EdenteV1, Main, Exploration, bibRecord, 001F47

Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior mandible (Type II bone) in dogs

Identifieur interne : 001F47 ( Main/Exploration ); précédent : 001F46; suivant : 001F48

Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior mandible (Type II bone) in dogs

Auteurs : Ulf M. E. Wikesjö [États-Unis] ; Andreas V. Xiropaidis [États-Unis] ; Mohammed Qahash [États-Unis] ; WON HEE LIM [États-Unis] ; Rachel G. Sorensen [États-Unis] ; Michael D. Rohrer [États-Unis] ; John M. Wozney [États-Unis] ; Jan Hall [Suède]

Source :

Journal of clinical periodontology [ 0303-6979 ] ; 2008.

RBID : Pascal:08-0513726

Descripteurs français

Pascal (Inist)
- Chirurgie maxillofaciale, Dent, Dentisterie, Génie tissulaire, Homme, Implant, Maxillaire, Os, Postérieur, Primates, Protéine BMP-2, Protéine morphogénétique osseuse, Protéine recombinante, Homme, Titane, Implant, Postérieur, Mandibule, Animal, Chien, Protéine morphogénétique osseuse, Dent, Voie orale, Génie tissulaire, Etude expérimentale, Dentisterie, Protéine BMP-2, Chirurgie maxillofaciale.
Wicri :
- topic : Homme, Titane.

English descriptors

KwdEn :
- Animal, Bone, Bone morphogenetic protein, Bone morphogenetic protein-2, Dentistry, Dog, Experimental study, Human, Implant, Mandible, Maxillary, Maxillofacial surgery, Oral administration, Posterior, Primates, Recombinant protein, Tissue engineering, Titanium, Tooth.

Abstract

Background: Conventional oral/maxillofacial implants reach osseointegration over several months during which the titanium fixtures interact with alveolar bone. The objective of this study was to determine if adsorbing recombinant human bone morphogenetic protein-2 (rhBMP-2) onto a titanium porous oxide (TPO) implant surface might enhance or accelerate local bone formation and support osseointegration in a large animal oral/maxillofacial orthotopic model. Material and Methods: Endosseous implants with a TPO surface were installed into the edentulated posterior mandible in eight adult Hound Labrador mongrel dogs. The implant surface had been adsorbed with rhBMP-2 at 0.2 or 4.0 mg/ml. TPO implants without rhBMP-2 served as control. Treatments were randomized between jaw quadrants. Mucosal flaps were advanced and sutured leaving the implants submerged. Clinical and radiographic evaluations were made immediately post-surgery, at day 10 (suture removal), and week 4 and 8 post-surgery. The animals received fluorescent bone markers at week 3, 4, and at week 8 post-surgery, when they were euthanized for histologic analysis. Results: TPO implants coated with rhBMP-2 exhibited dose-dependent bone re-modelling including immediate resorption and formation of implant adjacent bone, and early establishment of clinically relevant osseointegration. The resulting bone-implant contact, although clinically respectable, appeared significantly lower for rhBMP-2-coated implants compared with the control [rhBMP-2 (0.2 mg/ml) 43.3 ± 10.8% versus 71.7 ± 7.8%, p<0.02; rhBMP-2 (4.0 mg/ml) 35.4 ± 10.6% versus 68.2 ± 11.0%,p<0.03], Conclusions: rhBMP-2 adsorbed onto TPO implant surfaces initiates dose-dependent peri-implant bone re-modelling resulting in the formation of normal, physiologic bone and clinically relevant osseointegration within 8 weeks.

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Bone</term>
<term>Bone morphogenetic protein</term>
<term>Bone morphogenetic protein-2</term>
<term>Dentistry</term>
<term>Dog</term>
<term>Experimental study</term>
<term>Human</term>
<term>Implant</term>
<term>Mandible</term>
<term>Maxillary</term>
<term>Maxillofacial surgery</term>
<term>Oral administration</term>
<term>Posterior</term>
<term>Primates</term>
<term>Recombinant protein</term>
<term>Tissue engineering</term>
<term>Titanium</term>
<term>Tooth</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Chirurgie maxillofaciale</term>
<term>Dent</term>
<term>Dentisterie</term>
<term>Génie tissulaire</term>
<term>Homme</term>
<term>Implant</term>
<term>Maxillaire</term>
<term>Os</term>
<term>Postérieur</term>
<term>Primates</term>
<term>Protéine BMP-2</term>
<term>Protéine morphogénétique osseuse</term>
<term>Protéine recombinante</term>
<term>Homme</term>
<term>Titane</term>
<term>Implant</term>
<term>Postérieur</term>
<term>Mandibule</term>
<term>Animal</term>
<term>Chien</term>
<term>Protéine morphogénétique osseuse</term>
<term>Dent</term>
<term>Voie orale</term>
<term>Génie tissulaire</term>
<term>Etude expérimentale</term>
<term>Dentisterie</term>
<term>Protéine BMP-2</term>
<term>Chirurgie maxillofaciale</term>
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<front><div type="abstract" xml:lang="en">Background: Conventional oral/maxillofacial implants reach osseointegration over several months during which the titanium fixtures interact with alveolar bone. The objective of this study was to determine if adsorbing recombinant human bone morphogenetic protein-2 (rhBMP-2) onto a titanium porous oxide (TPO) implant surface might enhance or accelerate local bone formation and support osseointegration in a large animal oral/maxillofacial orthotopic model. Material and Methods: Endosseous implants with a TPO surface were installed into the edentulated posterior mandible in eight adult Hound Labrador mongrel dogs. The implant surface had been adsorbed with rhBMP-2 at 0.2 or 4.0 mg/ml. TPO implants without rhBMP-2 served as control. Treatments were randomized between jaw quadrants. Mucosal flaps were advanced and sutured leaving the implants submerged. Clinical and radiographic evaluations were made immediately post-surgery, at day 10 (suture removal), and week 4 and 8 post-surgery. The animals received fluorescent bone markers at week 3, 4, and at week 8 post-surgery, when they were euthanized for histologic analysis. Results: TPO implants coated with rhBMP-2 exhibited dose-dependent bone re-modelling including immediate resorption and formation of implant adjacent bone, and early establishment of clinically relevant osseointegration. The resulting bone-implant contact, although clinically respectable, appeared significantly lower for rhBMP-2-coated implants compared with the control [rhBMP-2 (0.2 mg/ml) 43.3 ± 10.8% versus 71.7 ± 7.8%, p<0.02; rhBMP-2 (4.0 mg/ml) 35.4 ± 10.6% versus 68.2 ± 11.0%,p<0.03], Conclusions: rhBMP-2 adsorbed onto TPO implant surfaces initiates dose-dependent peri-implant bone re-modelling resulting in the formation of normal, physiologic bone and clinically relevant osseointegration within 8 weeks.</div>
</front>
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Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior mandible (Type II bone) in dogs

Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior mandible (Type II bone) in dogs

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