Host restriction factors for hepatitis C virus
Identifieur interne : 000050 ( Pmc/Curation ); précédent : 000049; suivant : 000051Host restriction factors for hepatitis C virus
Auteurs : Li-Ya Zhou ; Lei-Liang ZhangSource :
- World Journal of Gastroenterology [ 1007-9327 ] ; 2016.
Abstract
Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.
Url:
DOI: 10.3748/wjg.v22.i4.1477
PubMed: 26819515
PubMed Central: 4721981
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<front><div type="abstract" xml:lang="en"><p>Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id>
<journal-id journal-id-type="iso-abbrev">World J. Gastroenterol</journal-id>
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<journal-title-group><journal-title>World Journal of Gastroenterology</journal-title>
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<issn pub-type="ppub">1007-9327</issn>
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<publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name>
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<title-group><article-title>Host restriction factors for hepatitis C virus</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Zhou</surname>
<given-names>Li-Ya</given-names>
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<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Lei-Liang</given-names>
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<aff>Li-Ya Zhou, Lei-Liang Zhang, MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China</aff>
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<author-notes><fn><p>Author contributions: Zhou LY and Zhang LL analyzed the literature and wrote the manuscript.</p>
<p>Correspondence to: Lei-Liang Zhang, PhD, MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9, Dongdan Santiao, Dongcheng District, Beijing 100730, China. <email>armzhang@hotmail.com</email>
</p>
<p>Telephone: +86-10-67837355 Fax: +86-10-67837132</p>
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<pub-date pub-type="ppub"><day>28</day>
<month>1</month>
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<volume>22</volume>
<issue>4</issue>
<fpage>1477</fpage>
<lpage>1486</lpage>
<history><date date-type="received"><day>28</day>
<month>4</month>
<year>2015</year>
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<date date-type="rev-recd"><day>30</day>
<month>9</month>
<year>2015</year>
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<date date-type="accepted"><day>13</day>
<month>11</month>
<year>2015</year>
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<permissions><copyright-statement>©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement>
<copyright-year>2016</copyright-year>
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<abstract><p>Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.</p>
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<kwd-group><kwd>Hepatitis C virus</kwd>
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