Host restriction factors for hepatitis C virus
Identifieur interne : 000050 ( Pmc/Corpus ); précédent : 000049; suivant : 000051Host restriction factors for hepatitis C virus
Auteurs : Li-Ya Zhou ; Lei-Liang ZhangSource :
- World Journal of Gastroenterology [ 1007-9327 ] ; 2016.
Abstract
Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.
Url:
DOI: 10.3748/wjg.v22.i4.1477
PubMed: 26819515
PubMed Central: 4721981
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Host restriction factors for hepatitis C virus</title><author><name sortKey="Zhou, Li Ya" sort="Zhou, Li Ya" uniqKey="Zhou L" first="Li-Ya" last="Zhou">Li-Ya Zhou</name></author><author><name sortKey="Zhang, Lei Liang" sort="Zhang, Lei Liang" uniqKey="Zhang L" first="Lei-Liang" last="Zhang">Lei-Liang Zhang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26819515</idno><idno type="pmc">4721981</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721981</idno><idno type="RBID">PMC:4721981</idno><idno type="doi">10.3748/wjg.v22.i4.1477</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000050</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Host restriction factors for hepatitis C virus</title><author><name sortKey="Zhou, Li Ya" sort="Zhou, Li Ya" uniqKey="Zhou L" first="Li-Ya" last="Zhou">Li-Ya Zhou</name></author><author><name sortKey="Zhang, Lei Liang" sort="Zhang, Lei Liang" uniqKey="Zhang L" first="Lei-Liang" last="Zhang">Lei-Liang Zhang</name></author></analytic><series><title level="j">World Journal of Gastroenterology</title><idno type="ISSN">1007-9327</idno><idno type="eISSN">2219-2840</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id><journal-id journal-id-type="iso-abbrev">World J. Gastroenterol</journal-id><journal-id journal-id-type="publisher-id">WJG</journal-id><journal-title-group><journal-title>World Journal of Gastroenterology</journal-title></journal-title-group><issn pub-type="ppub">1007-9327</issn><issn pub-type="epub">2219-2840</issn><publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26819515</article-id><article-id pub-id-type="pmc">4721981</article-id><article-id pub-id-type="other">jWJG.v22.i4.pg1477</article-id><article-id pub-id-type="doi">10.3748/wjg.v22.i4.1477</article-id><article-categories><subj-group subj-group-type="heading"><subject>Topic Highlight</subject></subj-group></article-categories><title-group><article-title>Host restriction factors for hepatitis C virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Li-Ya</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Lei-Liang</given-names></name></contrib><aff>Li-Ya Zhou, Lei-Liang Zhang, MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China</aff></contrib-group><author-notes><fn><p>Author contributions: Zhou LY and Zhang LL analyzed the literature and wrote the manuscript.</p><p>Correspondence to: Lei-Liang Zhang, PhD, MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9, Dongdan Santiao, Dongcheng District, Beijing 100730, China. <email>armzhang@hotmail.com</email></p><p>Telephone: +86-10-67837355 Fax: +86-10-67837132</p></fn></author-notes><pub-date pub-type="ppub"><day>28</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>1</month><year>2016</year></pub-date><volume>22</volume><issue>4</issue><fpage>1477</fpage><lpage>1486</lpage><history><date date-type="received"><day>28</day><month>4</month><year>2015</year></date><date date-type="rev-recd"><day>30</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>13</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year></permissions><abstract><p>Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.</p></abstract><kwd-group><kwd>Hepatitis C virus</kwd><kwd>Host restriction factor</kwd><kwd>Interferon</kwd><kwd>Entry</kwd><kwd>Replication</kwd><kwd>Propagation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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