Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.
Identifieur interne : 000949 ( PubMed/Checkpoint ); précédent : 000948; suivant : 000950Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.
Auteurs : Pingzheng Mo [République populaire de Chine] ; Yuanyuan Xing [République populaire de Chine] ; Yu Xiao [République populaire de Chine] ; Liping Deng [République populaire de Chine] ; Qiu Zhao [République populaire de Chine] ; Hongling Wang [République populaire de Chine] ; Yong Xiong [République populaire de Chine] ; Zhenshun Cheng [République populaire de Chine] ; Shicheng Gao [République populaire de Chine] ; Ke Liang [République populaire de Chine] ; Mingqi Luo [République populaire de Chine] ; Tielong Chen [République populaire de Chine] ; Shihui Song [République populaire de Chine] ; Zhiyong Ma [République populaire de Chine] ; Xiaoping Chen [République populaire de Chine] ; Ruiying Zheng [République populaire de Chine] ; Qian Cao [République populaire de Chine] ; Fan Wang [République populaire de Chine] ; Yongxi Zhang [République populaire de Chine]Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.
DOI: 10.1093/cid/ciaa270
PubMed: 32173725
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.</title><author><name sortKey="Mo, Pingzheng" sort="Mo, Pingzheng" uniqKey="Mo P" first="Pingzheng" last="Mo">Pingzheng Mo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xing, Yuanyuan" sort="Xing, Yuanyuan" uniqKey="Xing Y" first="Yuanyuan" last="Xing">Yuanyuan Xing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xiao, Yu" sort="Xiao, Yu" uniqKey="Xiao Y" first="Yu" last="Xiao">Yu Xiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Liping" sort="Deng, Liping" uniqKey="Deng L" first="Liping" last="Deng">Liping Deng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Qiu" sort="Zhao, Qiu" uniqKey="Zhao Q" first="Qiu" last="Zhao">Qiu Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Hongling" sort="Wang, Hongling" uniqKey="Wang H" first="Hongling" last="Wang">Hongling Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Yong" sort="Xiong, Yong" uniqKey="Xiong Y" first="Yong" last="Xiong">Yong Xiong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Zhenshun" sort="Cheng, Zhenshun" uniqKey="Cheng Z" first="Zhenshun" last="Cheng">Zhenshun Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Shicheng" sort="Gao, Shicheng" uniqKey="Gao S" first="Shicheng" last="Gao">Shicheng Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Ke" sort="Liang, Ke" uniqKey="Liang K" first="Ke" last="Liang">Ke Liang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Mingqi" sort="Luo, Mingqi" uniqKey="Luo M" first="Mingqi" last="Luo">Mingqi Luo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Tielong" sort="Chen, Tielong" uniqKey="Chen T" first="Tielong" last="Chen">Tielong Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Song, Shihui" sort="Song, Shihui" uniqKey="Song S" first="Shihui" last="Song">Shihui Song</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Zhiyong" sort="Ma, Zhiyong" uniqKey="Ma Z" first="Zhiyong" last="Ma">Zhiyong Ma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xiaoping" sort="Chen, Xiaoping" uniqKey="Chen X" first="Xiaoping" last="Chen">Xiaoping Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Ruiying" sort="Zheng, Ruiying" uniqKey="Zheng R" first="Ruiying" last="Zheng">Ruiying Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Qian" sort="Cao, Qian" uniqKey="Cao Q" first="Qian" last="Cao">Qian Cao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Fan" sort="Wang, Fan" uniqKey="Wang F" first="Fan" last="Wang">Fan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yongxi" sort="Zhang, Yongxi" uniqKey="Zhang Y" first="Yongxi" last="Zhang">Yongxi Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32173725</idno><idno type="pmid">32173725</idno><idno type="doi">10.1093/cid/ciaa270</idno><idno type="wicri:Area/PubMed/Corpus">000474</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000474</idno><idno type="wicri:Area/PubMed/Curation">000474</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000474</idno><idno type="wicri:Area/PubMed/Checkpoint">000949</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000949</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.</title><author><name sortKey="Mo, Pingzheng" sort="Mo, Pingzheng" uniqKey="Mo P" first="Pingzheng" last="Mo">Pingzheng Mo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xing, Yuanyuan" sort="Xing, Yuanyuan" uniqKey="Xing Y" first="Yuanyuan" last="Xing">Yuanyuan Xing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xiao, Yu" sort="Xiao, Yu" uniqKey="Xiao Y" first="Yu" last="Xiao">Yu Xiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Liping" sort="Deng, Liping" uniqKey="Deng L" first="Liping" last="Deng">Liping Deng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Qiu" sort="Zhao, Qiu" uniqKey="Zhao Q" first="Qiu" last="Zhao">Qiu Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Hongling" sort="Wang, Hongling" uniqKey="Wang H" first="Hongling" last="Wang">Hongling Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Yong" sort="Xiong, Yong" uniqKey="Xiong Y" first="Yong" last="Xiong">Yong Xiong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Zhenshun" sort="Cheng, Zhenshun" uniqKey="Cheng Z" first="Zhenshun" last="Cheng">Zhenshun Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Shicheng" sort="Gao, Shicheng" uniqKey="Gao S" first="Shicheng" last="Gao">Shicheng Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Ke" sort="Liang, Ke" uniqKey="Liang K" first="Ke" last="Liang">Ke Liang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Mingqi" sort="Luo, Mingqi" uniqKey="Luo M" first="Mingqi" last="Luo">Mingqi Luo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Tielong" sort="Chen, Tielong" uniqKey="Chen T" first="Tielong" last="Chen">Tielong Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Song, Shihui" sort="Song, Shihui" uniqKey="Song S" first="Shihui" last="Song">Shihui Song</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Zhiyong" sort="Ma, Zhiyong" uniqKey="Ma