Role of salivary and candidal proteins in denture stomatitis: an exploratory proteomic analysis.
Identifieur interne : 000856 ( PubMed/Corpus ); précédent : 000855; suivant : 000857Role of salivary and candidal proteins in denture stomatitis: an exploratory proteomic analysis.
Auteurs : Warren C. Byrd ; Sarah Schwartz-Baxter ; Jim Carlson ; Silvana Barros ; Steven Offenbacher ; Sompop BencharitSource :
- Molecular bioSystems [ 1742-2051 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Candida (metabolism), Case-Control Studies, Cluster Analysis, Dentures (adverse effects), Female, Humans, Male, Middle Aged, Principal Component Analysis (methods), Proteome (metabolism), Proteomics (methods), Saliva (metabolism), Salivary Proteins and Peptides (metabolism), Stomatitis, Denture (etiology), Stomatitis, Denture (metabolism).
- MESH :
- chemical , metabolism : Proteome, Salivary Proteins and Peptides.
- adverse effects : Dentures.
- etiology : Stomatitis, Denture.
- metabolism : Candida, Saliva, Stomatitis, Denture.
- methods : Principal Component Analysis, Proteomics.
- Aged, Case-Control Studies, Cluster Analysis, Female, Humans, Male, Middle Aged.
Abstract
Denture stomatitis, inflammation and redness beneath a denture, affects nearly half of all denture wearers. Candidal organisms, the presence of a denture, saliva, and host immunity are the key etiological factors for the condition. The role of salivary proteins in denture stomatitis is not clear. In this study 30 edentulous subjects wearing a maxillary complete denture were recruited. Unstimulated whole saliva from each subject was collected and pooled into two groups (n = 15 each), healthy and stomatitis (Newton classification II and III). Label-free multidimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS) proteomics on two mass spectrometry platforms were used to determine peptide mass differences between control and stomatitis groups. Cluster analysis and principal component analysis were used to determine the differential expression among the groups. The two proteomic platforms identified 97 and 176 proteins (ANOVA; p < 0.01) differentially expressed among the healthy, type 2 and 3 stomatitis groups. Three proteins including carbonic anhydrase 6, cystatin C, and cystatin SN were found to be the same as previous study. Salivary proteomic profiles of patients with denture stomatitis were found to be uniquely different from controls. Analysis of protein components suggests that certain salivary proteins may predispose some patients to denture stomatitis while others are believed to be involved in the reaction to fungal infection. Analysis of candidal proteins suggests that multiple species of candidal organisms play a role in denture stomatitis.
DOI: 10.1039/c4mb00185k
PubMed: 24947908
Links to Exploration step
pubmed:24947908Le document en format XML
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Sompop_Bencharit@dentistry.unc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Schwartz Baxter, Sarah" sort="Schwartz Baxter, Sarah" uniqKey="Schwartz Baxter S" first="Sarah" last="Schwartz-Baxter">Sarah Schwartz-Baxter</name></author><author><name sortKey="Carlson, Jim" sort="Carlson, Jim" uniqKey="Carlson J" first="Jim" last="Carlson">Jim Carlson</name></author><author><name sortKey="Barros, Silvana" sort="Barros, Silvana" uniqKey="Barros S" first="Silvana" last="Barros">Silvana Barros</name></author><author><name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name></author><author><name sortKey="Bencharit, Sompop" sort="Bencharit, Sompop" uniqKey="Bencharit S" first="Sompop" last="Bencharit">Sompop Bencharit</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24947908</idno><idno type="pmid">24947908</idno><idno type="doi">10.1039/c4mb00185k</idno><idno type="wicri:Area/PubMed/Corpus">000856</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000856</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Role of salivary and candidal proteins in denture stomatitis: an exploratory proteomic analysis.</title><author><name sortKey="Byrd, Warren C" sort="Byrd, Warren C" uniqKey="Byrd W" first="Warren C" last="Byrd">Warren C. Byrd</name><affiliation><nlm:affiliation>Department of Prosthodontics, School of Dentistry, Department of Pharmacology, School of Medicine, University of North Carolina, CB#7450, Chapel Hill, NC 27599-7450, USA. 