Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis
Identifieur interne : 000E42 ( Ncbi/Curation ); précédent : 000E41; suivant : 000E43Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis
Auteurs : Warren C. Byrd [États-Unis] ; Sarah Schwartz-Baxter [États-Unis] ; Jim Carlson [États-Unis] ; Silvana Barros [États-Unis] ; Steven Offenbacher [États-Unis] ; Sompop Bencharit [États-Unis]Source :
- Molecular bioSystems [ 1742-206X ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse de regroupements, Analyse en composantes principales (), Appareils de prothèse dentaire (effets indésirables), Candida (métabolisme), Femelle, Humains, Mâle, Protéines et peptides salivaires (métabolisme), Protéome (métabolisme), Protéomique (), Salive (métabolisme), Stomatite prothétique (métabolisme), Stomatite prothétique (étiologie), Sujet âgé, Études cas-témoins.
- MESH :
- effets indésirables : Appareils de prothèse dentaire.
- métabolisme : Candida, Protéines et peptides salivaires, Protéome, Salive, Stomatite prothétique.
- étiologie : Stomatite prothétique.
- Adulte d'âge moyen, Analyse de regroupements, Analyse en composantes principales, Femelle, Humains, Mâle, Protéomique, Sujet âgé, Études cas-témoins.
English descriptors
- KwdEn :
- Aged, Candida (metabolism), Case-Control Studies, Cluster Analysis, Dentures (adverse effects), Female, Humans, Male, Middle Aged, Principal Component Analysis (methods), Proteome (metabolism), Proteomics (methods), Saliva (metabolism), Salivary Proteins and Peptides (metabolism), Stomatitis, Denture (etiology), Stomatitis, Denture (metabolism).
- MESH :
- chemical , metabolism : Proteome, Salivary Proteins and Peptides.
- adverse effects : Dentures.
- etiology : Stomatitis, Denture.
- metabolism : Candida, Saliva, Stomatitis, Denture.
- methods : Principal Component Analysis, Proteomics.
- Aged, Case-Control Studies, Cluster Analysis, Female, Humans, Male, Middle Aged.
Abstract
Denture stomatitis, inflammation and redness beneath a denture, affects nearly half of all denture wearers. Candida organism, the presence of a denture, saliva, and host immunity are the key etiological factors for the condition. The role of salivary proteins in denture stomatitis is not clear. In this study 30 edentulous subjects wearing a maxillary complete denture were recruited. Unstimulated whole saliva from each subject was collected and pooled into two groups (n=15 each); healthy and stomatitis (Newton classification II and III). Label-free multidimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS) proteomics on two mass spectrometry platforms were used to determine peptide mass differences between control and stomatitis groups. Cluster analysis and principal component analysis were used to determine differential expression among the groups. The two proteomic platforms identified 97 and 176 proteins (ANOVA; p<0.01) differentially expressed among the healthy, type 2 and 3 stomatitis groups. Three proteins including carbonic anhydrase 6, cystatin C, and cystatin SN were found to be the same as previous study. Salivary proteomic profiles of patients with denture stomatitis were found to be uniquely different from controls. Analysis of protein components suggests that certain salivary proteins may predispose some patients to denture stomatitis while others are believed to be involved in the reaction to fungal infection. Analysis of candidal proteins suggest that multiple species of candidal organisms play a role in denture stomatitis.
Url:
DOI: 10.1039/c4mb00185k
PubMed: 24947908
PubMed Central: 4119604
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PMC:4119604Le document en format XML
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<term>Candida (metabolism)</term>
<term>Case-Control Studies</term>
<term>Cluster Analysis</term>
<term>Dentures (adverse effects)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Principal Component Analysis (methods)</term>
<term>Proteome (metabolism)</term>
<term>Proteomics (methods)</term>
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<term>Stomatitis, Denture (metabolism)</term>
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<term>Analyse de regroupements</term>
<term>Analyse en composantes principales ()</term>
<term>Appareils de prothèse dentaire (effets indésirables)</term>
<term>Candida (métabolisme)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Protéines et peptides salivaires (métabolisme)</term>
<term>Protéome (métabolisme)</term>
<term>Protéomique ()</term>
<term>Salive (métabolisme)</term>
<term>Stomatite prothétique (métabolisme)</term>
<term>Stomatite prothétique (étiologie)</term>
<term>Sujet âgé</term>
<term>Études cas-témoins</term>
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<term>Salivary Proteins and Peptides</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Appareils de prothèse dentaire</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stomatitis, Denture</term>
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<term>Saliva</term>
<term>Stomatitis, Denture</term>
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<term>Proteomics</term>
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<term>Protéines et peptides salivaires</term>
<term>Protéome</term>
<term>Salive</term>
<term>Stomatite prothétique</term>
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<term>Case-Control Studies</term>
<term>Cluster Analysis</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Denture stomatitis, inflammation and redness beneath a denture, affects nearly half of all denture wearers. Candida organism, the presence of a denture, saliva, and host immunity are the key etiological factors for the condition. The role of salivary proteins in denture stomatitis is not clear. In this study 30 edentulous subjects wearing a maxillary complete denture were recruited. Unstimulated whole saliva from each subject was collected and pooled into two groups (n=15 each); healthy and stomatitis (Newton classification II and III). Label-free multidimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS) proteomics on two mass spectrometry platforms were used to determine peptide mass differences between control and stomatitis groups. Cluster analysis and principal component analysis were used to determine differential expression among the groups. The two proteomic platforms identified 97 and 176 proteins (ANOVA; p<0.01) differentially expressed among the healthy, type 2 and 3 stomatitis groups. Three proteins including carbonic anhydrase 6, cystatin C, and cystatin SN were found to be the same as previous study. Salivary proteomic profiles of patients with denture stomatitis were found to be uniquely different from controls. Analysis of protein components suggests that certain salivary proteins may predispose some patients to denture stomatitis while others are believed to be involved in the reaction to fungal infection. Analysis of candidal proteins suggest that multiple species of candidal organisms play a role in denture stomatitis.</p>
</div>
</front>
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