Z" first="Zhiyong" last="Ma">Zhiyong Ma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xiaoping" sort="Chen, Xiaoping" uniqKey="Chen X" first="Xiaoping" last="Chen">Xiaoping Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Ruiying" sort="Zheng, Ruiying" uniqKey="Zheng R" first="Ruiying" last="Zheng">Ruiying Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Qian" sort="Cao, Qian" uniqKey="Cao Q" first="Qian" last="Cao">Qian Cao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Fan" sort="Wang, Fan" uniqKey="Wang F" first="Fan" last="Wang">Fan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yongxi" sort="Zhang, Yongxi" uniqKey="Zhang Y" first="Yongxi" last="Zhang">Yongxi Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32173725</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>16</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa270</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa270</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this retrospective single-center study, we included 155 consecutive patients with confirmed COVID-19 in Zhongnan Hospital of Wuhan University from January 1st to February 5th. The cases were divided into general and refractory COVID-19 groups according to the clinical efficacy after hospitalization, and the difference between groups were compared.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with general COVID-19 patients (45.2%), refractory patients had an older age, male sex, more underlying comorbidities, lower incidence of fever, higher levels of maximum temperature among fever cases, higher incidence of breath shortness and anorexia, severer disease assessment on admission, high levels of neutrophil, aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and C-reactive protein, lower levels of platelets and albumin, and higher incidence of bilateral pneumonia and pleural effusion (P<0.05). Refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, and adjunctive treatment including corticosteroid, antiviral drugs and immune enhancer (P<0.05). After adjustment, those with refractory COVID-19 were also more likely to have a male sex and manifestations of anorexia and fever on admission, and receive oxygen, expectorant and adjunctive agents (P<0.05) when considering the factors of disease severity on admission, mechanical ventilation, and ICU transfer.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization. The patients with male sex, anorexia and no fever on admission predicted poor efficacy.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mo</LastName><ForeName>Pingzheng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Yuanyuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Liping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Qiu</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hongling</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Yong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Zhenshun</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Shicheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Ke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Mingqi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Tielong</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Shihui</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Zhiyong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiaoping</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Ruiying</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Fan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yongxi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">clinical efficacy</Keyword><Keyword MajorTopicYN="N">predictors</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32173725</ArticleId><ArticleId IdType="pii">5805508</ArticleId><ArticleId IdType="doi">10.1093/cid/ciaa270</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Mo, Pingzheng" sort="Mo, Pingzheng" uniqKey="Mo P" first="Pingzheng" last="Mo">Pingzheng Mo</name></noRegion><name sortKey="Cao, Qian" sort="Cao, Qian" uniqKey="Cao Q" first="Qian" last="Cao">Qian Cao</name><name sortKey="Chen, Tielong" sort="Chen, Tielong" uniqKey="Chen T" first="Tielong" last="Chen">Tielong Chen</name><name sortKey="Chen, Xiaoping" sort="Chen, Xiaoping" uniqKey="Chen X" first="Xiaoping" last="Chen">Xiaoping Chen</name><name sortKey="Cheng, Zhenshun" sort="Cheng, Zhenshun" uniqKey="Cheng Z" first="Zhenshun" last="Cheng">Zhenshun Cheng</name><name sortKey="Deng, Liping" sort="Deng, Liping" uniqKey="Deng L" first="Liping" last="Deng">Liping Deng</name><name sortKey="Gao, Shicheng" sort="Gao, Shicheng" uniqKey="Gao S" first="Shicheng" last="Gao">Shicheng Gao</name><name sortKey="Liang, Ke" sort="Liang, Ke" uniqKey="Liang K" first="Ke" last="Liang">Ke Liang</name><name sortKey="Luo, Mingqi" sort="Luo, Mingqi" uniqKey="Luo M" first="Mingqi" last="Luo">Mingqi Luo</name><name sortKey="Ma, Zhiyong" sort="Ma, Zhiyong" uniqKey="Ma Z" first="Zhiyong" last="Ma">Zhiyong Ma</name><name sortKey="Song, Shihui" sort="Song, Shihui" uniqKey="Song S" first="Shihui" last="Song">Shihui Song</name><name sortKey="Wang, Fan" sort="Wang, Fan" uniqKey="Wang F" first="Fan" last="Wang">Fan Wang</name><name sortKey="Wang, Hongling" sort="Wang, Hongling" uniqKey="Wang H" first="Hongling" last="Wang">Hongling Wang</name><name sortKey="Xiao, Yu" sort="Xiao, Yu" uniqKey="Xiao Y" first="Yu" last="Xiao">Yu Xiao</name><name sortKey="Xing, Yuanyuan" sort="Xing, Yuanyuan" uniqKey="Xing Y" first="Yuanyuan" last="Xing">Yuanyuan Xing</name><name sortKey="Xiong, Yong" sort="Xiong, Yong" uniqKey="Xiong Y" first="Yong" last="Xiong">Yong Xiong</name><name sortKey="Zhang, Yongxi" sort="Zhang, Yongxi" uniqKey="Zhang Y" first="Yongxi" last="Zhang">Yongxi Zhang</name><name sortKey="Zhao, Qiu" sort="Zhao, Qiu" uniqKey="Zhao Q" first="Qiu" last="Zhao">Qiu Zhao</name><name sortKey="Zheng, Ruiying" sort="Zheng, Ruiying" uniqKey="Zheng R" first="Ruiying" last="Zheng">Ruiying 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