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Candidal organisms, the presence of a denture, saliva, and host immunity are the key etiological factors for the condition. The role of salivary proteins in denture stomatitis is not clear. In this study 30 edentulous subjects wearing a maxillary complete denture were recruited. Unstimulated whole saliva from each subject was collected and pooled into two groups (n = 15 each), healthy and stomatitis (Newton classification II and III). Label-free multidimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS) proteomics on two mass spectrometry platforms were used to determine peptide mass differences between control and stomatitis groups. Cluster analysis and principal component analysis were used to determine the differential expression among the groups. The two proteomic platforms identified 97 and 176 proteins (ANOVA; p < 0.01) differentially expressed among the healthy, type 2 and 3 stomatitis groups. Three proteins including carbonic anhydrase 6, cystatin C, and cystatin SN were found to be the same as previous study. Salivary proteomic profiles of patients with denture stomatitis were found to be uniquely different from controls. Analysis of protein components suggests that certain salivary proteins may predispose some patients to denture stomatitis while others are believed to be involved in the reaction to fungal infection. Analysis of candidal proteins suggests that multiple species of candidal organisms play a role in denture stomatitis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24947908</PMID><DateCompleted><Year>2015</Year><Month>10</Month><Day>15</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1742-2051</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>9</Issue><PubDate><Year>2014</Year><Month>Jul</Month><Day>29</Day></PubDate></JournalIssue><Title>Molecular bioSystems</Title><ISOAbbreviation>Mol Biosyst</ISOAbbreviation></Journal><ArticleTitle>Role of salivary and candidal proteins in denture stomatitis: an exploratory proteomic analysis.</ArticleTitle><Pagination><MedlinePgn>2299-304</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c4mb00185k</ELocationID><Abstract><AbstractText>Denture stomatitis, inflammation and redness beneath a denture, affects nearly half of all denture wearers. Candidal organisms, the presence of a denture, saliva, and host immunity are the key etiological factors for the condition. The role of salivary proteins in denture stomatitis is not clear. In this study 30 edentulous subjects wearing a maxillary complete denture were recruited. Unstimulated whole saliva from each subject was collected and pooled into two groups (n = 15 each), healthy and stomatitis (Newton classification II and III). Label-free multidimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS) proteomics on two mass spectrometry platforms were used to determine peptide mass differences between control and stomatitis groups. Cluster analysis and principal component analysis were used to determine the differential expression among the groups. The two proteomic platforms identified 97 and 176 proteins (ANOVA; p < 0.01) differentially expressed among the healthy, type 2 and 3 stomatitis groups. Three proteins including carbonic anhydrase 6, cystatin C, and cystatin SN were found to be the same as previous study. Salivary proteomic profiles of patients with denture stomatitis were found to be uniquely different from controls. Analysis of protein components suggests that certain salivary proteins may predispose some patients to denture stomatitis while others are believed to be involved in the reaction to fungal infection. Analysis of candidal proteins suggests that multiple species of candidal organisms play a role in denture stomatitis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Byrd</LastName><ForeName>Warren C</ForeName><Initials>WC</Initials><AffiliationInfo><Affiliation>Department of Prosthodontics, School of Dentistry, Department of Pharmacology, School of Medicine, University of North Carolina, CB#7450, Chapel Hill, NC 27599-7450, USA. Sompop_Bencharit@dentistry.unc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwartz-Baxter</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Carlson</LastName><ForeName>Jim</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Barros</LastName><ForeName>Silvana</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Offenbacher</LastName><ForeName>Steven</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Bencharit</LastName><ForeName>Sompop</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R21 HL092338</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 RR025747</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL092338</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1RR025747</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol Biosyst</MedlineTA><NlmUniqueID>101251620</NlmUniqueID><ISSNLinking>1742-2051</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020543">Proteome</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012471">Salivary Proteins and 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RefType="Cites"><RefSource>J Infect Dis. 1990 Apr;161(4):761-8</RefSource><PMID Version="1">2138655</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002175" MajorTopicYN="N">Candida</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003778" MajorTopicYN="N">Dentures</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" 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