</name></author><author><name sortKey="Pellegrino, Rg" uniqKey="Pellegrino R">RG Pellegrino</name></author><author><name sortKey="Pellegrino, G" uniqKey="Pellegrino G">G Pellegrino</name></author><author><name sortKey="Prosciutti, L" uniqKey="Prosciutti L">L Prosciutti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franek, E" uniqKey="Franek E">E Franek</name></author><author><name sortKey="Blach, A" uniqKey="Blach A">A Blach</name></author><author><name sortKey="Witula, A" uniqKey="Witula A">A Witula</name></author><author><name sortKey="Kolonko, A" uniqKey="Kolonko A">A Kolonko</name></author><author><name sortKey="Chudek, J" uniqKey="Chudek J">J Chudek</name></author><author><name sortKey="Drugacz, J" uniqKey="Drugacz J">J Drugacz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franek, E" uniqKey="Franek E">E Franek</name></author><author><name sortKey="Napora, M" uniqKey="Napora M">M Napora</name></author><author><name sortKey="Blach, A" uniqKey="Blach A">A Blach</name></author><author><name sortKey="Budlewski, T" uniqKey="Budlewski T">T Budlewski</name></author><author><name sortKey="Gozdowski, D" uniqKey="Gozdowski D">D Gozdowski</name></author><author><name sortKey="Jedynasty, K" uniqKey="Jedynasty K">K Jedynasty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amar, S" uniqKey="Amar S">S Amar</name></author><author><name sortKey="Gokce, N" uniqKey="Gokce N">N Gokce</name></author><author><name sortKey="Morgan, S" uniqKey="Morgan S">S Morgan</name></author><author><name sortKey="Loukideli, M" uniqKey="Loukideli M">M Loukideli</name></author><author><name sortKey="Van Dyke, Te" uniqKey="Van Dyke T">TE Van Dyke</name></author><author><name sortKey="Vita, Ja" uniqKey="Vita J">JA Vita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vlachopoulos, C" uniqKey="Vlachopoulos C">C Vlachopoulos</name></author><author><name sortKey="Dima, I" uniqKey="Dima I">I Dima</name></author><author><name sortKey="Aznaouridis, K" uniqKey="Aznaouridis K">K Aznaouridis</name></author><author><name sortKey="Vasiliadou, C" uniqKey="Vasiliadou C">C Vasiliadou</name></author><author><name sortKey="Ioakeimidis, N" uniqKey="Ioakeimidis N">N Ioakeimidis</name></author><author><name sortKey="Aggeli, C" uniqKey="Aggeli C">C Aggeli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsioufis, C" uniqKey="Tsioufis C">C Tsioufis</name></author><author><name sortKey="Kasiakogias, A" uniqKey="Kasiakogias A">A Kasiakogias</name></author><author><name sortKey="Thomopoulos, C" uniqKey="Thomopoulos C">C Thomopoulos</name></author><author><name sortKey="Stefanadis, C" uniqKey="Stefanadis C">C Stefanadis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reaven, Gm" uniqKey="Reaven G">GM Reaven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, Ss" uniqKey="Anand S">SS Anand</name></author><author><name sortKey="Yi, Q" uniqKey="Yi Q">Q Yi</name></author><author><name sortKey="Gerstein, H" uniqKey="Gerstein H">H Gerstein</name></author><author><name sortKey="Lonn, E" uniqKey="Lonn E">E Lonn</name></author><author><name sortKey="Jacobs, R" uniqKey="Jacobs R">R Jacobs</name></author><author><name sortKey="Vuksan, V" uniqKey="Vuksan V">V Vuksan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bray, Ga" uniqKey="Bray G">GA Bray</name></author><author><name sortKey="Champagne, Cm" uniqKey="Champagne C">CM Champagne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haffner, Sm" uniqKey="Haffner S">SM Haffner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Destefano, F" uniqKey="Destefano F">F DeStefano</name></author><author><name sortKey="Anda, Rf" uniqKey="Anda R">RF Anda</name></author><author><name sortKey="Kahn, Hs" uniqKey="Kahn H">HS Kahn</name></author><author><name sortKey="Williamson, Df" uniqKey="Williamson D">DF Williamson</name></author><author><name sortKey="Russell, Cm" uniqKey="Russell C">CM Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buhlin, K" uniqKey="Buhlin K">K Buhlin</name></author><author><name sortKey="M Ntyl, P" uniqKey="M Ntyl P">P Mäntylä</name></author><author><name sortKey="Paju, S" uniqKey="Paju S">S Paju</name></author><author><name sortKey="Peltola, Js" uniqKey="Peltola J">JS Peltola</name></author><author><name sortKey="Nieminen, Ms" uniqKey="Nieminen M">MS Nieminen</name></author><author><name sortKey="Sinisalo, J" uniqKey="Sinisalo J">J Sinisalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romagna, C" uniqKey="Romagna C">C Romagna</name></author><author><name sortKey="Dufour, L" uniqKey="Dufour L">L Dufour</name></author><author><name