CovidV2, PubMed, Checkpoint, bibRecord, 000655

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.

Identifieur interne : 000655 ( PubMed/Checkpoint ); précédent : 000654; suivant : 000656

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.

Auteurs : Hao Xu [République populaire de Chine] ; Liang Zhong [République populaire de Chine] ; Jiaxin Deng [République populaire de Chine] ; Jiakuan Peng [République populaire de Chine] ; Hongxia Dan [République populaire de Chine] ; Xin Zeng [République populaire de Chine] ; Taiwen Li [République populaire de Chine] ; Qianming Chen [République populaire de Chine]

Source :

International journal of oral science [ 2049-3169 ] ; 2020.

RBID : pubmed:32094336

Descripteurs français

KwdFr :
- Analyse de profil d'expression de gènes, Bases de données génétiques, Cellules épithéliales (métabolisme), Cellules épithéliales (virologie), Humains, Infections à coronavirus (génétique), Infections à coronavirus (transmission), Langue (métabolisme), Langue (virologie), Muqueuse de la bouche (enzymologie), Muqueuse de la bouche (virologie), Peptidyl-Dipeptidase A (métabolisme), Pneumopathie virale (génétique), Pneumopathie virale (transmission).
MESH :
- enzymologie : Muqueuse de la bouche.
- génétique : Infections à coronavirus, Pneumopathie virale.
- métabolisme : Cellules épithéliales, Langue, Peptidyl-Dipeptidase A.
- virologie : Cellules épithéliales, Langue, Muqueuse de la bouche.
- transmission : Analyse de profil d'expression de gènes, Bases de données génétiques, Humains, Infections à coronavirus, Pneumopathie virale.

English descriptors

KwdEn :
- Betacoronavirus (pathogenicity), Coronavirus Infections (genetics), Coronavirus Infections (transmission), Databases, Genetic, Epithelial Cells (metabolism), Epithelial Cells (virology), Gene Expression Profiling, Humans, Mouth Mucosa (enzymology), Mouth Mucosa (virology), Peptidyl-Dipeptidase A (metabolism), Pneumonia, Viral (genetics), Pneumonia, Viral (transmission), Tongue (metabolism), Tongue (virology).
MESH :
- chemical , metabolism : Peptidyl-Dipeptidase A.
- enzymology : Mouth Mucosa.
- genetics : Coronavirus Infections, Pneumonia, Viral.
- metabolism : Epithelial Cells, Tongue.
- pathogenicity : Betacoronavirus.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- virology : Epithelial Cells, Mouth Mucosa, Tongue.
- Databases, Genetic, Gene Expression Profiling, Humans.

Abstract

It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.

DOI: 10.1038/s41368-020-0074-x
PubMed: 32094336

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000A39
to stream PubMed, to step Curation: 000A39

