Interleukin-35 as an Emerging Player in Tumor Microenvironment
Identifieur interne : 000249 ( Pmc/Checkpoint ); précédent : 000248; suivant : 000250Interleukin-35 as an Emerging Player in Tumor Microenvironment
Auteurs : Wenhua Xue [République populaire de Chine] ; Dan Yan [République populaire de Chine] ; Quancheng Kan [République populaire de Chine]Source :
- Journal of Cancer [ 1837-9664 ] ; 2019.
Abstract
IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate subunits has manifested suppressive actions on immune system, which is counterproductive in the context of cancers. Various reports have confirmed its inhibitory role on immune system which is carried out via formation of IL-35-producing regulatory T cells (iTr35), increased Treg development and suppressive Th17 cells growth. Although last decade has seen a great deal of scientific interest on this subject, the exact role, precise signal transduction and elaborative functions of IL-35 in tumor microenvironment (TME) remained elusive. Search for anti-IL-35 therapies have exhibited limited success in animal models. Contrarily, few studies have denied the idea that IL-35 plays a role in cancer. The purpose of this review is to analyze the reported scientific data on continuous symphony of IL-35 in cancers since the inception of former.
Url:
DOI: 10.7150/jca.29170
PubMed: 31205568
PubMed Central: 6548173
Affiliations:
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sortKey="Xue, Wenhua" sort="Xue, Wenhua" uniqKey="Xue W" first="Wenhua" last="Xue">Wenhua Xue</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan</wicri:regionArea><wicri:noRegion>Henan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou</wicri:regionArea><wicri:noRegion>Zhengzhou</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Dan" sort="Yan, Dan" uniqKey="Yan D" first="Dan" last="Yan">Dan Yan</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan</wicri:regionArea><wicri:noRegion>Henan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou</wicri:regionArea><wicri:noRegion>Zhengzhou</wicri:noRegion></affiliation></author><author><name sortKey="Kan, Quancheng" sort="Kan, Quancheng" uniqKey="Kan Q" first="Quancheng" last="Kan">Quancheng Kan</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan</wicri:regionArea><wicri:noRegion>Henan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou</wicri:regionArea><wicri:noRegion>Zhengzhou</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Cancer</title><idno type="eISSN">1837-9664</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate subunits has manifested suppressive actions on immune system, which is counterproductive in the context of cancers. Various reports have confirmed its inhibitory role on immune system which is carried out via formation of IL-35-producing regulatory T cells (iTr35), increased Treg development and suppressive Th17 cells growth. Although last decade has seen a great deal of scientific interest on this subject, the exact role, precise signal transduction and elaborative functions of IL-35 in tumor microenvironment (TME) remained elusive. Search for anti-IL-35 therapies have exhibited limited success in animal models. Contrarily, few studies have denied the idea that IL-35 plays a role in cancer. The purpose of this review is to analyze the reported scientific data on continuous symphony of IL-35 in cancers since the inception of former.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Su, Lc" uniqKey="Su L">LC Su</name></author><author><name sortKey="Liu, Xy" uniqKey="Liu X">XY Liu</name></author><author><name sortKey="Huang, Af" uniqKey="Huang A">AF Huang</name></author><author><name sortKey="Xu, Wd" uniqKey="Xu W">WD Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teymouri, M" uniqKey="Teymouri M">M Teymouri</name></author><author><name sortKey="Pirro, M" uniqKey="Pirro M">M Pirro</name></author><author><name sortKey="Fallarino, F" uniqKey="Fallarino F">F Fallarino</name></author><author><name sortKey="Gargaro, M" uniqKey="Gargaro M">M Gargaro</name></author><author><name sortKey="Sahebkar, A" uniqKey="Sahebkar A">A 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">J Cancer</journal-id><journal-id journal-id-type="publisher-id">jca</journal-id><journal-title-group><journal-title>Journal of Cancer</journal-title></journal-title-group><issn pub-type="epub">1837-9664</issn><publisher><publisher-name>Ivyspring International Publisher</publisher-name><publisher-loc>Sydney</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31205568</article-id><article-id pub-id-type="pmc">6548173</article-id><article-id pub-id-type="doi">10.7150/jca.29170</article-id><article-id