sortKey="Troisgros, O" uniqKey="Troisgros O">O Troisgros</name></author><author><name sortKey="Lorgis, L" uniqKey="Lorgis L">L Lorgis</name></author><author><name sortKey="Richard, C" uniqKey="Richard C">C Richard</name></author><author><name sortKey="Buffet, P" uniqKey="Buffet P">P Buffet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimazaki, Y" uniqKey="Shimazaki Y">Y Shimazaki</name></author><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Yonemoto, K" uniqKey="Yonemoto K">K Yonemoto</name></author><author><name sortKey="Kiyohara, Y" uniqKey="Kiyohara Y">Y Kiyohara</name></author><author><name sortKey="Iida, M" uniqKey="Iida M">M Iida</name></author><author><name sortKey="Yamashita, Y" uniqKey="Yamashita Y">Y Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Iuto, F" uniqKey="D Iuto F">F D’Aiuto</name></author><author><name sortKey="Sabbah, W" uniqKey="Sabbah W">W Sabbah</name></author><author><name sortKey="Netuveli, G" uniqKey="Netuveli G">G Netuveli</name></author><author><name sortKey="Donos, N" uniqKey="Donos N">N Donos</name></author><author><name sortKey="Hingorani, Ad" uniqKey="Hingorani A">AD Hingorani</name></author><author><name sortKey="Deanfield, J" uniqKey="Deanfield J">J Deanfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khader, Y" uniqKey="Khader Y">Y Khader</name></author><author><name sortKey="Khassawneh, B" uniqKey="Khassawneh B">B Khassawneh</name></author><author><name sortKey="Obeidat, B" uniqKey="Obeidat B">B Obeidat</name></author><author><name sortKey="Hammad, M" uniqKey="Hammad M">M Hammad</name></author><author><name sortKey="El Salem, K" uniqKey="El Salem K">K El-Salem</name></author><author><name sortKey="Bawadi, H" uniqKey="Bawadi H">H Bawadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kushiyama, M" uniqKey="Kushiyama M">M Kushiyama</name></author><author><name sortKey="Shimazaki, Y" uniqKey="Shimazaki Y">Y Shimazaki</name></author><author><name sortKey="Yamashita, Y" uniqKey="Yamashita Y">Y Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morita, T" uniqKey="Morita T">T Morita</name></author><author><name sortKey="Ogawa, Y" uniqKey="Ogawa Y">Y Ogawa</name></author><author><name sortKey="Takada, K" uniqKey="Takada K">K Takada</name></author><author><name sortKey="Nishinoue, N" uniqKey="Nishinoue N">N Nishinoue</name></author><author><name sortKey="Sasaki, Y" uniqKey="Sasaki Y">Y Sasaki</name></author><author><name sortKey="Motohashi, M" uniqKey="Motohashi M">M Motohashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, P" uniqKey="Li P">P Li</name></author><author><name sortKey="He, L" uniqKey="He L">L He</name></author><author><name sortKey="Sha, Yq" uniqKey="Sha Y">YQ Sha</name></author><author><name sortKey="Luan, Qx" uniqKey="Luan Q">QX Luan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Timonen, P" uniqKey="Timonen P">P Timonen</name></author><author><name sortKey="Niskanen, M" uniqKey="Niskanen M">M Niskanen</name></author><author><name sortKey="Suominen Taipale, L" uniqKey="Suominen Taipale L">L Suominen-Taipale</name></author><author><name sortKey="Jula, A" uniqKey="Jula A">A Jula</name></author><author><name sortKey="Knuuttila, M" uniqKey="Knuuttila M">M Knuuttila</name></author><author><name sortKey="Ylostalo, P" uniqKey="Ylostalo P">P Ylöstalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morita, T" uniqKey="Morita T">T Morita</name></author><author><name sortKey="Yamazaki, Y" uniqKey="Yamazaki Y">Y Yamazaki</name></author><author><name sortKey="Mita, A" uniqKey="Mita A">A Mita</name></author><author><name sortKey="Takada, K" uniqKey="Takada K">K Takada</name></author><author><name sortKey="Seto, M" uniqKey="Seto M">M Seto</name></author><author><name sortKey="Nishinoue, N" uniqKey="Nishinoue N">N Nishinoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Dh" uniqKey="Han D">DH Han</name></author><author><name sortKey="Lim, Sy" uniqKey="Lim S">SY Lim</name></author><author><name sortKey="Sun, Bc" uniqKey="Sun B">BC Sun</name></author><author><name sortKey="Paek, D" uniqKey="Paek D">D Paek</name></author><author><name sortKey="Kim, Hd" uniqKey="Kim H">HD Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nesbitt, Mj" uniqKey="Nesbitt M">MJ Nesbitt</name></author><author><name sortKey="Reynolds, Ma" uniqKey="Reynolds M">MA Reynolds</name></author><author><name sortKey="Shiau, H" uniqKey="Shiau H">H Shiau</name></author><author><name sortKey="Choe, K" uniqKey="Choe K">K Choe</name></author><author><name sortKey="Simonsick, Em" uniqKey="Simonsick E">EM Simonsick</name></author><author><name