Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.
Identifieur interne : 000474 ( PubMed/Corpus ); précédent : 000473; suivant : 000475Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.
Auteurs : Pingzheng Mo ; Yuanyuan Xing ; Yu Xiao ; Liping Deng ; Qiu Zhao ; Hongling Wang ; Yong Xiong ; Zhenshun Cheng ; Shicheng Gao ; Ke Liang ; Mingqi Luo ; Tielong Chen ; Shihui Song ; Zhiyong Ma ; Xiaoping Chen ; Ruiying Zheng ; Qian Cao ; Fan Wang ; Yongxi ZhangSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.
DOI: 10.1093/cid/ciaa270
PubMed: 32173725
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.</title><author><name sortKey="Mo, Pingzheng" sort="Mo, Pingzheng" uniqKey="Mo P" first="Pingzheng" last="Mo">Pingzheng Mo</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xing, Yuanyuan" sort="Xing, Yuanyuan" uniqKey="Xing Y" first="Yuanyuan" last="Xing">Yuanyuan Xing</name><affiliation><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiao, Yu" sort="Xiao, Yu" uniqKey="Xiao Y" first="Yu" last="Xiao">Yu Xiao</name><affiliation><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Liping" sort="Deng, Liping" uniqKey="Deng L" first="Liping" last="Deng">Liping Deng</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Qiu" sort="Zhao, Qiu" uniqKey="Zhao Q" first="Qiu" last="Zhao">Qiu Zhao</name><affiliation><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hongling" sort="Wang, Hongling" uniqKey="Wang H" first="Hongling" last="Wang">Hongling Wang</name><affiliation><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiong, Yong" sort="Xiong, Yong" uniqKey="Xiong Y" first="Yong" last="Xiong">Yong Xiong</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Zhenshun" sort="Cheng, Zhenshun" uniqKey="Cheng Z" first="Zhenshun" last="Cheng">Zhenshun Cheng</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Shicheng" sort="Gao, Shicheng" uniqKey="Gao S" first="Shicheng" last="Gao">Shicheng Gao</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liang, Ke" sort="Liang, Ke" uniqKey="Liang K" first="Ke" last="Liang">Ke Liang</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Mingqi" sort="Luo, Mingqi" uniqKey="Luo M" first="Mingqi" last="Luo">Mingqi Luo</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Tielong" sort="Chen, Tielong" uniqKey="Chen T" first="Tielong" last="Chen">Tielong Chen</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Shihui" sort="Song, Shihui" uniqKey="Song S" first="Shihui" last="Song">Shihui Song</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Zhiyong" sort="Ma, Zhiyong" uniqKey="Ma Z" first="Zhiyong" last="Ma">Zhiyong Ma</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Xiaoping" sort="Chen, Xiaoping" uniqKey="Chen X" first="Xiaoping" last="Chen">Xiaoping Chen</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Ruiying" sort="Zheng, Ruiying" uniqKey="Zheng R" first="Ruiying" last="Zheng">Ruiying Zheng</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Qian" sort="Cao, Qian" uniqKey="Cao Q" first="Qian" last="Cao">Qian Cao</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Fan" sort="Wang, Fan" uniqKey="Wang F" first="Fan" last="Wang">Fan Wang</name><affiliation><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yongxi" sort="Zhang, Yongxi" uniqKey="Zhang Y" first="Yongxi" last="Zhang">Yongxi Zhang</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32173725</idno><idno type="pmid">32173725</idno><idno type="doi">10.1093/cid/ciaa270</idno><idno type="wicri:Area/PubMed/Corpus">000474</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000474</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.</title><author><name sortKey="Mo, Pingzheng" sort="Mo, Pingzheng" uniqKey="Mo P" first="Pingzheng" last="Mo">Pingzheng Mo</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xing, Yuanyuan" sort="Xing, Yuanyuan" uniqKey="Xing Y" first="Yuanyuan" last="Xing">Yuanyuan Xing</name><affiliation><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiao, Yu" sort="Xiao, Yu" uniqKey="Xiao Y" first="Yu" last="Xiao">Yu Xiao</name><affiliation><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Liping" sort="Deng, Liping" uniqKey="Deng L" first="Liping" last="Deng">Liping Deng</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Qiu" sort="Zhao, Qiu" uniqKey="Zhao Q" first="Qiu" last="Zhao">Qiu Zhao</name><affiliation><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hongling" sort="Wang, Hongling" uniqKey="Wang H" first="Hongling" last="Wang">Hongling Wang</name><affiliation><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiong, Yong" sort="Xiong, Yong" uniqKey="Xiong Y" first="Yong" last="Xiong">Yong Xiong</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Zhenshun" sort="Cheng, Zhenshun" uniqKey="Cheng Z" first="Zhenshun" last="Cheng">Zhenshun