Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
Identifieur interne : 000C80 ( Ncbi/Merge ); précédent : 000C79; suivant : 000C81Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
Auteurs : Fabian Duttenhoefer ; Stefan F. Hieber ; Andres Stricker ; Rainer Schmelzeisen ; Ralf Gutwald ; Sebastian SauerbierSource :
- BioResearch Open Access [ 2164-7844 ] ; 2014.
Abstract
Url:
DOI: 10.1089/biores.2014.0003
PubMed: 24804168
PubMed Central: 3995205
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans</title>
<author><name sortKey="Duttenhoefer, Fabian" sort="Duttenhoefer, Fabian" uniqKey="Duttenhoefer F" first="Fabian" last="Duttenhoefer">Fabian Duttenhoefer</name>
</author>
<author><name sortKey="Hieber, Stefan F" sort="Hieber, Stefan F" uniqKey="Hieber S" first="Stefan F." last="Hieber">Stefan F. Hieber</name>
</author>
<author><name sortKey="Stricker, Andres" sort="Stricker, Andres" uniqKey="Stricker A" first="Andres" last="Stricker">Andres Stricker</name>
</author>
<author><name sortKey="Schmelzeisen, Rainer" sort="Schmelzeisen, Rainer" uniqKey="Schmelzeisen R" first="Rainer" last="Schmelzeisen">Rainer Schmelzeisen</name>
</author>
<author><name sortKey="Gutwald, Ralf" sort="Gutwald, Ralf" uniqKey="Gutwald R" first="Ralf" last="Gutwald">Ralf Gutwald</name>
</author>
<author><name sortKey="Sauerbier, Sebastian" sort="Sauerbier, Sebastian" uniqKey="Sauerbier S" first="Sebastian" last="Sauerbier">Sebastian Sauerbier</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans</title>
<author><name sortKey="Duttenhoefer, Fabian" sort="Duttenhoefer, Fabian" uniqKey="Duttenhoefer F" first="Fabian" last="Duttenhoefer">Fabian Duttenhoefer</name>
</author>
<author><name sortKey="Hieber, Stefan F" sort="Hieber, Stefan F" uniqKey="Hieber S" first="Stefan F." last="Hieber">Stefan F. Hieber</name>
</author>
<author><name sortKey="Stricker, Andres" sort="Stricker, Andres" uniqKey="Stricker A" first="Andres" last="Stricker">Andres Stricker</name>
</author>
<author><name sortKey="Schmelzeisen, Rainer" sort="Schmelzeisen, Rainer" uniqKey="Schmelzeisen R" first="Rainer" last="Schmelzeisen">Rainer Schmelzeisen</name>
</author>
<author><name sortKey="Gutwald, Ralf" sort="Gutwald, Ralf" uniqKey="Gutwald R" first="Ralf" last="Gutwald">Ralf Gutwald</name>
</author>
<author><name sortKey="Sauerbier, Sebastian" sort="Sauerbier, Sebastian" uniqKey="Sauerbier S" first="Sebastian" last="Sauerbier">Sebastian Sauerbier</name>
</author>
</analytic>
<series><title level="j">BioResearch Open Access</title>
<idno type="ISSN">2164-7844</idno>
<idno type="eISSN">2164-7860</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Objective:</italic>
</bold>
Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation.</p>
<p><bold><italic>Methods:</italic>
</bold>
Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, <italic>n</italic>
=6 sinus) or BMAC (test group, <italic>n</italic>
=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R.</p>
<p><bold><italic>Results:</italic>
</bold>
Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (<italic>p</italic>
=0.381).</p>
<p><bold><italic>Conclusion:</italic>
</bold>
The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Duttenhoefer, F" uniqKey="Duttenhoefer F">F Duttenhoefer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smiler, D" uniqKey="Smiler D">D Smiler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sauerbier, S" uniqKey="Sauerbier S">S Sauerbier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hermann, Pc" uniqKey="Hermann P">PC Hermann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wongchuensoontorn, C" uniqKey="Wongchuensoontorn C">C Wongchuensoontorn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Therneau, Tm" uniqKey="Therneau T">TM Therneau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rickert, D" uniqKey="Rickert D">D Rickert</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biores Open Access</journal-id>
<journal-id journal-id-type="iso-abbrev">Biores Open Access</journal-id>
<journal-id journal-id-type="publisher-id">biores</journal-id>
<journal-title-group><journal-title>BioResearch Open Access</journal-title>
</journal-title-group>