sortKey="Ferrucci, L" uniqKey="Ferrucci L">L Ferrucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benguigui, C" uniqKey="Benguigui C">C Benguigui</name></author><author><name sortKey="Bongard, V" uniqKey="Bongard V">V Bongard</name></author><author><name sortKey="Ruidavets, Jb" uniqKey="Ruidavets J">JB Ruidavets</name></author><author><name sortKey="Chamontin, B" uniqKey="Chamontin B">B Chamontin</name></author><author><name sortKey="Sixou, M" uniqKey="Sixou M">M Sixou</name></author><author><name sortKey="Ferrieres, J" uniqKey="Ferrieres J">J Ferrières</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andriankaja, Om" uniqKey="Andriankaja O">OM Andriankaja</name></author><author><name sortKey="Sreenivasa, S" uniqKey="Sreenivasa S">S Sreenivasa</name></author><author><name sortKey="Dunford, R" uniqKey="Dunford R">R Dunford</name></author><author><name sortKey="Denardin, E" uniqKey="Denardin E">E DeNardin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwon, Ye" uniqKey="Kwon Y">YE Kwon</name></author><author><name sortKey="Ha, Je" uniqKey="Ha J">JE Ha</name></author><author><name sortKey="Paik, Di" uniqKey="Paik D">DI Paik</name></author><author><name sortKey="Jin, Bh" uniqKey="Jin B">BH Jin</name></author><author><name sortKey="Bae, Kh" uniqKey="Bae K">KH Bae</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Lp" uniqKey="Chen L">LP Chen</name></author><author><name sortKey="Hsu, Sp" uniqKey="Hsu S">SP Hsu</name></author><author><name sortKey="Peng, Ys" uniqKey="Peng Y">YS Peng</name></author><author><name sortKey="Chiang, Ck" uniqKey="Chiang C">CK Chiang</name></author><author><name sortKey="Hung, Ky" uniqKey="Hung K">KY Hung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Dh" uniqKey="Han D">DH Han</name></author><author><name sortKey="Lim, S" uniqKey="Lim S">S Lim</name></author><author><name sortKey="Paek, D" uniqKey="Paek D">D Paek</name></author><author><name sortKey="Kim, Hd" uniqKey="Kim H">HD Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garg, Mk" uniqKey="Garg M">MK Garg</name></author><author><name sortKey="Dutta, Mk" uniqKey="Dutta M">MK Dutta</name></author><author><name sortKey="Mahalle, N" uniqKey="Mahalle N">N Mahalle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurkan, A" uniqKey="Gurkan A">A Gürkan</name></author><author><name sortKey="Emingil, G" uniqKey="Emingil G">G Emingil</name></author><author><name sortKey="Saygan, Bh" uniqKey="Saygan B">BH Saygan</name></author><author><name sortKey="Cinarcik, S" uniqKey="Cinarcik S">S Cinarcik</name></author><author><name sortKey="Atilla, G" uniqKey="Atilla G">G Atilla</name></author><author><name sortKey="Kose, T" uniqKey="Kose T">T Köse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kornman, Ks" uniqKey="Kornman K">KS Kornman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairo, F" uniqKey="Cairo F">F Cairo</name></author><author><name sortKey="Nieri, M" uniqKey="Nieri M">M Nieri</name></author><author><name sortKey="Gori, Am" uniqKey="Gori A">AM Gori</name></author><author><name sortKey="Rotundo, R" uniqKey="Rotundo R">R Rotundo</name></author><author><name sortKey="Castellani, S" uniqKey="Castellani S">S Castellani</name></author><author><name sortKey="Abbate, R" uniqKey="Abbate R">R Abbate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakarai, H" uniqKey="Nakarai H">H Nakarai</name></author><author><name sortKey="Yamashita, A" uniqKey="Yamashita A">A Yamashita</name></author><author><name sortKey="Takagi, M" uniqKey="Takagi M">M Takagi</name></author><author><name sortKey="Adachi, M" uniqKey="Adachi M">M Adachi</name></author><author><name sortKey="Sugiyama, M" uniqKey="Sugiyama M">M Sugiyama</name></author><author><name sortKey="Noda, H" uniqKey="Noda H">H Noda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimada, Y" uniqKey="Shimada Y">Y Shimada</name></author><author><name sortKey="Komatsu, Y" uniqKey="Komatsu Y">Y Komatsu</name></author><author><name sortKey="Ikezawa Suzuki, I" uniqKey="Ikezawa Suzuki I">I Ikezawa-Suzuki</name></author><author><name sortKey="Tai, H" uniqKey="Tai H">H Tai</name></author><author><name sortKey="Sugita, N" uniqKey="Sugita N">N Sugita</name></author><author><name sortKey="Yoshie, H" uniqKey="Yoshie H">H Yoshie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acharya, A" uniqKey="Acharya A">A Acharya</name></author><author><name sortKey="Bhavsar, N" uniqKey="Bhavsar N">N Bhavsar</name></author><author><name sortKey="Jadav, B" uniqKey="Jadav B">B Jadav</name></author><author><name sortKey="Parikh, H" uniqKey="Parikh H">H