EdenteV1, Main, Exploration, bibRecord, 000767

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Identifieur interne : 000767 ( Main/Exploration ); précédent : 000766; suivant : 000768

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Auteurs : Fabian Duttenhoefer ; Stefan F. Hieber ; Andres Stricker ; Rainer Schmelzeisen ; Ralf Gutwald ; Sebastian Sauerbier

Source :

BioResearch Open Access [ 2164-7844 ] ; 2014.

RBID : PMC:3995205

Abstract

Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation.

Methods: Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R.

Results: Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (p=0.381).

Conclusion: The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995205

DOI: 10.1089/biores.2014.0003
PubMed: 24804168
PubMed Central: 3995205

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Objective:</italic>
</bold>
 Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation.</p>
<p><bold><italic>Methods:</italic>
</bold>
 Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, <italic>n</italic>
=6 sinus) or BMAC (test group, <italic>n</italic>
=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R.</p>
<p><bold><italic>Results:</italic>
</bold>
 Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (<italic>p</italic>
=0.381).</p>
<p><bold><italic>Conclusion:</italic>
</bold>
 The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration.</p>
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Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

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