Duration of challenge immunity to coronavirus JHM in mice
Identifieur interne : 000183 ( Pmc/Corpus ); précédent : 000182; suivant : 000184Duration of challenge immunity to coronavirus JHM in mice
Auteurs : S. W. Barthold ; Abigail L. SmithSource :
- Archives of Virology [ 0304-8608 ] ; 1989.
Abstract
The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalance of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.
Url:
DOI: 10.1007/BF01317914
PubMed: 2554852
PubMed Central: 7087252
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Duration of challenge immunity to coronavirus JHM in mice</title><author><name sortKey="Barthold, S W" sort="Barthold, S W" uniqKey="Barthold S" first="S. W." last="Barthold">S. W. Barthold</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Smith, Abigail L" sort="Smith, Abigail L" uniqKey="Smith A" first="Abigail L." last="Smith">Abigail L. Smith</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">2554852</idno><idno type="pmc">7087252</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087252</idno><idno type="RBID">PMC:7087252</idno><idno type="doi">10.1007/BF01317914</idno><date when="1989">1989</date><idno type="wicri:Area/Pmc/Corpus">000183</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Duration of challenge immunity to coronavirus JHM in mice</title><author><name sortKey="Barthold, S W" sort="Barthold, S W" uniqKey="Barthold S" first="S. W." last="Barthold">S. W. Barthold</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Smith, Abigail L" sort="Smith, Abigail L" uniqKey="Smith A" first="Abigail L." last="Smith">Abigail L. Smith</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><date when="1989">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalance of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barthold, Sw" uniqKey="Barthold S">SW Barthold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barthold, Sw" uniqKey="Barthold S">SW Barthold</name></author><author><name sortKey="Beck, Ds" uniqKey="Beck D">DS Beck</name></author><author><name sortKey="Smith, Al" uniqKey="Smith A">AL Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barthold, Sw" uniqKey="Barthold S">SW Barthold</name></author><author><name sortKey="Smith, Al" uniqKey="Smith A">AL Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barthold, S" uniqKey="Barthold S">S Barthold</name></author><author><name sortKey="Smith, Al" uniqKey="Smith A">AL Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frith, Ch" uniqKey="Frith C">CH Frith</name></author><author><name sortKey="Ward, Jm" uniqKey="Ward J">JM Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hummel, Kp" uniqKey="Hummel K">KP Hummel</name></author><author><name sortKey="Richardson, Fl" uniqKey="Richardson F">FL Richardson</name></author><author><name sortKey="Fekete, E" uniqKey="Fekete E">E Fekete</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Al" uniqKey="Smith A">AL Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Al" uniqKey="Smith A">AL Smith</name></author><author><name sortKey="Winograd, Df" uniqKey="Winograd D">DF Winograd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wege, H" uniqKey="Wege H">H Wege</name></author><author><name sortKey="Siddell, S" uniqKey="Siddell S">S Siddell</name></author><author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V ter Meulen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Arch Virol</journal-id><journal-id journal-id-type="iso-abbrev">Arch. Virol</journal-id><journal-title-group><journal-title>Archives of Virology</journal-title></journal-title-group><issn pub-type="ppub">0304-8608</issn><issn pub-type="epub">1432-8798</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Vienna</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">2554852</article-id><article-id pub-id-type="pmc">7087252</article-id><article-id pub-id-type="publisher-id">BF01317914</article-id><article-id pub-id-type="doi">10.1007/BF01317914</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Papers</subject></subj-group></article-categories><title-group><article-title>Duration of challenge immunity to coronavirus JHM in mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Barthold</surname><given-names>S. W.</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Abigail L.</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.47100.32</institution-id><institution-id institution-id-type="ISNI">0000000419368710</institution-id><institution>Section of Compariative Medicine,</institution><institution>Yale University School of Medicine,</institution></institution-wrap>New Haven, Connecticut USA</aff></contrib-group><pub-date pub-type="ppub"><year>1989</year></pub-date><volume>107</volume><issue>3</issue><fpage>171</fpage><lpage>177</lpage><history><date date-type="received"><day>15</day><month>5</month><year>1989</year></date><date date-type="accepted"><day>3</day><month>7</month><year>1989</year></date></history><permissions><copyright-statement>© Springer-Verlag 1989</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><title>Summary</title><p>The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalance of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Hepatitis</kwd><kwd>Infectious Disease</kwd><kwd>Tissue Culture</kwd><kwd>Lymphoid Tissue</kwd><kwd>Hepatitis Virus</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag 1989</meta-value></custom-meta></custom-meta-group></article-meta></front><back><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barthold</surname><given-names>SW</given-names></name></person-group><article-title>Olfactory neural pathway in mouse hepatitis virus nasoencephalitis</article-title><source>Acta Neuropathol</source><year>1988</year><volume>76</volume><fpage>502</fpage><lpage>506</lpage><pub-id 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