Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.
Identifieur interne : 000475 ( PubMed/Corpus ); précédent : 000474; suivant : 000476Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.
Auteurs : Fang Liu ; Aifang Xu ; Yan Zhang ; Weiling Xuan ; Tingbo Yan ; Kenv Pan ; Wenyan Yu ; Jun ZhangSource :
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [ 1878-3511 ] ; 2020.
Abstract
To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir.
DOI: 10.1016/j.ijid.2020.03.013
PubMed: 32173576
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.</title><author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Aifang" sort="Xu, Aifang" uniqKey="Xu A" first="Aifang" last="Xu">Aifang Xu</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yan" sort="Zhang, Yan" uniqKey="Zhang Y" first="Yan" last="Zhang">Yan Zhang</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xuan, Weiling" sort="Xuan, Weiling" uniqKey="Xuan W" first="Weiling" last="Xuan">Weiling Xuan</name><affiliation><nlm:affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Tingbo" sort="Yan, Tingbo" uniqKey="Yan T" first="Tingbo" last="Yan">Tingbo Yan</name><affiliation><nlm:affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pan, Kenv" sort="Pan, Kenv" uniqKey="Pan K" first="Kenv" last="Pan">Kenv Pan</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Wenyan" sort="Yu, Wenyan" uniqKey="Yu W" first="Wenyan" last="Yu">Wenyan Yu</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: jameszhang2000@zju.edu.cn.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32173576</idno><idno type="pmid">32173576</idno><idno type="doi">10.1016/j.ijid.2020.03.013</idno><idno type="wicri:Area/PubMed/Corpus">000475</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000475</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.</title><author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Aifang" sort="Xu, Aifang" uniqKey="Xu A" first="Aifang" last="Xu">Aifang Xu</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yan" sort="Zhang, Yan" uniqKey="Zhang Y" first="Yan" last="Zhang">Yan Zhang</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xuan, Weiling" sort="Xuan, Weiling" uniqKey="Xuan W" first="Weiling" last="Xuan">Weiling Xuan</name><affiliation><nlm:affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Tingbo" sort="Yan, Tingbo" uniqKey="Yan T" first="Tingbo" last="Yan">Tingbo Yan</name><affiliation><nlm:affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pan, Kenv" sort="Pan, Kenv" uniqKey="Pan K" first="Kenv" last="Pan">Kenv Pan</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Wenyan" sort="Yu, Wenyan" uniqKey="Yu W" first="Wenyan" last="Yu">Wenyan Yu</name><affiliation><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: jameszhang2000@zju.edu.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title><idno type="eISSN">1878-3511</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32173576</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3511</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>12</Day></PubDate></JournalIssue><Title>International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</Title><ISOAbbreviation>Int. J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1201-9712(20)30132-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijid.2020.03.013</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We collected data from ten COVID-19 patients admitted between January 22, 2020 and February 11, 2020 at Xixi hospital in Hangzhou, China.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of ten patients, secondary, tertiary and quartus patients emerged, the incubation period was 3-7 days. Mainly initial symptoms were cough and low fever (37.3-38.0 ℃). An asymptomatic case presented normal radiography, the others existed ground glass opacities. All cases (three transferred, seven discharged) exposed to lopinavir on initial hospitalization. Three patients stopped lopinavir using because of adverse effect, two of them deteriorated, one hospitalized longer than others who with sustained lopinavir using. Levels of potassium, albumin, lymphocyte were low, but increased persistently after treatment. Eosinophil values were low on initial hospitalization, then all returned to normal before discharge. Viral load of SARS-CoV-2, radiography and eosinophil improved continuously in 3-14, 6-8 and 7-9 days, respectively.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Increasing eosinophils may be an indicator of COVID-19 improvement. The COVID-19 patients may benefit from sustained lopinavir using. More researches on a larger scale are needed to verify these points.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Fang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Aifang</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xuan</LastName><ForeName>Weiling</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Tingbo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>Kenv</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Wenyan</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: jameszhang2000@zju.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>Int J Infect Dis</MedlineTA><NlmUniqueID>9610933</NlmUniqueID><ISSNLinking>1201-9712</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">2019-Coronavirus disease</Keyword><Keyword MajorTopicYN="N">Asymptomatic infection</Keyword><Keyword MajorTopicYN="N">Eosinophil</Keyword><Keyword MajorTopicYN="N">Lopinavir</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>02</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32173576</ArticleId><ArticleId IdType="pii">S1201-9712(20)30132-6</ArticleId><ArticleId IdType="doi">10.1016/j.ijid.2020.03.013</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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