Parikh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Wl" uniqKey="Sun W">WL Sun</name></author><author><name sortKey="Chen, Ll" uniqKey="Chen L">LL Chen</name></author><author><name sortKey="Zhang, Sz" uniqKey="Zhang S">SZ Zhang</name></author><author><name sortKey="Wu, Ym" uniqKey="Wu Y">YM Wu</name></author><author><name sortKey="Ren, Yz" uniqKey="Ren Y">YZ Ren</name></author><author><name sortKey="Qin, Gm" uniqKey="Qin G">GM Qin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="L Pez, Nj" uniqKey="L Pez N">NJ López</name></author><author><name sortKey="Quintero, A" uniqKey="Quintero A">A Quintero</name></author><author><name sortKey="Casanova, Pa" uniqKey="Casanova P">PA Casanova</name></author><author><name sortKey="Ibieta, Ci" uniqKey="Ibieta C">CI Ibieta</name></author><author><name sortKey="Baelum, V" uniqKey="Baelum V">V Baelum</name></author><author><name sortKey="L Pez, R" uniqKey="L Pez R">R López</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="iso-abbrev">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="publisher-id">DRJ</journal-id><journal-title-group><journal-title>Dental Research Journal</journal-title></journal-title-group><issn pub-type="ppub">1735-3327</issn><issn pub-type="epub">2008-0255</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24688553</article-id><article-id pub-id-type="pmc">3955301</article-id><article-id pub-id-type="publisher-id">DRJ-11-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>The association of periodontitis and metabolic syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gurav</surname><given-names>Abhijit N.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Abhijit N. Gurav, Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur - 416 137, Maharashtra, India. E-mail: <email xlink:href="dr_abhijitg@yahoo.co.in">dr_abhijitg@yahoo.co.in</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Feb</season><year>2014</year></pub-date><volume>11</volume><issue>1</issue><fpage>1</fpage><lpage>10</lpage><history><date date-type="received"><month>9</month><year>2012</year></date><date date-type="accepted"><month>5</month><year>2013</year></date></history><permissions><copyright-statement>Copyright: © Dental Research Journal</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Metabolic syndrome (MS) is a condition, which constitutes a group of risk factors that occur together and increase the risk for Coronary Artery Disease, Stroke and type 2 diabetes mellitus. This disorder is found prevalent in the industrialized societies of the world in epidemic proportions. Periodontitis is an oral disease of microbial origin characterized by loss of attachment apparatus of tooth, resulting in edentulism if untreated. Periodontitis has been attributed to produce a low grade systemic inflammatory condition. The link of periodontitis to various systemic disorders has led to the evolution of a new branch termed as “periodontal medicine.” Studies reviewed in the present paper have indicated a positive link between the MS and periodontitis and it is suggested that subjects displaying several components of MS should be submitted to periodontal examination. Present studies have displayed coherent relation between the two entities. This review will address the vicious association between MS and periodontitis, depicting the commonality of pathophysiological pathway between the two entities. Systematic reviews, meta-analysis addressing the concerned subject were screened. Whether the systematic periodontal therapy in individuals exhibiting MS has the potential to reduce the incidence of various adverse systemic complications remains a logical proposition. Further, longitudinal and controlled trials with a large population would be imperative to depict the robustness in the association between MS and periodontal disease in human subjects.</p></abstract><kwd-group><kwd>Metabolic syndrome</kwd><kwd>periodontitis</kwd><kwd>periodontal therapy</kwd><kwd>type 2 diabetes mellitus</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Gurav, Abhijit N" sort="Gurav, Abhijit N" uniqKey="Gurav A" first="Abhijit N." last="Gurav">Abhijit N. Gurav</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000051 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000051 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:3955301
|texte= The association of periodontitis and metabolic syndrome
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:24688553" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV1
| This area was generated with Dilib version V0.6.33. |  |