pub-id-type="publisher-id">jcav10p2074</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Interleukin-35 as an Emerging Player in Tumor Microenvironment</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xue</surname><given-names>Wenhua</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FNA_star">*</xref></contrib><contrib contrib-type="author"><name><surname>Yan</surname><given-names>Dan</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FNA_star">*</xref></contrib><contrib contrib-type="author"><name><surname>Kan</surname><given-names>Quancheng</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="FNA_envelop">✉</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China</aff><aff id="A2"><label>2</label>Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, China</aff><author-notes><corresp id="FNA_envelop">✉ Corresponding author: Quancheng Kan, Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou, Henan, PR China, E-mail: <email>kanqc@zzu.edu.cn</email>, Tel: +86 071 66913047</corresp><fn fn-type="equal" id="FNA_star"><p>*These authors contributed equally to this work.</p></fn><fn fn-type="COI-statement"><p>Competing Interests: The authors have declared that no competing interest exists.</p></fn></author-notes><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>12</day><month>5</month><year>2019</year></pub-date><volume>10</volume><issue>9</issue><fpage>2074</fpage><lpage>2082</lpage><history><date date-type="received"><day>12</day><month>8</month><year>2018</year></date><date date-type="accepted"><day>5</day><month>3</month><year>2019</year></date></history><permissions><copyright-statement>© Ivyspring International Publisher</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">https://creativecommons.org/licenses/by-nc/4.0/</ext-link>). See <ext-link ext-link-type="uri" xlink:href="http://ivyspring.com/terms">http://ivyspring.com/terms</ext-link> for full terms and conditions.</license-p></license></permissions><abstract><p>IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate subunits has manifested suppressive actions on immune system, which is counterproductive in the context of cancers. Various reports have confirmed its inhibitory role on immune system which is carried out via formation of IL-35-producing regulatory T cells (iTr35), increased Treg development and suppressive Th17 cells growth. Although last decade has seen a great deal of scientific interest on this subject, the exact role, precise signal transduction and elaborative functions of IL-35 in tumor microenvironment (TME) remained elusive. Search for anti-IL-35 therapies have exhibited limited success in animal models. Contrarily, few studies have denied the idea that IL-35 plays a role in cancer. The purpose of this review is to analyze the reported scientific data on continuous symphony of IL-35 in cancers since the inception of former.</p></abstract><kwd-group><kwd>IL-35</kwd><kwd>Cancer</kwd><kwd>Tumor microenvironment</kwd><kwd>Treg</kwd><kwd>Th17</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" position="float"><label>Figure 1</label><caption><p>Cells secreting IL-35 and overview of IL-35 signal transduction. IL-35 is secreted by variety of cells which then activates its receptors through JAK/STAT signaling to exert its anti-inflammatory and immunosuppressive effects.</p></caption><graphic xlink:href="jcav10p2074g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Signal transduction and tumorigenic effects of IL-35. IL-35 receptor consists of gp130 and IL-12Rβ2 which upon activation phosphorylates STAT signaling. IL-35 suppresses the conventional T cells and promotes its conversion into iTr35 which plays vital role in tumor immune evasion as they inhibit various immune responses owing to suppressive IL-35. Similarly pro-tumor activities are enhanced by the development of Treg cells and inhibition of Th17 responses.</p></caption><graphic xlink:href="jcav10p2074g002"></graphic></fig></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xue, Wenhua" sort="Xue, Wenhua" uniqKey="Xue W" first="Wenhua" last="Xue">Wenhua Xue</name></noRegion><name sortKey="Kan, Quancheng" sort="Kan, Quancheng" uniqKey="Kan Q" first="Quancheng" last="Kan">Quancheng Kan</name><name sortKey="Kan, Quancheng" sort="Kan, Quancheng" uniqKey="Kan Q" first="Quancheng" last="Kan">Quancheng Kan</name><name sortKey="Xue, Wenhua" sort="Xue, Wenhua" uniqKey="Xue W" first="Wenhua" last="Xue">Wenhua Xue</name><name sortKey="Yan, Dan" sort="Yan, Dan" uniqKey="Yan D" first="Dan" last="Yan">Dan Yan</name><name sortKey="Yan, Dan" sort="Yan, Dan" uniqKey="Yan D" first="Dan" last="Yan">Dan Yan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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