Genetic networks in osseointegration.
Identifieur interne : 000605 ( Ncbi/Checkpoint ); précédent : 000604; suivant : 000606Genetic networks in osseointegration.
Auteurs : I. Nishimura [États-Unis]Source :
- Journal of dental research [ 1544-0591 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Chondrogenèse, Densité osseuse, Ostéo-intégration, Ostéogenèse, Remodelage osseux, Rythme circadien, Réseaux de régulation génique, Transcriptome.
- physiologie : Vitamine D.
- Humains, Implants dentaires.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Vitamin D.
- chemical : Dental Implants.
- genetics : Bone Density, Bone Remodeling, Chondrogenesis, Circadian Rhythm, Gene Regulatory Networks, Osseointegration, Osteogenesis, Transcriptome.
- Humans.
Abstract
Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. The success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however, the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. Radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore, implant-induced bone formation continues to be intensively investigated. Increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. This review highlights genetic networks related to bone quality, the transient chondrogenic phase, the vitamin D axis, and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration.
DOI: 10.1177/0022034513504928
PubMed: 24158334
Affiliations:
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pubmed:24158334Le document en format XML
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<term>Circadian Rhythm (genetics)</term>
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<term>Gene Regulatory Networks</term>
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<front><div type="abstract" xml:lang="en">Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. The success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however, the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. Radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore, implant-induced bone formation continues to be intensively investigated. Increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. This review highlights genetic networks related to bone quality, the transient chondrogenic phase, the vitamin D axis, and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration.</div>
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