Genetic networks in osseointegration.
Identifieur interne : 001124 ( Main/Exploration ); précédent : 001123; suivant : 001125Genetic networks in osseointegration.
Auteurs : I. Nishimura [États-Unis]Source :
- Journal of dental research [ 1544-0591 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Chondrogenèse, Densité osseuse, Ostéo-intégration, Ostéogenèse, Remodelage osseux, Rythme circadien, Réseaux de régulation génique, Transcriptome.
- physiologie : Vitamine D.
- Humains, Implants dentaires.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Vitamin D.
- chemical : Dental Implants.
- genetics : Bone Density, Bone Remodeling, Chondrogenesis, Circadian Rhythm, Gene Regulatory Networks, Osseointegration, Osteogenesis, Transcriptome.
- Humans.
Abstract
Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. The success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however, the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. Radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore, implant-induced bone formation continues to be intensively investigated. Increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. This review highlights genetic networks related to bone quality, the transient chondrogenic phase, the vitamin D axis, and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration.
DOI: 10.1177/0022034513504928
PubMed: 24158334
Affiliations:
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Le document en format XML
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Nishimura</name><affiliation wicri:level="2"><nlm:affiliation>Weintraub Center for Reconstructive Biotechnology, Divisions of Advanced Prosthodontics and Oral Medicine & Biology, UCLA School of Dentistry, Los Angeles, CA 90095-1668.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Weintraub Center for Reconstructive Biotechnology, Divisions of Advanced Prosthodontics and Oral Medicine & Biology, UCLA School of Dentistry, Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of dental research</title><idno type="eISSN">1544-0591</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bone Density (genetics)</term><term>Bone Remodeling (genetics)</term><term>Chondrogenesis (genetics)</term><term>Circadian Rhythm (genetics)</term><term>Dental Implants</term><term>Gene Regulatory Networks (genetics)</term><term>Humans</term><term>Osseointegration (genetics)</term><term>Osteogenesis (genetics)</term><term>Transcriptome (genetics)</term><term>Vitamin D (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chondrogenèse (génétique)</term><term>Densité osseuse (génétique)</term><term>Humains</term><term>Implants dentaires</term><term>Ostéo-intégration (génétique)</term><term>Ostéogenèse (génétique)</term><term>Remodelage osseux (génétique)</term><term>Rythme circadien (génétique)</term><term>Réseaux de régulation génique (génétique)</term><term>Transcriptome (génétique)</term><term>Vitamine D (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bone Density</term><term>Bone Remodeling</term><term>Chondrogenesis</term><term>Circadian Rhythm</term><term>Gene Regulatory Networks</term><term>Osseointegration</term><term>Osteogenesis</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chondrogenèse</term><term>Densité osseuse</term><term>Ostéo-intégration</term><term>Ostéogenèse</term><term>Remodelage osseux</term><term>Rythme circadien</term><term>Réseaux de régulation génique</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vitamine D</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Implants dentaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. The success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however, the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. Radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore, implant-induced bone formation continues to be intensively investigated. Increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. This review highlights genetic networks related to bone quality, the transient chondrogenic phase, the vitamin D axis, and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Nishimura, I" sort="Nishimura, I" uniqKey="Nishimura I" first="I" last="Nishimura">I. Nishimura</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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