High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.
Identifieur interne : 000A39 ( PubMed/Curation ); précédent : 000A38; suivant : 000A40High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.
Auteurs : Hao Xu [République populaire de Chine] ; Liang Zhong [République populaire de Chine] ; Jiaxin Deng [République populaire de Chine] ; Jiakuan Peng [République populaire de Chine] ; Hongxia Dan [République populaire de Chine] ; Xin Zeng [République populaire de Chine] ; Taiwen Li [République populaire de Chine] ; Qianming Chen [République populaire de Chine]Source :
- International journal of oral science [ 2049-3169 ] ; 2020.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Bases de données génétiques, Cellules épithéliales (métabolisme), Cellules épithéliales (virologie), Humains, Infections à coronavirus (génétique), Infections à coronavirus (transmission), Langue (métabolisme), Langue (virologie), Muqueuse de la bouche (enzymologie), Muqueuse de la bouche (virologie), Peptidyl-Dipeptidase A (métabolisme), Pneumopathie virale (génétique), Pneumopathie virale (transmission).
- MESH :
- enzymologie : Muqueuse de la bouche.
- génétique : Infections à coronavirus, Pneumopathie virale.
- métabolisme : Cellules épithéliales, Langue, Peptidyl-Dipeptidase A.
- virologie : Cellules épithéliales, Langue, Muqueuse de la bouche.
- transmission : Analyse de profil d'expression de gènes, Bases de données génétiques, Humains, Infections à coronavirus, Pneumopathie virale.
English descriptors
- KwdEn :
- Betacoronavirus (pathogenicity), Coronavirus Infections (genetics), Coronavirus Infections (transmission), Databases, Genetic, Epithelial Cells (metabolism), Epithelial Cells (virology), Gene Expression Profiling, Humans, Mouth Mucosa (enzymology), Mouth Mucosa (virology), Peptidyl-Dipeptidase A (metabolism), Pneumonia, Viral (genetics), Pneumonia, Viral (transmission), Tongue (metabolism), Tongue (virology).
- MESH :
- chemical , metabolism : Peptidyl-Dipeptidase A.
- enzymology : Mouth Mucosa.
- genetics : Coronavirus Infections, Pneumonia, Viral.
- metabolism : Epithelial Cells, Tongue.
- pathogenicity : Betacoronavirus.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- virology : Epithelial Cells, Mouth Mucosa, Tongue.
- Databases, Genetic, Gene Expression Profiling, Humans.
Abstract
It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.
DOI: 10.1038/s41368-020-0074-x
PubMed: 32094336
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<term>Databases, Genetic</term>
<term>Epithelial Cells (metabolism)</term>
<term>Epithelial Cells (virology)</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
<term>Mouth Mucosa (enzymology)</term>
<term>Mouth Mucosa (virology)</term>
<term>Peptidyl-Dipeptidase A (metabolism)</term>
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<front><div type="abstract" xml:lang="en">It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.</div>
</front>
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<Title>International journal of oral science</Title>
<ISOAbbreviation>Int J Oral Sci</ISOAbbreviation>
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<ArticleTitle>High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.</ArticleTitle>
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<Abstract><AbstractText>It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.</AbstractText>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.</Affiliation>
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