<issn pub-type="ppub">2164-7844</issn>
<issn pub-type="epub">2164-7860</issn>
<publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24804168</article-id>
<article-id pub-id-type="pmc">3995205</article-id>
<article-id pub-id-type="publisher-id">10.1089/biores.2014.0003</article-id>
<article-id pub-id-type="doi">10.1089/biores.2014.0003</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Technical Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Duttenhoefer</surname>
<given-names>Fabian</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hieber</surname>
<given-names>Stefan F.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Stricker</surname>
<given-names>Andres</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Schmelzeisen</surname>
<given-names>Rainer</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Gutwald</surname>
<given-names>Ralf</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sauerbier</surname>
<given-names>Sebastian</given-names>
</name>
</contrib>
<aff id="aff1">Department of Oral and Craniomaxillofacial Surgery,<institution>University Hospital Freiburg</institution>
, Freiburg,<country>Germany</country>
.</aff>
</contrib-group>
<author-notes><corresp><addr-line>Address correspondence to:</addr-line>
<addr-line><italic>Fabian Duttenhoefer, MD</italic>
</addr-line>
<institution><italic>Universitätsklinik für Zahn-, Mund- und Kieferheilkunde</italic>
</institution>
<addr-line><italic>Abteilung Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie</italic>
</addr-line>
<addr-line><italic>Hugstetter Str. 55</italic>
</addr-line>
<addr-line><italic>D-79106 Freiburg</italic>
</addr-line>
<country>Germany</country>
<break></break>
<italic>E-mail:</italic>
<email xlink:href="mailto:fabian.duttenhoefer@uniklinik-freiburg.de">fabian.duttenhoefer@uniklinik-freiburg.de</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>4</month>
<year>2014</year>
<pmc-comment>string-date: April 2014</pmc-comment>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>4</month>
<year>2014</year>
<pmc-comment>string-date: April 2014</pmc-comment>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>3</volume>
<issue>2</issue>
<fpage>75</fpage>
<lpage>76</lpage>
<permissions><copyright-statement>Copyright 2014, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="biores.2014.0003.pdf"></self-uri>
<abstract><title>Abstract</title>
<p><bold><italic>Objective:</italic>
</bold>
Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation.</p>
<p><bold><italic>Methods:</italic>
</bold>
Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, <italic>n</italic>
=6 sinus) or BMAC (test group, <italic>n</italic>
=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R.</p>
<p><bold><italic>Results:</italic>
</bold>
Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (<italic>p</italic>
=0.381).</p>
<p><bold><italic>Conclusion:</italic>
</bold>
The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration.</p>
</abstract>
<kwd-group kwd-group-type="author"><title><bold>Key words:</bold>
</title>
<kwd>biomaterials</kwd>
<kwd>cell culture</kwd>
<kwd>tissue engineering</kwd>
</kwd-group>
<counts><fig-count count="1"></fig-count>
<ref-count count="8"></ref-count>
<page-count count="2"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Duttenhoefer, Fabian" sort="Duttenhoefer, Fabian" uniqKey="Duttenhoefer F" first="Fabian" last="Duttenhoefer">Fabian Duttenhoefer</name>
<name sortKey="Gutwald, Ralf" sort="Gutwald, Ralf" uniqKey="Gutwald R" first="Ralf" last="Gutwald">Ralf Gutwald</name>
<name sortKey="Hieber, Stefan F" sort="Hieber, Stefan F" uniqKey="Hieber S" first="Stefan F." last="Hieber">Stefan F. Hieber</name>
<name sortKey="Sauerbier, Sebastian" sort="Sauerbier, Sebastian" uniqKey="Sauerbier S" first="Sebastian" last="Sauerbier">Sebastian Sauerbier</name>
<name sortKey="Schmelzeisen, Rainer" sort="Schmelzeisen, Rainer" uniqKey="Schmelzeisen R" first="Rainer" last="Schmelzeisen">Rainer Schmelzeisen</name>
<name sortKey="Stricker, Andres" sort="Stricker, Andres" uniqKey="Stricker A" first="Andres" last="Stricker">Andres Stricker</name>
</noCountry>
</tree>
</affiliations>
</record>
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