Links to Exploration step

pubmed:32094336

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.</title>
<author><name sortKey="Xu, Hao" sort="Xu, Hao" uniqKey="Xu H" first="Hao" last="Xu">Hao Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhong, Liang" sort="Zhong, Liang" uniqKey="Zhong L" first="Liang" last="Zhong">Liang Zhong</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deng, Jiaxin" sort="Deng, Jiaxin" uniqKey="Deng J" first="Jiaxin" last="Deng">Jiaxin Deng</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peng, Jiakuan" sort="Peng, Jiakuan" uniqKey="Peng J" first="Jiakuan" last="Peng">Jiakuan Peng</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dan, Hongxia" sort="Dan, Hongxia" uniqKey="Dan H" first="Hongxia" last="Dan">Hongxia Dan</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zeng, Xin" sort="Zeng, Xin" uniqKey="Zeng X" first="Xin" last="Zeng">Xin Zeng</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Taiwen" sort="Li, Taiwen" uniqKey="Li T" first="Taiwen" last="Li">Taiwen Li</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. litaiwen@scu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Qianming" sort="Chen, Qianming" uniqKey="Chen Q" first="Qianming" last="Chen">Qianming Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32094336</idno>
<idno type="pmid">32094336</idno>
<idno type="doi">10.1038/s41368-020-0074-x</idno>
<idno type="wicri:Area/PubMed/Corpus">000A39</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A39</idno>
<idno type="wicri:Area/PubMed/Curation">000A39</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A39</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000655</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000655</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.</title>
<author><name sortKey="Xu, Hao" sort="Xu, Hao" uniqKey="Xu H" first="Hao" last="Xu">Hao Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhong, Liang" sort="Zhong, Liang" uniqKey="Zhong L" first="Liang" last="Zhong">Liang Zhong</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deng, Jiaxin" sort="Deng, Jiaxin" uniqKey="Deng J" first="Jiaxin" last="Deng">Jiaxin Deng</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peng, Jiakuan" sort="Peng, Jiakuan" uniqKey="Peng J" first="Jiakuan" last="Peng">Jiakuan Peng</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dan, Hongxia" sort="Dan, Hongxia" uniqKey="Dan H" first="Hongxia" last="Dan">Hongxia Dan</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zeng, Xin" sort="Zeng, Xin" uniqKey="Zeng X" first="Xin" last="Zeng">Xin Zeng</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Taiwen" sort="Li, Taiwen" uniqKey="Li T" first="Taiwen" last="Li">Taiwen Li</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. litaiwen@scu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Qianming" sort="Chen, Qianming" uniqKey="Chen Q" first="Qianming" last="Chen">Qianming Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of oral science</title>
<idno type="eISSN">2049-3169</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (pathogenicity)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Databases, Genetic</term>
<term>Epithelial Cells (metabolism)</term>
<term>Epithelial Cells (virology)</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
<term>Mouth Mucosa (enzymology)</term>
<term>Mouth Mucosa (virology)</term>
<term>Peptidyl-Dipeptidase A (metabolism)</term>
<term>Pneumonia, Viral (genetics)</term>
<term>Pneumonia, Viral (transmission)</term>
<term>Tongue (metabolism)</term>
<term>Tongue (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Bases de données génétiques</term>
<term>Cellules épithéliales (métabolisme)</term>
<term>Cellules épithéliales (virologie)</term>
<term>Humains</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (transmission)</term>
<term>Langue (métabolisme)</term>
<term>Langue (virologie)</term>
<term>Muqueuse de la bouche (enzymologie)</term>
<term>Muqueuse de la bouche (virologie)</term>
<term>Peptidyl-Dipeptidase A (métabolisme)</term>
<term>Pneumopathie virale (génétique)</term>
<term>Pneumopathie virale (transmission)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Muqueuse de la bouche</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Mouth Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelial Cells</term>
<term>Tongue</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Langue</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Langue</term>
<term>Muqueuse de la bouche</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Epithelial Cells</term>
<term>Mouth Mucosa</term>
<term>Tongue</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Databases, Genetic</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Bases de données génétiques</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32094336</PMID>
<DateCompleted><Year>2020</Year>
<Month>03</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2049-3169</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>02</Month>
<Day>24</Day>
</PubDate>
</JournalIssue>
<Title>International journal of oral science</Title>
<ISOAbbreviation>Int J Oral Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.</ArticleTitle>
<Pagination><MedlinePgn>8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41368-020-0074-x</ELocationID>
<Abstract><AbstractText>It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Hao</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhong</LastName>
<ForeName>Liang</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deng</LastName>
<ForeName>Jiaxin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peng</LastName>
<ForeName>Jiakuan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dan</LastName>
<ForeName>Hongxia</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zeng</LastName>
<ForeName>Xin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Taiwen</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. litaiwen@scu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Qianming</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>02</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>India</Country>
<MedlineTA>Int J Oral Sci</MedlineTA>
<NlmUniqueID>101504351</NlmUniqueID>
<ISSNLinking>1674-2818</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber>
<NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber>
<NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>D</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D030541" MajorTopicYN="N">Databases, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009061" MajorTopicYN="Y">Mouth Mucosa</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014059" MajorTopicYN="Y">Tongue</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>02</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>02</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>02</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>2</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>2</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>3</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32094336</ArticleId>
<ArticleId IdType="doi">10.1038/s41368-020-0074-x</ArticleId>
<ArticleId IdType="pii">10.1038/s41368-020-0074-x</ArticleId>
<ArticleId IdType="pmc">PMC7039956</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nature. 2014 Mar 27;507(7493):462-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24670764</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2020 Feb 22;395(10224):565-574</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32007145</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2020 Feb 15;395(10223):470-473</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31986257</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 2002 Dec 4;532(1-2):107-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12459472</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Biol Evol. 2013 Apr;30(4):772-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23329690</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2005 May 31;102(22):7988-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15897467</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2020 Feb 3;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32015507</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Pathol. 2004 Jun;203(2):631-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15141377</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAMA. 2020 Feb 7;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Virol. 2020 Apr;92(4):418-423</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31967327</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Microbiol. 2016 Aug;14(8):523-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27344959</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci China Life Sci. 2020 Mar;63(3):457-460</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32009228</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 2017 Aug;591(15):2213-2225</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28524227</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>EBioMedicine. 2015 Jul 10;2(8):851-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26425691</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Cancer. 2015 Feb 1;136(3):503-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24482244</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2006 Jun;87(Pt 6):1691-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16690935</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Cancer. 2009 Feb;45(3):490-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19087901</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Oral Sci. 2011 Dec;53(4):451-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22167030</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2003 Nov 27;426(6965):450-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14647384</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Hao" sort="Xu, Hao" uniqKey="Xu H" first="Hao" last="Xu">Hao Xu</name>
</noRegion>
<name sortKey="Chen, Qianming" sort="Chen, Qianming" uniqKey="Chen Q" first="Qianming" last="Chen">Qianming Chen</name>
<name sortKey="Dan, Hongxia" sort="Dan, Hongxia" uniqKey="Dan H" first="Hongxia" last="Dan">Hongxia Dan</name>
<name sortKey="Deng, Jiaxin" sort="Deng, Jiaxin" uniqKey="Deng J" first="Jiaxin" last="Deng">Jiaxin Deng</name>
<name sortKey="Li, Taiwen" sort="Li, Taiwen" uniqKey="Li T" first="Taiwen" last="Li">Taiwen Li</name>
<name sortKey="Peng, Jiakuan" sort="Peng, Jiakuan" uniqKey="Peng J" first="Jiakuan" last="Peng">Jiakuan Peng</name>
<name sortKey="Zeng, Xin" sort="Zeng, Xin" uniqKey="Zeng X" first="Xin" last="Zeng">Xin Zeng</name>
<name sortKey="Zhong, Liang" sort="Zhong, Liang" uniqKey="Zhong L" first="Liang" last="Zhong">Liang Zhong</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000655 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000655 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    CovidV2
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:32094336
   |texte=   High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:32094336" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidV2

This area was generated with Dilib version V0.6.33.
Data generation: Sat Mar 28 17:51:24 2020. Site generation: Sun Jan 31 15:35:48 2021

	Serveur d'exploration Covid (26 mars)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Covid (26 mars)

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki