CovidV2, PascalFrancis, Corpus, bibRecord, 000007

Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome

Identifieur interne : 000007 ( PascalFrancis/Corpus ); précédent : 000006; suivant : 000008

Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome

Auteurs : A. Kaparianos ; E. Argyropoulou

Source :

Current medicinal chemistry [ 0929-8673 ] ; 2011.

RBID : Pascal:12-0238940

Descripteurs français

Pascal (Inist)
- Système renin angiotensine, Angiotensine II, Peptidyl-dipeptidase A, Pathogénie, Bronchopneumopathie chronique obstructive, Hypertension artérielle pulmonaire, Syndrome de détresse respiratoire de l'adulte, Asthme, Article synthèse.

English descriptors

KwdEn :
- Adult respiratory distress syndrome, Angiotensin II, Asthma, Chronic obstructive pulmonary disease, Pathogenesis, Peptidyl-dipeptidase A, Pulmonary hypertension, Renin angiotensin system, Review.

Abstract

Renin-angiotensin II-aldosterone axis has long been known as a regulator of blood pressure and fluid homeostasis. Yet, local renin-angiotensin II systems have been discovered and novel actions of angiotensin II (AngII) have emerged among which its ability to act as a immunomodulator and profibrotic molecule. The enzyme responsible for its synthesis, Angiotensin-converting-enzyme (ACE), is present in high concentrations in lung tissue. In the present paper, we review data from studies of the past decade that implicate AngII and functional polymorphisms of the ACE gene that increase ACE activity with increased susceptibility for asthma and chronic obstructive pulmonary disease (COPD) and for pulmonary hypertension. Moreover, drugs that inhibit the synthesis of AngII (ACE inhibitors) or that antagonize its actions on its receptors (Angiotensin II receptor blockers -ARBs) have been shown to provide beneficial effects. Another recent discovery reviewed is the presence of a homologue of ACE, ACE2, which cleaves a single amino acid from AngII and forms a heptapeptide with vasodilatory actions, Ang 1-7. The balance between ACE and ACE2 is crucial for controlling AngII levels. ACE and ACE2 also appear to modify the severity of Acute Respiratory Distress Syndrome (ARDS), with ACE2 playing a protective role. Finally, mention is made to the recent discovery of ACE2 as a receptor for the SARS Corona Virus.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 12-0238940 INIST
ET :	Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome
AU :	KAPARIANOS (A.); ARGYROPOULOU (E.)
AF :	University of Patras, School of Medicine, Division of Pulmonology/Patras/Grèce (1 aut., 2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Current medicinal chemistry; ISSN 0929-8673; Etats-Unis; Da. 2011; Vol. 18; No. 23; Pp. 3506-3515; Bibl. 184 ref.
LA :	Anglais
EA :	Renin-angiotensin II-aldosterone axis has long been known as a regulator of blood pressure and fluid homeostasis. Yet, local renin-angiotensin II systems have been discovered and novel actions of angiotensin II (AngII) have emerged among which its ability to act as a immunomodulator and profibrotic molecule. The enzyme responsible for its synthesis, Angiotensin-converting-enzyme (ACE), is present in high concentrations in lung tissue. In the present paper, we review data from studies of the past decade that implicate AngII and functional polymorphisms of the ACE gene that increase ACE activity with increased susceptibility for asthma and chronic obstructive pulmonary disease (COPD) and for pulmonary hypertension. Moreover, drugs that inhibit the synthesis of AngII (ACE inhibitors) or that antagonize its actions on its receptors (Angiotensin II receptor blockers -ARBs) have been shown to provide beneficial effects. Another recent discovery reviewed is the presence of a homologue of ACE, ACE2, which cleaves a single amino acid from AngII and forms a heptapeptide with vasodilatory actions, Ang 1-7. The balance between ACE and ACE2 is crucial for controlling AngII levels. ACE and ACE2 also appear to modify the severity of Acute Respiratory Distress Syndrome (ARDS), with ACE2 playing a protective role. Finally, mention is made to the recent discovery of ACE2 as a receptor for the SARS Corona Virus.
CC :	002B11C; 002B11B
FD :	Système renin angiotensine; Angiotensine II; Peptidyl-dipeptidase A; Pathogénie; Bronchopneumopathie chronique obstructive; Hypertension artérielle pulmonaire; Syndrome de détresse respiratoire de l'adulte; Asthme; Article synthèse
FG :	Peptidyl-dipeptidases; Peptidases; Hydrolases; Enzyme; Pathologie de l'appareil circulatoire; Pathologie de l'appareil respiratoire; Bronchopneumopathie obstructive; Pathologie des bronches; Pathologie des poumons; Peptide
ED :	Renin angiotensin system; Angiotensin II; Peptidyl-dipeptidase A; Pathogenesis; Chronic obstructive pulmonary disease; Pulmonary hypertension; Adult respiratory distress syndrome; Asthma; Review
EG :	Peptidyl-dipeptidases; Peptidases; Hydrolases; Enzyme; Cardiovascular disease; Respiratory disease; Obstructive pulmonary disease; Bronchus disease; Lung disease; Peptides
SD :	Sistema renin angiotensina; Angiotensina II; Peptidyl-dipeptidase A; Patogenia; Enfermedad pulmonar obstructiva crónica; Hipertensión arterial pulmonar; Trastorno respiratorio adulto síndrome; Asma; Artículo síntesis
LO :	INIST-22999.354000191160120100
ID :	12-0238940

Links to Exploration step

Pascal:12-0238940

Le document en format XML

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<fC03 i1="07" i2="X" l="ENG"><s0>Adult respiratory distress syndrome</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Trastorno respiratorio adulto síndrome</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Asthme</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Asthma</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Asma</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Article synthèse</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Review</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Artículo síntesis</s0>
<s5>09</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Peptidyl-dipeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Peptidyl-dipeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Peptidyl-dipeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>54</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>54</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>54</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>55</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>55</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>55</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Bronchopneumopathie obstructive</s0>
<s5>56</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Obstructive pulmonary disease</s0>
<s5>56</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Enfermedad pulmonar obstructiva</s0>
<s5>56</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Pathologie des bronches</s0>
<s5>57</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Bronchus disease</s0>
<s5>57</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Bronquio patología</s0>
<s5>57</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Pathologie des poumons</s0>
<s5>58</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>58</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>58</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Peptide</s0>
<s5>59</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Peptides</s0>
<s5>59</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Péptido</s0>
<s5>59</s5>
</fC07>
<fN21><s1>184</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 12-0238940 INIST</NO>
<ET>Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome</ET>
<AU>KAPARIANOS (A.); ARGYROPOULOU (E.)</AU>
<AF>University of Patras, School of Medicine, Division of Pulmonology/Patras/Grèce (1 aut., 2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Current medicinal chemistry; ISSN 0929-8673; Etats-Unis; Da. 2011; Vol. 18; No. 23; Pp. 3506-3515; Bibl. 184 ref.</SO>
<LA>Anglais</LA>
<EA>Renin-angiotensin II-aldosterone axis has long been known as a regulator of blood pressure and fluid homeostasis. Yet, local renin-angiotensin II systems have been discovered and novel actions of angiotensin II (AngII) have emerged among which its ability to act as a immunomodulator and profibrotic molecule. The enzyme responsible for its synthesis, Angiotensin-converting-enzyme (ACE), is present in high concentrations in lung tissue. In the present paper, we review data from studies of the past decade that implicate AngII and functional polymorphisms of the ACE gene that increase ACE activity with increased susceptibility for asthma and chronic obstructive pulmonary disease (COPD) and for pulmonary hypertension. Moreover, drugs that inhibit the synthesis of AngII (ACE inhibitors) or that antagonize its actions on its receptors (Angiotensin II receptor blockers -ARBs) have been shown to provide beneficial effects. Another recent discovery reviewed is the presence of a homologue of ACE, ACE2, which cleaves a single amino acid from AngII and forms a heptapeptide with vasodilatory actions, Ang 1-7. The balance between ACE and ACE2 is crucial for controlling AngII levels. ACE and ACE2 also appear to modify the severity of Acute Respiratory Distress Syndrome (ARDS), with ACE2 playing a protective role. Finally, mention is made to the recent discovery of ACE2 as a receptor for the SARS Corona Virus.</EA>
<CC>002B11C; 002B11B</CC>
<FD>Système renin angiotensine; Angiotensine II; Peptidyl-dipeptidase A; Pathogénie; Bronchopneumopathie chronique obstructive; Hypertension artérielle pulmonaire; Syndrome de détresse respiratoire de l'adulte; Asthme; Article synthèse</FD>
<FG>Peptidyl-dipeptidases; Peptidases; Hydrolases; Enzyme; Pathologie de l'appareil circulatoire; Pathologie de l'appareil respiratoire; Bronchopneumopathie obstructive; Pathologie des bronches; Pathologie des poumons; Peptide</FG>
<ED>Renin angiotensin system; Angiotensin II; Peptidyl-dipeptidase A; Pathogenesis; Chronic obstructive pulmonary disease; Pulmonary hypertension; Adult respiratory distress syndrome; Asthma; Review</ED>
<EG>Peptidyl-dipeptidases; Peptidases; Hydrolases; Enzyme; Cardiovascular disease; Respiratory disease; Obstructive pulmonary disease; Bronchus disease; Lung disease; Peptides</EG>
<SD>Sistema renin angiotensina; Angiotensina II; Peptidyl-dipeptidase A; Patogenia; Enfermedad pulmonar obstructiva crónica; Hipertensión arterial pulmonar; Trastorno respiratorio adulto síndrome; Asma; Artículo síntesis</SD>
<LO>INIST-22999.354000191160120100</LO>
<ID>12-0238940</ID>
</server>
</inist>
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Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome

Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome

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