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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models</title><author><name sortKey="Hansson, A S" sort="Hansson, A S" uniqKey="Hansson A" first="A-S" last="Hansson">A-S Hansson</name></author><author><name sortKey="Lu, S" sort="Lu, S" uniqKey="Lu S" first="S" last="Lu">S. Lu</name></author><author><name sortKey="Holmdahl, R" sort="Holmdahl, R" uniqKey="Holmdahl R" first="R" last="Holmdahl">R. Holmdahl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">11882030</idno><idno type="pmc">1906294</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906294</idno><idno type="RBID">PMC:1906294</idno><idno type="doi">10.1046/j.1365-2249.2002.01712.x</idno><date when="2002">2002</date><idno type="wicri:Area/Pmc/Corpus">000688</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000688</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models</title><author><name sortKey="Hansson, A S" sort="Hansson, A S" uniqKey="Hansson A" first="A-S" last="Hansson">A-S Hansson</name></author><author><name sortKey="Lu, S" sort="Lu, S" uniqKey="Lu S" first="S" last="Lu">S. Lu</name></author><author><name sortKey="Holmdahl, R" sort="Holmdahl, R" uniqKey="Holmdahl R" first="R" last="Holmdahl">R. Holmdahl</name></author></analytic><series><title level="j">Clinical and Experimental Immunology</title><idno type="ISSN">0009-9104</idno><idno type="eISSN">1365-2249</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A, LEW.1F and DA rats). We found that nasal and tracheolaryngeal cartilage is affected in LEW.1 A and DA rats to varying degrees in collagen-induced arthritis but not in any strain in the pristane-induced model. Antibodies to matrilin-1, a cartilage-specific protein expressed mainly in tracheolaryngeal and nasal cartilage but not in joints, were positively associated with the presence of inflammation in nasal cartilage. In contrast, no antibody response to matrilin-1 could be detected in pristane-induced arthritis. In addition, nasal vaccination with collagen type II prior to immunization in DA rats significantly decreased the antibody response to matrilin-1 at day 56, but not at earlier time points, indicating a late protective effect on extra-articular cartilage. We conclude that pristane-induced arthritis is a joint-specific model whereas collagen-induced arthritis affect joints as well as extra-articular cartilage. Furthermore, collagen immunization induces an antibody response to matrilin-1.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Exp Immunol</journal-id><journal-id journal-id-type="publisher-id">cei</journal-id><journal-title>Clinical and Experimental Immunology</journal-title><issn pub-type="ppub">0009-9104</issn><issn pub-type="epub">1365-2249</issn><publisher><publisher-name>Blackwell Science Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">11882030</article-id><article-id pub-id-type="pmc">1906294</article-id><article-id pub-id-type="doi">10.1046/j.1365-2249.2002.01712.x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Animal Studies</subject></subj-group></article-categories><title-group><article-title>Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hansson</surname><given-names>A-S</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>S</given-names></name></contrib><contrib contrib-type="author"><name><surname>Holmdahl</surname><given-names>R</given-names></name></contrib><aff><institution>Medical Inflammation Research, Biomedical Center, Lund University</institution><addr-line>Lund, Sweden</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Correspondence: Ann-Sofie Hansson, Medical Inflammation Research, Sölvegatan 19, I11 BMC, Lund University, S-22184 Lund, Sweden. E-mail: <email>Ann-Sofie.Hansson@inflam.lu.se</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2002</year></pub-date><volume>127</volume><issue>1</issue><fpage>37</fpage><lpage>42</lpage><history><date date-type="accepted"><day>04</day><month>9</month><year>2001</year></date></history><copyright-statement>© 2002 Blackwell Science Ltd</copyright-statement><copyright-year>2002</copyright-year><abstract><p>Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A, LEW.1F and DA rats). We found that nasal and tracheolaryngeal cartilage is affected in LEW.1 A and DA rats to varying degrees in collagen-induced arthritis but not in any strain in the pristane-induced model. Antibodies to matrilin-1, a cartilage-specific protein expressed mainly in tracheolaryngeal and nasal cartilage but not in joints, were positively associated with the presence of inflammation in nasal cartilage. In contrast, no antibody response to matrilin-1 could be detected in pristane-induced arthritis. In addition, nasal vaccination with collagen type II prior to immunization in DA rats significantly decreased the antibody response to matrilin-1 at day 56, but not at earlier time points, indicating a late protective effect on extra-articular cartilage. We conclude that pristane-induced arthritis is a joint-specific model whereas collagen-induced arthritis affect joints as well as extra-articular cartilage. Furthermore, collagen immunization induces an antibody response to matrilin-1.</p></abstract><kwd-group><kwd>arthritis</kwd><kwd>CIA</kwd><kwd>collagen</kwd><kwd>matrilin-1</kwd><kwd>PIA</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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