Cheng</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Shicheng" sort="Gao, Shicheng" uniqKey="Gao S" first="Shicheng" last="Gao">Shicheng Gao</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liang, Ke" sort="Liang, Ke" uniqKey="Liang K" first="Ke" last="Liang">Ke Liang</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Mingqi" sort="Luo, Mingqi" uniqKey="Luo M" first="Mingqi" last="Luo">Mingqi Luo</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Tielong" sort="Chen, Tielong" uniqKey="Chen T" first="Tielong" last="Chen">Tielong Chen</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Shihui" sort="Song, Shihui" uniqKey="Song S" first="Shihui" last="Song">Shihui Song</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Zhiyong" sort="Ma, Zhiyong" uniqKey="Ma Z" first="Zhiyong" last="Ma">Zhiyong Ma</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Xiaoping" sort="Chen, Xiaoping" uniqKey="Chen X" first="Xiaoping" last="Chen">Xiaoping Chen</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Ruiying" sort="Zheng, Ruiying" uniqKey="Zheng R" first="Ruiying" last="Zheng">Ruiying Zheng</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Qian" sort="Cao, Qian" uniqKey="Cao Q" first="Qian" last="Cao">Qian Cao</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Fan" sort="Wang, Fan" uniqKey="Wang F" first="Fan" last="Wang">Fan Wang</name><affiliation><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yongxi" sort="Zhang, Yongxi" uniqKey="Zhang Y" first="Yongxi" last="Zhang">Yongxi Zhang</name><affiliation><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32173725</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>16</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa270</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa270</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this retrospective single-center study, we included 155 consecutive patients with confirmed COVID-19 in Zhongnan Hospital of Wuhan University from January 1st to February 5th. The cases were divided into general and refractory COVID-19 groups according to the clinical efficacy after hospitalization, and the difference between groups were compared.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with general COVID-19 patients (45.2%), refractory patients had an older age, male sex, more underlying comorbidities, lower incidence of fever, higher levels of maximum temperature among fever cases, higher incidence of breath shortness and anorexia, severer disease assessment on admission, high levels of neutrophil, aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and C-reactive protein, lower levels of platelets and albumin, and higher incidence of bilateral pneumonia and pleural effusion (P<0.05). Refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, and adjunctive treatment including corticosteroid, antiviral drugs and immune enhancer (P<0.05). After adjustment, those with refractory COVID-19 were also more likely to have a male sex and manifestations of anorexia and fever on admission, and receive oxygen, expectorant and adjunctive agents (P<0.05) when considering the factors of disease severity on admission, mechanical ventilation, and ICU transfer.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization. The patients with male sex, anorexia and no fever on admission predicted poor efficacy.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mo</LastName><ForeName>Pingzheng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Yuanyuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Liping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Qiu</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hongling</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Yong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Zhenshun</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Shicheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Ke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Mingqi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Tielong</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Shihui</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Zhiyong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiaoping</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Ruiying</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Fan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yongxi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">clinical efficacy</Keyword><Keyword MajorTopicYN="N">predictors</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32173725</ArticleId><ArticleId IdType="pii">5805508</ArticleId><ArticleId IdType="doi">10.1093/cid/ciaa270</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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